Maureane Hoffman

Summary

Affiliation: Duke University
Location: Durham, United States

Publications

  1. ncbi request reprint A cell-based model of hemostasis
    M Hoffman
    Pathology and Laboratory Medicine Service, Durham VA, Medical Center, NC 27705, USA
    Thromb Haemost 85:958-65. 2001
  2. ncbi request reprint The cellular basis of traumatic bleeding
    Maureane Hoffman
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Mil Med 169:5-7, 4. 2004
  3. doi request reprint The coagulation cascade in cirrhosis
    Dougald M Monroe
    Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Clin Liver Dis 13:1-9. 2009
  4. ncbi request reprint Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B
    A McDonald
    Duke University, Durham Veterans Affairs and University of North Carolia Medical Centers, Durham, NC 27705, USA
    J Thromb Haemost 5:1577-83. 2007
  5. ncbi request reprint Tissue factor around dermal vessels has bound factor VII in the absence of injury
    M Hoffman
    Duke University Medical Center, Durham, NC, USA
    J Thromb Haemost 5:1403-8. 2007
  6. ncbi request reprint Coagulation 2006: a modern view of hemostasis
    Maureane Hoffman
    Pathology and Laboratory Medicine Service 113, Durham Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Hematol Oncol Clin North Am 21:1-11. 2007
  7. ncbi request reprint Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia
    Derrick L Sauls
    Pathology and Lab Medicine Service, Durham Veterans Affairs Medical Center, Durham, Nutrition Program, Department Food Science, NC State University, Raleigh, NC, USA
    Thromb Res 120:117-26. 2007
  8. ncbi request reprint Cutaneous wound healing is impaired in hemophilia B
    Maureane Hoffman
    Laboratory Service 113, Durham Veterans Affairs Medical Center, 508 Fulton St, Durham, NC 27705, USA
    Blood 108:3053-60. 2006
  9. ncbi request reprint Modification of fibrinogen by homocysteine thiolactone increases resistance to fibrinolysis: a potential mechanism of the thrombotic tendency in hyperhomocysteinemia
    Derrick L Sauls
    Research Service, Durham Veteran s Affairs Medical Center, 508 Fulton Street, Durham, North Carolina 27705, USA
    Biochemistry 45:2480-7. 2006
  10. ncbi request reprint What does it take to make the perfect clot?
    Dougald M Monroe
    Durham Veterans Affairs Medical Center, Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Arterioscler Thromb Vasc Biol 26:41-8. 2006

Collaborators

Detail Information

Publications74

  1. ncbi request reprint A cell-based model of hemostasis
    M Hoffman
    Pathology and Laboratory Medicine Service, Durham VA, Medical Center, NC 27705, USA
    Thromb Haemost 85:958-65. 2001
    ..This cell based model explains some aspects of hemostasis that a protein-centric model does not...
  2. ncbi request reprint The cellular basis of traumatic bleeding
    Maureane Hoffman
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Mil Med 169:5-7, 4. 2004
    ..These articles discuss the causes of posttraumatic microvascular bleeding and the potential treatment options for controlling catastrophic hemorrhage in combat areas...
  3. doi request reprint The coagulation cascade in cirrhosis
    Dougald M Monroe
    Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Clin Liver Dis 13:1-9. 2009
    ..This allows the coagulation system to be more easily tipped into a state favoring either hemorrhage or thrombosis...
  4. ncbi request reprint Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B
    A McDonald
    Duke University, Durham Veterans Affairs and University of North Carolia Medical Centers, Durham, NC 27705, USA
    J Thromb Haemost 5:1577-83. 2007
    ..The wounds show abnormal histology: s.c. hematoma formation; delayed re-epithelialization; delayed macrophage influx; and an increase in wound site angiogenesis...
  5. ncbi request reprint Tissue factor around dermal vessels has bound factor VII in the absence of injury
    M Hoffman
    Duke University Medical Center, Durham, NC, USA
    J Thromb Haemost 5:1403-8. 2007
    ..Idling' or ongoing low-level activity of the tissue factor (TF) pathway is a postulated mechanism by which the coagulation process can become active without a lag period at sites of injury...
  6. ncbi request reprint Coagulation 2006: a modern view of hemostasis
    Maureane Hoffman
    Pathology and Laboratory Medicine Service 113, Durham Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Hematol Oncol Clin North Am 21:1-11. 2007
    ..Generation of the right amount of thrombin during the coagulation process not only may be essential for effective hemostasis but also may set the stage for effective wound healing...
  7. ncbi request reprint Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia
    Derrick L Sauls
    Pathology and Lab Medicine Service, Durham Veterans Affairs Medical Center, Durham, Nutrition Program, Department Food Science, NC State University, Raleigh, NC, USA
    Thromb Res 120:117-26. 2007
    ..Our findings suggest that an acquired dysfibrinogenemia could play a role in the increased risk of atherothrombotic disease in mildly hyperhomocysteinemic human subjects...
  8. ncbi request reprint Cutaneous wound healing is impaired in hemophilia B
    Maureane Hoffman
    Laboratory Service 113, Durham Veterans Affairs Medical Center, 508 Fulton St, Durham, NC 27705, USA
    Blood 108:3053-60. 2006
    ..Our findings have significant implications for treatment of patients with hemophilia, and also highlight the importance of rapidly establishing hemostasis following trauma or surgery...
  9. ncbi request reprint Modification of fibrinogen by homocysteine thiolactone increases resistance to fibrinolysis: a potential mechanism of the thrombotic tendency in hyperhomocysteinemia
    Derrick L Sauls
    Research Service, Durham Veteran s Affairs Medical Center, 508 Fulton Street, Durham, North Carolina 27705, USA
    Biochemistry 45:2480-7. 2006
    ..We hypothesize that the modification of lysine by Hcys thiolactone might occur in vivo, lead to abnormal resistance of clots to lysis, and thereby contribute to the prothrombotic state associated with homocysteinemia...
  10. ncbi request reprint What does it take to make the perfect clot?
    Dougald M Monroe
    Durham Veterans Affairs Medical Center, Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Arterioscler Thromb Vasc Biol 26:41-8. 2006
    ..Our understanding of how specific cellular features control the processes of hemostasis and thrombosis is developing rapidly. This review discusses some aspects of the cellular control of coagulation...
  11. doi request reprint Wound healing in haemophilia--breaking the vicious cycle
    M Hoffman
    Pathology and Laboratory Medicine Service, Durham VA Medical Center, Durham, NC 27705, USA
    Haemophilia 16:13-8. 2010
    ..Thus, normalizing haemostasis, until the process of angiogenesis has resolved, may be required to prevent re-bleeding and additional tissue damage...
  12. ncbi request reprint A cell-based model of coagulation and the role of factor VIIa
    Maureane Hoffman
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27705, USA
    Blood Rev 17:S1-5. 2003
    ..We believe that even in the presence of the FIXa/FVIIIa complex, rFVIIa may be able to enhance both FXa and FIXa levels on the surface of activated platelets, thus increasing the production of thrombin...
  13. ncbi request reprint The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients
    Zhi Hong Meng
    Department of Pathology, Duke University Medical Center, Durham, NC 27705, USA
    J Trauma 55:886-91. 2003
    ..High-dose FVIIa has also been used off-label to manage hemorrhage in trauma and surgical patients, many of whom also develop hypothermia and acidosis...
  14. ncbi request reprint Localization of heparin cofactor II in injured human skin: a potential role in wound healing
    Maureane Hoffman
    Duke University School of Medicine and Pathology and Laboratory Medicine Service, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
    Exp Mol Pathol 75:109-18. 2003
    ..These findings support the notion that HCII could function as an extravascular thrombin inhibitor and might play a role in the regulation of wound healing...
  15. ncbi request reprint Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia
    Anna G McDonald
    Duke University, Durham, NC, USA
    Blood 111:2046-8. 2008
    ..Thus, perivascular TF expression is down-regulated during wound healing. This may prevent thrombosis of neovessels during angiogenesis but renders hemophiliacs vulnerable to hemorrhage during healing...
  16. ncbi request reprint Animal models of bleeding and tissue repair
    M Hoffman
    Pathology and Laboratory Medicine Service, Durham VA Medical Center, Durham, NC 27705, USA
    Haemophilia 14:62-7. 2008
    ..However, there is much yet to be learned about the effects of bleeding on tissue responses, including validating the results of animal studies in clinical trials...
  17. doi request reprint Low intensity laser therapy speeds wound healing in hemophilia by enhancing platelet procoagulant activity
    Maureane Hoffman
    Department of Pathology, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina 27705, USA
    Wound Repair Regen 20:770-7. 2012
    ..These data suggest that trials of LILT as an adjunct to the usual hemostatic therapies in hemophilia are warranted...
  18. doi request reprint Mechanisms and monitoring of bypassing agent therapy
    M Hoffman
    Duke University, Durham VA Medical Center, Durham, NC 27705, USA
    J Thromb Haemost 10:1478-85. 2012
    ....
  19. ncbi request reprint The multiple roles of tissue factor in wound healing
    Maureane Hoffman
    Pathology and Laboratory Medicine Service, Durham VA Medical Center, Durham, NC 27705, USA
    Front Biosci (Schol Ed) 4:713-21. 2012
    ..The literature in this are remains somewhat sparse, but suggests that modulation of TF expression plays a role in modulating the host response to injury...
  20. doi request reprint Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress
    Maureane Hoffman
    Pathology and Laboratory Medicine Service, Durham VA Medical Center, Durham, NC 27705, USA
    Med Hypotheses 77:1088-93. 2011
    ....
  21. doi request reprint Homocysteinylated fibrinogen forms disulfide-linked complexes with albumin
    Derrick L Sauls
    Research Service, Durham Veterans Affairs Medical Center, Durham, NC 27705, United States
    Thromb Res 127:576-81. 2011
    ....
  22. doi request reprint Prophylactic correction of the international normalized ratio in neurosurgery: a brief review of a brief literature
    Kelly L West
    Department of Pathology, Duke University, Durham, North Carolina, USA
    J Neurosurg 114:9-18. 2011
    ..Based on their review of the literature, the authors suggest that in a hemodynamically stable patient population there is a range of mildly prolonged INR values for which FFP transfusion is not beneficial, and is potentially harmful...
  23. pmc Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin
    Shahid M Nimjee
    Department of Surgery, Division of Surgical Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    RNA 15:2105-11. 2009
    ..This combination of exosite 1 and exosite 2 inhibitors may provide a particularly effective antithrombotic approach...
  24. doi request reprint A rationally designed heparin, M118, has anticoagulant activity similar to unfractionated heparin and different from Lovenox in a cell-based model of thrombin generation
    Zoya Volovyk
    Duke University Medical Center, Durham, NC 27710, USA
    J Thromb Thrombolysis 28:132-9. 2009
    ..Our data suggest that the ability to inhibit platelet surface IIa generation correlates with the therapeutic level of heparins and confirms similarities between the anticoagulant properties of M118 and UFH...
  25. ncbi request reprint Some things I thought I knew about tissue factor that turn out to be wrong
    Maureane Hoffman
    Department of Pathology, Duke University Medical Center, Durham Veterans Affairs Medical Center, Durham, NC, USA
    Thromb Res 122:S73-7. 2008
    ..The observed down-regulation of TF expression may serve to prevent thrombosis of developing neovessels and contribute to the well-recognized tendency of granulation tissue to bleed readily and profusely...
  26. ncbi request reprint Alterations of fibrinogen structure in human disease
    M Hoffman
    Pathology and Laboratory Medicine Service 113, Durham Veterans Affairs, Medical Center, 508 Fulton St, Durham, NC 27705, USA
    Cardiovasc Hematol Agents Med Chem 6:206-11. 2008
    ..However, direct evidence is still lacking that these modifications contribute to the increased atherothrombotic risk associated with hyperhomocysteinemia and diabetes...
  27. ncbi request reprint Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: implications for the mechanism of thrombosis in hyperhomocysteinemia
    D L Sauls
    Pathology and Laboratory Medicine Service, Durham Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    J Thromb Haemost 1:300-6. 2003
    ..The formation of clots that are abnormally resistant to fibrinolysis could directly contribute to the increased risk of thrombosis in hyperhomocysteinemia...
  28. ncbi request reprint Generation of species cross-reactive aptamers using "toggle" SELEX
    R White
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Ther 4:567-73. 2001
    ..This strategy should facilitate the isolation of ligands with needed properties for gene therapy and other therapeutic and diagnostic applications...
  29. ncbi request reprint Activated factor VII activates factors IX and X on the surface of activated platelets: thoughts on the mechanism of action of high-dose activated factor VII
    M Hoffman
    Department of Pathology, Durham Veterans Affairs Medical Center, NC 27705, USA
    Blood Coagul Fibrinolysis 9:S61-5. 1998
    ..Activation of FIX and FX on platelet surfaces in thrombocytopenia would result in more thrombin generation per platelet, possibly leading to formation of a stable fibrin network even in the absence of an optimal initial platelet plug...
  30. ncbi request reprint The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis
    M Hoffman
    Duke University, and Durham Veterans Affairs Medical Centers, NC 27705, USA
    Semin Hematol 38:6-9. 2001
    ..Our data suggest that in a cellular system high-dose FVIIa acts primarily by enhancing the rate of thrombin generation on platelet surfaces and not by overcoming inhibition by zymogen FVII of TF-dependent activation of FX...
  31. ncbi request reprint Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces
    Julie A Oliver
    Duke University and the Durham VA Medical Hospital, Durham, NC, USA
    Blood 100:539-46. 2002
    ..From the studies reported here, we conclude that in vivo, despite the important role of the protein C system in regulating thrombosis, activated protein C does not serve as a primary regulator of platelet-dependent thrombin generation...
  32. doi request reprint Platelet binding and activity of recombinant factor VIIa
    Maureane Hoffman
    Pathology and Laboratory Medicine Service, Durham VA Medical Center, 508 Fulton St, Durham, NC 27705, USA
    Thromb Res 125:S16-8. 2010
    ..Thus, there are still unanswered questions in fully understanding the mechanism of hemostatic action of recombinant FVIIa...
  33. ncbi request reprint Coagulation factor interaction with platelets
    Dougald M Monroe
    Center for Thrombosis and Hemostasis, University of North Carolina, Chapel Hill, NC, USA
    Thromb Haemost 88:179. 2002
  34. ncbi request reprint A cell-based model of thrombin generation
    Harold R Roberts
    School of Medicine, Division of Hematology Oncology, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina 27599 7035, USA
    Semin Thromb Hemost 32:32-8. 2006
    ..We have also shown that activated protein C does not inactivate Va on the platelet surface but rather on endothelial cell surfaces...
  35. ncbi request reprint Fathers of modern coagulation
    Dougald M Monroe
    UNC Medical School Hematology Oncology, 932 Mary Ellen Jones, CB 7035 Chapel Hill, North Carolina 27599 7035, USA
    Thromb Haemost 98:3-5. 2007
  36. ncbi request reprint High dose factor VIIa improves clot structure and stability in a model of haemophilia B
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, NC 27599 7525, USA
    Br J Haematol 131:645-55. 2005
    ....
  37. ncbi request reprint Platelets and thrombin generation
    Dougald M Monroe
    Center for Thrombosis and Hemostasis, University of North Carolina, Chapel Hill 27599 7035, USA
    Arterioscler Thromb Vasc Biol 22:1381-9. 2002
    ..Individual differences in platelet thrombin generation might be accounted for by differences in platelet-binding proteins...
  38. ncbi request reprint Recombinant activated factor VII: its mechanism of action and role in the control of hemorrhage
    Geoffrey A Allen
    Center for Thrombosis and Hemostasis and Pediatric Hematology Oncology, University of North Carolina School of Medicine, Chapel Hill 27599 7220, USA
    Can J Anaesth 49:S7-14. 2002
    ..We have attempted to reconcile the various proposed mechanisms of action of rFVIIa with its apparent efficacy in such diverse clinical settings...
  39. ncbi request reprint A possible mechanism of action of activated factor VII independent of tissue factor
    D M Monroe
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7035, USA
    Blood Coagul Fibrinolysis 9:S15-20. 1998
    ..We speculate that this platelet-localized thrombin generation may, in part, account for the clinical efficacy of high-dose FVIIa...
  40. ncbi request reprint Impact of procoagulant concentration on rate, peak and total thrombin generation in a model system
    G A Allen
    Department of Pediatrics Department of Pathology and Laboratory Medicine Department of Medicine Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC, USA
    J Thromb Haemost 2:402-13. 2004
    ....
  41. ncbi request reprint The factor VII-platelet interplay: effectiveness of recombinant factor VIIa in the treatment of bleeding in severe thrombocytopathia
    D M Monroe
    Center for Thrombosis and Hemostasis, UNC School of Medicine, Chapel Hill, North Carolina, USA
    Semin Thromb Hemost 26:373-7. 2000
    ..Finally, enhanced thrombin generation on platelets would mean that fewer platelets are required for hemostasis...
  42. ncbi request reprint Hemostatic properties of the FVIIa analog NN1731
    Maureane Hoffman
    Duke University and Durham Veterans Affairs Medical Centers, Pathology and Laboratory Medicine Svc, Durham, North Carolina 27705, USA
    Thromb Res 129:S49-50. 2012
    ..This molecule exhibits greater potency than FVIIa in biochemical assays, in vitro and animal models, and in early phase clinical trials...
  43. ncbi request reprint Differences in the metabolic response to exogenous homocysteine in juvenile and adult rabbits
    Derrick L Sauls
    Department of Pathology, Duke University Medical Center, City, NC, USA
    J Nutr Biochem 15:96-102. 2004
    ..The difference in metabolism of homocysteine may protect the juvenile rabbits from the damaging effects of homocysteine. Future studies are planned to elucidate the mechanism of this adaptive response...
  44. ncbi request reprint Remodeling the blood coagulation cascade
    Maureane Hoffman
    Department of Pathology, Duke University Medical Center and Durham VA Medical Center, Durham, NC 27705, USA
    J Thromb Thrombolysis 16:17-20. 2003
    ..This cell-based model suggests that the "intrinsic" and "extrinsic" pathways are in fact not redundant systems, but operate in parallel on different cell surfaces...
  45. doi request reprint The clotting system - a major player in wound healing
    Dougald M Monroe
    Division of Hematology Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7035, USA
    Haemophilia 18:11-6. 2012
    ..The goal of such treatment would be to avoid a feedback cycle in which bleeding tends to lead to further bleeding. Once initiated, this cycle may be difficult to control...
  46. ncbi request reprint Response of blood leukocytes to thrombin receptor peptides
    M Hoffman
    Laboratory Service, Durham Veterans Affairs Medical Center, NC 27705
    J Leukoc Biol 54:145-51. 1993
    ..We conclude that human monocytes possess a thrombin receptor similar to that present on platelets. Furthermore, the residue corresponding to Arg 46 of the thrombin receptor is critical for receptor agonist activity...
  47. ncbi request reprint Links between the immune and coagulation systems: how do "antiphospholipid antibodies" cause thrombosis?
    M Hoffman
    Duke University Medical Center, Durham, NC, USA
    Immunol Res 22:191-7. 2000
    ..Antiphospholipid" antibodies against the phospholipid-binding protein beta-2-glycoprotein-1 enhance thrombin generation in this model system, primarily by enhancing procoagulant reactions on tissue factor-bearing cells...
  48. ncbi request reprint One more way that mice and men are different
    M Hoffman
    Duke University and Durham VA Medical Centers, Durham, NC 27705, USA
    J Thromb Haemost 3:448-9. 2005
  49. pmc Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2
    D W Thomas
    Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina 27705, USA
    J Clin Invest 102:1994-2001. 1998
    ..In summary, Tp-/- mice have a mild bleeding disorder and altered vascular responses to TXA2 and arachidonic acid. Our studies suggest that most of the recognized functions of TXA2 are mediated by the single known Tp gene locus...
  50. ncbi request reprint Analyzing fibrin clot structure using a microplate reader
    A S Wolberg
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27705, USA
    Blood Coagul Fibrinolysis 13:533-9. 2002
    ..We suggest that plate-reading spectrophotometers can provide a convenient, rapid, and inexpensive means of analyzing fibrin clot structure...
  51. ncbi request reprint Safety profile of recombinant factor VIIa
    Harold R Roberts
    Division of Hematology, Center for Thrombosis and Hemostasis, University of North Carolina at Chapel Hill, USA
    Semin Hematol 41:101-8. 2004
    ..Finally, those situations in which rFVIIa therapy may not be safe, such as disseminated intravascular coagulation (DIC) and sepsis, will also be discussed...
  52. ncbi request reprint Manipulation of prothrombin concentration improves response to high-dose factor VIIa in a cell-based model of haemophilia
    Geoffrey A Allen
    Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Br J Haematol 134:314-9. 2006
    ..Furthermore, these results suggest that increasing plasma prothrombin concentration prior to rFVIIa administration may offer advantages over the use of rFVIIa alone in the treatment of haemophilic bleeding...
  53. ncbi request reprint The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis
    Maureane Hoffman
    Dis Mon 49:14-21. 2003
    ..Our data suggest that in a cellular system high-dose FVIIa acts primarily by enhancing the rate of thrombin generation on platelet surfaces and not by overcoming inhibition by zymogen FVII of TF-dependent activation of FX...
  54. ncbi request reprint Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo
    Tong Gui
    Department of Biology, University of North Carolina at Chapel Hill, 27599 3280, USA
    Blood 100:153-8. 2002
    ..Our results suggest that factor IX Gla-domain mediated binding to endothelial cells/collagen IV plays a role in controlling factor IX concentration in the blood...
  55. ncbi request reprint Laboratory monitoring of high-dose factor VIIa therapy
    Maureane Hoffman
    Ann Intern Med 139:791. 2003
  56. ncbi request reprint New insights into the coagulation system and implications for new therapeutic options with recombinant factor VIIa
    Alex Veldman
    J W Goethe University Hospital, Dept Pediatrics, Frankfurt, Germany
    Curr Med Chem 10:797-811. 2003
    ....
  57. ncbi request reprint Platelet-dependent action of high-dose factor VIIa
    Maureane Hoffman
    Blood 100:364-5; author reply 365. 2002
  58. ncbi request reprint Platelet heterogeneity: variation in coagulation complexes on platelet subpopulations
    Christine L Kempton
    University of North Carolina, Chapel Hill, NC 27599 7035, USA
    Arterioscler Thromb Vasc Biol 25:861-6. 2005
    ....
  59. ncbi request reprint Elevated prothrombin results in clots with an altered fiber structure: a possible mechanism of the increased thrombotic risk
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, USA
    Blood 101:3008-13. 2003
    ..We hypothesize that this alteration in fibrin clot structure is an important determinant of the risk of thrombosis...
  60. ncbi request reprint Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management
    Stephen H Caldwell
    University of Virginia, Digestive Health Center of Excellence, GI Hepatology Division, Charlottesville, VA 22908 0705, USA
    Hepatology 44:1039-46. 2006
    ....
  61. ncbi request reprint A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    J Trauma 56:1221-8. 2004
    ..Hypothermia-associated bleeding has been hypothesized to result from dysregulation of enzymatic function, reduced platelet activity, and/or altered fibrinolysis...