Robert W Hoffman

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. doi request reprint Immune pathogenesis of Mixed Connective Tissue Disease: a short analytical review
    Robert W Hoffman
    Division of Rheumatology and Immunology, Department of Medicine, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Suite 986, Miami, FL 33136, USA
    Clin Immunol 128:8-17. 2008
  2. ncbi request reprint T cells in the pathogenesis of systemic lupus erythematosus
    Robert W Hoffman
    Division of Rheumatology and Immunology, Department of Medicine, University of Miami and the Miami Veterans Affairs Medical Center, Miami, FL 33136, USA
    Clin Immunol 113:4-13. 2004
  3. pmc CD4+ T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue disease
    Eric L Greidinger
    Division of Rheumatology and Immunology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Immunol 180:8444-54. 2008
  4. pmc Tissue targeting of anti-RNP autoimmunity: effects of T cells and myeloid dendritic cells in a murine model
    Eric L Greidinger
    Miami VA Medical Center, and University of Miami Miller School of Medicine, Miami, Florida, USA
    Arthritis Rheum 60:534-42. 2009
  5. ncbi request reprint A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen
    Eric L Greidinger
    Division of Rheumatology and Immunology, University of Miami, Miami, Florida 33136, USA
    Arthritis Rheum 54:661-9. 2006
  6. pmc U1 RNA induces innate immunity signaling
    Robert W Hoffman
    University of Miami and the Miami VA Medical Center, Miami, Florida 33136, USA
    Arthritis Rheum 50:2891-6. 2004
  7. ncbi request reprint Autoantibodies in the pathogenesis of mixed connective tissue disease
    Eric L Greidinger
    Division of Rheumatology and Immunology, University of Miami, Miami, FL 33136, USA
    Rheum Dis Clin North Am 31:437-50, vi. 2005
  8. pmc Clinical and immunologic manifestations of mixed connective tissue disease in a Miami population compared to a Midwestern US Caucasian population
    Marcos E Maldonado
    Division of Rheumatology and Immunology, Department of Medicine, University of Miami Miller School of Medicine and the Miami VA Medical Center, Miama, Florida 33136, USA
    J Rheumatol 35:429-37. 2008
  9. ncbi request reprint Human T cell clones specific for heterogeneous nuclear ribonucleoprotein A2 autoantigen from connective tissue disease patients assist in autoantibody production
    Eric L Greidinger
    University of Miami, and the Veterans Affairs Medical Center, Miami, Florida, USA
    Arthritis Rheum 50:2216-22. 2004
  10. ncbi request reprint Differential tissue targeting of autoimmunity manifestations by autoantigen-associated Y RNAs
    Eric L Greidinger
    Veterans Affairs Medical Center, and the University of Miami Miller School of Medicine, Miami, Florida USA
    Arthritis Rheum 56:1589-97. 2007

Research Grants

  1. Immune Response to Small Nuclear Ribonucleoprotein Autoantigens
    Robert Hoffman; Fiscal Year: 2007
  2. Human T Cell Response to Sm Autoantigen
    Robert Hoffman; Fiscal Year: 2006
  3. Immune Recognition of Modified Antigen in Scleroderma
    Robert Hoffman; Fiscal Year: 2003
  4. HUMAN T CELL RESPONSE TO THE SM AUTOANTIGEN
    Robert Hoffman; Fiscal Year: 2001

Collaborators

Detail Information

Publications22

  1. doi request reprint Immune pathogenesis of Mixed Connective Tissue Disease: a short analytical review
    Robert W Hoffman
    Division of Rheumatology and Immunology, Department of Medicine, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Suite 986, Miami, FL 33136, USA
    Clin Immunol 128:8-17. 2008
    ....
  2. ncbi request reprint T cells in the pathogenesis of systemic lupus erythematosus
    Robert W Hoffman
    Division of Rheumatology and Immunology, Department of Medicine, University of Miami and the Miami Veterans Affairs Medical Center, Miami, FL 33136, USA
    Clin Immunol 113:4-13. 2004
    ..The focus will be on recent studies characterizing autoantigen-reactive human T cells and signaling abnormalities identified in T cells from patients with SLE...
  3. pmc CD4+ T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue disease
    Eric L Greidinger
    Division of Rheumatology and Immunology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Immunol 180:8444-54. 2008
    ....
  4. pmc Tissue targeting of anti-RNP autoimmunity: effects of T cells and myeloid dendritic cells in a murine model
    Eric L Greidinger
    Miami VA Medical Center, and University of Miami Miller School of Medicine, Miami, Florida, USA
    Arthritis Rheum 60:534-42. 2009
    ..To explore the role of immune cells in anti-RNP autoimmunity in a murine model of pneumonitis or glomerulonephritis, using adoptive transfer techniques...
  5. ncbi request reprint A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen
    Eric L Greidinger
    Division of Rheumatology and Immunology, University of Miami, Miami, Florida 33136, USA
    Arthritis Rheum 54:661-9. 2006
    ..To test whether immunizing mice with autoantigens closely linked to mixed connective tissue disease (MCTD) could induce an MCTD-like clinical syndrome distinguishable from systemic lupus erythematosus (SLE)...
  6. pmc U1 RNA induces innate immunity signaling
    Robert W Hoffman
    University of Miami and the Miami VA Medical Center, Miami, Florida 33136, USA
    Arthritis Rheum 50:2891-6. 2004
    ..The U1-70-kd RNP is a prominent target of autoimmunity in connective tissue diseases. In this study, we explored whether its endogenous ligand, U1 RNA, mediates a proimmune signal and may be immunogenic...
  7. ncbi request reprint Autoantibodies in the pathogenesis of mixed connective tissue disease
    Eric L Greidinger
    Division of Rheumatology and Immunology, University of Miami, Miami, FL 33136, USA
    Rheum Dis Clin North Am 31:437-50, vi. 2005
    ..Further studies are needed to establish whether anti-RNP antibodies have prognostic importance that is relevant to practicing clinicians...
  8. pmc Clinical and immunologic manifestations of mixed connective tissue disease in a Miami population compared to a Midwestern US Caucasian population
    Marcos E Maldonado
    Division of Rheumatology and Immunology, Department of Medicine, University of Miami Miller School of Medicine and the Miami VA Medical Center, Miama, Florida 33136, USA
    J Rheumatol 35:429-37. 2008
    ..A cross-sectional study of mixed connective tissue disease (MCTD) was performed to determine if there were identifiable differences in the clinical expression of MCTD associated with race or ethnicity...
  9. ncbi request reprint Human T cell clones specific for heterogeneous nuclear ribonucleoprotein A2 autoantigen from connective tissue disease patients assist in autoantibody production
    Eric L Greidinger
    University of Miami, and the Veterans Affairs Medical Center, Miami, Florida, USA
    Arthritis Rheum 50:2216-22. 2004
    ..To identify and characterize human T cells reactive with heterogeneous nuclear RNP A2 (hnRNP A2) antigen, and to determine the ability of hnRNP-reactive T cells to assist in the production of human autoantibodies...
  10. ncbi request reprint Differential tissue targeting of autoimmunity manifestations by autoantigen-associated Y RNAs
    Eric L Greidinger
    Veterans Affairs Medical Center, and the University of Miami Miller School of Medicine, Miami, Florida USA
    Arthritis Rheum 56:1589-97. 2007
    ..To assess the Y RNAs, a family of homologous RNAs that bind to the Ro autoantigen, for the ability to contribute to autoimmune disease by activating RNA-responsive Toll-like receptors (TLRs)...
  11. ncbi request reprint An external validation study of a classification of mixed connective tissue disease and systemic lupus erythematosus patients
    Robert W Hoffman
    University of Miami Miller School of Medicine, USA
    J Appl Meas 13:205-16. 2012
    ..This procedure was replicated in the present research with a sample of largely African American and Hispanic patients. Results verified separate dimensions for MCTD and SLE, which suggests MCTD is a separate disease from SLE...
  12. ncbi request reprint A Rasch analysis for classification of systemic lupus erythematosus and mixed connective tissue disease
    Kyle Perkins
    Florida International University, University Park, PC 543, 11200 S W 8th St, Miami, FL 33199, USA
    J Appl Meas 9:136-50. 2008
    ..Using Rasch model parameterization, and fit and residuals analyses, the researchers identified separate dimensions for MCTD and SLE, thereby lending support to the position that MCTD is its own separate disease, distinct from SLE...
  13. ncbi request reprint A major B cell epitope present on the apoptotic but not the intact form of the U1-70-kDa ribonucleoprotein autoantigen
    Eric L Greidinger
    Division of Rheumatology, University of Miami, Miami, FL 33136, USA
    J Immunol 172:709-16. 2004
    ..Immunization of mice against this epitope induces an immune response with features seen in human anti-70k autoimmune disease...
  14. ncbi request reprint Anti-ribonucleoprotein antibodies mediate enhanced lung injury following mesenteric ischemia/reperfusion in Rag-1(-/-) mice
    Michael P Keith
    Department of Rheumatology, National Naval Medical Center, Bethesda, MD, USA
    Autoimmunity 40:208-16. 2007
    ..These experiments reveal a novel mechanism whereby anti-RNP Abs contributes to the development of pulmonary pathology in patients with autoimmune diseases following exposure of remote organs to I/R injury...
  15. ncbi request reprint Cloned human TCR from patients with autoimmune disease can respond to two structurally distinct autoantigens
    Mihiri De Silva-Udawatta
    Division of Immunology and Rheumatology, Department of Internal Medicine, University of Missouri, Columbia, MO 65212, USA
    J Immunol 172:3940-7. 2004
    ..These studies support an important role of plasticity of the TCR in the development of human autoimmunity...
  16. ncbi request reprint T cells and the loss of immunologic tolerance in Sjögren's syndrome and systemic lupus erythematosus
    Robert W Hoffman
    Arthritis Rheum 56:3180-2. 2007
  17. ncbi request reprint A genome-wide study of lupus: preliminary analysis and data release
    Alessandra C L Cervino
    Scripps Florida, 5353 Parkside Drive, RF A, Jupiter, FL 33458, USA
    Ann N Y Acad Sci 1110:131-9. 2007
    ..The analysis of the 165 cases and controls leads to 28 SNPs being associated with an uncorrected P-value < 0.0001...
  18. ncbi request reprint Epitope spreading in systemic lupus erythematosus: comment on the article by Monneaux and Muller
    Robert W Hoffman
    Arthritis Rheum 48:582-3. 2003
  19. ncbi request reprint T cell immunity in connective tissue disease patients targets the RNA binding domain of the U1-70kDa small nuclear ribonucleoprotein
    Eric L Greidinger
    Division of Immunology and Rheumatology, University of Missouri, Columbia, MO 65212, USA
    J Immunol 169:3429-37. 2002
    ..The T cell autoimmune response to U1-70kDa appears to have less diversity than is seen in the humoral response; and therefore, may be a favorable target for therapeutic intervention...
  20. pmc Circulating 20S proteasome levels in patients with mixed connective tissue disease and systemic lupus erythematosus
    Matthias Majetschak
    The Burn and Shock Trauma Institute and Department of Surgery, Loyola University Chicago Stritch School of Medicine, Chicago, Illinois, USA
    Clin Vaccine Immunol 15:1489-93. 2008
    ..We present the initial report that c20S levels are elevated in MCTD and correlate with clinically relevant changes in disease activity in SLE and MCTD...
  21. ncbi request reprint Apoptotic U1-70 kd is antigenically distinct from the intact form of the U1-70-kd molecule
    Eric L Greidinger
    University of Missouri and Department of Veterans Affairs Medical Research Service, Harry S Truman Memorial Veterans Hospital, Columbia, Missouri, USA
    Arthritis Rheum 46:1264-9. 2002
    ..To determine whether immune responses to an apoptotically modified form of a human lupus autoantigen can be distinguished from immune responses to the intact form of the same antigen...
  22. ncbi request reprint Sicca symptoms and anti-SSA/Ro antibodies are common in mixed connective tissue disease
    Yatish N Setty
    Department of Internal Medicine, University of Missouri Columbia, and Department of Veterans Affairs, Harry S Truman Memorial Veterans Hospital, 65212, USA
    J Rheumatol 29:487-9. 2002
    ..To examine a large well characterized cohort of patients with mixed connective tissue disease (MCTD) and determine longitudinally the prevalence of clinical and serologic features of Sjogren's syndrome in these patients...

Research Grants14

  1. Immune Response to Small Nuclear Ribonucleoprotein Autoantigens
    Robert Hoffman; Fiscal Year: 2007
    ..Our research goal is to develop new and effective treatments of these disorders. ..
  2. Human T Cell Response to Sm Autoantigen
    Robert Hoffman; Fiscal Year: 2006
    ..Stimulation of PBMC by Sm dominant peptides will determine whether the number of IFN-gamma positive cells from peripheral blood correlates with other established measures of disease activity. ..
  3. Immune Recognition of Modified Antigen in Scleroderma
    Robert Hoffman; Fiscal Year: 2003
    ..These Fab may then serve as valuable reagents for a series of future experiments derived directly from the work proposed. ..
  4. HUMAN T CELL RESPONSE TO THE SM AUTOANTIGEN
    Robert Hoffman; Fiscal Year: 2001
    ....