Henry H Holcomb

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Effects of noncompetitive NMDA receptor blockade on anterior cingulate cerebral blood flow in volunteers with schizophrenia
    Henry H Holcomb
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 30:2275-82. 2005
  2. ncbi request reprint Practice, learning, and the likelihood of making an error: how task experience shapes physiological response in patients with schizophrenia
    Henry H Holcomb
    Functional Neuroimaging Laboratory, Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, P O Box 21247, Baltimore, MD 21228 0247, USA
    Psychopharmacology (Berl) 174:136-42. 2004
  3. ncbi request reprint How schizophrenia and depression disrupt reward circuitry
    Henry H Holcomb
    Henry H Holcomb, MD Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, 55 Wade Avenue, Baltimore, MD 21228, USA
    Curr Treat Options Neurol 9:357-62. 2007
  4. ncbi request reprint Parametric study of accuracy and response time in schizophrenic persons making visual or auditory discriminations
    Henry H Holcomb
    Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Psychiatry Res 127:207-16. 2004
  5. ncbi request reprint Brain activation patterns in schizophrenic and comparison volunteers during a matched-performance auditory recognition task
    H H Holcomb
    Maryland Psychiatric Research Center, University of Maryland at Baltimore, 21228, USA
    Am J Psychiatry 157:1634-45. 2000
  6. ncbi request reprint Clozapine but not haloperidol Re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 29:171-8. 2004
  7. pmc Modulation of limbic circuitry predicts treatment response to antipsychotic medication: a functional imaging study in schizophrenia
    Adrienne C Lahti
    Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuropsychopharmacology 34:2675-90. 2009
  8. ncbi request reprint Functional effects of single dose first- and second-generation antipsychotic administration in subjects with schizophrenia
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Psychiatry Res 139:19-30. 2005
  9. pmc Sequential neural changes during motor learning in schizophrenia
    Laura M Rowland
    Maryland Psychiatric Research Center and Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Psychiatry Res 163:1-12. 2008
  10. pmc Neural changes associated with relational learning in schizophrenia
    Laura M Rowland
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 36:496-503. 2010

Research Grants

Detail Information

Publications30

  1. ncbi request reprint Effects of noncompetitive NMDA receptor blockade on anterior cingulate cerebral blood flow in volunteers with schizophrenia
    Henry H Holcomb
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 30:2275-82. 2005
    ..The loss of inhibition and increased glutamate release may cause the distorted thoughts and diminished cognitive abilities elicited by NMDAR blockade...
  2. ncbi request reprint Practice, learning, and the likelihood of making an error: how task experience shapes physiological response in patients with schizophrenia
    Henry H Holcomb
    Functional Neuroimaging Laboratory, Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, P O Box 21247, Baltimore, MD 21228 0247, USA
    Psychopharmacology (Berl) 174:136-42. 2004
    ..This review considers how functional imaging has helped improve our understanding of learning, practice, and error detection in persons with schizophrenia...
  3. ncbi request reprint How schizophrenia and depression disrupt reward circuitry
    Henry H Holcomb
    Henry H Holcomb, MD Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, 55 Wade Avenue, Baltimore, MD 21228, USA
    Curr Treat Options Neurol 9:357-62. 2007
    ..Other neuropsychiatric disorders such as schizophrenia and depression may provide models of disturbed reward biology that may prove useful when thinking about altered reward circuitry and behavior in PD and other neurological disorders...
  4. ncbi request reprint Parametric study of accuracy and response time in schizophrenic persons making visual or auditory discriminations
    Henry H Holcomb
    Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Psychiatry Res 127:207-16. 2004
    ..The schizophrenia group's tendency to process high and low error conditions with similar behavioral resources may reflect a relatively static, non-dynamic cognitive repertoire...
  5. ncbi request reprint Brain activation patterns in schizophrenic and comparison volunteers during a matched-performance auditory recognition task
    H H Holcomb
    Maryland Psychiatric Research Center, University of Maryland at Baltimore, 21228, USA
    Am J Psychiatry 157:1634-45. 2000
    ..In this report, investigators used an auditory recognition task to assess brain blood flow patterns and behavioral correlates of schizophrenic patient volunteers trained on the task...
  6. ncbi request reprint Clozapine but not haloperidol Re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 29:171-8. 2004
    ..Based on these preliminary data, we propose that this pattern may account for the superior therapeutic effect of clozapine and represents a surrogate marker of this action...
  7. pmc Modulation of limbic circuitry predicts treatment response to antipsychotic medication: a functional imaging study in schizophrenia
    Adrienne C Lahti
    Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuropsychopharmacology 34:2675-90. 2009
    ..After 1 week of treatment, greater rCBF increase in the ventral striatum and greater decrease in the hippocampus were associated with good response...
  8. ncbi request reprint Functional effects of single dose first- and second-generation antipsychotic administration in subjects with schizophrenia
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Psychiatry Res 139:19-30. 2005
    ..Differences in the involvement in basal ganglia parallel known differences between the drugs in the emergence of acute EPS upon emergency administration...
  9. pmc Sequential neural changes during motor learning in schizophrenia
    Laura M Rowland
    Maryland Psychiatric Research Center and Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Psychiatry Res 163:1-12. 2008
    ..The visual system, however, appears to be highly compensated in schizophrenia and the inability to rapidly modulate the motor cortex may be substantially corrected by the schizophrenic group's visuomotor adaptations...
  10. pmc Neural changes associated with relational learning in schizophrenia
    Laura M Rowland
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 36:496-503. 2010
    ..These findings suggest that the parietal lobe may be receptive to cognitive training interventions and that successful relational learning may be achieved in schizophrenia through the use of alternative extrahippocampal brain regions...
  11. ncbi request reprint Correlations between rCBF and symptoms in two independent cohorts of drug-free patients with schizophrenia
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 31:221-30. 2006
    ..The involvement of both frontal and parietal regions is implicated in the pathophysiology of negative symptoms...
  12. ncbi request reprint Schizophrenia, VIII: pharmacologic models
    Adrienne C Lahti
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 160:2091. 2003
  13. pmc The interactive effects of ketamine and nicotine on human cerebral blood flow
    Laura M Rowland
    Department of Psychiatry, Functional Neuroimaging Laboratory, Maryland Psychiatric Research Center, University of Maryland School of Medicine, 55 Wade Avenue, Baltimore, MD 21228 0247, USA
    Psychopharmacology (Berl) 208:575-84. 2010
    ..The purpose of this study was to determine if acute nicotine attenuated ketamine-induced regional cerebral blood flow (rCBF)...
  14. pmc In vivo measurements of glutamate, GABA, and NAAG in schizophrenia
    Laura M Rowland
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Schizophr Bull 39:1096-104. 2013
    ..The study also highlights the importance of studies that combine MRS measurements of NAAG, GABA, and Glu for a more comprehensive neurochemical characterization of schizophrenia. ..
  15. pmc A test of the cognitive self-medication hypothesis of tobacco smoking in schizophrenia
    Britta Hahn
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Biol Psychiatry 74:436-43. 2013
    ..This study tested predictions of the cognitive self-medication hypothesis...
  16. ncbi request reprint The effects of clozapine and high-dose olanzapine on brain function in treatment-resistant schizophrenia: a case study
    Robert R Conley
    Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD 21228, USA
    J Psychopharmacol 18:429-31. 2004
    ..These findings suggest that high doses of olanzapine do not produce similar brain activation patterns as clozapine in people with treatment-resistant schizophrenia...
  17. ncbi request reprint Functional effects of antipsychotic drugs: comparing clozapine with haloperidol
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 53:601-8. 2003
    ....
  18. ncbi request reprint Evaluating glutamatergic transmission in schizophrenia
    Carol A Tamminga
    University of Texas Southwestern Medical School, Dallas, Texas, 75390, USA
    Ann N Y Acad Sci 1003:113-8. 2003
    ..What I will report in this paper has been individually reported elsewhere but brought together here in a new synthesis...
  19. ncbi request reprint Drugs under investigation for attention-deficit hyperactivity disorder
    Julie B Schweitzer
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA
    Curr Opin Investig Drugs 3:1207-11. 2002
    ..The recent developments in the pharmacological treatment of ADHD should increase therapeutic options and the percentage of individuals with the disorder who can be effectively treated...
  20. ncbi request reprint Abnormal patterns of regional cerebral blood flow in schizophrenia with primary negative symptoms during an effortful auditory recognition task
    A C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA
    Am J Psychiatry 158:1797-808. 2001
    ..Using functional brain imaging, the authors sought to replicate their earlier finding of low metabolism in the middle frontal and inferior parietal cortices of schizophrenic patients with primary negative symptoms...
  21. ncbi request reprint Cerebral blood flow relationships associated with a difficult tone recognition task in trained normal volunteers
    H H Holcomb
    Maryland Psychiatric Research Center, Johns Hopkins Medical Institutes, Baltimore 21228 0247, USA
    Cereb Cortex 8:534-42. 1998
    ....
  22. ncbi request reprint Probing the human hippocampus using rCBF: contrasts in schizophrenia
    D R Medoff
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA
    Hippocampus 11:543-50. 2001
    ..These data show an abnormality of hippocampal function in schizophrenia and suggest that this abnormality may be associated with the pathophysiology of the illness...
  23. ncbi request reprint Inhibitory control of competing motor memories
    R Shadmehr
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205 2195, USA
    Exp Brain Res 126:235-51. 1999
    ....
  24. ncbi request reprint Neural correlates of motor memory consolidation
    R Shadmehr
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, 419 Traylor, Baltimore, MD 21205 2195, USA
    Science 277:821-5. 1997
    ....
  25. pmc Anterior cingulate GABA levels predict whole-brain cerebral blood flow
    Benjamin W Krause
    Neuroimaging Research Program, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Neurosci Lett 561:188-91. 2014
    ..We hypothesize that GABA-mediated inhibition of AC activation of the locus coeruleus-norepinephrine pathway may influence global CBF. ..
  26. pmc Schizophrenia in translation: the presence of absence: habenular regulation of dopamine neurons and the encoding of negative outcomes
    Paul D Shepard
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA
    Schizophr Bull 32:417-21. 2006
    ..Collectively, these data suggest that the habenula may play a critical role in mediating the feedback-processing deficits of schizophrenia...
  27. ncbi request reprint Sequential regional cerebral blood flow brain scans using PET with H2(15)O demonstrate ketamine actions in CNS dynamically
    H H Holcomb
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, UMAB, Baltimore, MD 21228, USA
    Neuropsychopharmacology 25:165-72. 2001
    ..This experimental design provides direct characterization of drug action in the CNS in ways heretofore unavailable...
  28. ncbi request reprint Phenotype of schizophrenia: a review and formulation
    C A Tamminga
    Department of Psychiatry, UT Southwestern Medical School, Dallas, TX 75390, USA
    Mol Psychiatry 10:27-39. 2005
    ..This paper reviews the status of general knowledge in this area and proposes an approach to discovery, including identifying brain regions of dysfunction and subsequent localized, hypothesis-driven molecular screening...
  29. ncbi request reprint Long-term adaptation to dynamics of reaching movements: a PET study
    R Nezafat
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    Exp Brain Res 140:66-76. 2001
    ..This suggests that, during long-term recall, the same input to the cerebellar cortex would produce less synaptic activity at the DCN, possibly because of reduced cerebellar cortex output to the DCN...

Research Grants3

  1. Psychotic Symptoms on Visual Learning in Schizophrenia
    Henry Holcomb; Fiscal Year: 2003
    ..Our understanding of how symptom clusters contribute to abnormal physiological activity patterns associated with learning visual recognition. ..