Irving F Hoffman

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint A peer-educator network HIV prevention intervention among injection drug users: results of a randomized controlled trial in St. Petersburg, Russia
    Irving F Hoffman
    Division of Infectious Diseases, Department of Medicine, UNC Hospitals, University of North Carolina, CB 7030, Chapel Hill, NC, 27599, USA
    AIDS Behav 17:2510-20. 2013
  2. pmc Drug choice, spatial distribution, HIV risk, and HIV prevalence among injection drug users in St. Petersburg, Russia
    Gina Rae Kruse
    Department of Epidemiology and Public Health and the Center for Interdisciplinary Research on AIDS, Yale School of Public Health, PO Box 208034, 60 College Street New Haven, CT 06520 8034 USA
    Harm Reduct J 6:22. 2009
  3. ncbi request reprint Human immunodeficiency virus type 1 RNA in breast-milk components
    Irving F Hoffman
    Center for Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599 7030, USA
    J Infect Dis 188:1209-12. 2003
  4. doi request reprint The year-long effect of HIV-positive test results on pregnancy intentions, contraceptive use, and pregnancy incidence among Malawian women
    Irving F Hoffman
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA
    J Acquir Immune Defic Syndr 47:477-83. 2008
  5. pmc Morbidity and mortality among a cohort of human immunodeficiency virus type 1-infected and uninfected pregnant women and their infants from Malawi, Zambia, and Tanzania
    David Chilongozi
    University of North Carolina Project, Lilongwe, Malawi
    Pediatr Infect Dis J 27:808-14. 2008
  6. ncbi request reprint The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration
    I F Hoffman
    University of North Carolina, Division of Infectious Diseases, Chapel Hill, USA
    AIDS 13:487-94. 1999
  7. ncbi request reprint Nonoxynol-9 100 mg gel: multi-site safety study from sub-Saharan Africa
    Irving F Hoffman
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA
    AIDS 18:2191-5. 2004
  8. pmc Predicting partner HIV testing and counseling following a partner notification intervention
    Lillian B Brown
    Department of Epidemiology, CB 7435, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
    AIDS Behav 16:1148-55. 2012
  9. pmc Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection
    Christopher D Pilcher
    Center for Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    AIDS 21:1723-30. 2007
  10. pmc Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithm
    Kimberly A Powers
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    AIDS 21:2237-42. 2007

Detail Information

Publications47

  1. doi request reprint A peer-educator network HIV prevention intervention among injection drug users: results of a randomized controlled trial in St. Petersburg, Russia
    Irving F Hoffman
    Division of Infectious Diseases, Department of Medicine, UNC Hospitals, University of North Carolina, CB 7030, Chapel Hill, NC, 27599, USA
    AIDS Behav 17:2510-20. 2013
    ..73, permutation p value = 0.16). Retention rate was 67 % with a third of the loss due to incarceration or death. The results show a promising trend that this strategy would be successful in reducing the acquisition of HIV among IDUs. ..
  2. pmc Drug choice, spatial distribution, HIV risk, and HIV prevalence among injection drug users in St. Petersburg, Russia
    Gina Rae Kruse
    Department of Epidemiology and Public Health and the Center for Interdisciplinary Research on AIDS, Yale School of Public Health, PO Box 208034, 60 College Street New Haven, CT 06520 8034 USA
    Harm Reduct J 6:22. 2009
    ..However, attention to neighborhood differences might improve the intervention impact for injectors who favor different drugs...
  3. ncbi request reprint Human immunodeficiency virus type 1 RNA in breast-milk components
    Irving F Hoffman
    Center for Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599 7030, USA
    J Infect Dis 188:1209-12. 2003
    ..Whole milk demonstrated higher sensitivity and mean concentration than any other single component. Sensitivity was enhanced by analyzing all 4 components of breast milk...
  4. doi request reprint The year-long effect of HIV-positive test results on pregnancy intentions, contraceptive use, and pregnancy incidence among Malawian women
    Irving F Hoffman
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA
    J Acquir Immune Defic Syndr 47:477-83. 2008
    ....
  5. pmc Morbidity and mortality among a cohort of human immunodeficiency virus type 1-infected and uninfected pregnant women and their infants from Malawi, Zambia, and Tanzania
    David Chilongozi
    University of North Carolina Project, Lilongwe, Malawi
    Pediatr Infect Dis J 27:808-14. 2008
    ..Morbidity and mortality patterns among pregnant women and their infants (before antiretroviral therapy was widely available) determines HIV-1 diagnostic, monitoring, and care interventions...
  6. ncbi request reprint The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration
    I F Hoffman
    University of North Carolina, Division of Infectious Diseases, Chapel Hill, USA
    AIDS 13:487-94. 1999
    ..This study was undertaken to determine the relative effect of malaria infection on HIV concentration in blood plasma, and prospectively to monitor viral concentrations after antimalarial therapy...
  7. ncbi request reprint Nonoxynol-9 100 mg gel: multi-site safety study from sub-Saharan Africa
    Irving F Hoffman
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA
    AIDS 18:2191-5. 2004
    ..To evaluate the safety of 100 mg nonoxynol-9 (N-9) gel, a vaginal microbicide, on the genital mucosa of women from Malawi and Zimbabwe in preparation for a phase III efficacy study...
  8. pmc Predicting partner HIV testing and counseling following a partner notification intervention
    Lillian B Brown
    Department of Epidemiology, CB 7435, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
    AIDS Behav 16:1148-55. 2012
    ..A risk score to target partner notification can reduce the resources required to locate all partners in the community while increasing the testing yield compared to patient-referral...
  9. pmc Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection
    Christopher D Pilcher
    Center for Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    AIDS 21:1723-30. 2007
    ..This study was conducted to compare viral dynamics in blood and semen between subjects with antibody negative, acute HIV-1 infection and other subjects with later stages of infection...
  10. pmc Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithm
    Kimberly A Powers
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    AIDS 21:2237-42. 2007
    ..To facilitate the efficient use of these tests, we sought to develop a risk score algorithm for identifying likely AHI cases and targeting the tests towards those individuals...
  11. pmc The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling study
    Kimberly A Powers
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7030, USA
    Lancet 378:256-68. 2011
    ..We estimated the contribution of early infection to HIV incidence in Lilongwe, Malawi, and predict the future effect of hypothetical prevention interventions targeted at early infection only, chronic infection only, or both stages...
  12. pmc Sexual partnership patterns in malawi: implications for HIV/STI transmission
    Kimberly A Powers
    Department s of Epidemiology, The University of North Carolina, Chapel Hill, NC 27599 7030, USA
    Sex Transm Dis 38:657-66. 2011
    ..To contribute to the understanding of sexual partnership patterns in this region, we estimated partnership lengths, temporal gaps between partners, and periods of overlap across partners at an STI clinic in Lilongwe, Malawi...
  13. pmc HIV partner notification is effective and feasible in sub-Saharan Africa: opportunities for HIV treatment and prevention
    Lillian B Brown
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
    J Acquir Immune Defic Syndr 56:437-42. 2011
    ..However, many African countries do not have a standardized protocol for partner notification, and the effectiveness of partner notification has not been evaluated in developing countries ...
  14. doi request reprint Impact of aciclovir on ulcer healing, lesional, genital and plasma HIV-1 RNA among patients with genital ulcer disease in Malawi
    SAM PHIRI
    Lighthouse Centre, Kamuzu Central Hospital, Lilongwe, Malawi
    Sex Transm Infect 86:345-52. 2010
    ..By a randomised, double-blind, placebo-controlled trial of aciclovir 800 mg twice daily for 5 days added to the syndromic management of genital ulcer disease (GUD) to determine the impact on ulcer healing and HIV outcomes...
  15. ncbi request reprint Trichomoniasis in men and HIV infection: data from 2 outpatient clinics at Lilongwe Central Hospital, Malawi
    Matthew A Price
    School of Medicine, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7030, USA
    J Infect Dis 190:1448-55. 2004
    ..Among men presenting for care for symptomatic sexually transmitted infections (STIs) in Malawi, trichomoniasis is not considered for first-line treatment...
  16. doi request reprint Prevention and control of sexually transmissible infections among hotel-based female sex workers in Dhaka, Bangladesh
    Duncan F McCormick
    University of North Carolina, Department of Medicine, Chapel Hill, NC 27517, USA
    Sex Health 10:478-86. 2013
    ..Two monthly clinic-based strategies were compared: periodic presumptive treatment (PPT) and enhanced syndromic management (ESM) - one round of presumptive treatment followed by treatment based on assessment and laboratory tests...
  17. ncbi request reprint HIV-1 populations in blood and breast milk are similar
    Gavin J Henderson
    UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Virology 330:295-303. 2004
    ..The absence of unique variants and the lack of significant differences in the relative abundance of variants between these compartments support the conclusion that viruses in the blood plasma and breast milk are well equilibrated...
  18. ncbi request reprint Rapid, real-time detection of acute HIV infection in patients in Africa
    Susan A Fiscus
    Department of Microbiology and Immunology, University of North Carolina UNC at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    J Infect Dis 195:416-24. 2007
    ..We conducted a prospective study to evaluate methods of detecting clients with sexually transmitted diseases (STDs) who were acutely coinfected with human immunodeficiency virus (HIV) in Lilongwe, Malawi...
  19. pmc Hospital-based injury data in Malawi: strategies for data collection and feasibility of trauma scoring tools
    Jonathan C Samuel
    Department of Surgery, Kamuzu Central Hospital, Lilongwe, Malawi
    Trop Doct 40:98-9. 2010
    ....
  20. doi request reprint Neisseria gonorrhoeae antimicrobial susceptibility in Lilongwe, Malawi, 2007
    Lillian B Brown
    Division of Infectious Diseases, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Sex Transm Dis 37:169-72. 2010
    ..We sought to establish current laboratory-based Neisseria gonorrhoeae antibiotic susceptibility patterns for Malawi and describe the pattern of susceptibility since syndromic management began...
  21. ncbi request reprint Frequent detection of acute primary HIV infection in men in Malawi
    Christopher D Pilcher
    Departments of Medicine and Epidemiology at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    AIDS 18:517-24. 2004
    ..Acute (antibody-negative) HIV infection is associated with high transmission potential but is rarely recognized...
  22. ncbi request reprint Effects of HIV-1 serostatus, HIV-1 RNA concentration, and CD4 cell count on the incidence of malaria infection in a cohort of adults in rural Malawi
    Padmaja Patnaik
    Department of Epidemiology, University of North Carolina at Chapel Hill, 27599, USA
    J Infect Dis 192:984-91. 2005
    ....
  23. pmc Maternal or infant antiretroviral drugs to reduce HIV-1 transmission
    Charles S Chasela
    University of North Carolina Project, Lilongwe, Malawi
    N Engl J Med 362:2271-81. 2010
    ..We evaluated the efficacy of a maternal triple-drug antiretroviral regimen or infant nevirapine prophylaxis for 28 weeks during breast-feeding to reduce postnatal transmission of human immunodeficiency virus type 1 (HIV-1) in Malawi...
  24. doi request reprint Etiology of genital ulcer disease and association with HIV infection in Malawi
    SAM PHIRI
    From the Lighthouse Centre, Lilongwe, Malawi University of North Carolina, Chapel Hill, NC Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK University of North Carolina Project, Lilongwe, Malawi Centres for Disease Control and Prevention, Atlanta, GA and Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Sex Transm Dis 40:923-8. 2013
    ..However, effective treatment guidelines depend on a current country-specific GUD etiological profile, which may change over time...
  25. pmc Prevalence of hepatitis C virus infection among human immunodeficiency virus-1-infected pregnant women in Malawi: the BAN study
    Charles S Chasela
    UNC Project, Lilongwe, Malawi
    J Clin Virol 54:318-20. 2012
    ..In Sub-Saharan Africa, prevalence estimates of hepatitis C virus (HCV) vary widely...
  26. pmc Bacterial infections in Lilongwe, Malawi: aetiology and antibiotic resistance
    Mwai H Makoka
    National AIDS Commission, Lilongwe, Malawi
    BMC Infect Dis 12:67. 2012
    ..This study was conducted to determine antimicrobial susceptibility patterns in order to inform treatment choices and generate hospital-wide baseline data...
  27. pmc Detection of acute HIV infection: a field evaluation of the determine® HIV-1/2 Ag/Ab combo test
    Nora E Rosenberg
    Departments of Epidemiology, University of North Carolina, Chapel Hill 27599, USA
    J Infect Dis 205:528-34. 2012
    ..In the absence of antibodies, p24 antigen and RNA typically indicate acute HIV infection. We conducted a field evaluation of the Determine® HIV-1/2 Ag/Ab Combo rapid test (Combo RT)...
  28. doi request reprint Use of nutritional and water hygiene packages for diarrhoeal prevention among HIV-exposed infants in Lilongwe, Malawi: an evaluation of a pilot prevention of mother-to-child transmission post-natal care service
    Jiayin Xue
    The University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Trop Med Int Health 15:1156-62. 2010
    ..To evaluate a pilot prevention of mother-to-child transmission post-natal programme in Lilongwe, Malawi, through observed retention and infant diarrhoeal rates...
  29. pmc Prevention of HIV-1 infection with early antiretroviral therapy
    Myron S Cohen
    University of North Carolina at Chapel Hill, Institute for Global Health and Infectious Diseases, Suite 2115, Bioinformatics Bldg, 130 Mason Farm Rd, CB 7030, Chapel Hill, NC 27599, USA
    N Engl J Med 365:493-505. 2011
    ..Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples...
  30. pmc High HIV incidence and sexual behavior change among pregnant women in Lilongwe, Malawi: implications for the risk of HIV acquisition
    Maria A Keating
    University of North Carolina Project, Lilongwe, Malawi
    PLoS ONE 7:e39109. 2012
    ..Our aims were (1) to estimate HIV incidence during pregnancy and (2) to compare sexual activity between pregnant, postpartum, and non-pregnant women...
  31. ncbi request reprint Plasma HIV burden in Malawian children co-infected with rotavirus
    C Jere
    Department of Microbiology, University of North Carolina, Chapel Hill, USA
    AIDS 15:1439-42. 2001
    ..Low CD4 cell counts, but not HIV-1-RNA concentrations, were predictive of Death. Local, enteric rotavirus infection did not appear to affect blood HIV viral load or CD4 cell counts in this small group of children...
  32. ncbi request reprint Genotypic analysis of the protease and reverse transcriptase of HIV type 1 subtype C isolates from antiretroviral drug-naive adults in Malawi
    L A Petch
    UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    AIDS Res Hum Retroviruses 21:799-805. 2005
    ..Further studies will be needed to determine the clinical impact of these polymorphisms on viral susceptibility to existing antiretroviral drugs...
  33. ncbi request reprint Selective screening for chlamydial infection: which criteria to use?
    W C Miller
    Department of Medicine School of Medicine, University of North Carolina at Chapel Hill, USA
    Am J Prev Med 18:115-22. 2000
    ..In order to guide local programs in the choice of selective screening criteria, we examined the performance of previously proposed screening criteria for C. trachomatis...
  34. ncbi request reprint Trends of gonorrhea and chlamydial infection during 1985-1996 among active-duty soldiers at a United States Army installation
    A C Seña
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA
    Clin Infect Dis 30:742-8. 2000
    ..STDs continue to lead to significant morbidity in this representative military population...
  35. ncbi request reprint Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Research Group
    M S Cohen
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7030, USA
    Lancet 349:1868-73. 1997
    ..We investigated the hypothesis that STDs increase the likelihood of transmission of HIV-1 through increased concentration of the virus in semen...
  36. ncbi request reprint Addition of treatment for trichomoniasis to syndromic management of urethritis in Malawi: a randomized clinical trial
    Matthew A Price
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Sex Transm Dis 30:516-22. 2003
    ..Male urethritis is generally treated syndromically, but failure of empirical treatment is common...
  37. pmc Epidemiology of injuries at a tertiary care center in Malawi
    Jonathan C Samuel
    Department of Surgery, University of North Carolina, Chapel Hill, NC 27599, USA
    World J Surg 33:1836-41. 2009
    ..Injury surveillance is an ongoing process required for primary, secondary, and tertiary injury prevention. In Malawi, hospital-based injury data are not available...
  38. doi request reprint Bacterial vaginosis and the risk of trichomonas vaginalis acquisition among HIV-1-negative women
    Jennifer E Balkus
    From the Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington Departments of Global Health and Biostatistics, University of Washington, Seattle, Washington Magee Womens Research Institute, Pittsburgh, Pennsylvania Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland Department of Obstetrics and Gynecology College of Health Science, University of Zimbabwe, Harare, Zimbabwe Center for Infectious Disease Research in Zambia, Lusaka, Zambia HIV Prevention Research Unit, South Africa Medical Research Council, Durban, South Africa Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina Centre for the AIDS Program of Research in South Africa, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella, South Africa and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York
    Sex Transm Dis 41:123-8. 2014
    ..The vaginal microbiota may play a role in mediating susceptibility to sexually transmitted infections, including Trichomonas vaginalis (TV)...
  39. ncbi request reprint Immune activation and induction of HIV-1 replication within CD14 macrophages during acute Plasmodium falciparum malaria coinfection
    Tracy L Pisell
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA
    AIDS 16:1503-9. 2002
    ..To determine the impact of Plasmodium falciparum malaria coinfection and its treatment on cellular reservoirs of viral replication in HIV-1-infected persons and to relate this to changes in systemic immune activation...
  40. ncbi request reprint Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study
    James G Kublin
    Department of Community Health, University of Malawi College of Medicine, Blantyre, Malawi
    Lancet 365:233-40. 2005
    ..To assess the effect of Plasmodium falciparum malaria on concentrations of HIV in blood, we did a prospective cohort study in Malawi...
  41. ncbi request reprint HIV incidence and factors associated with HIV acquisition among injection drug users in St Petersburg, Russia
    Andrei P Kozlov
    Biomedical Center and St Petersburg State University, St Petersburg, Russia
    AIDS 20:901-6. 2006
    ..The Russian HIV-1 epidemic has been driven by injection drug use...
  42. ncbi request reprint HIV prevalence, sociodemographic, and behavioral correlates and recruitment methods among injection drug users in St. Petersburg, Russia
    Alla V Shaboltas
    The Biomedical Center and St Petersburg State University, 7 Pudozhskaya Street, St Petersburg, 197110 Russia
    J Acquir Immune Defic Syndr 41:657-63. 2006
    ....
  43. ncbi request reprint A phase III clinical trial of antibiotics to reduce chorioamnionitis-related perinatal HIV-1 transmission
    Taha E Taha
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    AIDS 20:1313-21. 2006
    ..A multisite study was conducted in Africa to assess the efficacy of antibiotics to reduce mother-to-child transmission (MTCT) of HIV-1...
  44. pmc Spatial distribution of HIV prevalence and incidence among injection drugs users in St Petersburg: implications for HIV transmission
    Robert Heimer
    Center for Interdisciplinary Research on AIDS, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    AIDS 22:123-30. 2008
    ..Understanding the dynamics of the epidemic is important in developing appropriate responses in the resource-constrained context of Russian cities such as St Petersburg...
  45. pmc Correlates of syphilis seroreactivity among pregnant women: the HIVNET 024 Trial in Malawi, Tanzania, and Zambia
    Dara Potter
    School of Public Health, University of Alabama at Birmingham, USA
    Sex Transm Dis 33:604-9. 2006
    ....
  46. ncbi request reprint Distribution of the CCR5 gene 32-base pair deletion and CCR5 expression in Chinese minorities
    Tao Feng
    Department of Clinical Immunology, Peking Union Medical College Hospital, Beijing, People s Republic of China
    J Acquir Immune Defic Syndr 32:131-4. 2003
    ..CCR5 expression appears to be greater in the Dai minority than in the other minorities investigated. The mechanism for this increased expression requires further study...
  47. ncbi request reprint Syphilis management in St. Petersburg, Russia: 1995-2001
    Andrew Yakubovsky
    Department of Dermatology and Venereal Diseases, Pavlov State Medical University, St Petersburg, Russia
    Sex Transm Dis 33:244-9. 2006
    ..The objectives of this study were to describe the recent syphilis epidemic in St. Petersburg, Russia; and to document the syphilis management practices in Russia to help inform the best way forward for a system in transition...