Linda Z Holland

Summary

Affiliation: University of California
Country: USA

Publications

  1. Holland L. Tunicates. Curr Biol. 2016;26:R146-52 pubmed publisher
    ..An outstanding question is what happened to allow tunicates to evolve so much faster than their nearest relatives, cephalochordates and vertebrates. ..
  2. request reprint
    Holland L, Schubert M, Kozmik Z, Holland N. AmphiPax3/7, an amphioxus paired box gene: insights into chordate myogenesis, neurogenesis, and the possible evolutionary precursor of definitive vertebrate neural crest. Evol Dev. 1999;1:153-65 pubmed
    ....
  3. Holland L. Chordate roots of the vertebrate nervous system: expanding the molecular toolkit. Nat Rev Neurosci. 2009;10:736-46 pubmed publisher
    ..Recent advances in genomics have provided insights into the elaboration of the molecular toolkit at the invertebrate-vertebrate transition that may have facilitated the evolution of these vertebrate characteristics. ..
  4. Holland L, Short S. Alternative splicing in development and function of chordate endocrine systems: a focus on Pax genes. Integr Comp Biol. 2010;50:22-34 pubmed publisher
    ....
  5. Holland L. Evolution of new characters after whole genome duplications: insights from amphioxus. Semin Cell Dev Biol. 2013;24:101-9 pubmed publisher
    ..In addition, while cis-regulatory changes are likely of primary importance in evolution of vertebrate-specific structures, changes in protein structure including alternative splicing are non-trivial. ..
  6. Holland L, Carvalho J, Escriva H, Laudet V, Schubert M, Shimeld S, et al. Evolution of bilaterian central nervous systems: a single origin?. Evodevo. 2013;4:27 pubmed publisher
    ....
  7. request reprint
    Holland L, Laudet V, Schubert M. The chordate amphioxus: an emerging model organism for developmental biology. Cell Mol Life Sci. 2004;61:2290-308 pubmed
    ..This relative structural and genomic simplicity in a vertebrate-like organism makes amphioxus ideal as a model organism for understanding mechanisms of vertebrate development...
  8. request reprint
    Holland L, Panfilio K, Chastain R, Schubert M, Holland N. Nuclear beta-catenin promotes non-neural ectoderm and posterior cell fates in amphioxus embryos. Dev Dyn. 2005;233:1430-43 pubmed
    ....
  9. request reprint
    Holland L. Body-plan evolution in the Bilateria: early antero-posterior patterning and the deuterostome-protostome dichotomy. Curr Opin Genet Dev. 2000;10:434-42 pubmed
    ..Comparisons with Drosophila and Cnidarians suggest a scheme for evolution of the Bilaterian body plan and emphasize the pressing need for similar studies in a wider variety of organisms, especially more basal protostomes. ..
  10. request reprint
    Holland L. Heads or tails? Amphioxus and the evolution of anterior-posterior patterning in deuterostomes. Dev Biol. 2002;241:209-28 pubmed
    ..Thus, roles for Wnt-signaling in dorso-ventral patterning of embryos may be a vertebrate innovation that arose in connection with the evolution of yolky eggs and gastrulation by extensive involution. ..

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Collaborators

Detail Information

Publications13

  1. Holland L. Tunicates. Curr Biol. 2016;26:R146-52 pubmed publisher
    ..An outstanding question is what happened to allow tunicates to evolve so much faster than their nearest relatives, cephalochordates and vertebrates. ..
  2. request reprint
    Holland L, Schubert M, Kozmik Z, Holland N. AmphiPax3/7, an amphioxus paired box gene: insights into chordate myogenesis, neurogenesis, and the possible evolutionary precursor of definitive vertebrate neural crest. Evol Dev. 1999;1:153-65 pubmed
    ....
  3. Holland L. Chordate roots of the vertebrate nervous system: expanding the molecular toolkit. Nat Rev Neurosci. 2009;10:736-46 pubmed publisher
    ..Recent advances in genomics have provided insights into the elaboration of the molecular toolkit at the invertebrate-vertebrate transition that may have facilitated the evolution of these vertebrate characteristics. ..
  4. Holland L, Short S. Alternative splicing in development and function of chordate endocrine systems: a focus on Pax genes. Integr Comp Biol. 2010;50:22-34 pubmed publisher
    ....
  5. Holland L. Evolution of new characters after whole genome duplications: insights from amphioxus. Semin Cell Dev Biol. 2013;24:101-9 pubmed publisher
    ..In addition, while cis-regulatory changes are likely of primary importance in evolution of vertebrate-specific structures, changes in protein structure including alternative splicing are non-trivial. ..
  6. Holland L, Carvalho J, Escriva H, Laudet V, Schubert M, Shimeld S, et al. Evolution of bilaterian central nervous systems: a single origin?. Evodevo. 2013;4:27 pubmed publisher
    ....
  7. request reprint
    Holland L, Laudet V, Schubert M. The chordate amphioxus: an emerging model organism for developmental biology. Cell Mol Life Sci. 2004;61:2290-308 pubmed
    ..This relative structural and genomic simplicity in a vertebrate-like organism makes amphioxus ideal as a model organism for understanding mechanisms of vertebrate development...
  8. request reprint
    Holland L, Panfilio K, Chastain R, Schubert M, Holland N. Nuclear beta-catenin promotes non-neural ectoderm and posterior cell fates in amphioxus embryos. Dev Dyn. 2005;233:1430-43 pubmed
    ....
  9. request reprint
    Holland L. Body-plan evolution in the Bilateria: early antero-posterior patterning and the deuterostome-protostome dichotomy. Curr Opin Genet Dev. 2000;10:434-42 pubmed
    ..Comparisons with Drosophila and Cnidarians suggest a scheme for evolution of the Bilaterian body plan and emphasize the pressing need for similar studies in a wider variety of organisms, especially more basal protostomes. ..
  10. request reprint
    Holland L. Heads or tails? Amphioxus and the evolution of anterior-posterior patterning in deuterostomes. Dev Biol. 2002;241:209-28 pubmed
    ..Thus, roles for Wnt-signaling in dorso-ventral patterning of embryos may be a vertebrate innovation that arose in connection with the evolution of yolky eggs and gastrulation by extensive involution. ..
  11. request reprint
    Holland L. Non-neural ectoderm is really neural: evolution of developmental patterning mechanisms in the non-neural ectoderm of chordates and the problem of sensory cell homologies. J Exp Zool B Mol Dev Evol. 2005;304:304-23 pubmed
    ..Thus, similarities between the ectodermal sensory cells of any one species of tunicate and craniate hair cells may well represent convergent evolution rather than homology...
  12. Holland L, Albalat R, Azumi K, Benito Gutiérrez E, Blow M, Bronner Fraser M, et al. The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res. 2008;18:1100-11 pubmed publisher
    ..Our results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates...
  13. Yue J, Kozmikova I, Ono H, Nossa C, Kozmik Z, Putnam N, et al. Conserved Noncoding Elements in the Most Distant Genera of Cephalochordates: The Goldilocks Principle. Genome Biol Evol. 2016;8:2387-405 pubmed publisher
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