Research Topics
| M D HolmesSummaryAffiliation: University of Washington Country: USA Publications
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Detail Information
Publications
Sleep apnea and excessive daytime somnolence induced by vagal nerve stimulationMark D Holmes
Department of Neurology, University of Washington School of Medicine, Seattle, USA
Neurology 61:1126-9. 2003..The authors present a patient who developed excessive daytime sleepiness after VNS placement, as a consequence of apneas and arousals associated with intermittent electrical stimulation of the left vagus nerve...- Predicting outcome following reoperation for medically intractable epilepsyM D Holmes
Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
Seizure 8:103-6. 1999..Furthermore, we may be able to identify those individuals most likely to have an excellent result from a second operation... - Does hyperventilation elicit epileptic seizures?Mark D Holmes
Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington 98104, USA
Epilepsia 45:618-20. 2004..This study was undertaken to determine the effects of hyperventilation in patients with proven epilepsy... - Effect of vagus nerve stimulation on adults with pharmacoresistant generalized epilepsy syndromesMark D Holmes
Department of Neurology, University of Washington Regional Epilepsy Center, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104 2419, USA
Seizure 13:340-5. 2004..This Investigational Device Exemption assessed the outcome of VNS therapy among patients with generalized epilepsy syndromes... 
Comparing noninvasive dense array and intracranial electroencephalography for localization of seizuresMark D Holmes
Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington 98104, USA
Neurosurgery 66:354-62. 2010....- Are "generalized" seizures truly generalized? Evidence of localized mesial frontal and frontopolar discharges in absenceMark D Holmes
Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington 98006, USA
Epilepsia 45:1568-79. 2004..To determine whether specific regions of cerebral cortex are activated at the onset and during the propagation of absence seizures... - Dense array EEG: methodology and new hypothesis on epilepsy syndromesMark D Holmes
Regional Epilepsy Center, Department of Neurology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
Epilepsia 49:3-14. 2008..Future research will determine if the method will reduce the need for invasive EEG recordings, or assist in the appropriate placement of novel treatment devices... - Localization of extratemporal seizure with noninvasive dense-array EEG. Comparison with intracranial recordingsMark D Holmes
Department of Neurology, University of Washington, Seattle, WA 98105, USA
Pediatr Neurosurg 44:474-9. 2008..Noninvasive dense-array EEG, used in conjunction with realistic source analysis methods, may have the potential to assist in localizing seizure onsets when standard methods fail... - Evidence that juvenile myoclonic epilepsy is a disorder of frontotemporal corticothalamic networksMark D Holmes
Regional Epilepsy Center, Department of Neurology, University of Washington Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98006, USA
Neuroimage 49:80-93. 2010..Rather, discharges have both localized onsets and a restricted cortical network during propagation that includes regions of frontal and temporal cortex... - Identifying potential surgical candidates in patients with evidence of bitemporal epilepsyMark D Holmes
Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
Epilepsia 44:1075-9. 2003..To determine which patients with evidence of medically refractory bitemporal epilepsy are potentially good candidates for surgical therapy... - Is the left cerebral hemisphere more prone to epileptogenesis than the right?M D Holmes
EEG and Clinical Neurophysiology Laboratory, Harborview Medical Center, Box 359722, 325 Ninth Ave, Seattle, Washington, USA
Epileptic Disord 3:137-41. 2001..To determine if there is evidence that the left cerebral hemisphere is more prone to epileptogenesis than the right hemisphere... - Interictal, unifocal spikes in refractory extratemporal epilepsy predict ictal origin and postsurgical outcomeM D Holmes
Regional Epilepsy Center, University of Washington School of Medicine, WA, Seattle, USA
Clin Neurophysiol 111:1802-8. 2000..To evaluate the significance of exclusively unifocal, unilateral, interictal epileptiform patterns on scalp electroencephalography (EEG) in surgical candidates with medically intractable extratemporal epilepsy... - Outcome after surgery in patients with refractory temporal lobe epilepsy and normal MRIM D Holmes
Regional Epilepsy Center, University of Washington, Seattle, 98104, USA
Seizure 9:407-11. 2000..Unfavorable outcomes are most likely to occur when ictal origins are from mid-posterior temporal regions and when interictal discharges are bitemporal or multifocal in distribution... - The absence of interictal spikes with documented seizures suggests extratemporal epilepsyO Stuve
Regional Epilepsy Center, University of Washington, Harborview Medical Center, 325 9th Ave, Seattle, WA 98104 2499, U S A
Epilepsia 42:778-81. 2001..To determine the demographic and clinical characteristics of patients who have documented epileptic seizures on long-term video-EEG monitoring who do not have interictal spikes... - Very slow EEG responses lateralize temporal lobe seizures: an evaluation of non-invasive DC-EEGS Vanhatalo
Regional Epilepsy Center, Department of Neurology, University of Washington, Seattle 98104, USA
Neurology 60:1098-104. 2003..This method may hold promise in reducing the need for invasive monitoring in patients with TLE where other noninvasive tests are equivocal... - Topography and elimination of slow EEG responses related to tongue movementsS Vanhatalo
Regional Epilepsy Center, Departments of Neurology and Neurological Surgery, University of Washington, Seattle, WA, USA
Neuroimage 20:1419-23. 2003..The topography and small amplitude of TMPs make their off-line rejection difficult, while an isolation method of the kind used here may substantially diminish TMP artifacts in studies on slow cognitive potentials... - Vagal nerve stimulation induces intermittent hypocapniaMark D Holmes
Department of Neurology, Regional Epilepsy Center, University of Washington, Seattle, WA, U.S.A
Epilepsia 44:1588-91. 2003..Because carbon dioxide (CO2) has potent effects on various brain functions, it is possible that these transient CO2 changes may have an effect on the state transitions between interictal and preictal states... - Age at focal epilepsy onset varies by sex and hemispheric lateralizationM J Doherty
Regional Epilepsy Center and Department of Neurology, University of Washington, Seattle 98195, USA
Neurology 60:1473-7. 2003..This may be due to sex-influenced asymmetric brain maturation. To clarify this relationship, the authors analyzed age at epilepsy onset by sex and by lateralization of epileptiform activity... - Ictal localization by source analysis of infraslow activity in DC-coupled scalp EEG recordingsJohn W Miller
Regional Epilepsy Center, Department of Neurology, University of Washington Regional Epilepsy Center, Box 359745, 325 Ninth Ave, Seattle, WA 98104, USA
Neuroimage 35:583-97. 2007..The value of this method is increased by source analysis tools that reveal localized changes more clearly than direct visual inspection... - Dexmedetomidine sedation during awake craniotomy for seizure resection: effects on electrocorticographyMichael J Souter
Department of Anesthesiology, University of Washington, Seattle 98104, USA
J Neurosurg Anesthesiol 19:38-44. 2007..Individual dose ranges vary, but a bolus of 0.3 mcg kg-1 with an infusion of 0.2 mcg kg-1 min-1 is a good starting point, allowing accurate mapping of epileptic foci and subsequent resection... - Long-term seizure monitoring using a 256 contact dense array systemPaul Thompson
Regional Epilepsy Center, University of Washington, Seattle, Washington, USA
Am J Electroneurodiagnostic Technol 48:93-106. 2008..Areas of concern are patient comfort, electrode maintenance, and increased time for record review... - Comparative analysis of temporal dynamics of EEG and phase synchronization of EEG to localize epileptic sites from high density scalp EEG interictal recordingsCeon Ramon
Department of Neurology, University of Washington, Seattle, 98195, USA
Conf Proc IEEE Eng Med Biol Soc 2008:4548-50. 2008..It was found that the LRTC of SI was highest at the location of the epileptic sites. A similar pattern was not found in the LRTC of EEGs. This provides a noninvasive way to localize seizure areas from scalp EEG data... - Localization and classification of phonemes using high spatial resolution electrocorticography (ECoG) gridsTimothy Blakely
University of Washington, Bioengineering Department, USA
Conf Proc IEEE Eng Med Biol Soc 2008:4964-7. 2008..In addition, we found that sub-regions of our miniature array were specific for distinct pairs of phonemes, showing that cortical phoneme processing occurs at a higher resolution than previously though... - Cognitive impairment is not equal in patients with epileptic and psychogenic nonepileptic seizuresDaniel L Drane
Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104, USA
Epilepsia 47:1879-86. 2006..We reexamined neurocognitive function in patients with ESs and PNES by using symptom validity testing to control for variability in effort... - Deblurring visual evoked potentials using commercially available softwarePaul A Zarkowski
University of Washington, Seattle, WA 98195, USA
Comput Methods Programs Biomed 82:81-5. 2006..After deblurring, the visual evoked potentials were only found at the electrodes closest to the visual cortex, as would be predicted by our current knowledge of neuroanatomy... - Determination of language dominance with near-infrared spectroscopy: comparison with the intracarotid amobarbital procedureNathaniel F Watson
Department of Neurology, University of Washington Regional Epilepsy Center, Box 359745, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
Seizure 13:399-402. 2004.... - Do nonspecific focal EEG slowing and epileptiform abnormalities favor one hemisphere?Michael J Doherty
Department of Neurology and Regional Epilepsy Center, University of Washington, Seattle, Washington 98195, USA
Epilepsia 43:1593-5. 2002..In contrast, other pathophysiologies such as stroke lateralize relatively symmetrically. Study of focal slowing and other EEG abnormalities allows assessment of favoring as well as referral and interpretation bias... - Factors predicting outcome of surgery for intractable epilepsy with pathologically verified mesial temporal sclerosisSteven G Hardy
Department of Neurology, Regional Epilepsy Center, University of Washington School of Medicine, Seattle, Washington, USA
Epilepsia 44:565-8. 2003..Neurosurgical treatment of MTS can be very effective even in the presence of significant etiologic factors, or of bilateral or extratemporal abnormalities on EEG or MRI... - Valproate therapy for prevention of posttraumatic seizures: a randomized trialN R Temkin
Department of Neurological Surgery, University of Washington, Seattle 98104 2499, USA
J Neurosurg 91:593-600. 1999..In this study the authors compare the safety and effectiveness of valproate with those of short-term phenytoin for prevention of seizures following traumatic brain injury... - Singing seizuresM J Doherty
Regional Epilepsy Center, Harborview Medical Center, University of Washington, Seattle, WA 98195, USA
Neurology 59:1435-8. 2002..Complex automatisms are less common and striking. The authors report two cases of seizure-associated singing where song expression may be recognizable... - Vagus nerve stimulation does not lead to significant changes in body weight in patients with epilepsyMikhail S Koren
Division of Endocrinology, Department of Medicine, University of Washington, Seattle, WA, USA
Epilepsy Behav 8:246-9. 2006..A well-controlled prospective study is necessary for more precise evaluation of the effect of VNS therapy on body weight... - Flash visual evoked potentials predict visual outcome in traumatic optic neuropathyMark D Holmes
Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
Ophthal Plast Reconstr Surg 20:342-6. 2004..Finding FVEP amplitudes that are at least 50% of the normal eye appears to be critical in anticipating good, long-term visual outcome... - Discharges in ventromedial frontal cortex during absence spellsDon M Tucker
Electrical Geodesics, Inc, Riverfront Research Park, 1600 Millrace Drive, Suite 307, Eugene, OR 97403, USA
Epilepsy Behav 11:546-57. 2007..Disrupted in absence, this circuit appears to regulate important aspects of the voluntary control of conscious attention... - Aperiodic phase re-setting in scalp EEG of beta-gamma oscillations by state transitions at alpha-theta ratesWalter J Freeman
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
Hum Brain Mapp 19:248-72. 2003..Cortex functions by serial changes in state. The Hilbert transform of EEG from high-density arrays can visualize these state transitions with high temporal and spatial resolution and should be useful in relating EEG to cognition... - Spatial spectra of scalp EEG and EMG from awake humansWalter J Freeman
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, LSA 142, MC 3200, Berkeley, CA 94720, USA
Clin Neurophysiol 114:1053-68. 2003..Evaluate spectral scaling properties of scalp electroencephalogram (EEG) and electromyogram (EMG), optimal spacing of electrodes, and strategies for mitigating EMG... - Epileptogenic neocortical networks are revealed by abnormal temporal dynamics in seizure-free subdural EEGSimo Monto
BioMag Laboratory, Helsinki University Central Hospital, FIN 00029 HUS, Finland
Cereb Cortex 17:1386-93. 2007..We propose that this method may become a promising candidate for routine invasive and noninvasive presurgical localization of epileptic foci... - Fine spatiotemporal structure of phase in human intracranial EEGWalter J Freeman
Department of Molecular and Cell Biology University of California at Berkeley, Berkeley, CA 94720 3206, USA
Clin Neurophysiol 117:1228-43. 2006..To transfer to the clinic for humans the technology and theory for high-resolution EEG analysis that have been developed in the laboratory with animals... - Metastability, instability, and state transition in neocortexWalter J Freeman
University of California at Berkeley, Berkeley, CA 94720, USA
Neural Netw 18:497-504. 2005..A model based on the intentional action-perception cycle is proposed to complement the information processing model...