KRISTIN HOGQUIST

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Thymic emigration revisited
    Tom M McCaughtry
    Center for Immunology, Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455
    J Exp Med 204:2513-20. 2007
  2. pmc Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
    Tom M McCaughtry
    Center for Immunology, Laboratory Medicine, and Pathology, University of Minnesota, Minneapolis, MN 55454, USA
    J Exp Med 205:2575-84. 2008
  3. pmc The timing of TCR alpha expression critically influences T cell development and selection
    Troy A Baldwin
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 202:111-21. 2005
  4. pmc Primary Epstein-Barr virus infection does not erode preexisting CD8⁺ T cell memory in humans
    Oludare A Odumade
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Exp Med 209:471-8. 2012
  5. pmc T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    Amy E Moran
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55414, USA
    J Exp Med 208:1279-89. 2011
  6. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
  7. pmc Primary EBV Infection Induces an Expression Profile Distinct from Other Viruses but Similar to Hemophagocytic Syndromes
    Samantha K Dunmire
    Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
    PLoS ONE 9:e85422. 2014
  8. pmc Selection of self-reactive T cells in the thymus
    Gretta L Stritesky
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Immunol 30:95-114. 2012
  9. ncbi request reprint Receptor sensitivity: when T cells lose their sense of self
    Kristin A Hogquist
    University of Minnesota, Center for Immunology, 312 Church Street, S E, Minneapolis, Minnesota 55455, USA
    Curr Biol 13:R239-41. 2003
  10. doi request reprint Why CD8+ T cells need diversity when growing up
    Kristin A Hogquist
    Center for Immunology, University of Minnesota, Minneapolis, MN 55414, USA
    Immunity 32:5-6. 2010

Research Grants

  1. Cortical epithelial cells in the selection and maturation of CD8 T cells
    Kristin A Hogquist; Fiscal Year: 2010
  2. AUTUMN IMMUNOLOGY CONFERENCE
    KRISTIN HOGQUIST; Fiscal Year: 2007
  3. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2007
  4. Receptor editing in development T cells
    KRISTIN HOGQUIST; Fiscal Year: 2007
  5. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2006
  6. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2005
  7. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2004
  8. BD LSR II
    KRISTIN HOGQUIST; Fiscal Year: 2004
  9. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2003
  10. Receptor editing in developing T cells
    KRISTIN HOGQUIST; Fiscal Year: 2003

Collaborators

Detail Information

Publications39

  1. pmc Thymic emigration revisited
    Tom M McCaughtry
    Center for Immunology, Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455
    J Exp Med 204:2513-20. 2007
    ..Furthermore, emigration occurs via a strict "conveyor belt" mechanism, where the oldest thymocytes leave first...
  2. pmc Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
    Tom M McCaughtry
    Center for Immunology, Laboratory Medicine, and Pathology, University of Minnesota, Minneapolis, MN 55454, USA
    J Exp Med 205:2575-84. 2008
    ..Rather, thymocytes undergoing clonal deletion were preferentially associated with rare CD11c(+) cortical dendritic cells, and elimination of such cells impaired deletion...
  3. pmc The timing of TCR alpha expression critically influences T cell development and selection
    Troy A Baldwin
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 202:111-21. 2005
    ..Collectively, these data establish the importance of proper timing of TCR expression in thymic development and selection and emphasize the need to use models that most accurately reflect the physiologic process...
  4. pmc Primary Epstein-Barr virus infection does not erode preexisting CD8⁺ T cell memory in humans
    Oludare A Odumade
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Exp Med 209:471-8. 2012
    ..The data support the concept that, in humans, a robust CD8(+) T cell response creates a new memory CD8(+) T cell niche without substantially depleting preexisting memory for heterologous infections...
  5. pmc T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    Amy E Moran
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55414, USA
    J Exp Med 208:1279-89. 2011
    ..However, although T(reg) cells continued to perceive strong TCR signals in the periphery, iNKT cells did not. Finally, we show that T(reg) cell progenitors compete for recognition of rare stimulatory TCR self-ligands...
  6. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
    ..This suggests that dermal LCs can mediate CHS and provides an explanation for previous differences observed in the two-model systems...
  7. pmc Primary EBV Infection Induces an Expression Profile Distinct from Other Viruses but Similar to Hemophagocytic Syndromes
    Samantha K Dunmire
    Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
    PLoS ONE 9:e85422. 2014
    ..These data provide an important first description of the response to a natural herpesvirus infection in humans. ..
  8. pmc Selection of self-reactive T cells in the thymus
    Gretta L Stritesky
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Immunol 30:95-114. 2012
    ..We also outline molecular pathways unique to each lineage and consider possible commonalities to their development and survival...
  9. ncbi request reprint Receptor sensitivity: when T cells lose their sense of self
    Kristin A Hogquist
    University of Minnesota, Center for Immunology, 312 Church Street, S E, Minneapolis, Minnesota 55455, USA
    Curr Biol 13:R239-41. 2003
    ..The T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports disagree as to whether this interaction sensitizes or desensitizes the receptor. Here we discuss how these findings might be reconciled...
  10. doi request reprint Why CD8+ T cells need diversity when growing up
    Kristin A Hogquist
    Center for Immunology, University of Minnesota, Minneapolis, MN 55414, USA
    Immunity 32:5-6. 2010
    ..In this issue of Immunity, Nitta et al. (2010) suggest that beta5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells...
  11. ncbi request reprint Central tolerance: learning self-control in the thymus
    Kristin A Hogquist
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 312 Church Street South East, Minneapolis, Minnesota 55455, USA
    Nat Rev Immunol 5:772-82. 2005
    ..In this Review, we discuss the emerging consensus about which models of clonal deletion are most physiological, and we review recent data that define the molecular mechanisms of central tolerance...
  12. ncbi request reprint Central tolerance to self-antigen expressed by cortical epithelial cells
    Dita Mayerova
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, USA
    J Immunol 172:851-6. 2004
    ..These results suggest that different TCRs show intrinsic differences in thymic tolerance mechanism...
  13. ncbi request reprint Positive and negative selection of T cells
    Timothy K Starr
    Center for Immunology and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455, USA
    Annu Rev Immunol 21:139-76. 2003
    ..We also discuss emerging data on the selection of regulatory T cells. Such cells require a high-affinity interaction with self-antigens, yet differentiate into regulatory cells instead of being eliminated...
  14. pmc A requirement for sustained ERK signaling during thymocyte positive selection in vivo
    Lisa K McNeil
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 102:13574-9. 2005
    ..These results demonstrate that the in vivo duration of ERK signaling must be sustained to support positive selection...
  15. ncbi request reprint The central tolerance response to male antigen in normal mice is deletion and not receptor editing
    Philmore O Holman
    Department of Laboratory Medicine and Pathology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 171:4048-53. 2003
    ..Thus, it would appear that receptor editing is not a predominant tolerance mechanism for this self-Ag...
  16. ncbi request reprint The regulated expression of a diverse set of genes during thymocyte positive selection in vivo
    Verity E Mick
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 173:5434-44. 2004
    ....
  17. ncbi request reprint Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state
    Dita Mayerova
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 312 Church Street SE, Minneapolis 55455, USA
    Immunity 21:391-400. 2004
    ..Furthermore, tolerance was dominant when the antigen was presented by both Langerhans cells and other APC. These data suggest that Langerhans cells do not have tolerogenic properties in the steady state...
  18. ncbi request reprint Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: a partial role for sialylation
    Timothy K Starr
    Center for Immunology, Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis MN 55455, USA
    J Immunol 171:4512-20. 2003
    ..These studies identify sialylation as one of the factors that regulate CD8 T cell tuning during development...
  19. pmc Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues
    Kerry A Casey
    Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 188:4866-75. 2012
    ....
  20. pmc Langerhans cells are not required for the CD8 T cell response to epidermal self-antigens
    Laura S Bursch
    Center for Immunology, Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 182:4657-64. 2009
    ..These data suggest that radioresistant non-LC present self-Ag in K14-OVAp mice and drive a robust CD8 T cell response...
  21. pmc Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire
    H Hamlet Chu
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:11241-5. 2009
    ..Therefore, although positive selection on MHC(A) was not required to produce foreign peptide:MHC(A)-binding clones, it had a large effect on selecting responsive clones...
  22. ncbi request reprint A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter
    Maureen A McGargill
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 169:2141-7. 2002
    ..We discuss the potential relationship between autoimmunity and self-Ags that are expressed in stratified epithelium...
  23. pmc Thymic emigration: when and how T cells leave home
    Michael A Weinreich
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 181:2265-70. 2008
    ..Additionally, we review current understanding of the molecules involved in thymocyte emigration, including the sphingolipid receptor S1P(1) and its regulation by the Krüppel-like transcription factor KLF2...
  24. ncbi request reprint Tec kinases in T cell development: a clue behind the mask?
    Kristin A Hogquist
    Center for Immunology, University of Minnesota, Minneapolis, 55455, USA
    Immunity 25:9-11. 2006
    ..The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common developmental pathway...
  25. ncbi request reprint Conditioning of Langerhans cells induced by a primary CD8 T cell response to self-antigen in vivo
    Dita Mayerova
    Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 176:4658-65. 2006
    ..Our study suggests that conditioning of dendritic cells may play a role in maintaining unresponsiveness to self-Ag during chronic inflammation...
  26. ncbi request reprint Kruppel-like factor 2 regulates thymocyte and T-cell migration
    Corey M Carlson
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 442:299-302. 2006
    ..Our findings suggest that KLF2 serves to license mature T cells for trafficking from the thymus and recirculation through secondary lymphoid tissues...
  27. ncbi request reprint The fourth way? Harnessing aggressive tendencies in the thymus
    Troy A Baldwin
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 173:6515-20. 2004
    ..In this review, we will discuss where and when agonist selection is induced and whether this should be considered as a novel form of thymic selection or as an alternative differentiation state for Ag-exposed T cells...
  28. ncbi request reprint Central tolerance: what have we learned from mice?
    Tom M McCaughtry
    Center for Immunology, Laboratory Medicine and Pathology, University of Minnesota, Mayo Mail Code 334, 420 Delaware Street SE, Minneapolis, MN, 55454, USA
    Semin Immunopathol 30:399-409. 2008
    ....
  29. pmc T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells
    Michael A Weinreich
    The Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
    Nat Immunol 11:709-16. 2010
    ..Our findings identify a previously unknown mechanism of regulation of CD8(+) T cells via the production of IL-4 by PLZF(+) T cells...
  30. pmc Krüppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells
    Oludare A Odumade
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55414, USA
    J Immunol 184:6060-6. 2010
    ..Thus, KLF2 is critically important for the homeostasis and trafficking of gammadelta T cells...
  31. ncbi request reprint Sweet 'n' sour: the impact of differential glycosylation on T cell responses
    Mark A Daniels
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Nat Immunol 3:903-10. 2002
    ..However, there is considerable evidence that glycosylation plays a key role in immune regulation. We will focus here on examples in which differential glycosylation affects the development, survival or reactivity of T cells...
  32. pmc Epidermal Langerhans cells are not required for UV-induced immunosuppression
    Liangchun Wang
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:5548-53. 2009
    ..We found that dermal langerin(+) cells, but not LC, were essential for the CD8 T cell response. Furthermore, in the selective absence of LC, UV light still caused suppression of both CD8 T cell expansion and contact hypersensitivity...
  33. ncbi request reprint Transcriptional analysis of clonal deletion in vivo
    Troy A Baldwin
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 179:837-44. 2007
    ..These included three up-regulated genes, bim, nur77, and ian1, and one down-regulated gene, lip1. Collectively, these data provide a framework for understanding the molecular basis of clonal deletion...
  34. ncbi request reprint Langerin expressing cells promote skin immune responses under defined conditions
    Liangchun Wang
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 180:4722-7. 2008
    ..Overall, our results reconcile previous conflicting data in the literature, and suggest that Langerin(+) cells do promote T cell responses to skin Ags, but only under defined conditions...
  35. pmc KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors
    Michael A Weinreich
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunity 31:122-30. 2009
    ..Our findings support a model where KLF2 regulates T cell trafficking by direct regulation of S1P(1) and CD62L and restrains spontaneous cytokine production in naive T cells...
  36. ncbi request reprint Rare, structurally homologous self-peptides promote thymocyte positive selection
    Fabio R Santori
    Michael Heidelberger Division of Immunology, Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, 550 First Avenue, NY 10016, USA
    Immunity 17:131-42. 2002
    ..These results demonstrate that selecting self-peptides are rare and can be identified by homology-based search strategies...
  37. pmc T-cell migration: Kruppeled T cells move again
    Kristin A Hogquist
    Immunol Cell Biol 86:297-8. 2008
  38. pmc Immunodeficiency: when T cells are stuck at home
    Kristin A Hogquist
    Nat Immunol 9:1207-8. 2008
  39. ncbi request reprint CD53, a thymocyte selection marker whose induction requires a lower affinity TCR-MHC interaction than CD69, but is up-regulated with slower kinetics
    Kirsten L Puls
    The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    Int Immunol 14:249-58. 2002
    ..Thus a combination of the CD69 and CD53 selection markers may be a powerful tool to isolate thymocytes that have either been very recently selected or have arisen from differing MHC--TCR affinity interactions during selection...

Research Grants20

  1. Cortical epithelial cells in the selection and maturation of CD8 T cells
    Kristin A Hogquist; Fiscal Year: 2010
    ....
  2. AUTUMN IMMUNOLOGY CONFERENCE
    KRISTIN HOGQUIST; Fiscal Year: 2007
    ..Finally, scholarship programs, career development workshops, and mentoring luncheons promote the inclusion of minority scientists and seek to recruit undergraduates into the discipline of Immunology. ..
  3. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2007
    ..The second one is a transcription factor KLF2, which we hypothesize is required for mature thymocytes to emigrate from the thymus and access peripheral lymph nodes to survive and participate in immune responses. ..
  4. Receptor editing in development T cells
    KRISTIN HOGQUIST; Fiscal Year: 2007
    ..abstract_text> ..
  5. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2006
    ..The second one is a transcription factor KLF2, which we hypothesize is required for mature thymocytes to emigrate from the thymus and access peripheral lymph nodes to survive and participate in immune responses. ..
  6. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2005
    ..abstract_text> ..
  7. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2004
    ..abstract_text> ..
  8. BD LSR II
    KRISTIN HOGQUIST; Fiscal Year: 2004
    ..This instrument will allow us to better understand the complex functional roles of subsets of lymphocytes and dendritic cells. ..
  9. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2003
    ..abstract_text> ..
  10. Receptor editing in developing T cells
    KRISTIN HOGQUIST; Fiscal Year: 2003
    ..abstract_text> ..
  11. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2009
    ..The second one is a transcription factor KLF2, which we hypothesize is required for mature thymocytes to emigrate from the thymus and access peripheral lymph nodes to survive and participate in immune responses. ..
  12. PEPTIDE INDUCTION OF POSITIVE SELECTION
    Kristin A Hogquist; Fiscal Year: 2010
    ..The second one is a transcription factor KLF2, which we hypothesize is required for mature thymocytes to emigrate from the thymus and access peripheral lymph nodes to survive and participate in immune responses. ..
  13. Receptor editing in development T cells
    KRISTIN HOGQUIST; Fiscal Year: 2006
    ..abstract_text> ..
  14. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2003
    ..abstract_text> ..
  15. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2002
    ..abstract_text> ..
  16. PEPTIDE INDUCTION OF POSITIVE SELECTION
    KRISTIN HOGQUIST; Fiscal Year: 2001
    ..abstract_text> ..