John E Hokanson

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint A common promoter polymorphism in the hepatic lipase gene (LIPC-480C>T) is associated with an increase in coronary calcification in type 1 diabetes
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes 51:1208-13. 2002
  2. ncbi request reprint Effects of the hepatic lipase gene and physical activity on coronary heart disease risk
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Epidemiol 158:836-43. 2003
  3. ncbi request reprint Evaluating changes in coronary artery calcium: an analytic method that accounts for interscan variability
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, 4200 E Ninth Ave, B 119, Denver, CO 80262, USA
    AJR Am J Roentgenol 182:1327-32. 2004
  4. ncbi request reprint Susceptibility to type 1 diabetes is associated with ApoCIII gene haplotypes
    John E Hokanson
    Department of Preventive Medicine and Biometrics, Box B119, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Diabetes 55:834-8. 2006
  5. ncbi request reprint Pleiotropy and heterogeneity in the expression of atherogenic lipoproteins: the IRAS Family Study
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Hum Hered 55:46-50. 2003
  6. ncbi request reprint Hypertriglyceridemia and risk of coronary heart disease
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Box B119, 4200 East 9th Avenue, Denver, CO 80262, USA
    Curr Cardiol Rep 4:488-93. 2002
  7. ncbi request reprint Determinants of serum adiponectin in persons with and without type 1 diabetes
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Epidemiol 166:731-40. 2007
  8. ncbi request reprint Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study
    Dana Dabelea
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes 52:2833-9. 2003
  9. ncbi request reprint Low plasma adiponectin levels predict progression of coronary artery calcification
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Circulation 111:747-53. 2005
  10. ncbi request reprint Statin and statin-fibrate use was significantly associated with increased myositis risk in a managed care population
    David L McClure
    Clinical Research Unit, Kaiser Permanente Colorado, Denver, CO 80237 8066, USA
    J Clin Epidemiol 60:812-8. 2007

Detail Information

Publications35

  1. ncbi request reprint A common promoter polymorphism in the hepatic lipase gene (LIPC-480C>T) is associated with an increase in coronary calcification in type 1 diabetes
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes 51:1208-13. 2002
    ..In conclusion, the LIPC-480C>T polymorphism was associated with subclinical CHD in type 1 diabetes. This genetic variant may identify subjects in which early intervention to prevent CHD may be appropriate...
  2. ncbi request reprint Effects of the hepatic lipase gene and physical activity on coronary heart disease risk
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Epidemiol 158:836-43. 2003
    ..Thus, in this prospective cohort study, the LIPC-480 TT genotype increased susceptibility to CHD only in those subjects with normal levels of physical activity, not in those with the high-risk genotype who were vigorously active...
  3. ncbi request reprint Evaluating changes in coronary artery calcium: an analytic method that accounts for interscan variability
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, 4200 E Ninth Ave, B 119, Denver, CO 80262, USA
    AJR Am J Roentgenol 182:1327-32. 2004
    ..The transformation that stabilized the variation in calcium volume scores was applied to progression of calcium volume scores in 109 subjects with diabetes...
  4. ncbi request reprint Susceptibility to type 1 diabetes is associated with ApoCIII gene haplotypes
    John E Hokanson
    Department of Preventive Medicine and Biometrics, Box B119, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Diabetes 55:834-8. 2006
    ..00, 0.97, and 0.73, respectively; P = 0.03). This haplotype block contains an insulin response element. Screening for this haplotype may identify at-risk individuals, and this pathway may offer a target for prevention of type 1 diabetes...
  5. ncbi request reprint Pleiotropy and heterogeneity in the expression of atherogenic lipoproteins: the IRAS Family Study
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Hum Hered 55:46-50. 2003
    ..Dyslipidemia is an important determinant of coronary disease. Phenotypic correlations between atherogenic lipids are well established, but the contribution of common genetic influences is less clear...
  6. ncbi request reprint Hypertriglyceridemia and risk of coronary heart disease
    John E Hokanson
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Box B119, 4200 East 9th Avenue, Denver, CO 80262, USA
    Curr Cardiol Rep 4:488-93. 2002
    ..Understanding the physiologic processes that lead to the metabolic disturbances associated with hypertriglyceridemia is essential in investigating the effect of triglyceride on CHD risk...
  7. ncbi request reprint Determinants of serum adiponectin in persons with and without type 1 diabetes
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Epidemiol 166:731-40. 2007
    ..Although some of the difference can be explained, further study is needed to better understand the relation between elevated adiponectin levels and patient outcomes, including coronary heart disease...
  8. ncbi request reprint Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study
    Dana Dabelea
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes 52:2833-9. 2003
    ..In conclusion, gender differences in insulin resistance-associated fat distribution may explain why type 1 diabetes increases coronary calcification in women relatively more than in men...
  9. ncbi request reprint Low plasma adiponectin levels predict progression of coronary artery calcification
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Circulation 111:747-53. 2005
    ..However, it is not known whether low adiponectin levels predict development of atherosclerosis independently of other cardiovascular risk factors...
  10. ncbi request reprint Statin and statin-fibrate use was significantly associated with increased myositis risk in a managed care population
    David L McClure
    Clinical Research Unit, Kaiser Permanente Colorado, Denver, CO 80237 8066, USA
    J Clin Epidemiol 60:812-8. 2007
    ..We quantified the risk of myositis associated with statin and fibrate drug use with other covariates within a managed care organization (MCO) population...
  11. ncbi request reprint Progression of coronary artery calcification in type 1 diabetes: the importance of glycemic control
    Janet K Snell-Bergeon
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes Care 26:2923-8. 2003
    ....
  12. doi request reprint Plasminogen activator inhibitor-1 is associated with coronary artery calcium in Type 1 diabetes
    Katherine A Pratte
    Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, CO 80262, USA
    J Diabetes Complications 23:387-93. 2009
    ..It is not known if PAI-1 is associated with sub-clinical CAD in Type 1 diabetes or if this association is independent of IR...
  13. pmc Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes
    Kendra A Young
    Colorado School of Public Health, University of Colorado, Denver, Colorado, USA
    Diabetes Care 34:454-8. 2011
    ....
  14. ncbi request reprint Awareness and treatment of dyslipidemia in young adults with type 1 diabetes
    R Paul Wadwa
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B140, Denver, CO 80262, USA
    Diabetes Care 28:1051-6. 2005
    ..In this report, we describe the prevalence of dyslipidemia and adequacy of pharmacological treatment in patients with type 1 diabetes and comparable nondiabetic subjects...
  15. pmc Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality
    John J Arcaroli
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver, and Health Sciences Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 179:105-12. 2009
    ..An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart disease...
  16. pmc Genetic epidemiology of COPD (COPDGene) study design
    Elizabeth A Regan
    National Jewish Health, Denver, Colorado, USA
    COPD 7:32-43. 2010
    ..Finally, subtypes of COPD based on these phenotypes will be used in a comprehensive genome-wide study to identify COPD susceptibility genes...
  17. ncbi request reprint Genetic and physiologic correlates of longitudinal immunoreactive trypsinogen decline in infants with cystic fibrosis identified through newborn screening
    Marci K Sontag
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Pediatr 149:650-657. 2006
    ..To characterize the time course and physiologic significance of decline in serum immunoreactive trypsinogen (IRT) levels in infants with cystic fibrosis (CF) by mode of diagnosis and genotype, and to examine IRT heritability...
  18. ncbi request reprint Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis
    Adam Kretowski
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
    Diabetes 56:863-71. 2007
    ....
  19. pmc Reproductive history and hormonal birth control use are associated with coronary calcium progression in women with type 1 diabetes mellitus
    Janet K Snell-Bergeon
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    J Clin Endocrinol Metab 93:2142-8. 2008
    ..Coronary artery disease is increased in women with type 1 diabetes (T1D), compared with nondiabetic (Non-DM) women. Women with T1D have more menstrual dysfunction and are less likely to use hormonal birth control (BC) than Non-DM women...
  20. doi request reprint The relationship between gender and clinical management after exercise stress testing
    Stacie L Daugherty
    Division of Cardiology, University of Colorado Denver, Aurora, CO 80045, USA
    Am Heart J 156:301-7. 2008
    ..Controversy remains regarding whether gender differences exist in clinical management after exercise treadmill testing (ETT)...
  21. pmc Evaluation of urinary biomarkers for coronary artery disease, diabetes, and diabetic kidney disease
    Janet K Snell-Bergeon
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, 80045, USA
    Diabetes Technol Ther 11:1-9. 2009
    ..In this study we sought to validate urinary biomarkers for diabetes and two common complications, coronary artery disease (CAD) and diabetic nephropathy (DN)...
  22. pmc Relationship between cystatin C and coronary artery atherosclerosis progression differs by type 1 diabetes
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Diabetes Technol Ther 12:25-33. 2010
    ..To expand on our previous report, we investigated whether the relationship of cystatin C to progression of coronary artery atherosclerosis (CA) differed between individuals with type 1 diabetes (T1D) and persons without diabetes...
  23. doi request reprint Effects of mineralocorticoid receptor antagonists on the risk of sudden cardiac death in patients with left ventricular systolic dysfunction: a meta-analysis of randomized controlled trials
    Srinivas R Bapoje
    Department of Medicine, Denver Health and Hospital Authority, Denver, CO, USA
    Circ Heart Fail 6:166-73. 2013
    ..Mineralocorticoid receptor antagonists (MRAs) may attenuate this risk. The objective of this meta-analysis was to assess the impact of MRAs on SCD in patients with left ventricular systolic dysfunction...
  24. pmc Gender differences of airway dimensions in anatomically matched sites on CT in smokers
    Yu Il Kim
    Department of Medicine, National Jewish Health, Denver, CO, USA
    COPD 8:285-92. 2011
    ..Multi-detector CT (MDCT) images were analyzed to examine whether gender could explain differences in airway dimensions of anatomically matched airways in smokers...
  25. doi request reprint Complementary approaches to assessing risk factors for interval breast cancer
    Jan T Lowery
    Colorado School of Public Health, University of Colorado, Denver, CO, USA
    Cancer Causes Control 22:23-31. 2011
    ..To examine risk factors for interval breast cancer among women screened in a population-based mammography program...
  26. ncbi request reprint Increased platelet Fc receptor expression in diabetes is limited to those with type 2 disease and low LDL cholesterol levels
    David C Calverley
    Department of Medicine, University of Colorado, UCHSC Box B171, 4200 East 9th Avenue, Denver, CO 80262, USA
    Atherosclerosis 185:173-6. 2006
    ....
  27. ncbi request reprint The complex role of triglycerides in cardiovascular disease
    Madiha F Abdel-Maksoud
    The Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver CO 80262, USA
    Semin Vasc Med 2:325-33. 2002
    ..Multivariable adjusted RRs were determined only for the studies reporting adjustment for HDL-C (9 studies in men, 2 studies in women). These analyses indicate plasma triglycerides are an independent predictor of cardiovascular disease...
  28. ncbi request reprint Investigation of DUSP8 and CALCA in alcohol dependence
    Raquel L Hink
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Addict Biol 8:305-12. 2003
    ..Genotyping of this functional variant in 463 Southwestern Native Americans revealed no significant association between the DUSP8 C712T (Ala193Val) polymorphism and alcohol dependence (odds ratio = 1.48 95% CI 0.6-3.92)...
  29. ncbi request reprint Systematic review and meta-analysis of clinically relevant adverse events from HMG CoA reductase inhibitor trials worldwide from 1982 to present
    David L McClure
    Kaiser Foundation Health Plan of Colorado, Clinical Research Unit, Denver, CO 80237 8066, USA
    Pharmacoepidemiol Drug Saf 16:132-43. 2007
    ..Our objective was to determine the association of clinically relevant adverse events from a systematic review and meta-analysis of statin randomized controlled trials (RCT)...
  30. ncbi request reprint Progression of coronary artery calcification in diabetics with and without chronic kidney disease
    Rajnish Mehrotra
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Kidney Int 68:1258-66. 2005
    ..There is limited information on the progression of CAC during earlier stages of diabetic chronic kidney disease (CKD)...
  31. ncbi request reprint Haplotypes in the lipoprotein lipase gene influence fasting insulin and discovery of a new risk haplotype
    Mark O Goodarzi
    Cedars Sinai Medical Center, Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Boulevard, Becker B 131, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 92:293-6. 2007
    ..The most common haplotype (haplotype 1) was protective, whereas the fourth most common haplotype (haplotype 4) conferred risk for insulin resistance and atherosclerosis...
  32. ncbi request reprint Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families: the Insulin Resistance Atherosclerosis Study Family Study
    Carl D Langefeld
    Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1063, USA
    Diabetes 53:1170-4. 2004
    ..These results contribute to the growing evidence that chromosome 1q harbors at least one locus related to the metabolic precursors of diabetes...
  33. doi request reprint VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men
    Kathleen C Torkko
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Clin Cancer Res 14:3223-9. 2008
    ..This study tested the interactions of VDR (CDX2, FokI) and SRD5A2 (V89L, A49T) polymorphisms, and their associations with prostate cancer...
  34. doi request reprint Effects of modifying triglycerides and triglyceride-rich lipoproteins on cardiovascular outcomes
    Madiha Abdel-Maksoud
    Department of Public Health, Preventive, and Social Medicine, Tanta University, Egypt
    J Cardiovasc Pharmacol 51:331-51. 2008
    ....
  35. pmc Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the Diabetes Control and Complications Trial
    Jonathan Q Purnell
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
    Diabetes 52:2623-9. 2003
    ..These data support the hypothesis that increased weight gain with intensive therapy might be explained, in part, by genetic traits...