Roger P Hollis
Affiliation: University of Southern California
- Phage integrases for the construction and manipulation of transgenic mammalsRoger P Hollis
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
Reprod Biol Endocrinol 1:79. 2003..The results reviewed here introduce these bacteriophage integrases as tools for site-specific modification of the genome for the creation and manipulation of transgenic mammals...
- Site-specific genomic integration produces therapeutic Factor IX levels in miceEric C Olivares
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
Nat Biotechnol 20:1124-8. 2002..Integration was documented at two pseudo-attP sites, native sequences with partial identity to attP, with one site highly predominant. This study demonstrates in vivo gene transfer in an animal by site-specific genomic integration...