P L Hoffman

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure
    Peter Clapp
    University of Colorado Denver, School of Medicine, MS 8303, P O Box 6511, 12800 E 19th Avenue, Aurora, CO 80045, USA
    J Pharmacol Exp Ther 332:720-9. 2010
  2. ncbi request reprint Platelet adenylyl cyclase activity as a state or trait marker in alcohol dependence: results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence
    Paula L Hoffman
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Alcohol Clin Exp Res 26:1078-87. 2002
  3. ncbi request reprint Gene expression in animals with different acute responses to ethanol
    Paula Hoffman
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Addict Biol 10:63-9. 2005
  4. ncbi request reprint Transgenic and gene "knockout" models in alcohol research
    P L Hoffman
    University of Colorado Health Sciences Center, Denver, Colorado 80262 0001, USA
    Alcohol Clin Exp Res 25:60S-66S. 2001
  5. ncbi request reprint Phosphorylation cascades control the actions of ethanol on cell cAMP signalling
    B Tabakoff
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 E 9th Ave, Box C236, Denver, CO 80262, USA
    J Biomed Sci 8:44-51. 2001
  6. ncbi request reprint Chronic ethanol exposure delays the 'developmental switch' of the NMDA receptor 2A and 2B subunits in cultured cerebellar granule neurons
    L D Snell
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, USA
    J Neurochem 78:396-405. 2001
  7. ncbi request reprint WHP/ISBRA study on state and trait markers in alcoholism
    B Tabakoff
    University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Alcohol Clin Exp Res 25:99S-103S. 2001
  8. pmc Genomic insights into acute alcohol tolerance
    Wei Hu
    Department of Pharmacology, University of Colorado School of Medicine, Mail Stop 8303, P O Box 6511, Aurora, CO 80045 0511, USA
    J Pharmacol Exp Ther 326:792-800. 2008
  9. ncbi request reprint Chronic ethanol exposure results in increased acute functional tolerance in selected lines of HAFT and LAFT mice
    P H Wu
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200E 9th Ave, Box C236, Denver, CO 80262, USA
    Psychopharmacology (Berl) 155:405-12. 2001
  10. ncbi request reprint Overexpression of type 7 adenylyl cyclase in the mouse brain enhances acute and chronic actions of morphine
    M Yoshimura
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Mol Pharmacol 58:1011-6. 2000

Collaborators

Detail Information

Publications26

  1. pmc Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure
    Peter Clapp
    University of Colorado Denver, School of Medicine, MS 8303, P O Box 6511, 12800 E 19th Avenue, Aurora, CO 80045, USA
    J Pharmacol Exp Ther 332:720-9. 2010
    ....
  2. ncbi request reprint Platelet adenylyl cyclase activity as a state or trait marker in alcohol dependence: results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence
    Paula L Hoffman
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Alcohol Clin Exp Res 26:1078-87. 2002
    ..We have now measured platelet adenylyl cyclase activity in more than 1400 well-characterized subjects, which allows us to investigate the influence of a broad range of factors on this activity...
  3. ncbi request reprint Gene expression in animals with different acute responses to ethanol
    Paula Hoffman
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Addict Biol 10:63-9. 2005
    ..Microarray analysis can also be used to assess changes in gene expression that accompany transgene introduction and/or gene 'knock-out', which may modulate the influence of the targeted gene on behaviour...
  4. ncbi request reprint Transgenic and gene "knockout" models in alcohol research
    P L Hoffman
    University of Colorado Health Sciences Center, Denver, Colorado 80262 0001, USA
    Alcohol Clin Exp Res 25:60S-66S. 2001
    ..Phillips; (4) ICAM-1 is involved in early alcohol-induced liver injury in the mouse given enteral alcohol, by Hiroshi Kono; and (5) Strategies for targeted and regulated knockouts, by Robert O. Messing and Doo-Sup Choi...
  5. ncbi request reprint Phosphorylation cascades control the actions of ethanol on cell cAMP signalling
    B Tabakoff
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 E 9th Ave, Box C236, Denver, CO 80262, USA
    J Biomed Sci 8:44-51. 2001
    ..These data demonstrate that AC7 can be phosphorylated by PKC, leading to an increase in functional activity, and ethanol can potentiate AC7 activity through a PKC delta-mediated phosphorylation of AC7...
  6. ncbi request reprint Chronic ethanol exposure delays the 'developmental switch' of the NMDA receptor 2A and 2B subunits in cultured cerebellar granule neurons
    L D Snell
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, USA
    J Neurochem 78:396-405. 2001
    ..Changes in the proportion of NR2A and NR2B subunits may contribute to effects of ethanol on neuronal development...
  7. ncbi request reprint WHP/ISBRA study on state and trait markers in alcoholism
    B Tabakoff
    University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Alcohol Clin Exp Res 25:99S-103S. 2001
    ..Conigrave; (4) Relationship of body water to carbohydrate-deficient transferrin measures, by Larry Martinez; and (5) Platelet adenylyl cyclase activity as a trait marker of alcohol dependence, by Paula L. Hoffman...
  8. pmc Genomic insights into acute alcohol tolerance
    Wei Hu
    Department of Pharmacology, University of Colorado School of Medicine, Mail Stop 8303, P O Box 6511, Aurora, CO 80045 0511, USA
    J Pharmacol Exp Ther 326:792-800. 2008
    ....
  9. ncbi request reprint Chronic ethanol exposure results in increased acute functional tolerance in selected lines of HAFT and LAFT mice
    P H Wu
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200E 9th Ave, Box C236, Denver, CO 80262, USA
    Psychopharmacology (Berl) 155:405-12. 2001
    ..However, the increase in acute tolerance that occurred after chronic ethanol exposure was similar in both selected lines of mice, indicating little or no genetic correlation between acute tolerance and chronic tolerance...
  10. ncbi request reprint Overexpression of type 7 adenylyl cyclase in the mouse brain enhances acute and chronic actions of morphine
    M Yoshimura
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Mol Pharmacol 58:1011-6. 2000
    ..Interestingly, the signs of physical dependence on morphine in the transgenic mice did not differ from those in their wild-type litter mates, indicating that separate mechanisms may modulate opiate tolerance and opiate dependence...
  11. pmc Genetical genomic determinants of alcohol consumption in rats and humans
    Boris Tabakoff
    Department of Pharmacology, University of Colorado, Denver, Aurora, CO, USA
    BMC Biol 7:70. 2009
    ....
  12. pmc The genomic determinants of alcohol preference in mice
    Boris Tabakoff
    Department of Pharmacology, University of Colorado Denver School of Medicine, Mail Stop F 8303, P O Box 6511, Aurora, CO 80045 0511, USA
    Mamm Genome 19:352-65. 2008
    ..The importance of olfactory cues, learning and memory formation (Pavlovian conditioning), and cortical executive function, for regulating alcohol intake by animals (including humans), is discussed...
  13. ncbi request reprint Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion
    L D Snell
    Department of Pharmacology C236, University of Colorado Health Sciences Center, Denver 80262, USA
    Brain Res Mol Brain Res 40:71-8. 1996
    ..The changes in NMDA receptor subunit expression in discrete areas of the brain may contribute to the previously observed changes in ligand binding and, possibly, signs of ethanol withdrawal...
  14. pmc The PhenoGen informatics website: tools for analyses of complex traits
    Sanjiv V Bhave
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    BMC Genet 8:59. 2007
    ..Managing this diverse data and integrating with other biological data are major challenges for the bioinformatics community. Comprehensive new tools are needed to store, integrate and analyze the data efficiently...
  15. ncbi request reprint Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors
    Boris Tabakoff
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 23:4491-8. 2003
    ....
  16. ncbi request reprint Gene expression in brain: a window on ethanol dependence, neuroadaptation, and preference
    Paula L Hoffman
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Alcohol Clin Exp Res 27:155-68. 2003
    ....
  17. ncbi request reprint A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line
    K Hellevuo
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262
    Biochem Biophys Res Commun 192:311-8. 1993
    ..The smallest amount of novel AC mRNA in the tested brain tissue was found in the cortex. The mRNA for the novel AC was relatively abundant in human liver...
  18. ncbi request reprint Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice
    Sanjiv V Bhave
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045 0511, USA
    Alcohol Clin Exp Res 30:1659-69. 2006
    ..Differences in ethanol metabolizing enzymes expressed in brain have been suggested to contribute to the significant differences in ethanol (alcohol) preference between inbred C57BL/6 and DBA/2 mouse strains...
  19. ncbi request reprint Effect of ethanol on DARPP-32 phosphorylation in transgenic mice that express human type VII adenylyl cyclase in brain
    Timothy Donohue
    University of Colorado Health Sciences Center, Department of Pharmacology, Aurora, CO 80045, USA
    Alcohol Clin Exp Res 29:310-6. 2005
    ..Phosphorylation of DARPP-32 on threonine-75 (T75) is regulated by cyclin-dependent kinase 5 and protein phosphatase 2A. DARPP-32 has been implicated in the motivational effects of ethanol...
  20. ncbi request reprint NMDA receptors in alcoholism
    Paula L Hoffman
    Department of Pharmacology C 236, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Int Rev Neurobiol 56:35-82. 2003
  21. pmc Type 7 adenylyl cyclase-mediated hypothalamic-pituitary-adrenal axis responsiveness: influence of ethanol and sex
    Sergey P Pronko
    Department of Pharmacology, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA
    J Pharmacol Exp Ther 334:44-52. 2010
    ..The data provide evidence for an integral role of AC7 in the increase of plasma adrenocorticotropin and corticosterone levels during alcohol intoxication...
  22. ncbi request reprint Candidate genes and their regulatory elements: alcohol preference and tolerance
    Laura Saba
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Mamm Genome 17:669-88. 2006
    ....
  23. ncbi request reprint A sex-specific role of type VII adenylyl cyclase in depression
    Lisa M Hines
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurosci 26:12609-19. 2006
    ..Collectively, our results demonstrate a sex-specific influence of the AC7 gene on a heritable form of depressive illness...
  24. ncbi request reprint Phosphatidylinositol 3'-OH kinase and protein kinase A pathways mediate the anti-apoptotic effect of pituitary adenylyl cyclase-activating polypeptide in cultured cerebellar granule neurons: modulation by ethanol
    Sanjiv V Bhave
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurochem 88:359-69. 2004
    ....
  25. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
    ..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
  26. ncbi request reprint World Health Organization/International Society for Biomedical Research on Alcoholism study on state and trait markers of alcohol use and dependence: back to the future
    Friedrich M Wurst
    Psychiatric University Hospital Basel, Switzerland
    Alcohol Clin Exp Res 29:1268-75. 2005

Research Grants4

  1. Role of Glutamate Receptors in Excessive Ethanol Drinki*
    Paula Hoffman; Fiscal Year: 2006
    ..These studies will allow a more detailed investigation in Aim 3 of molecular mechanisms leading to changes in NMDA and/or AMPA receptor properties associated with the alcohol deprivation effect. ..
  2. BEHAVIORAL PHARMACOGENETICS OF DRUG AND ALCOHOL ABUSE
    Paula Hoffman; Fiscal Year: 2007
    ..Past trainees from this program have been very successful, and a number are continuing to make significant contributions in the alcohol and drug abuse fields. ..
  3. Alcohol Drinking after Modulation of Differentially Expressed Genes in HAP and LA
    Paula Hoffman; Fiscal Year: 2007
    ..These experiments will systematically investigate the role of identified candidate genes, alone and in combinations reflecting signal transduction pathways, in the modulation of voluntary alcohol consumption. ..