Research Topics
| Scott HollisterSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Scaffold engineering: a bridge to where?Scott J Hollister
Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, 2208 Lurie Biomedical Engineering Building, 1101 Beal Avenue, Ann Arbor, MI 48109, USA
Biofabrication 1:012001. 2009..At the same time, such manufacturing capabilities would broaden the scientific horizons in cell therapy...
Scaffold translation: barriers between concept and clinicScott J Hollister
Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 48109, USA
Tissue Eng Part B Rev 17:459-74. 2011..We argue that envisioning and engineering scaffolds as modular systems with a sliding scale of complexity offers the best path to addressing these translational challenges...- Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injuryHuina Zhang
Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, 1500 E, Medical Center Drive, Ann Arbor, Michigan 48109, USA
Arthritis Res Ther 11:R172. 2009..In this study, we expand on our earlier work to test the effectiveness of simvastatin on disc degeneration utilizing a rat tail disc degeneration model... 
Scaffold design and manufacturing: from concept to clinicScott J Hollister
Adv Mater 21:3330-42. 2009..This paper argues that better integration of all these factors is needed to bring scaffolds from "concept to clinic". It reviews current work in all these areas and suggests where future work and funding is needed...- An image-based approach for designing and manufacturing craniofacial scaffoldsS J Hollister
Department of Biomedical Engineering, Sugery Orthopaedics and Mechanical Engineering and Applied Mechanics, The Unviersity of Michigan, Ann Arbor, USA
Int J Oral Maxillofac Surg 29:67-71. 2000..Several preliminary applications for craniofacial surgery, including a mandibular condyle scaffold, an orbital floor scaffold, and a general mandibular defect scaffold, are illustrated. Finally, we show applications to in vivo models... - Porous scaffold design for tissue engineeringScott J Hollister
Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 41809, USA
Nat Mater 4:518-24. 2005.... - Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraintsS J Hollister
Department of Biomedical Engineering, The University of Michigan, Ann Arbor 48109 2125, USA
Biomaterials 23:4095-103. 2002..Results showed excellent agreement between native bone properties and designed scaffold properties (all R2 > 0.89). Finally, example scaffolds were built from hydroxyapatite using a SFF casting technique... - Functional bone engineering using ex vivo gene therapy and topology-optimized, biodegradable polymer composite scaffoldsChia-Ying Lin
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
Tissue Eng 11:1589-98. 2005..Furthermore, the total stiffness of the constructs was retained for up to 12 weeks after implantation, as scaffold degradation and tissue invasion took place... - Experimental and computational characterization of designed and fabricated 50:50 PLGA porous scaffolds for human trabecular bone applicationsEiji Saito
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
J Mater Sci Mater Med 21:2371-83. 2010..In the present study, we successfully fabricated scaffolds with designed architectures as well as predicted their mechanical properties in a nondestructive manner... - Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sinteringJessica M Williams
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2125, USA
Biomaterials 26:4817-27. 2005.... - A novel method for biomaterial scaffold internal architecture design to match bone elastic properties with desired porosityCheng Yu Lin
Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
J Biomech 37:623-36. 2004..Finally, we also demonstrate that prototypes of the designed structures can be fabricated using solid free-form fabrication (SFF) techniques... - A comparison of the influence of material on in vitro cartilage tissue engineering with PCL, PGS, and POC 3D scaffold architecture seeded with chondrocytesClaire G Jeong
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2125, USA
Biomaterials 31:4304-12. 2010..PCL still provided microenvironments suitable for cells to be active yet it seemed to cause de-differentiation (Col1) of chondrocytes inside the scaffold while many cells migrated out, growing cartilage outside the scaffold... - Mechanical, permeability, and degradation properties of 3D designed poly(1,8 octanediol-co-citrate) scaffolds for soft tissue engineeringClaire G Jeong
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2125, USA
J Biomed Mater Res B Appl Biomater 93:141-9. 2010..Scaffold characterization in this article will provide design guidance for POC scaffolds to meet the mechanical and biological parameters needed for engineering soft tissues such as cartilage... - Tailoring the mechanical properties of 3D-designed poly(glycerol sebacate) scaffolds for cartilage applicationsJessica M Kemppainen
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2125, USA
J Biomed Mater Res A 94:9-18. 2010..Lastly, we demonstrate that this relatively new biomedical material supports cartilaginous matrix production by chondrocytes in vitro. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010... - Delivery and protection of adenoviruses using biocompatible hydrogels for localized gene therapyRachel Maddox Schek
Department of Oral Medicine, Pathology, and Oncology, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
Mol Ther 9:130-8. 2004..These results demonstrated that hydrogels may be used as carriers to control delivery of the virus and resultant tissue regeneration... - The use of reactive polymer coatings to facilitate gene delivery from poly (epsilon-caprolactone) scaffoldsWei Wen Hu
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
Biomaterials 30:5785-92. 2009..Because CVD was functional in different hierarchies, this surface modification should be able to custom-tailor bioconjugation for different applications... - Engineered osteochondral grafts using biphasic composite solid free-form fabricated scaffoldsRachel M Schek
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
Tissue Eng 10:1376-85. 2004..This combination of IBD and SFF-fabricated biphasic scaffolds with gene and cell therapy is a promising approach to regenerate osteochondral defects... - Poly(glycerol-dodecanoate), a biodegradable polyester for medical devices and tissue engineering scaffoldsFrancesco Migneco
Department of Biomedical Engineering, University of Michigan, 2248 LBME, 1101 Beal Ave, Ann Arbor, MI 48109, USA
Biomaterials 30:6479-84. 2009..The mechanical properties together with biocompatibility/biodegradability and shape memory features make PGD an attractive polymer for biomedical applications... - Brain cortex regeneration affected by scaffold architecturesDarice Y Wong
Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
J Neurosurg 109:715-22. 2008..The aim of this study was to compare designed scaffolds with a random-pored sponge scaffold to determine what role scaffold architecture plays in a cortical injury model... - Stress analysis of the interface between cervical vertebrae end plates and the Bryan, Prestige LP, and ProDisc-C cervical disc prostheses: an in vivo image-based finite element studyChia Ying Lin
Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
Spine (Phila Pa 1976) 34:1554-60. 2009..Segmental motion and bone-implant interface stresses were analyzed at C5-C6 levels with Bryan, Prestige LP, and ProDisc-C cervical disc prostheses using an image-based finite element modeling technique... - Osteocyte lacuna size and shape in women with and without osteoporotic fractureBarbara R McCreadie
Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, The University of Michigan, G 0161 400 North Ingalls, Ann Arbor, MI 48109 0486, USA
J Biomech 37:563-72. 2004..In addition, this study provides geometric measures of lacunae that are important in computational modeling of the mechanical environment of osteocytes... - Non-invasive monitoring of tissue scaffold degradation using ultrasound elasticity imagingKang Kim
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
Acta Biomater 4:783-90. 2008..This novel non-invasive monitoring tool will provide direct, time-dependent feedback on scaffold degradation and tissue ingrowth for tissue engineers to improve the design process... - Poly(epsilon-caprolactone) and poly (L-lactic-co-glycolic acid) degradable polymer sponges attenuate astrocyte response and lesion growth in acute traumatic brain injuryDarice Y Wong
Department of Biomedical Engineering, University of Michigan at Ann Arbor, Ann Arbor, MI 48109, USA
Tissue Eng 13:2515-23. 2007..These findings suggest that both polymers attenuate secondary death and scarring and that PCL might have advantages over PLGA... - Structural and mechanical evaluations of a topology optimized titanium interbody fusion cage fabricated by selective laser melting processChia Ying Lin
Spine Research Laboratory, Department of Neurosurgery, The University of Michigan, Ann Arbor, Michigan, USA
J Biomed Mater Res A 83:272-9. 2007.... - Mechanical and in vivo performance of hydroxyapatite implants with controlled architecturesT M Gabriel Chu
Department of Biological and Materials Sciences, University of Michigan, Ann Arbor 48109, USA
Biomaterials 23:1283-93. 2002..These preliminary results showed that controlling the overall geometry of the regenerated bone tissue is possible through the internal architectural design of the scaffolds... - Acoustic microscopy analyses to determine good vs. failed tissue engineered oral mucosa under normal or thermally stressed culture conditionsFrank Winterroth
Department of Biomedical Engineering, University of Michigan, 1101 Beal Ave, Lurie BME Bldg, No 2122, Ann Arbor, MI 48109, USA
Ann Biomed Eng 39:44-52. 2011..Elevated thermal stress retards cellular differentiation, increasing root mean square values; these results show that SAM can potentially monitor cell/tissue development... - Combined use of designed scaffolds and adenoviral gene therapy for skeletal tissue engineeringRachel M Schek
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
Biomaterials 27:1160-6. 2006..Though both scaffold base materials allowed bone growth, hydoxyapatite scaffolds generated twice as much bone as PPF/TCP scaffolds. The pore sizes tested had no significant effect on tissue generation... - Design and fabrication of scaffolds for anatomic bone reconstructionScott J Hollister
Skeletal Engineering Group and Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI, USA
Med J Malaysia 59:131-2. 2004 - Macro-architectures in spinal cord scaffold implants influence regenerationDarice Y Wong
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2106, USA
J Neurotrauma 25:1027-37. 2008..The open-path scaffold architectures enhanced spinal cord regeneration compared to the three other designs without the use of biological factors... - Tissue-engineered heart valve prostheses: 'state of the heart'Francesco Migneco
Section of Cardiac Surgery, The University of Michigan, B560 Medical Science Research Building II, 1150 West Medical Center Drive, Ann Arbor, MI 48109 2110, USA
Regen Med 3:399-419. 2008..g., biomaterials, cells and bioreactors). Technological hurdles, which need to be overcome for advancement of the field, are also discussed... - The interaction between bone marrow stromal cells and RGD-modified three-dimensional porous polycaprolactone scaffoldsHuina Zhang
Scaffold Tissue Engineering Group, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
Biomaterials 30:4063-9. 2009.... - The pore size of polycaprolactone scaffolds has limited influence on bone regeneration in an in vivo modelSara M Mantila Roosa
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2099, USA
J Biomed Mater Res A 92:359-68. 2010.... - Tissue-engineered cartilage constructs using composite hyaluronic acid/collagen I hydrogels and designed poly(propylene fumarate) scaffoldsElly Liao
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
Tissue Eng 13:537-50. 2007.... - Comparison of bone marrow stromal cell behaviors on poly(caprolactone) with or without surface modification: studies on cell adhesion, survival and proliferationHuina Zhang
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
J Biomater Sci Polym Ed 20:1975-93. 2009..The present results provide more evidence that functionalizing PCL with RGD peptides may be a feasible way to improve the interaction between BMSC and PCL substrate, which is important in tissue engineering... - Biomimetic hybrid scaffolds for engineering human tooth-ligament interfacesChan Ho Park
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 1078, USA
Biomaterials 31:5945-52. 2010..This approach offers potential for the clinical implementation of customized periodontal scaffolds that may enable regeneration of multi-tissue interfaces required for oral, dental and craniofacial engineering applications... - Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle punctureHuina Zhang
Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
J Neurosurg Spine 10:522-30. 2009..The goal in this study was to develop a convenient, less-invasive animal model to monitor progression of intervertebral disc (IVD) degeneration for future testing of new treatments for disc degeneration... - Interbody fusion cage design using integrated global layout and local microstructure topology optimizationChia-Ying Lin
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
Spine 29:1747-54. 2004.... - Differential effects of designed scaffold permeability on chondrogenesis by chondrocytes and bone marrow stromal cellsJessica M Kemppainen
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2125, USA
Biomaterials 31:279-87. 2010..The ability to direct cell differentiation and chondrogenesis through a physical design parameter, such as permeability, establishes the capability to incorporate chondrogenic potential into a material design... - Nondestructive micro-computed tomography for biological imaging and quantification of scaffold-bone interaction in vivoG Harry Van Lenthe
Institute for Biomechanics, ETH Zurich, Moussonstrasse 18, 8092 Zurich, Switzerland
Biomaterials 28:2479-90. 2007.... - Framework for optimal design of porous scaffold microstructure by computational simulation of bone regenerationTaiji Adachi
Department of Mechanical Engineering and Science, Graduate School of Engineering, Kyoto University, Yoshida Honmachi, Sakyo, Kyoto 606 8501, Japan
Biomaterials 27:3964-72. 2006..In addition, the regeneration process was found to be very complex even though the simple rate equations for scaffold regeneration and new bone formation were used because of the coupling effects of these phenomena...
Research Grants
- Optimizing Mandibular Scaffold Modulus/Porosity BalanceScott Hollister; Fiscal Year: 2009..This information will provide guidelines for designing scaffolds to optimize transition from scaffold load bearing to bone regeneration and load bearing. ..
- Relative Influence of Scaffold Design/Material Parameters On Bone RegenerationScott Hollister; Fiscal Year: 2007....
- Optimizing Mandibular Scaffold Modulus/Porosity BalanceScott Hollister; Fiscal Year: 2007..This information will provide guidelines for designing scaffolds to optimize transition from scaffold load bearing to bone regeneration and load bearing. ..
- Engineering Joint Scaffolds for Function/RegenerationScott Hollister; Fiscal Year: 2005..The remaining four specific aims are to investigate the performance of these scaffolds mechanically and using subcutaneous models, resulting in the in vivo minipig test of a prototype CRU. ..
- DESIGNED SCAFFOLD ARCHITECTURE AFFECTS BONE REGENERATIONScott Hollister; Fiscal Year: 2003..Results from this study will assist us in optimizing biomaterial scaffold performance via computational design to enhance regenerate tissue structure and function via tissue engineering treatments. ..
- Relative Influence of Scaffold Design/Material Parameters On Bone RegenerationScott J Hollister; Fiscal Year: 2010....