M D Holmes

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Sleep apnea and excessive daytime somnolence induced by vagal nerve stimulation
    Mark D Holmes
    Department of Neurology, University of Washington School of Medicine, Seattle, USA
    Neurology 61:1126-9. 2003
  2. ncbi request reprint Does hyperventilation elicit epileptic seizures?
    Mark D Holmes
    Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington 98104, USA
    Epilepsia 45:618-20. 2004
  3. ncbi request reprint Effect of vagus nerve stimulation on adults with pharmacoresistant generalized epilepsy syndromes
    Mark D Holmes
    Department of Neurology, University of Washington Regional Epilepsy Center, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104 2419, USA
    Seizure 13:340-5. 2004
  4. ncbi request reprint Predicting outcome following reoperation for medically intractable epilepsy
    M D Holmes
    Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
    Seizure 8:103-6. 1999
  5. ncbi request reprint Are "generalized" seizures truly generalized? Evidence of localized mesial frontal and frontopolar discharges in absence
    Mark D Holmes
    Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington 98006, USA
    Epilepsia 45:1568-79. 2004
  6. doi request reprint Dense array EEG: methodology and new hypothesis on epilepsy syndromes
    Mark D Holmes
    Regional Epilepsy Center, Department of Neurology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    Epilepsia 49:3-14. 2008
  7. doi request reprint Localization of extratemporal seizure with noninvasive dense-array EEG. Comparison with intracranial recordings
    Mark D Holmes
    Department of Neurology, University of Washington, Seattle, WA 98105, USA
    Pediatr Neurosurg 44:474-9. 2008
  8. doi request reprint Evidence that juvenile myoclonic epilepsy is a disorder of frontotemporal corticothalamic networks
    Mark D Holmes
    Regional Epilepsy Center, Department of Neurology, University of Washington Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98006, USA
    Neuroimage 49:80-93. 2010
  9. doi request reprint Comparing noninvasive dense array and intracranial electroencephalography for localization of seizures
    Mark D Holmes
    Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington 98104, USA
    Neurosurgery 66:354-62. 2010
  10. ncbi request reprint Identifying potential surgical candidates in patients with evidence of bitemporal epilepsy
    Mark D Holmes
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    Epilepsia 44:1075-9. 2003

Detail Information

Publications39

  1. ncbi request reprint Sleep apnea and excessive daytime somnolence induced by vagal nerve stimulation
    Mark D Holmes
    Department of Neurology, University of Washington School of Medicine, Seattle, USA
    Neurology 61:1126-9. 2003
    ..The authors present a patient who developed excessive daytime sleepiness after VNS placement, as a consequence of apneas and arousals associated with intermittent electrical stimulation of the left vagus nerve...
  2. ncbi request reprint Does hyperventilation elicit epileptic seizures?
    Mark D Holmes
    Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington 98104, USA
    Epilepsia 45:618-20. 2004
    ..This study was undertaken to determine the effects of hyperventilation in patients with proven epilepsy...
  3. ncbi request reprint Effect of vagus nerve stimulation on adults with pharmacoresistant generalized epilepsy syndromes
    Mark D Holmes
    Department of Neurology, University of Washington Regional Epilepsy Center, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104 2419, USA
    Seizure 13:340-5. 2004
    ..This Investigational Device Exemption assessed the outcome of VNS therapy among patients with generalized epilepsy syndromes...
  4. ncbi request reprint Predicting outcome following reoperation for medically intractable epilepsy
    M D Holmes
    Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
    Seizure 8:103-6. 1999
    ..Furthermore, we may be able to identify those individuals most likely to have an excellent result from a second operation...
  5. ncbi request reprint Are "generalized" seizures truly generalized? Evidence of localized mesial frontal and frontopolar discharges in absence
    Mark D Holmes
    Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington 98006, USA
    Epilepsia 45:1568-79. 2004
    ..To determine whether specific regions of cerebral cortex are activated at the onset and during the propagation of absence seizures...
  6. doi request reprint Dense array EEG: methodology and new hypothesis on epilepsy syndromes
    Mark D Holmes
    Regional Epilepsy Center, Department of Neurology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    Epilepsia 49:3-14. 2008
    ..Future research will determine if the method will reduce the need for invasive EEG recordings, or assist in the appropriate placement of novel treatment devices...
  7. doi request reprint Localization of extratemporal seizure with noninvasive dense-array EEG. Comparison with intracranial recordings
    Mark D Holmes
    Department of Neurology, University of Washington, Seattle, WA 98105, USA
    Pediatr Neurosurg 44:474-9. 2008
    ..Noninvasive dense-array EEG, used in conjunction with realistic source analysis methods, may have the potential to assist in localizing seizure onsets when standard methods fail...
  8. doi request reprint Evidence that juvenile myoclonic epilepsy is a disorder of frontotemporal corticothalamic networks
    Mark D Holmes
    Regional Epilepsy Center, Department of Neurology, University of Washington Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98006, USA
    Neuroimage 49:80-93. 2010
    ..Rather, discharges have both localized onsets and a restricted cortical network during propagation that includes regions of frontal and temporal cortex...
  9. doi request reprint Comparing noninvasive dense array and intracranial electroencephalography for localization of seizures
    Mark D Holmes
    Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington 98104, USA
    Neurosurgery 66:354-62. 2010
    ....
  10. ncbi request reprint Identifying potential surgical candidates in patients with evidence of bitemporal epilepsy
    Mark D Holmes
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    Epilepsia 44:1075-9. 2003
    ..To determine which patients with evidence of medically refractory bitemporal epilepsy are potentially good candidates for surgical therapy...
  11. ncbi request reprint Outcome after surgery in patients with refractory temporal lobe epilepsy and normal MRI
    M D Holmes
    Regional Epilepsy Center, University of Washington, Seattle, 98104, USA
    Seizure 9:407-11. 2000
    ..Unfavorable outcomes are most likely to occur when ictal origins are from mid-posterior temporal regions and when interictal discharges are bitemporal or multifocal in distribution...
  12. ncbi request reprint Is the left cerebral hemisphere more prone to epileptogenesis than the right?
    M D Holmes
    EEG and Clinical Neurophysiology Laboratory, Harborview Medical Center, Box 359722, 325 Ninth Ave, Seattle, Washington, USA
    Epileptic Disord 3:137-41. 2001
    ..To determine if there is evidence that the left cerebral hemisphere is more prone to epileptogenesis than the right hemisphere...
  13. ncbi request reprint Interictal, unifocal spikes in refractory extratemporal epilepsy predict ictal origin and postsurgical outcome
    M D Holmes
    Regional Epilepsy Center, University of Washington School of Medicine, WA, Seattle, USA
    Clin Neurophysiol 111:1802-8. 2000
    ..To evaluate the significance of exclusively unifocal, unilateral, interictal epileptiform patterns on scalp electroencephalography (EEG) in surgical candidates with medically intractable extratemporal epilepsy...
  14. ncbi request reprint The absence of interictal spikes with documented seizures suggests extratemporal epilepsy
    O Stuve
    Regional Epilepsy Center, University of Washington, Harborview Medical Center, 325 9th Ave, Seattle, WA 98104 2499, U S A
    Epilepsia 42:778-81. 2001
    ..To determine the demographic and clinical characteristics of patients who have documented epileptic seizures on long-term video-EEG monitoring who do not have interictal spikes...
  15. ncbi request reprint Very slow EEG responses lateralize temporal lobe seizures: an evaluation of non-invasive DC-EEG
    S Vanhatalo
    Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle 98104, USA
    Neurology 60:1098-104. 2003
    ....
  16. ncbi request reprint Topography and elimination of slow EEG responses related to tongue movements
    S Vanhatalo
    Regional Epilepsy Center, Departments of Neurology and Neurological Surgery, University of Washington, Seattle, WA, USA
    Neuroimage 20:1419-23. 2003
    ..The topography and small amplitude of TMPs make their off-line rejection difficult, while an isolation method of the kind used here may substantially diminish TMP artifacts in studies on slow cognitive potentials...
  17. ncbi request reprint Vagal nerve stimulation induces intermittent hypocapnia
    Mark D Holmes
    Department of Neurology, Regional Epilepsy Center, University of Washington, Seattle, WA, U S A
    Epilepsia 44:1588-91. 2003
    ..To study whether respiratory alteration caused by vagal nerve stimulation (VNS) can change end-tidal carbon dioxide (EtCO2) levels...
  18. ncbi request reprint Age at focal epilepsy onset varies by sex and hemispheric lateralization
    M J Doherty
    Regional Epilepsy Center and Department of Neurology, University of Washington, Seattle 98195, USA
    Neurology 60:1473-7. 2003
    ..This may be due to sex-influenced asymmetric brain maturation. To clarify this relationship, the authors analyzed age at epilepsy onset by sex and by lateralization of epileptiform activity...
  19. doi request reprint Comparative analysis of temporal dynamics of EEG and phase synchronization of EEG to localize epileptic sites from high density scalp EEG interictal recordings
    Ceon Ramon
    Department of Neurology, University of Washington, Seattle, 98195, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:4548-50. 2008
    ..It was found that the LRTC of SI was highest at the location of the epileptic sites. A similar pattern was not found in the LRTC of EEGs. This provides a noninvasive way to localize seizure areas from scalp EEG data...
  20. ncbi request reprint Cognitive impairment is not equal in patients with epileptic and psychogenic nonepileptic seizures
    Daniel L Drane
    Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Epilepsia 47:1879-86. 2006
    ..We reexamined neurocognitive function in patients with ESs and PNES by using symptom validity testing to control for variability in effort...
  21. ncbi request reprint Dexmedetomidine sedation during awake craniotomy for seizure resection: effects on electrocorticography
    Michael J Souter
    Department of Anesthesiology, University of Washington, Seattle 98104, USA
    J Neurosurg Anesthesiol 19:38-44. 2007
    ..Individual dose ranges vary, but a bolus of 0.3 mcg kg-1 with an infusion of 0.2 mcg kg-1 min-1 is a good starting point, allowing accurate mapping of epileptic foci and subsequent resection...
  22. ncbi request reprint Ictal localization by source analysis of infraslow activity in DC-coupled scalp EEG recordings
    John W Miller
    Regional Epilepsy Center, Department of Neurology, University of Washington Regional Epilepsy Center, Box 359745, 325 Ninth Ave, Seattle, WA 98104, USA
    Neuroimage 35:583-97. 2007
    ..The value of this method is increased by source analysis tools that reveal localized changes more clearly than direct visual inspection...
  23. doi request reprint Localization and classification of phonemes using high spatial resolution electrocorticography (ECoG) grids
    Timothy Blakely
    University of Washington, Bioengineering Department, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:4964-7. 2008
    ..In addition, we found that sub-regions of our miniature array were specific for distinct pairs of phonemes, showing that cortical phoneme processing occurs at a higher resolution than previously though...
  24. ncbi request reprint Deblurring visual evoked potentials using commercially available software
    Paul A Zarkowski
    University of Washington, Seattle, WA 98195, USA
    Comput Methods Programs Biomed 82:81-5. 2006
    ..After deblurring, the visual evoked potentials were only found at the electrodes closest to the visual cortex, as would be predicted by our current knowledge of neuroanatomy...
  25. ncbi request reprint Determination of language dominance with near-infrared spectroscopy: comparison with the intracarotid amobarbital procedure
    Nathaniel F Watson
    Department of Neurology, University of Washington Regional Epilepsy Center, Box 359745, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    Seizure 13:399-402. 2004
    ....
  26. ncbi request reprint Do nonspecific focal EEG slowing and epileptiform abnormalities favor one hemisphere?
    Michael J Doherty
    Department of Neurology and Regional Epilepsy Center, University of Washington, Seattle, Washington 98195, USA
    Epilepsia 43:1593-5. 2002
    ..In contrast, other pathophysiologies such as stroke lateralize relatively symmetrically. Study of focal slowing and other EEG abnormalities allows assessment of favoring as well as referral and interpretation bias...
  27. ncbi request reprint Long-term seizure monitoring using a 256 contact dense array system
    Paul Thompson
    Regional Epilepsy Center, University of Washington, Seattle, Washington, USA
    Am J Electroneurodiagnostic Technol 48:93-106. 2008
    ..Areas of concern are patient comfort, electrode maintenance, and increased time for record review...
  28. ncbi request reprint Factors predicting outcome of surgery for intractable epilepsy with pathologically verified mesial temporal sclerosis
    Steven G Hardy
    Department of Neurology, Regional Epilepsy Center, University of Washington School of Medicine, Seattle, Washington, USA
    Epilepsia 44:565-8. 2003
    ....
  29. ncbi request reprint Singing seizures
    M J Doherty
    Regional Epilepsy Center, Harborview Medical Center, University of Washington, Seattle, WA 98195, USA
    Neurology 59:1435-8. 2002
    ..Complex automatisms are less common and striking. The authors report two cases of seizure-associated singing where song expression may be recognizable...
  30. ncbi request reprint Valproate therapy for prevention of posttraumatic seizures: a randomized trial
    N R Temkin
    Department of Neurological Surgery, University of Washington, Seattle 98104 2499, USA
    J Neurosurg 91:593-600. 1999
    ..In this study the authors compare the safety and effectiveness of valproate with those of short-term phenytoin for prevention of seizures following traumatic brain injury...
  31. ncbi request reprint Vagus nerve stimulation does not lead to significant changes in body weight in patients with epilepsy
    Mikhail S Koren
    Division of Endocrinology, Department of Medicine, University of Washington, Seattle, WA, USA
    Epilepsy Behav 8:246-9. 2006
    ..The effect of this therapy on body weight is unclear. VNS could cause weight loss by engaging vagal afferents from the gastrointestinal tract mediating satiety...
  32. ncbi request reprint Flash visual evoked potentials predict visual outcome in traumatic optic neuropathy
    Mark D Holmes
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    Ophthal Plast Reconstr Surg 20:342-6. 2004
    ..To determine the significance of flash visual evoked potentials (FVEP) in the evaluation of patients with traumatic optic neuropathy (TON)...
  33. ncbi request reprint Discharges in ventromedial frontal cortex during absence spells
    Don M Tucker
    Electrical Geodesics, Inc, Riverfront Research Park, 1600 Millrace Drive, Suite 307, Eugene, OR 97403, USA
    Epilepsy Behav 11:546-57. 2007
    ..Disrupted in absence, this circuit appears to regulate important aspects of the voluntary control of conscious attention...
  34. ncbi request reprint Epileptogenic neocortical networks are revealed by abnormal temporal dynamics in seizure-free subdural EEG
    Simo Monto
    BioMag Laboratory, Helsinki University Central Hospital, FIN 00029 HUS, Finland
    Cereb Cortex 17:1386-93. 2007
    ..We propose that this method may become a promising candidate for routine invasive and noninvasive presurgical localization of epileptic foci...
  35. ncbi request reprint Fine spatiotemporal structure of phase in human intracranial EEG
    Walter J Freeman
    Department of Molecular and Cell Biology University of California at Berkeley, Berkeley, CA 94720 3206, USA
    Clin Neurophysiol 117:1228-43. 2006
    ..To transfer to the clinic for humans the technology and theory for high-resolution EEG analysis that have been developed in the laboratory with animals...
  36. ncbi request reprint Aperiodic phase re-setting in scalp EEG of beta-gamma oscillations by state transitions at alpha-theta rates
    Walter J Freeman
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    Hum Brain Mapp 19:248-72. 2003
    ..Cortex functions by serial changes in state. The Hilbert transform of EEG from high-density arrays can visualize these state transitions with high temporal and spatial resolution and should be useful in relating EEG to cognition...
  37. ncbi request reprint Spatial spectra of scalp EEG and EMG from awake humans
    Walter J Freeman
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, LSA 142, MC 3200, Berkeley, CA 94720, USA
    Clin Neurophysiol 114:1053-68. 2003
    ..Evaluate spectral scaling properties of scalp electroencephalogram (EEG) and electromyogram (EMG), optimal spacing of electrodes, and strategies for mitigating EMG...
  38. ncbi request reprint Metastability, instability, and state transition in neocortex
    Walter J Freeman
    University of California at Berkeley, Berkeley, CA 94720, USA
    Neural Netw 18:497-504. 2005
    ..A model based on the intentional action-perception cycle is proposed to complement the information processing model...