Alexander Hoffmann

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Circuitry of nuclear factor kappaB signaling
    Alexander Hoffmann
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Immunol Rev 210:171-86. 2006
  2. ncbi request reprint Transcriptional regulation via the NF-kappaB signaling module
    A Hoffmann
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92037, USA
    Oncogene 25:6706-16. 2006
  3. pmc Stabilization of RelB requires multidomain interactions with p100/p52
    Amanda J Fusco
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    J Biol Chem 283:12324-32. 2008
  4. pmc A fourth IkappaB protein within the NF-kappaB signaling module
    Soumen Basak
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 128:369-81. 2007
  5. pmc Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways
    Brian Zarnegar
    Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:8108-13. 2004
  6. pmc Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways
    Vincent F S Shih
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry and San Diego Center for Systems Biology, University of California, San Diego, La Jolla, California, USA
    Nat Immunol 13:1162-70. 2012
  7. pmc NF-kappaB dictates the degradation pathway of IkappaBalpha
    Erika Mathes
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0375, USA
    EMBO J 27:1357-67. 2008
  8. pmc A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity
    Ellen L O'Dea
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, UCSD, La Jolla, CA 92037, USA
    Mol Syst Biol 3:111. 2007
  9. pmc Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20
    Shannon L Werner
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 22:2093-101. 2008
  10. pmc A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation
    Shomyseh Sanjabi
    Howard Hughes Medical Institute, Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095 1662, USA
    Genes Dev 19:2138-51. 2005

Research Grants

  1. NFkB during TLR signaling in macrophages
    Alexander Hoffmann; Fiscal Year: 2010
  2. Regulation of signaling via the lkB-NF-kB interaction
    Alexander Hoffmann; Fiscal Year: 2009
  3. The NF-kB signaling system as a regulator of B-cell activation
    Alexander Hoffmann; Fiscal Year: 2010
  4. The NF-kB signaling system as a regulator of B-cell activation
    Alexander Hoffmann; Fiscal Year: 2011

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Circuitry of nuclear factor kappaB signaling
    Alexander Hoffmann
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Immunol Rev 210:171-86. 2006
    ..Understanding the genetic regulatory circuitry of NF-kappaB functionalities involves system-wide measurements, biophysical studies, and computational modeling...
  2. ncbi request reprint Transcriptional regulation via the NF-kappaB signaling module
    A Hoffmann
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92037, USA
    Oncogene 25:6706-16. 2006
    ....
  3. pmc Stabilization of RelB requires multidomain interactions with p100/p52
    Amanda J Fusco
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    J Biol Chem 283:12324-32. 2008
    ..This association-mediated stabilization of RelB implies a possible role for RelB in the processing of p100 into p52...
  4. pmc A fourth IkappaB protein within the NF-kappaB signaling module
    Soumen Basak
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 128:369-81. 2007
    ..Our results have important implications for physiological and pathological scenarios in which inflammatory and developmental signals converge...
  5. pmc Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways
    Brian Zarnegar
    Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:8108-13. 2004
    ..Overall, our studies suggest that both type 1 and type 2 NF-kappaB pathways contribute to the gene expression and biological program unique for CD40 in B cell activation...
  6. pmc Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways
    Vincent F S Shih
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry and San Diego Center for Systems Biology, University of California, San Diego, La Jolla, California, USA
    Nat Immunol 13:1162-70. 2012
    ..This work illustrates the potential utility of systems analyses in guiding the development of combination therapeutics for modulating DC-dependent T cell responses...
  7. pmc NF-kappaB dictates the degradation pathway of IkappaBalpha
    Erika Mathes
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0375, USA
    EMBO J 27:1357-67. 2008
    ..In addition, we find that both free and bound IkappaBalpha are similar substrates for IKK, and the preferential phosphorylation of NF-kappaB-bound IkappaBalpha is due to stabilization of IkappaBalpha by NF-kappaB...
  8. pmc A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity
    Ellen L O'Dea
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, UCSD, La Jolla, CA 92037, USA
    Mol Syst Biol 3:111. 2007
    ....
  9. pmc Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20
    Shannon L Werner
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 22:2093-101. 2008
    ..Our results delineate the nonredundant functions implied by the knockout phenotypes of ikappabalpha and a20, and identify the latter as a signaling cross-talk mediator controlling inflammatory and developmental responses...
  10. pmc A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation
    Shomyseh Sanjabi
    Howard Hughes Medical Institute, Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095 1662, USA
    Genes Dev 19:2138-51. 2005
    ....
  11. doi request reprint The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes
    Olga V Savinova
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 34:591-602. 2009
    ..Our biochemical evidence suggests an assembly pathway in which kinetic mechanisms control NF-kappaB dimer formation via processing and assembly of large complexes that contain IkappaB activities...
  12. doi request reprint The transcriptional specificity of NF-κB dimers is coded within the κB DNA response elements
    Vivien Ya Fan Wang
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell Rep 2:824-39. 2012
    ..Therefore, through sensing of bp differences within κB sites, NF-κB dimers modulate biological programs by activating, repressing, and altering the expression of effector genes...
  13. ncbi request reprint Stimulus specificity of gene expression programs determined by temporal control of IKK activity
    Shannon L Werner
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, 9500 Gilman Drive, Mailcode 0375, La Jolla, CA 92093 0375, USA
    Science 309:1857-61. 2005
    ..Thus, the distinct biological responses to LPS and TNFalpha depend on signaling pathway-specific mechanisms that regulate the temporal profile of IKK activity...
  14. pmc Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice
    Sibylle von Vietinghoff
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92122, USA
    J Immunol 185:670-8. 2010
    ..These neutrophil effects may limit the usefulness of global NF-kappaB inhibitors for the treatment of inflammatory diseases...
  15. pmc A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation
    Smarajit Polley
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
    PLoS Biol 11:e1001581. 2013
    ..Moreover, oligomerization through the interfaces identified in this study and subsequent trans auto-phosphorylation account for the rapid amplification of IKK2 phosphorylation observed even in the absence of any upstream kinase...
  16. pmc NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα
    Bärbel Schröfelbauer
    Signaling Systems Laboratory, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0375, USA
    Mol Cell 47:111-21. 2012
    ..Our work establishes a role for scaffolds such as NEMO in determining stimulus-specific signal transduction via the pleiotropic signaling hub IKK...
  17. pmc Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity
    Vincent F S Shih
    Signaling Systems Laboratory and Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0375, USA
    Proc Natl Acad Sci U S A 106:9619-24. 2009
    ..Finally, we found that IkappaB delta provides signaling memory owing to its long half-life; it integrates the inflammatory history of the cell to dampen NF-kappaB responsiveness during sequential stimulation events...
  18. pmc Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis
    Norihiko Takeda
    University of California at San Diego, La Jolla, 92093, USA
    Genes Dev 24:491-501. 2010
    ....
  19. ncbi request reprint Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators
    Jin Mo Park
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
    Immunity 23:319-29. 2005
    ..Here we describe key roles for transcription factor CREB, a target for p38 signaling, and the plasminogen activator 2 (PAI-2) gene, a target for CREB, in maintenance of macrophage survival...
  20. pmc How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members?
    Bärbel Schröfelbauer
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0375, USA
    Immunol Rev 244:29-43. 2011
    ..In this review, we discuss these strategies in the context of TNFR superfamily member signaling...
  21. pmc IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression
    Jeffrey D Kearns
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 173:659-64. 2006
    ....
  22. pmc Antigen-mediated T cell expansion regulated by parallel pathways of death
    Irene L Ch'en
    Division of Biological Sciences and Department of Cellular and Molecular Medicine, University of California, San Diego, CA 92093, USA
    Proc Natl Acad Sci U S A 105:17463-8. 2008
    ..The selective genetic ablation of caspase-8, NFkappaB, and Ripk1, reveals two forms of cell death that can regulate virus-specific T cell expansion...
  23. pmc UV as an amplifier rather than inducer of NF-kappaB activity
    Ellen L O'Dea
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0375, USA
    Mol Cell 30:632-41. 2008
    ..Our work suggests that the human health relevance of NF-kappaB activation by UV lies with cellular homeostatic states that are associated with pathology rather than with healthy physiology...
  24. doi request reprint NF-kappaB as a determinant of distinct cell death pathways
    Irene L Ch'en
    Division of Biological Sciences and the Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California
    Methods Enzymol 446:175-87. 2008
    ..Together, these may discriminate distinct cell death pathways and lead to a better understanding of the underlying regulatory mechanisms...
  25. pmc Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
    Sumito Ogawa
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Cell 122:707-21. 2005
    ..These findings reveal combinatorial control of homeostasis and immune responses by nuclear receptors and suggest new approaches for treatment of inflammatory diseases...
  26. ncbi request reprint Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli
    Liming Pei
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    J Biol Chem 280:29256-62. 2005
    ..These results identified NR4A nuclear receptors as potential transcriptional mediators of inflammatory signals in activated macrophages...
  27. pmc Characterizing the relationship between steady state and response using analytical expressions for the steady states of mass action models
    Paul Michael Loriaux
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
    PLoS Comput Biol 9:e1002901. 2013
    ..All code is available at http://signalingsystems.ucsd.edu/models-and-code/ or as supplementary material accompanying this paper...
  28. pmc The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50
    Christine S Cheng
    Signaling Systems Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Sci Signal 4:ra11. 2011
    ....
  29. pmc NF-κB potentiates caspase independent hydrogen peroxide induced cell death
    Jessica Q Ho
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 6:e16815. 2011
    ..Although there have been a few reports addressing the pro-cell death role of NF-κB, the precise mechanism of NF-κB's pro-cell death function still remains elusive...
  30. pmc Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha
    Simon Bergqvist
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093 0378, USA
    Proc Natl Acad Sci U S A 106:19328-33. 2009
    ..Mutational stabilization of these repeats reduces the efficiency with which IkappaBalpha enhances the dissociation rate...
  31. pmc A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling
    Vladimir R Ramirez-Carrozzi
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Cell 138:114-28. 2009
    ..By activating a diverse set of transcription factors, Toll-like receptors induce both classes and others for an optimal response to microbial pathogens...
  32. pmc Generation and activation of multiple dimeric transcription factors within the NF-kappaB signaling system
    Soumen Basak
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0375, USA
    Mol Cell Biol 28:3139-50. 2008
    ..Our results inform a wiring diagram to delineate NF-kappaB dimer formation that emphasizes that inflammatory and developmental signaling cannot be considered separately but are highly interconnected...
  33. pmc Ex vivo innate immune cytokine signature of enhanced risk of relapsing brucellosis
    Kristyn E Feldman
    Signaling Systems Laboratory, University of California San Diego, La Jolla, California, United States of America
    PLoS Negl Trop Dis 7:e2424. 2013
    ..In this study, we examined the ex vivo immune cytokine profiles of recovered patients with a history of acute and relapsing brucellosis...
  34. pmc The dynamics of signaling as a pharmacological target
    Marcelo Behar
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA San Diego Center for Systems Biology, University of California, San Diego, La Jolla, CA 92093, USA Computational Biosciences Institute, University of California, Los Angeles, Los Angeles, CA 90025, USA Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90025, USA
    Cell 155:448-61. 2013
    ....
  35. pmc ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK
    Arvin B Tam
    Division of Biological Sciences, Section of Molecular Biology, University of California, San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e45078. 2012
    ..Inhibition of IKK by an IKK inhibitor, which significantly decreases NF-κB activity, is overridden by UPR induction, arguing for the importance of considering UPR activation in cancer treatment...
  36. doi request reprint A framework for modeling the relationship between cellular steady-state and stimulus-responsiveness
    Paul M Loriaux
    Signaling Systems Laboratory, San Diego Center for Systems Biology of Cellular Stress Responses, Program in Bioinformatics and Systems Biology, University of California San Diego, La Jolla, California, USA
    Methods Cell Biol 110:81-109. 2012
    ....
  37. pmc The regulatory logic of the NF-kappaB signaling system
    Ellen O'Dea
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Cold Spring Harb Perspect Biol 2:a000216. 2010
    ..We discuss the prevailing mechanisms that mediate signaling cross talk...
  38. doi request reprint Understanding the logic of IκB:NF-κB regulation in structural terms
    Tom Huxford
    Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 1030, USA
    Curr Top Microbiol Immunol 349:1-24. 2011
    ..Here we provide a detailed description of these fundamental NF-κB regulatory events using as a basis macromolecular structures and experimental data derived from structure-based biochemistry...
  39. ncbi request reprint Inflammatory tales of liver cancer
    Alexander Hoffmann
    Signaling Systems Laboratory, University of California, San Diego, La Jolla, CA 92093, USA
    Cancer Cell 11:99-101. 2007
    ..These studies suggest careful examination of NF-kappaB inhibitors as a therapeutic modality for cancer...
  40. pmc Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression"
    Derren Barken
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry and Bioinformatics Graduate Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0375, USA
    Science 308:52; author reply 52. 2005
  41. pmc Crosstalk via the NF-kappaB signaling system
    Soumen Basak
    Department of Chemistry and Biochemistry, Signaling Systems Laboratory, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States
    Cytokine Growth Factor Rev 19:187-97. 2008
    ..We argue that a systems approach will be valuable for understanding questions of specificity and emergent properties of highly networked cellular signaling systems...
  42. ncbi request reprint Cutting edge: innate immunity conferred by B cells is regulated by caspase-8
    Daniel R Beisner
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 175:3469-73. 2005
    ..The activation of NF-kappaB or IFN regulatory factor 3 was found to be unaffected by the loss of caspase-8, implicating it in a novel pathway important for some forms of innate immunity mediated by B cells...
  43. pmc Tunable signal processing through a kinase control cycle: the IKK signaling node
    Marcelo Behar
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California, USA
    Biophys J 105:231-41. 2013
    ..Finally, we discuss the extension of the results to other regulatory motifs that could be understood in terms of the regimes of the three-state cycle...
  44. pmc Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-κB-driven transcription
    Sulakshana P Mukherjee
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS Biol 11:e1001647. 2013
    ..Additionally, chromatin analyses of RelA target gene promoters showed constitutive recruitment of CBP/p300, thus indicating a possible role of CBP/p300 in recruitment of RelA to its target promoter sites...
  45. pmc Lessons from mathematically modeling the NF-κB pathway
    Soumen Basak
    Systems Immunology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India
    Immunol Rev 246:221-38. 2012
    ..We also discuss the biological relevance of these regulatory systems properties...
  46. pmc Of elections and cell-death decisions
    Paul Loriaux
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA
    Mol Cell 34:257-8. 2009
    ....
  47. pmc A single NFκB system for both canonical and non-canonical signaling
    Vincent Feng Sheng Shih
    Signaling Systems Laboratory and San Diego Center for Systems Biology, Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gillman Dr, La Jolla, CA 92093, USA
    Cell Res 21:86-102. 2011
    ....
  48. pmc NF-κB signaling
    Ellen O'Dea
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA
    Wiley Interdiscip Rev Syst Biol Med 1:107-15. 2009
    ..In addition, we summarize the evidence for cross-talk mechanisms that allow for different stimuli to be integrated within the NF-κB signaling module to produce synergistic or qualitatively different signaling outcomes...
  49. pmc A protein turnover signaling motif controls the stimulus-sensitivity of stress response pathways
    Paul Michael Loriaux
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
    PLoS Comput Biol 9:e1002932. 2013
    ....
  50. pmc Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes
    Hajir Dadgostar
    Molecular Biology Institute and Medical Scientist Training Program, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:1497-502. 2002
    ....
  51. pmc Understanding the temporal codes of intra-cellular signals
    Marcelo Behar
    Signaling Systems Laboratory, BioCircuits Institute, and San Diego Center for Systems Biology of Cellular Stress Responses, University of California, San Diego, 9500 Gillman Dr, La Jolla, CA 92093, United States
    Curr Opin Genet Dev 20:684-93. 2010
    ..The present challenge is to identify the features of temporal activity profile that represent information about a given stimulus and understand how cells read the temporal codes to control their responses...
  52. pmc Epigenetic control: slow and global, nimble and local
    Christine S Cheng
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Genes Dev 22:1110-4. 2008
    ....
  53. ncbi request reprint CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response
    Tomohisa Kato
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 12:829-39. 2003
    ..Inhibition of this pathway prevents UV-induced IkappaBalpha degradation and increases UV-induced cell death. Thus, the p38-CK2-NF-kappaB axis is an important component of the mammalian UV response...
  54. ncbi request reprint One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers
    Thomas H Leung
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 118:453-64. 2004
    ..This suggests that binding sites may impart a specific configuration to bound transcription factors...
  55. pmc Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities
    Alexander Hoffmann
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 22:5530-9. 2003
    ....
  56. pmc Understanding NF-kappaB signaling via mathematical modeling
    Raymond Cheong
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21208, USA
    Mol Syst Biol 4:192. 2008
    ..We anticipate that computational techniques will enable further progress in the NF-kappaB field, and the signal transduction field in general, and we discuss potential upcoming developments...
  57. doi request reprint Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1
    Tomohisa Kato
    Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    Genes Cells 13:509-20. 2008
    ..TRAF1 phosphorylation by the ubiquitously expressed kinase PKN1 thereby plays a critical role in the negative regulation of tonic activity of the two central inflammatory signaling pathways...
  58. ncbi request reprint The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation
    Alexander Hoffmann
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 298:1241-5. 2002
    ..Bimodal signal-processing characteristics with respect to stimulus duration are revealed by the model and are shown to generate specificity in gene expression...
  59. ncbi request reprint Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses
    Raymond Cheong
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 281:2945-50. 2006
    ....
  60. pmc Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues
    James C Lo
    Committee on Immunology and Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Blood 107:1048-55. 2006
    ....
  61. ncbi request reprint Initiation and termination of NF-kappaB signaling by the intracellular protozoan parasite Toxoplasma gondii
    Sagi Shapira
    Department of Pathobiology, University of Pennsylvania, Philadelphia PA 19104, USA
    J Cell Sci 118:3501-8. 2005
    ..Thus, these studies demonstrate for the first time that the phosphorylation of p65/RelA represents an event downstream of IkappaB degradation that may be targeted by pathogens to subvert NF-kappaB signaling...
  62. ncbi request reprint Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras
    Maria Emily R Gapuzan
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Oncogene 24:6574-83. 2005
    ..These results suggest that RelA is a potential protein target for human tumors driven by oncogenic Ras mutations, but caution that inhibition of RelA may promote tumorigenesis in some circumstances...

Research Grants8

  1. NFkB during TLR signaling in macrophages
    Alexander Hoffmann; Fiscal Year: 2010
    ..Here we will undertake quantitative experimental studies in conjunction with computational modeling to produce a predictive understanding and predictive research tool of the regulatory mechanisms controlling inflammatory responses. ..
  2. Regulation of signaling via the lkB-NF-kB interaction
    Alexander Hoffmann; Fiscal Year: 2009
    ..abstract_text> ..
  3. The NF-kB signaling system as a regulator of B-cell activation
    Alexander Hoffmann; Fiscal Year: 2010
    ....
  4. The NF-kB signaling system as a regulator of B-cell activation
    Alexander Hoffmann; Fiscal Year: 2011
    ....