LEXIE HOLLIDAY

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Rational identification of enoxacin as a novel V-ATPase-directed osteoclast inhibitor
    Edgardo J Toro
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    Curr Protein Pept Sci 13:180-91. 2012
  2. doi request reprint Osteoclast polarization and orthodontic tooth movement
    L S Holliday
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, Florida 32610, USA
    Orthod Craniofac Res 12:105-12. 2009
  3. ncbi request reprint Interactions between vacuolar H+-ATPases and microfilaments in osteoclasts
    L Shannon Holliday
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, Florida, USA
    J Bioenerg Biomembr 37:419-23. 2005
  4. ncbi request reprint Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts
    L S Holliday
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    Calcif Tissue Int 72:206-14. 2003
  5. ncbi request reprint Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B
    Shih Hua Chen
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, Florida 32610, USA
    J Biol Chem 279:7988-98. 2004
  6. pmc Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening
    David A Ostrov
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Med Chem 52:5144-51. 2009
  7. ncbi request reprint Effects of basic fibroblast growth factor on osteoclasts and osteoclast-like cells
    Jian Zuo
    Department of Orthodontics, University of Florida College of Dentistry, USA
    Biochem Biophys Res Commun 318:162-7. 2004
  8. doi request reprint Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase
    Jian Zuo
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    J Exp Biol 211:1102-8. 2008
  9. ncbi request reprint The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function
    Ming Lu
    Department of Medicine University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 277:38409-15. 2002
  10. ncbi request reprint Calcium hydroxide reduces lipopolysaccharide-stimulated osteoclast formation
    Jin Jiang
    College of Dentistry, Department of Endodontics, University of Florida, Gainsville 32610 0436, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:348-54. 2003

Research Grants

  1. Osteoclast activation in uremic bone disease
    LEXIE HOLLIDAY; Fiscal Year: 2001
  2. Osteoclast activation in uremic bone disease
    LEXIE HOLLIDAY; Fiscal Year: 2002
  3. Osteoclast activation in uremic bone disease
    LEXIE HOLLIDAY; Fiscal Year: 2003
  4. Osteoclast activation in uremic bone disease
    LEXIE HOLLIDAY; Fiscal Year: 2004
  5. Osteoclast activation in uremic bone disease
    LEXIE HOLLIDAY; Fiscal Year: 2005

Collaborators

Detail Information

Publications16

  1. pmc Rational identification of enoxacin as a novel V-ATPase-directed osteoclast inhibitor
    Edgardo J Toro
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    Curr Protein Pept Sci 13:180-91. 2012
    ....
  2. doi request reprint Osteoclast polarization and orthodontic tooth movement
    L S Holliday
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, Florida 32610, USA
    Orthod Craniofac Res 12:105-12. 2009
    ..One potential use of such agents is to block tooth movement in spatially discrete locations to provide orthodontic anchorage...
  3. ncbi request reprint Interactions between vacuolar H+-ATPases and microfilaments in osteoclasts
    L Shannon Holliday
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, Florida, USA
    J Bioenerg Biomembr 37:419-23. 2005
    ..Studies are ongoing to establish the physiological role of the microfilament-binding activity of subunit B in osteoclasts and in other cells...
  4. ncbi request reprint Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts
    L S Holliday
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    Calcif Tissue Int 72:206-14. 2003
    ..These data support the hypothesis that cleaved collagen stimulates osteoclastic bone resorption by triggering cytoskeletal reorganization and transport of V-ATPase from cytoplasmic stores to ruffled membranes...
  5. ncbi request reprint Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B
    Shih Hua Chen
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, Florida 32610, USA
    J Biol Chem 279:7988-98. 2004
    ..This response was fully reversible. The actin binding activities of the B subunits of V-ATPase required 11-amino acid actin-binding motifs that are similar in sequence to the actin-binding site of mammalian profilin I...
  6. pmc Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening
    David A Ostrov
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Med Chem 52:5144-51. 2009
    ..In summary, enoxacin is a novel small molecule inhibitor of osteoclast bone resorption that acts by an unique mechanism and is therefore an attractive lead molecule for the development of a new class of antiosteoclastic agents...
  7. ncbi request reprint Effects of basic fibroblast growth factor on osteoclasts and osteoclast-like cells
    Jian Zuo
    Department of Orthodontics, University of Florida College of Dentistry, USA
    Biochem Biophys Res Commun 318:162-7. 2004
    ..7 osteoclast-like cells. These results suggest that FGF-2 has both direct and indirect effects on osteoclast formation and bone resorption...
  8. doi request reprint Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase
    Jian Zuo
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    J Exp Biol 211:1102-8. 2008
    ..These results suggest that actin-binding activity confers on the B subunit of yeast a function that is distinct from its role in the enzymatic activity of the proton pump...
  9. ncbi request reprint The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function
    Ming Lu
    Department of Medicine University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 277:38409-15. 2002
    ..Our data demonstrate the physiological significance of the interaction between the E and H subunits of V-ATPase and extend previous studies on the arrangement of subunits on the peripheral stalk of V-ATPase...
  10. ncbi request reprint Calcium hydroxide reduces lipopolysaccharide-stimulated osteoclast formation
    Jin Jiang
    College of Dentistry, Department of Endodontics, University of Florida, Gainsville 32610 0436, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:348-54. 2003
    ..The purpose of this study was to determine the direct effects of lipopolysaccharide (LPS) on osteoclastogenesis and to assess the ability of calcium hydroxide-Ca(OH)(2)-to inhibit the osteoclast formation stimulated by LPS...
  11. ncbi request reprint The synergistic effect of peptidoglycan and lipopolysaccaride on osteoclast formation
    Jin Jiang
    Department of Endodontics, College of Dentistry, University of Florida, Gainesville 32610 0436, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:738-43. 2003
    ..The purpose of this study was to investigate the mechanisms leading to periapical tissue destruction by the Gram-positive bacterial cell component, peptidoglycan (PGN) and Gram-negative bacterial cell component lipopolysaccaride (LPS)...
  12. ncbi request reprint Actin binding activity of subunit B of vacuolar H+-ATPase is involved in its targeting to ruffled membranes of osteoclasts
    Jian Zuo
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, 32610, USA
    J Bone Miner Res 21:714-21. 2006
    ..B1, which is not normally expressed in osteoclasts, was correctly targeted to ruffled membranes of resorbing osteoclasts. Mutant subunit B1 that lacked a functional actin-binding site did not accumulate in ruffled membranes...
  13. ncbi request reprint Actin-related protein 2/3 complex is required for actin ring formation
    I Rita Hurst
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, Florida 32610 0444, USA
    J Bone Miner Res 19:499-506. 2004
    ..A short interfering RNA knocked down expression of actin-related protein 2 in osteoclasts and disrupted actin rings, suggesting that the complex is crucial to actin ring formation...
  14. pmc Regulation of vacuolar H(+)-ATPase in microglia by RANKL
    Eric M Serrano
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    Biochem Biophys Res Commun 389:193-7. 2009
    ..In summary, microglia express the a3-subunit of V-ATPase. The expression of a3 and the interaction between V-ATPases and microfilaments was modulated by RANKL. These data suggest a novel molecular pathway for regulating microglia...
  15. pmc Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells
    Kaleb M Pauley
    Department of Oral Biology, University of Florida, Gainesville, FL 32610 0424, USA
    Immunol Cell Biol 88:205-12. 2010
    ..These data show that the increase in size and number of GWB may serve as a biomarker for miRNA-mediated gene regulation, and miR-146a has a significant role in the regulation of LPS-induced cytokine production in THP-1 cells...
  16. ncbi request reprint The 1.4-MDa apoptosome is a critical intermediate in apoptosome maturation
    Elaine Beem
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, PO Box 100224, Gainesville, FL 32610, USA
    Am J Physiol Cell Physiol 287:C664-72. 2004
    ..Consistent with these results, in vivo data suggest that blocking acidification during the induction of apoptosis inhibits activation of procaspase-3. On the basis of these results, we propose a model of apoptosome maturation...

Research Grants5

  1. Osteoclast activation in uremic bone disease
    LEXIE HOLLIDAY; Fiscal Year: 2001
    ....
  2. Osteoclast activation in uremic bone disease
    LEXIE HOLLIDAY; Fiscal Year: 2002
    ....
  3. Osteoclast activation in uremic bone disease
    LEXIE HOLLIDAY; Fiscal Year: 2003
    ....
  4. Osteoclast activation in uremic bone disease
    LEXIE HOLLIDAY; Fiscal Year: 2004
    ....
  5. Osteoclast activation in uremic bone disease
    LEXIE HOLLIDAY; Fiscal Year: 2005
    ....