Research Topics
Genomes and GenesSpecies | Nina HollandSummaryAffiliation: University of California Country: USA Publications
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Publications
Molecular epidemiology biomarkers--sample collection and processing considerationsNina T Holland
Environmental Health Sciences, School of Public Health, University of California, 317 Warren Hall, Berkeley 94720 7360, USA
Toxicol Appl Pharmacol 206:261-8. 2005..New software and biorepository technologies are being developed by many companies that will help to bring biological banking to a new level required by molecular epidemiology of the 21st century...
The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gapsNina Holland
School of Public Health, University of California, Berkeley, CA 94720 7460, USA
Mutat Res 659:93-108. 2008....
Reduced intracellular T-helper 1 interferon-gamma in blood of newly diagnosed children with Crohn's disease and age-related changes in Th1/Th2 cytokine profilesNina Holland
School of Public Health, University of California, San Francisco, California 94143, USA
Pediatr Res 63:257-62. 2008..In future studies of pediatric IBD patients, it will be critical to consider the effect of age and disease progression on cytokine status in intestinal mucosa and peripheral blood...- Cytogenetic damage in blood lymphocytes and exfoliated epithelial cells of children with inflammatory bowel diseaseNina Holland
School of Public Health, University of California, Berkeley, Berkeley, California 94720, USA
Pediatr Res 61:209-14. 2007.... - Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variablesNina Holland
School of Public Health, 733 University Hall, University of California, Berkeley, CA 94720 7360, USA
Mutagenesis 26:51-6. 2011..Emerging 'omic' and other novel molecular technologies may shed light on the molecular mechanisms and biological pathways associated with the MN levels in children... - Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural communityKaren Huen
Center for Environmental Research and Children s Health, School of Public Health, University of California, Berkeley, 1995 University Avenue Suite 265, Berkeley CA 94720, USA
Environ Res 117:8-16. 2012..However, compared to their mothers, newborns have much lower quantities of the detoxifying PON1 enzyme suggesting that infants may be especially vulnerable to organophosphate pesticide exposures... - Longitudinal changes in PON1 enzymatic activities in Mexican-American mothers and children with different genotypes and haplotypesKaren Huen
Center for Children s Environmental Health, 50 University Hall, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Toxicol Appl Pharmacol 244:181-9. 2010..In addition to known PON1 polymorphisms, unidentified environmental, genetic, or epigenetic factors may also influence variability of PON1 expression and therefore susceptibility to OPs and oxidative stress... - Vitamin C treatment reduces elevated C-reactive proteinGladys Block
University of California, Berkeley, 94720, USA
Free Radic Biol Med 46:70-7. 2009..But research on clinical benefits of antioxidants should limit participants to persons with elevations in the target biomarkers... - Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and childrenKaren Huen
Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California, USA
Environ Mol Mutagen 52:105-16. 2011..Functional effects of PON genetic variation related to susceptibility to OPs and oxidative stress also differed by age and should be considered in protecting vulnerable subpopulations... - Determinants of organophosphorus pesticide urinary metabolite levels in young children living in an agricultural communityAsa Bradman
Center for Environmental Research and Children s Health, School of Public Health, University of California at Berkeley, 1995 University Avenue, Berkeley, CA 94720, USA
Int J Environ Res Public Health 8:1061-83. 2011..The impact of these determinants varied by age and class of DAP metabolite... - Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancyJonathan Chevrier
Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, Berkeley, CA 94704 7380, USA
Am J Epidemiol 168:298-310. 2008..These findings are of particular significance, since thyroid hormones of maternal origin may play an essential role in fetal neurodevelopment... - Is there an association between lifetime cumulative exposure and acute pulmonary responses to ozone?Mehrdad Arjomandi
Lung Biology Center, University of California, San Francisco, California 94143 0845, USA
J Occup Environ Med 50:341-9. 2008..To investigate the potential effects of lifetime cumulative ozone (O3) exposure on acute pulmonary responses to O3... - Serum persistent organic pollutants and duration of lactation among Mexican-American womenRosana H Weldon
Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94704, USA
J Environ Public Health 2010:861757. 2010..Research suggests that estrogenic endocrine-disrupting chemicals interfere with lactation... - Developmental changes in PON1 enzyme activity in young children and effects of PON1 polymorphismsKaren Huen
Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California, USA
Environ Health Perspect 117:1632-8. 2009..Paraoxonase 1 (PON1) is an enzyme that detoxifies activated organophosphorus pesticides (OPs) and is also involved in oxidative stress pathways... - Folate concentrations in pediatric patients with newly diagnosed inflammatory bowel diseaseMelvin B Heyman
Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143 0136, USA
Am J Clin Nutr 89:545-50. 2009..Folate deficiency has been shown to be associated with inflammatory bowel disease (IBD). However, folate concentrations are poorly delineated in children with IBD... - PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in uteroBrenda Eskenazi
Center for Environmental Research and Children s Health, School of Public Health, University of California, Berkeley, Berkeley, California 94602, USA
Environ Health Perspect 118:1775-81. 2010.... - A pilot study of pesticides and PCBs in the breast milk of women residing in urban and agricultural communities of CaliforniaRosana Hernandez Weldon
Center for Environmental Research and Children s Health, School of Public Health, University of California, 1995 University Ave, Suite 265, Berkeley, CA 94704, USA
J Environ Monit 13:3136-44. 2011..02 and 4.32 pg g(-1) milk for chlorpyrifos-methyl and propoxur, respectively. These results suggest that neonates and young children may be exposed to persistent and non-persistent pesticides and PCBs via breast milk... - Cytokine profiles in peripheral blood of children and adults with Crohn diseaseSeung Pak
School of Public Health, University of California, Berkeley, CA, USA
J Pediatr Gastroenterol Nutr 54:769-75. 2012..The present pilot study examines the hypothesis that cytokine profiles differ between pediatric and adult patients with CD... - A comparison of PBDE serum concentrations in Mexican and Mexican-American children living in CaliforniaBrenda Eskenazi
Center for Environmental Research and Children s Health, School of Public Health, University of California at Berkeley, Berkeley, California, USA
Environ Health Perspect 119:1442-8. 2011..Polybrominated diphenyl ethers (PBDE), which are used as flame retardants, have been found to be higher in residents of California than of other parts of the United States... - Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adultsConnie Chen
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Environ Health Perspect 115:1732-7. 2007..There is growing evidence for the role of oxidative damage in chronic diseases. Although ozone (O3) is an oxidant pollutant to which many people are exposed, few studies have examined whether O3 induces oxidative stress in humans... - Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1Gladys Block
School of Public Health, University of California at Berkeley, 94720 7360, USA
Am J Clin Nutr 94:929-37. 2011..Glutathione S-transferases (GSTs) detoxify environmental chemicals and are involved in oxidative stress pathways. Deletion polymorphisms affect enzyme activities and have been associated with risk of disease... - Validation of PON1 enzyme activity assays for longitudinal studiesKaren Huen
Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, CA 94720 7360, United States
Clin Chim Acta 402:67-74. 2009..Length of sample storage, temperature and other factors may influence variability of PON1 measurements, especially in longitudinal studies... - Cytogenetic damage in buccal epithelia and peripheral lymphocytes of young healthy individuals exposed to ozoneConnie Chen
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, 94720-7360, USA
Mutagenesis 21:131-7. 2006..p.b. O(3). This cytogenetic evidence, along with recent studies linking O(3) exposure to elevated lung cancer risk and mortality, suggest potential public health implications from exposures to high oxidant environments... - Maternal Thyroid Function during the Second Half of Pregnancy and Child Neurodevelopment at 6, 12, 24, and 60 Months of AgeJonathan Chevrier
Center for Environmental Research and Children s Health CERCH, School of Public Health, University of California, Berkeley, CA 94704 7392, USA
J Thyroid Res 2011:426427. 2011..At 60 months, there was inconsistent evidence that higher TSH was related to improved attention. We found no convincing evidence that maternal TH during the second half of pregnancy was related to impaired child neurodevelopment... - Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newbornsNina Holland
Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, California, USA
Environ Health Perspect 114:985-91. 2006..Most of the newborn children and some pregnant women in this Latino cohort may have elevated susceptibility to organophosphate toxicity because of their PON1192 genotype and low PON1 plasma levels... - Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humansMaria Bastaki
Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA 94608, USA
Pharmacogenet Genomics 16:279-86. 2006..This study examined the association between genetic polymorphisms and enzyme activity for antioxidant enzymes that share a common detoxification pathway: manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1) and catalase... - Pesticide toxicity and the developing brainBrenda Eskenazi
Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94704, USA
Basic Clin Pharmacol Toxicol 102:228-36. 2008..We also observed adverse associations of prenatal but not postnatal organophosphate pesticide exposure with mental development and pervasive developmental disorder at 24 months... - Application of a geographic information system to explore associations between air pollution and micronucleus frequencies in African American children and adultsKaren Huen
School of Public Health, University of California, Berkeley, Oakland, California 94608, USA
Environ Mol Mutagen 47:236-46. 2006..This approach helped to demonstrate elevated cytogenetic damage in exposed minority children... - The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline levelGladys Block
School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Free Radic Biol Med 45:377-84. 2008..Further studies are needed to establish whether treatment with vitamins C or E in persons with concentrations above that cut point could slow the development of cardiovascular disease... - An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humansStefano Bonassi
Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
Carcinogenesis 28:625-31. 2007..The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs... - The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivoMicheline Kirsch-Volders
Laboratory of Cell Genetics, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
Cancer Epidemiol Biomarkers Prev 15:1038-42. 2006..79). This study confirms that pooled analyses, by increasing the statistical power, are adequate for assessing the involvement of genetic variants on genome stability and for resolving discrepancies among individual studies... - Children's exposure to environmental pollutants and biomarkers of genetic damage. II. Results of a comprehensive literature search and meta-analysisMonica Neri
Unit of Epidemiology and Biostatistics, Department of Epidemiology and Prevention, National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132 Genoa, Italy
Mutat Res 612:14-39. 2006.... - Children's exposure to environmental pollutants and biomarkers of genetic damage. I. Overview and critical issuesMonica Neri
Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
Mutat Res 612:1-13. 2006..Examples of field studies that are focused on the effects of pesticides, air pollution and formaldehyde are used to illustrate advantages and limitations of biomarker studies in children... - Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus projectStefano Bonassi
Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi, Genoa, Italy
Mutat Res 543:155-66. 2003..The presence of an interaction between smoking habit and occupational exposure to genotoxic agents should be always tested... - Harmonisation of the micronucleus assay in human buccal cells--a Human Micronucleus (HUMN) project (www.humn.org) initiative commencing in 2007Michael Fenech
CSIRO Human Nutrition, Adelaide, South Australia 5000, Australia
Mutagenesis 22:3-4. 2007 - PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivityClement E Furlong
Department of Genome Sciences, Division of Medical Genetics, University of Washington, Seattle, Washington 98195 7720, USA
Pharmacogenet Genomics 16:183-90. 2006..Of particular concern are exposures of pregnant mothers and newborns with low PON1 status... - Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN projectMichael Fenech
CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
Mutat Res 534:45-64. 2003....
Research Grants
- PON1 and Developmental Sensitivity to OP PesticidesNina Holland; Fiscal Year: 2007..These data will support planning for the National Children's Study, identify subpopulations susceptible to chemical warfare agents, and inform policy decisions for implementation of the Food Quality Protection Act. ..
- PON1 and Developmental Sensitivity to OP PesticidesNina Holland; Fiscal Year: 2009..These data will support planning for the National Children's Study, identify subpopulations susceptible to chemical warfare agents, and inform policy decisions for implementation of the Food Quality Protection Act. ..
- PON1 and Developmental Sensitivity to OP PesticidesNina T Holland; Fiscal Year: 2010..These data will support planning for the National Children's Study, identify subpopulations susceptible to chemical warfare agents, and inform policy decisions for implementation of the Food Quality Protection Act. ..
- PON1 and Developmental Sensitivity to OP PesticidesNina Holland; Fiscal Year: 2009..These data will support planning for the National Children's Study, identify subpopulations susceptible to chemical warfare agents, and inform policy decisions for implementation of the Food Quality Protection Act. ..