Nina Holland

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults
    Connie Chen
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Environ Health Perspect 115:1732-7. 2007
  2. pmc Developmental changes in PON1 enzyme activity in young children and effects of PON1 polymorphisms
    Karen Huen
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California, USA
    Environ Health Perspect 117:1632-8. 2009
  3. pmc Early environmental exposures and intracellular Th1/Th2 cytokine profiles in 24-month-old children living in an agricultural area
    Paurene Duramad
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California 94720 7460, USA
    Environ Health Perspect 114:1916-22. 2006
  4. doi request reprint The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps
    Nina Holland
    School of Public Health, University of California, Berkeley, CA 94720 7460, USA
    Mutat Res 659:93-108. 2008
  5. ncbi request reprint Cytogenetic damage in blood lymphocytes and exfoliated epithelial cells of children with inflammatory bowel disease
    Nina Holland
    School of Public Health, University of California, Berkeley, Berkeley, California 94720, USA
    Pediatr Res 61:209-14. 2007
  6. pmc Reduced intracellular T-helper 1 interferon-gamma in blood of newly diagnosed children with Crohn's disease and age-related changes in Th1/Th2 cytokine profiles
    Nina Holland
    School of Public Health, University of California, San Francisco, California 94143, USA
    Pediatr Res 63:257-62. 2008
  7. pmc Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables
    Nina Holland
    School of Public Health, 733 University Hall, University of California, Berkeley, CA 94720 7360, USA
    Mutagenesis 26:51-6. 2011
  8. ncbi request reprint Molecular epidemiology biomarkers--sample collection and processing considerations
    Nina T Holland
    Environmental Health Sciences, School of Public Health, University of California, 317 Warren Hall, Berkeley 94720 7360, USA
    Toxicol Appl Pharmacol 206:261-8. 2005
  9. doi request reprint Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community
    Karen Huen
    Center for Environmental Research and Children s Health, School of Public Health, University of California, Berkeley, 1995 University Avenue Suite 265, Berkeley CA 94720, USA
    Environ Res 117:8-16. 2012
  10. doi request reprint Effects of age, sex, and persistent organic pollutants on DNA methylation in children
    Karen Huen
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California
    Environ Mol Mutagen 55:209-22. 2014

Detail Information

Publications43

  1. pmc Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults
    Connie Chen
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Environ Health Perspect 115:1732-7. 2007
    ..There is growing evidence for the role of oxidative damage in chronic diseases. Although ozone (O3) is an oxidant pollutant to which many people are exposed, few studies have examined whether O3 induces oxidative stress in humans...
  2. pmc Developmental changes in PON1 enzyme activity in young children and effects of PON1 polymorphisms
    Karen Huen
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California, USA
    Environ Health Perspect 117:1632-8. 2009
    ..Paraoxonase 1 (PON1) is an enzyme that detoxifies activated organophosphorus pesticides (OPs) and is also involved in oxidative stress pathways...
  3. pmc Early environmental exposures and intracellular Th1/Th2 cytokine profiles in 24-month-old children living in an agricultural area
    Paurene Duramad
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California 94720 7460, USA
    Environ Health Perspect 114:1916-22. 2006
    ..Endotoxin and allergens stimulate maturation of the immune response in early childhood, but little is known about the effect of exposures to OPs or to the three combined...
  4. doi request reprint The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps
    Nina Holland
    School of Public Health, University of California, Berkeley, CA 94720 7460, USA
    Mutat Res 659:93-108. 2008
    ....
  5. ncbi request reprint Cytogenetic damage in blood lymphocytes and exfoliated epithelial cells of children with inflammatory bowel disease
    Nina Holland
    School of Public Health, University of California, Berkeley, Berkeley, California 94720, USA
    Pediatr Res 61:209-14. 2007
    ....
  6. pmc Reduced intracellular T-helper 1 interferon-gamma in blood of newly diagnosed children with Crohn's disease and age-related changes in Th1/Th2 cytokine profiles
    Nina Holland
    School of Public Health, University of California, San Francisco, California 94143, USA
    Pediatr Res 63:257-62. 2008
    ..In future studies of pediatric IBD patients, it will be critical to consider the effect of age and disease progression on cytokine status in intestinal mucosa and peripheral blood...
  7. pmc Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables
    Nina Holland
    School of Public Health, 733 University Hall, University of California, Berkeley, CA 94720 7360, USA
    Mutagenesis 26:51-6. 2011
    ..Emerging 'omic' and other novel molecular technologies may shed light on the molecular mechanisms and biological pathways associated with the MN levels in children...
  8. ncbi request reprint Molecular epidemiology biomarkers--sample collection and processing considerations
    Nina T Holland
    Environmental Health Sciences, School of Public Health, University of California, 317 Warren Hall, Berkeley 94720 7360, USA
    Toxicol Appl Pharmacol 206:261-8. 2005
    ..New software and biorepository technologies are being developed by many companies that will help to bring biological banking to a new level required by molecular epidemiology of the 21st century...
  9. doi request reprint Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community
    Karen Huen
    Center for Environmental Research and Children s Health, School of Public Health, University of California, Berkeley, 1995 University Avenue Suite 265, Berkeley CA 94720, USA
    Environ Res 117:8-16. 2012
    ..However, compared to their mothers, newborns have much lower quantities of the detoxifying PON1 enzyme suggesting that infants may be especially vulnerable to organophosphate pesticide exposures...
  10. doi request reprint Effects of age, sex, and persistent organic pollutants on DNA methylation in children
    Karen Huen
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California
    Environ Mol Mutagen 55:209-22. 2014
    ..Accounting for co-exposure to different types of chemicals and adjusting for blood cell types may increase sensitivity of epigenetic analyses for epidemiological studies...
  11. pmc Associations of PON1 and genetic ancestry with obesity in early childhood
    Karen Huen
    Center for Environmental Research and Children s Health, School of Public Health, University of California, Berkeley, Berkeley, California, United States of America
    PLoS ONE 8:e62565. 2013
    ..Our findings suggest that PON1 may play a role in obesity independent of genetic ancestry and that studies of PON1 and health outcomes, especially in admixed populations, should account for differences due to population stratification...
  12. pmc Longitudinal changes in PON1 enzymatic activities in Mexican-American mothers and children with different genotypes and haplotypes
    Karen Huen
    Center for Children s Environmental Health, 50 University Hall, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Toxicol Appl Pharmacol 244:181-9. 2010
    ..In addition to known PON1 polymorphisms, unidentified environmental, genetic, or epigenetic factors may also influence variability of PON1 expression and therefore susceptibility to OPs and oxidative stress...
  13. pmc Vitamin C treatment reduces elevated C-reactive protein
    Gladys Block
    University of California, Berkeley, 94720, USA
    Free Radic Biol Med 46:70-7. 2009
    ..But research on clinical benefits of antioxidants should limit participants to persons with elevations in the target biomarkers...
  14. pmc Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children
    Karen Huen
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California, USA
    Environ Mol Mutagen 52:105-16. 2011
    ..Functional effects of PON genetic variation related to susceptibility to OPs and oxidative stress also differed by age and should be considered in protecting vulnerable subpopulations...
  15. pmc Is there an association between lifetime cumulative exposure and acute pulmonary responses to ozone?
    Mehrdad Arjomandi
    Lung Biology Center, University of California, San Francisco, California 94143 0845, USA
    J Occup Environ Med 50:341-9. 2008
    ..To investigate the potential effects of lifetime cumulative ozone (O3) exposure on acute pulmonary responses to O3...
  16. pmc Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy
    Jonathan Chevrier
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, Berkeley, CA 94704 7380, USA
    Am J Epidemiol 168:298-310. 2008
    ..These findings are of particular significance, since thyroid hormones of maternal origin may play an essential role in fetal neurodevelopment...
  17. pmc Determinants of organophosphorus pesticide urinary metabolite levels in young children living in an agricultural community
    Asa Bradman
    Center for Environmental Research and Children s Health, School of Public Health, University of California at Berkeley, 1995 University Avenue, Berkeley, CA 94720, USA
    Int J Environ Res Public Health 8:1061-83. 2011
    ..The impact of these determinants varied by age and class of DAP metabolite...
  18. pmc Serum persistent organic pollutants and duration of lactation among Mexican-American women
    Rosana H Weldon
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94704, USA
    J Environ Public Health 2010:861757. 2010
    ..Research suggests that estrogenic endocrine-disrupting chemicals interfere with lactation...
  19. pmc Folate concentrations in pediatric patients with newly diagnosed inflammatory bowel disease
    Melvin B Heyman
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143 0136, USA
    Am J Clin Nutr 89:545-50. 2009
    ..Folate deficiency has been shown to be associated with inflammatory bowel disease (IBD). However, folate concentrations are poorly delineated in children with IBD...
  20. pmc PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero
    Brenda Eskenazi
    Center for Environmental Research and Children s Health, School of Public Health, University of California, Berkeley, Berkeley, California 94602, USA
    Environ Health Perspect 118:1775-81. 2010
    ....
  21. ncbi request reprint Cytogenetic damage in buccal epithelia and peripheral lymphocytes of young healthy individuals exposed to ozone
    Connie Chen
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, 94720 7360, USA
    Mutagenesis 21:131-7. 2006
    ..p.b. O(3). This cytogenetic evidence, along with recent studies linking O(3) exposure to elevated lung cancer risk and mortality, suggest potential public health implications from exposures to high oxidant environments...
  22. pmc Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns
    Nina Holland
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California, USA
    Environ Health Perspect 114:985-91. 2006
    ..Most of the newborn children and some pregnant women in this Latino cohort may have elevated susceptibility to organophosphate toxicity because of their PON1192 genotype and low PON1 plasma levels...
  23. doi request reprint Maternal bisphenol a exposure during pregnancy and its association with adipokines in Mexican-American children
    Vitaly Volberg
    Center for Environmental Research and Children s Health CERCH, Environmental Health Sciences, School of Public Health, University of California, Berkeley, California
    Environ Mol Mutagen 54:621-8. 2013
    ..Overall, our data suggest that prenatal BPA concentrations may influence adipokine levels in 9-year-old children...
  24. doi request reprint A pilot study of pesticides and PCBs in the breast milk of women residing in urban and agricultural communities of California
    Rosana Hernandez Weldon
    Center for Environmental Research and Children s Health, School of Public Health, University of California, 1995 University Ave, Suite 265, Berkeley, CA 94704, USA
    J Environ Monit 13:3136-44. 2011
    ..02 and 4.32 pg g(-1) milk for chlorpyrifos-methyl and propoxur, respectively. These results suggest that neonates and young children may be exposed to persistent and non-persistent pesticides and PCBs via breast milk...
  25. pmc Cytokine profiles in peripheral blood of children and adults with Crohn disease
    Seung Pak
    School of Public Health, University of California, Berkeley, CA, USA
    J Pediatr Gastroenterol Nutr 54:769-75. 2012
    ..The present pilot study examines the hypothesis that cytokine profiles differ between pediatric and adult patients with CD...
  26. pmc A comparison of PBDE serum concentrations in Mexican and Mexican-American children living in California
    Brenda Eskenazi
    Center for Environmental Research and Children s Health, School of Public Health, University of California at Berkeley, Berkeley, California, USA
    Environ Health Perspect 119:1442-8. 2011
    ..Polybrominated diphenyl ethers (PBDE), which are used as flame retardants, have been found to be higher in residents of California than of other parts of the United States...
  27. pmc Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1
    Gladys Block
    School of Public Health, University of California at Berkeley, 94720 7360, USA
    Am J Clin Nutr 94:929-37. 2011
    ..Glutathione S-transferases (GSTs) detoxify environmental chemicals and are involved in oxidative stress pathways. Deletion polymorphisms affect enzyme activities and have been associated with risk of disease...
  28. ncbi request reprint Application of a geographic information system to explore associations between air pollution and micronucleus frequencies in African American children and adults
    Karen Huen
    School of Public Health, University of California, Berkeley, Oakland, California 94608, USA
    Environ Mol Mutagen 47:236-46. 2006
    ..This approach helped to demonstrate elevated cytogenetic damage in exposed minority children...
  29. ncbi request reprint Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans
    Maria Bastaki
    Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA 94608, USA
    Pharmacogenet Genomics 16:279-86. 2006
    ..This study examined the association between genetic polymorphisms and enzyme activity for antioxidant enzymes that share a common detoxification pathway: manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1) and catalase...
  30. pmc Associations between perinatal factors and adiponectin and leptin in 9-year-old Mexican-American children
    Vitaly Volberg
    Center for Environmental Research and Children s Health CERCH, School of Public Health, University of California, Berkeley, Berkeley, CA, USA
    Pediatr Obes 8:454-63. 2013
    ..Features of the perinatal environment, including maternal nutrition, anthropometry, glucose tolerance and growth rate during infancy are implicated in programming of obesity in the offspring...
  31. pmc Adiponectin and leptin trajectories in Mexican-American children from birth to 9 years of age
    Vitaly Volberg
    Center for Environmental Research and Children s Health CERCH, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 8:e77964. 2013
    ..To address molecular mechanisms underlying obesity development, we examined patterns of critical metabolism-related hormones, adiponectin and leptin (adipokines), over childhood...
  32. pmc Validation of PON1 enzyme activity assays for longitudinal studies
    Karen Huen
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, CA 94720 7360, United States
    Clin Chim Acta 402:67-74. 2009
    ..Length of sample storage, temperature and other factors may influence variability of PON1 measurements, especially in longitudinal studies...
  33. doi request reprint Pesticide toxicity and the developing brain
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94704, USA
    Basic Clin Pharmacol Toxicol 102:228-36. 2008
    ..We also observed adverse associations of prenatal but not postnatal organophosphate pesticide exposure with mental development and pervasive developmental disorder at 24 months...
  34. pmc Maternal Thyroid Function during the Second Half of Pregnancy and Child Neurodevelopment at 6, 12, 24, and 60 Months of Age
    Jonathan Chevrier
    Center for Environmental Research and Children s Health CERCH, School of Public Health, University of California, Berkeley, CA 94704 7392, USA
    J Thyroid Res 2011:426427. 2011
    ..At 60 months, there was inconsistent evidence that higher TSH was related to improved attention. We found no convincing evidence that maternal TH during the second half of pregnancy was related to impaired child neurodevelopment...
  35. pmc The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level
    Gladys Block
    School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Free Radic Biol Med 45:377-84. 2008
    ..Further studies are needed to establish whether treatment with vitamins C or E in persons with concentrations above that cut point could slow the development of cardiovascular disease...
  36. ncbi request reprint Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project
    Stefano Bonassi
    Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi, Genoa, Italy
    Mutat Res 543:155-66. 2003
    ..The presence of an interaction between smoking habit and occupational exposure to genotoxic agents should be always tested...
  37. ncbi request reprint Children's exposure to environmental pollutants and biomarkers of genetic damage. I. Overview and critical issues
    Monica Neri
    Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
    Mutat Res 612:1-13. 2006
    ..Examples of field studies that are focused on the effects of pesticides, air pollution and formaldehyde are used to illustrate advantages and limitations of biomarker studies in children...
  38. ncbi request reprint Children's exposure to environmental pollutants and biomarkers of genetic damage. II. Results of a comprehensive literature search and meta-analysis
    Monica Neri
    Unit of Epidemiology and Biostatistics, Department of Epidemiology and Prevention, National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132 Genoa, Italy
    Mutat Res 612:14-39. 2006
    ....
  39. ncbi request reprint The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo
    Micheline Kirsch-Volders
    Laboratory of Cell Genetics, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    Cancer Epidemiol Biomarkers Prev 15:1038-42. 2006
    ..79). This study confirms that pooled analyses, by increasing the statistical power, are adequate for assessing the involvement of genetic variants on genome stability and for resolving discrepancies among individual studies...
  40. ncbi request reprint An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 28:625-31. 2007
    ..The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs...
  41. ncbi request reprint PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity
    Clement E Furlong
    Department of Genome Sciences, Division of Medical Genetics, University of Washington, Seattle, Washington 98195 7720, USA
    Pharmacogenet Genomics 16:183-90. 2006
    ..Of particular concern are exposures of pregnant mothers and newborns with low PON1 status...
  42. ncbi request reprint Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
    Mutat Res 534:45-64. 2003
    ....
  43. ncbi request reprint Harmonisation of the micronucleus assay in human buccal cells--a Human Micronucleus (HUMN) project (www.humn.org) initiative commencing in 2007
    Michael Fenech
    CSIRO Human Nutrition, Adelaide, South Australia 5000, Australia
    Mutagenesis 22:3-4. 2007

Research Grants7

  1. PON1 and Developmental Sensitivity to OP Pesticides
    Nina Holland; Fiscal Year: 2006
    ..These data will support planning for the National Children's Study, identify subpopulations susceptible to chemical warfare agents, and inform policy decisions for implementation of the Food Quality Protection Act. ..
  2. PON1 and Developmental Sensitivity to OP Pesticides
    Nina Holland; Fiscal Year: 2007
    ..These data will support planning for the National Children's Study, identify subpopulations susceptible to chemical warfare agents, and inform policy decisions for implementation of the Food Quality Protection Act. ..
  3. PON1 and Developmental Sensitivity to OP Pesticides
    Nina Holland; Fiscal Year: 2007
    ..These data will support planning for the National Children's Study, identify subpopulations susceptible to chemical warfare agents, and inform policy decisions for implementation of the Food Quality Protection Act. ..
  4. PON1 and Developmental Sensitivity to OP Pesticides
    Nina Holland; Fiscal Year: 2009
    ..These data will support planning for the National Children's Study, identify subpopulations susceptible to chemical warfare agents, and inform policy decisions for implementation of the Food Quality Protection Act. ..
  5. PON1 and Developmental Sensitivity to OP Pesticides
    Nina T Holland; Fiscal Year: 2010
    ..These data will support planning for the National Children's Study, identify subpopulations susceptible to chemical warfare agents, and inform policy decisions for implementation of the Food Quality Protection Act. ..
  6. PON1 and Developmental Sensitivity to OP Pesticides
    Nina Holland; Fiscal Year: 2009
    ..These data will support planning for the National Children's Study, identify subpopulations susceptible to chemical warfare agents, and inform policy decisions for implementation of the Food Quality Protection Act. ..