Genomes and Genes
Robert W Hoffman
Affiliation: University of Miami
- Immune pathogenesis of Mixed Connective Tissue Disease: a short analytical reviewRobert W Hoffman
Division of Rheumatology and Immunology, Department of Medicine, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Suite 986, Miami, FL 33136, USA
Clin Immunol 128:8-17. 2008....
- T cells in the pathogenesis of systemic lupus erythematosusRobert W Hoffman
Division of Rheumatology and Immunology, Department of Medicine, University of Miami and the Miami Veterans Affairs Medical Center, Miami, FL 33136, USA
Clin Immunol 113:4-13. 2004..The focus will be on recent studies characterizing autoantigen-reactive human T cells and signaling abnormalities identified in T cells from patients with SLE...
- CD4+ T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue diseaseEric L Greidinger
Division of Rheumatology and Immunology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
J Immunol 180:8444-54. 2008....
- Tissue targeting of anti-RNP autoimmunity: effects of T cells and myeloid dendritic cells in a murine modelEric L Greidinger
Miami VA Medical Center, and University of Miami Miller School of Medicine, Miami, Florida, USA
Arthritis Rheum 60:534-42. 2009..To explore the role of immune cells in anti-RNP autoimmunity in a murine model of pneumonitis or glomerulonephritis, using adoptive transfer techniques...
- A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigenEric L Greidinger
Division of Rheumatology and Immunology, University of Miami, Miami, Florida 33136, USA
Arthritis Rheum 54:661-9. 2006..To test whether immunizing mice with autoantigens closely linked to mixed connective tissue disease (MCTD) could induce an MCTD-like clinical syndrome distinguishable from systemic lupus erythematosus (SLE)...
- U1 RNA induces innate immunity signalingRobert W Hoffman
University of Miami and the Miami VA Medical Center, Miami, Florida 33136, USA
Arthritis Rheum 50:2891-6. 2004..The U1-70-kd RNP is a prominent target of autoimmunity in connective tissue diseases. In this study, we explored whether its endogenous ligand, U1 RNA, mediates a proimmune signal and may be immunogenic...
- Autoantibodies in the pathogenesis of mixed connective tissue diseaseEric L Greidinger
Division of Rheumatology and Immunology, University of Miami, Miami, FL 33136, USA
Rheum Dis Clin North Am 31:437-50, vi. 2005..Further studies are needed to establish whether anti-RNP antibodies have prognostic importance that is relevant to practicing clinicians...
- Clinical and immunologic manifestations of mixed connective tissue disease in a Miami population compared to a Midwestern US Caucasian populationMarcos E Maldonado
Division of Rheumatology and Immunology, Department of Medicine, University of Miami Miller School of Medicine and the Miami VA Medical Center, Miama, Florida 33136, USA
J Rheumatol 35:429-37. 2008..A cross-sectional study of mixed connective tissue disease (MCTD) was performed to determine if there were identifiable differences in the clinical expression of MCTD associated with race or ethnicity...
- Human T cell clones specific for heterogeneous nuclear ribonucleoprotein A2 autoantigen from connective tissue disease patients assist in autoantibody productionEric L Greidinger
University of Miami, and the Veterans Affairs Medical Center, Miami, Florida, USA
Arthritis Rheum 50:2216-22. 2004..To identify and characterize human T cells reactive with heterogeneous nuclear RNP A2 (hnRNP A2) antigen, and to determine the ability of hnRNP-reactive T cells to assist in the production of human autoantibodies...
- Differential tissue targeting of autoimmunity manifestations by autoantigen-associated Y RNAsEric L Greidinger
Veterans Affairs Medical Center, and the University of Miami Miller School of Medicine, Miami, Florida USA
Arthritis Rheum 56:1589-97. 2007..To assess the Y RNAs, a family of homologous RNAs that bind to the Ro autoantigen, for the ability to contribute to autoimmune disease by activating RNA-responsive Toll-like receptors (TLRs)...
- An external validation study of a classification of mixed connective tissue disease and systemic lupus erythematosus patientsRobert W Hoffman
University of Miami Miller School of Medicine, USA
J Appl Meas 13:205-16. 2012..This procedure was replicated in the present research with a sample of largely African American and Hispanic patients. Results verified separate dimensions for MCTD and SLE, which suggests MCTD is a separate disease from SLE...
- A Rasch analysis for classification of systemic lupus erythematosus and mixed connective tissue diseaseKyle Perkins
Florida International University, University Park, PC 543, 11200 S W 8th St, Miami, FL 33199, USA
J Appl Meas 9:136-50. 2008..Using Rasch model parameterization, and fit and residuals analyses, the researchers identified separate dimensions for MCTD and SLE, thereby lending support to the position that MCTD is its own separate disease, distinct from SLE...
- A major B cell epitope present on the apoptotic but not the intact form of the U1-70-kDa ribonucleoprotein autoantigenEric L Greidinger
Division of Rheumatology, University of Miami, Miami, FL 33136, USA
J Immunol 172:709-16. 2004..Immunization of mice against this epitope induces an immune response with features seen in human anti-70k autoimmune disease...
- Anti-ribonucleoprotein antibodies mediate enhanced lung injury following mesenteric ischemia/reperfusion in Rag-1(-/-) miceMichael P Keith
Department of Rheumatology, National Naval Medical Center, Bethesda, MD, USA
Autoimmunity 40:208-16. 2007..These experiments reveal a novel mechanism whereby anti-RNP Abs contributes to the development of pulmonary pathology in patients with autoimmune diseases following exposure of remote organs to I/R injury...
- Cloned human TCR from patients with autoimmune disease can respond to two structurally distinct autoantigensMihiri De Silva-Udawatta
Division of Immunology and Rheumatology, Department of Internal Medicine, University of Missouri, Columbia, MO 65212, USA
J Immunol 172:3940-7. 2004..These studies support an important role of plasticity of the TCR in the development of human autoimmunity...
- T cells and the loss of immunologic tolerance in Sjögren's syndrome and systemic lupus erythematosusRobert W Hoffman
Arthritis Rheum 56:3180-2. 2007
- A genome-wide study of lupus: preliminary analysis and data releaseAlessandra C L Cervino
Scripps Florida, 5353 Parkside Drive, RF A, Jupiter, FL 33458, USA
Ann N Y Acad Sci 1110:131-9. 2007..The analysis of the 165 cases and controls leads to 28 SNPs being associated with an uncorrected P-value < 0.0001...
- Epitope spreading in systemic lupus erythematosus: comment on the article by Monneaux and MullerRobert W Hoffman
Arthritis Rheum 48:582-3. 2003
- T cell immunity in connective tissue disease patients targets the RNA binding domain of the U1-70kDa small nuclear ribonucleoproteinEric L Greidinger
Division of Immunology and Rheumatology, University of Missouri, Columbia, MO 65212, USA
J Immunol 169:3429-37. 2002..The T cell autoimmune response to U1-70kDa appears to have less diversity than is seen in the humoral response; and therefore, may be a favorable target for therapeutic intervention...
- Circulating 20S proteasome levels in patients with mixed connective tissue disease and systemic lupus erythematosusMatthias Majetschak
The Burn and Shock Trauma Institute and Department of Surgery, Loyola University Chicago Stritch School of Medicine, Chicago, Illinois, USA
Clin Vaccine Immunol 15:1489-93. 2008..We present the initial report that c20S levels are elevated in MCTD and correlate with clinically relevant changes in disease activity in SLE and MCTD...
- Apoptotic U1-70 kd is antigenically distinct from the intact form of the U1-70-kd moleculeEric L Greidinger
University of Missouri and Department of Veterans Affairs Medical Research Service, Harry S Truman Memorial Veterans Hospital, Columbia, Missouri, USA
Arthritis Rheum 46:1264-9. 2002..To determine whether immune responses to an apoptotically modified form of a human lupus autoantigen can be distinguished from immune responses to the intact form of the same antigen...
- Sicca symptoms and anti-SSA/Ro antibodies are common in mixed connective tissue diseaseYatish N Setty
Department of Internal Medicine, University of Missouri Columbia, and Department of Veterans Affairs, Harry S Truman Memorial Veterans Hospital, 65212, USA
J Rheumatol 29:487-9. 2002..To examine a large well characterized cohort of patients with mixed connective tissue disease (MCTD) and determine longitudinally the prevalence of clinical and serologic features of Sjogren's syndrome in these patients...