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| Lorne J HofsethSummaryAffiliation: University of South Carolina Country: USA Publications
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Publications
Nitric oxide as a target of complementary and alternative medicines to prevent and treat inflammation and cancerLorne J Hofseth
Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, 770 Sumter Street, Coker Life Sciences, Room 513C, Columbia, SC 29208, USA
Cancer Lett 268:10-30. 2008....
Inflammation, cancer, and targets of ginsengLorne J Hofseth
Department of Basic Pharmaceutical Sciences, South Carolina College of Pharmacy, SC, USA
J Nutr 137:183S-185S. 2007..Here, we use ginseng as an example of an antiinflammatory molecule that targets many of the key players in the inflammation-to-cancer sequence...- The adaptive imbalance to genotoxic stress: genome guardians rear their ugly headsLorne J Hofseth
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
Carcinogenesis 25:1787-93. 2004..Here, key pathways that adaptively respond to genotoxic stress are reviewed and mechanisms by which this response may have pro-carcinogenic implications are discussed... - Identifying and defusing weapons of mass inflammation in carcinogenesisLorne J Hofseth
Department of Basic Pharmaceutical Sciences, College of Pharmacy, Coker Life Sciences, University of South Carolina, Columbia, SC 29208, USA
Biochim Biophys Acta 1765:74-84. 2006..Here, we review some of the key factors and the cancer pathways they disturb as a necessary prerequisite to the identification of targets for chemoprevention... 
Suppression of DNA damage in human peripheral blood lymphocytes by a juice concentrate: a randomized, double-blind, placebo-controlled trialXiangli Cui
Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29205, USA
Mol Nutr Food Res 56:666-70. 2012..These data suggest a potential health benefit by consuming the juice concentrate capsules through their ability to suppress DNA damage as measured in surrogate tissues (PBL)...- American ginseng suppresses inflammation and DNA damage associated with mouse colitisYu Jin
Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, SC 29208, USA
Carcinogenesis 29:2351-9. 2008..Results are consistent with this hypothesis. The use of American ginseng extract represents a novel therapeutic approach for the prevention and treatment of UC... - An essential role of Nrf2 in American ginseng-mediated anti-oxidative actions in cardiomyocytesJinqing Li
Department of Cell Biology and Anatomy, University of South Carolina, Columbia, SC 29208, USA
J Ethnopharmacol 130:222-30. 2010..Thus, we investigated role of Nrf2, a master transcription factor of endogenous anti-oxidative defense systems, in the regulation of American ginseng-mediated anti-oxidative actions in cardiomyocytes... - A limited role of p53 on the ability of a Hexane fraction of American ginseng to suppress mouse colitisDeepak Poudyal
Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina and Medical University of South Carolina, Columbia, SC 29208, USA
J Biomed Biotechnol 2012:785739. 2012..Therefore, HAG might be very effective in targeting the inflammatory cells and cancer cells since it induces apoptosis of inflammatory cells and cell cycle arrest in both p53-/- and WT p53 colon cancer cells... - Role of resveratrol-induced CD11b(+) Gr-1(+) myeloid derived suppressor cells (MDSCs) in the reduction of CXCR3(+) T cells and amelioration of chronic colitis in IL-10(-/-) miceUdai P Singh
Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
Brain Behav Immun 26:72-82. 2012..The induction of immunosuppressive CD11b(+) Gr-1(+) cells by resveratrol during colitis is unique, and suggests an as-yet-unidentified mode of anti-inflammatory action of this plant polyphenol... - Resveratrol suppresses colitis and colon cancer associated with colitisXiangli Cui
Department of Biomedical and Pharmaceutical Sciences, South Carolina College of Pharmacy, University of South Carolina, 770 Sumter Street, Columbia, SC 29208, USA
Cancer Prev Res (Phila) 3:549-59. 2010..2 +/- 0.13 tumors per animal. The current study indicates that resveratrol is a useful, nontoxic complementary and alternative strategy to abate colitis and potentially colon cancer associated with colitis... - American ginseng suppresses colitis through p53-mediated apoptosis of inflammatory cellsYu Jin
Department of Biomedical and Pharmaceutical Sciences, South Carolina College of Pharmacy, 770 Sumter Street, Coker Life Sciences, University of South Carolina, Columbia, SC 29208, USA
Cancer Prev Res (Phila) 3:339-47. 2010..Results are consistent with our in vitro data and with the hypothesis that AG drives inflammatory cell apoptosis in vivo, providing a mechanism by which AG protects from colitis in this DSS mouse model... - A hexane fraction of American ginseng suppresses mouse colitis and associated colon cancer: anti-inflammatory and proapoptotic mechanismsDeepak Poudyal
Department of Biomedical and Pharmaceutical Sciences, South Carolina College of Pharmacy, University of South Carolina, 770 Sumter St, Coker Life Sciences, Columbia, SC 29208, USA
Cancer Prev Res (Phila) 5:685-96. 2012..This study moves us closer to understanding the molecular components of American ginseng that suppress colitis and prevent colon cancer associated with colitis... - Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitisUdai P Singh
Department of Pathology, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
J Pharmacol Exp Ther 332:829-39. 2010..Furthermore, our results indicate that resveratrol may protect against colitis through up-regulation of SIRT1 in immune cells in the colon... - Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinaseAlexander A Chumanevich
Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina and Medical University of South Carolina, Columbia, SC 29208, USA
Carcinogenesis 31:1787-93. 2010.... - Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitorAlexander A Chumanevich
Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, 29208, USA
Am J Physiol Gastrointest Liver Physiol 300:G929-38. 2011..In total, these data help validate the PADs as therapeutic targets for the treatment of IBD and further suggest Cl-amidine as a candidate therapy for this disease... - Nitric oxide inactivates the retinoblastoma pathway in chronic inflammationLei Ying
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
Cancer Res 67:9286-93. 2007..Our results reveal a link between NO and pRb inactivation and provide insight into molecules that can be targeted in the prevention of the inflammation-to-cancer sequence... - The Induction of microRNA-16 in Colon Cancer Cells by Protein Arginine Deiminase Inhibition Causes a p53-Dependent Cell Cycle ArrestXiangli Cui
Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States of America Shanxi Medical University, Shanxi, China
PLoS ONE 8:e53791. 2013..Our study sheds light into the mechanisms by which PAD inhibition can protect against or treat colon cancer... - American ginseng preferentially suppresses STAT/iNOS signaling in activated macrophagesTomonaga Ichikawa
Department of Cell Biology and Anatomy, University of South Carolina, Columbia, SC 29208, USA
J Ethnopharmacol 125:145-50. 2009.... - Systemic inflammatory load in humans is suppressed by consumption of two formulations of dried, encapsulated juice concentrateYu Jin
Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29205, USA
Mol Nutr Food Res 54:1506-14. 2010..Data suggest a potential health benefit by consuming either formulation of the encapsulated juice concentrates through their anti-inflammatory properties... - Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosisVenkata S Kotakadi
Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
Carcinogenesis 29:1799-806. 2008..This current study is in agreement with previous studies supporting a use of EGb 761 as a complementary and alternative strategy to abate colitis and associated colon cancer... - Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cellsVenkatesh L Hegde
Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, 6439 Garners Ferry Rd, Columbia, SC 29209, USA
Mol Pharmacol 74:20-33. 2008..Our data demonstrate that targeting cannabinoid receptors using exogenous or endogenous cannabinoids and use of FAAH inhibitors may constitute novel therapeutic modalities to treat immune-mediated liver inflammation... - Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylaseLarry E Jones
Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
Carcinogenesis 30:2123-9. 2009..RNS-induced posttranslational modification of AAG is one mechanism of BER dysregulation, and the type of modification may define the role of AAG during carcinogenesis... - Circadian disruption, Per3, and human cytokine secretionJaclyn Guess
Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA
Integr Cancer Ther 8:329-36. 2009..Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role... - An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancerLei Ying
Department of Basic Pharmaceutical Sciences, South Carolina College of Pharmacy, University of South Carolina, 770 Sumter Street, Columbia, SC 29208, USA
Cancer Res 67:1407-10. 2007..We review the literature linking eNOS to carcinogenesis to encourage future research assessing the role of eNOS in cancer prevention and treatment... - Nitric oxide is a signaling molecule that regulates gene expressionLorne J Hofseth
College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
Methods Enzymol 396:326-40. 2005.... - Resveratrol (trans-3,5,4'-trihydroxystilbene) ameliorates experimental allergic encephalomyelitis, primarily via induction of apoptosis in T cells involving activation of aryl hydrocarbon receptor and estrogen receptorNarendra P Singh
Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC 29208, USA
Mol Pharmacol 72:1508-21. 2007..Data from the present study demonstrate, for the first time, the ability of resveratrol to trigger apoptosis in activated T cells and its potential use in the treatment of inflammatory and autoimmune diseases including, MS... - Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activationLei Ying
Laboratory of Inflammatory-Driven Carcinogenesis, Department of Basic Pharmaceutical Sciences, South Carolina College of Pharmacy
Cancer Res 65:9132-6. 2005..These observations provide insight into the in vivo mechanisms associated with chronic colon inflammation and increased colon cancer risk... - Colorectal cancer disparities in South Carolina: descriptive epidemiology, screening, special programs, and future directionVirginie G Daguise
South Carolina Cancer Alliance, P.O. Box 2722, Columbia, SC 29202, USA
J S C Med Assoc 102:212-20. 2006 - Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload diseaseJulie E Goodman
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Environ Mol Mutagen 44:3-9. 2004..These studies identified a potential mechanistic link between NO(.) and p53 in UC and sporadic colon cancer... - Nitric oxide-induced cellular stress and p53 activation in chronic inflammationLorne J Hofseth
Laboratories of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:143-8. 2003..Our study highlights a pivotal role of NO in the induction of cellular stress and the activation of a p53 response pathway during chronic inflammation... - Radical causes of cancerS Perwez Hussain
Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, Maryland 20892-4255, USA
Nat Rev Cancer 3:276-85. 2003..In particular, we highlight the interaction between nitric oxide and p53 as a crucial pathway in inflammatory-mediated carcinogenesis... - The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammationLorne J Hofseth
Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA
J Clin Invest 112:1887-94. 2003.... - The role of p53 in base excision repair following genotoxic stressIrit Zurer
Department of Molecular Cell Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
Carcinogenesis 25:11-9. 2004..When p53 is present, it down regulates the transcription of 3-MeAde DNA glycosylase. This provides a new model by which p53 prevents the creation of a mutator phenotype... - Nitric oxide in cancer and chemopreventionLorne J Hofseth
Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 34:955-68. 2003..These findings highlight the importance of further study of the use of NO inhibitors to inhibit human carcinogenesis... - The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stressFrank Staib
Laboratories of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA
Cancer Res 65:10255-64. 2005..In summary, the inflammatory stress response is a complex, integrated biological network in which p53 is a key molecular node regulating gene expression... - TP53 and liver carcinogenesisFrank Staib
Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA
Hum Mutat 21:201-16. 2003..The resultant molecular changes in the ras and Wnt signal-transduction pathways, and the p53 and Rb tumor suppressor pathways significantly contribute to liver carcinogenesis.. - p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosisS Perwez Hussain
Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
Cancer Res 64:2350-6. 2004..These results identify a novel mechanism of p53-dependent apoptosis in which p53-mediated up-regulation of MnSOD and GPx, but not CAT, produces an imbalance in antioxidant enzymes and oxidative stress... - p53: 25 years after its discoveryLorne J Hofseth
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Trends Pharmacol Sci 25:177-81. 2004..In this article, we briefly review the first 25 years of research on p53... - Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53Chun-Qi Li
Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA
Cancer Res 64:3022-9. 2004..Collectively, these data show that NO* exposure activated a complex network of responses leading to p53-dependent apoptosis via both mitochondrial and Fas receptor pathways, which were abrogated in the presence of mutant p53... - p53: at the crossroads of molecular carcinogenesis and molecular epidemiologyLorne J Hofseth
Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA
Chest 125:83S-5S. 2004 - Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxideDouglas D Thomas
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:8894-9. 2004..The findings show that concentration and duration of NO exposure are critical determinants in the regulation of tumor-related proteins... - Nitric oxide, a mediator of inflammation, suppresses tumorigenesisS Perwez Hussain
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
Cancer Res 64:6849-53. 2004..Furthermore, mice deficient in both p53 and NOS2 produced a high level of anti-inflammatory interleukin 10 when compared with p53-deficient mice. These studies provide genetic and mechanistic evidence that NO* can suppress tumorigenesis... - Inflammation and IGF-I activate the Akt pathway in breast cancerRobyn L Prueitt
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Int J Cancer 120:796-805. 2007..In summary, a proinflammatory environment was found to activate the Akt pathway in breast cancer, and may modify the association between the Akt phosphorylation status and breast cancer survival... - Nitric oxide is a key component in inflammation-accelerated tumorigenesisS Perwez Hussain
Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
Cancer Res 68:7130-6. 2008..These data provide genetic and mechanistic evidence that an inflammatory microenvironment and an increased level of NO(*) can accelerate tumor development... - Molecular pathogenesis of human hepatocellular carcinomaXin W Wang
Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Toxicology 181:43-7. 2002..Our studies implicate both viral and endogenous chemical processes in the etiology of HCC, and p53 may be a common target for the inactivation during liver carcinogenesis...