HAROLD M HOFFMAN

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever
    H M Hoffman
    Department of Medicine, University of California at San Diego, La Jolla, 92093-0635, USA
    J Allergy Clin Immunol 108:615-20. 2001
  2. doi request reprint Long-term efficacy and safety profile of rilonacept in the treatment of cryopryin-associated periodic syndromes: results of a 72-week open-label extension study
    Hal M Hoffman
    University of California San Diego, La Jolla, USA
    Clin Ther 34:2091-103. 2012
  3. pmc Inflammasome and IL-1beta-mediated disorders
    Hal M Hoffman
    Division of Allergy and Immunology, University of California at San Diego and Rady Children s Hospital of San Diego, La Jolla, CA 92093, USA
    Curr Allergy Asthma Rep 10:229-35. 2010
  4. doi request reprint Therapy of autoinflammatory syndromes
    Hal M Hoffman
    Department of Pediatrics and Medicine, Division of Allergy, Immunology, and Rheumatology, University of California at San Diego, School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 124:1129-38; quiz 1139-40. 2009
  5. doi request reprint Recurrent febrile syndromes: what a rheumatologist needs to know
    Hal M Hoffman
    University of California at San Diego, La Jolla, CA 92093, USA
    Nat Rev Rheumatol 5:249-56. 2009
  6. ncbi request reprint Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS)
    Hal M Hoffman
    University of California at San Diego, Division of Rheumatology and Allergy Immunology, Mail Code 0635, 9500 Gilman Drive, La Jolla, CA 92093 0635, USA
    Expert Opin Biol Ther 9:519-31. 2009
  7. ncbi request reprint Cryopyrin-associated periodic syndromes: development of a patient-reported outcomes instrument to assess the pattern and severity of clinical disease activity
    Hal M Hoffman
    University of California at San Diego, La Jolla, CA 92093 0635, USA
    Curr Med Res Opin 24:2531-43. 2008
  8. ncbi request reprint Hereditary immunologic disorders caused by pyrin and cryopyrin
    Hal M Hoffman
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego Medical School, 9500 Gilman Drive, La Jolla, CA 92093 0635, USA
    Curr Allergy Asthma Rep 7:323-30. 2007
  9. ncbi request reprint Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
    Hal M Hoffman
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego School of Medicine, La Jolla, CA 92093 0635, USA
    Lancet 364:1779-85. 2004
  10. ncbi request reprint Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P
    Hal M Hoffman
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0635, USA
    Hum Genet 112:209-16. 2003

Research Grants

Detail Information

Publications16

  1. ncbi request reprint Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever
    H M Hoffman
    Department of Medicine, University of California at San Diego, La Jolla, 92093-0635, USA
    J Allergy Clin Immunol 108:615-20. 2001
    ..On the basis of the analysis of genotype and phenotype of FCAS, we formulated clinical diagnostic criteria that can be used to distinguish FCAS from other hereditary periodic fever syndromes...
  2. doi request reprint Long-term efficacy and safety profile of rilonacept in the treatment of cryopryin-associated periodic syndromes: results of a 72-week open-label extension study
    Hal M Hoffman
    University of California San Diego, La Jolla, USA
    Clin Ther 34:2091-103. 2012
    ..The interleukin-1 inhibitor rilonacept has been shown to be well-tolerated and effective in preventing CAPS symptoms in 2 pivotal studies...
  3. pmc Inflammasome and IL-1beta-mediated disorders
    Hal M Hoffman
    Division of Allergy and Immunology, University of California at San Diego and Rady Children s Hospital of San Diego, La Jolla, CA 92093, USA
    Curr Allergy Asthma Rep 10:229-35. 2010
    ..However, many other diseases are likely to be mediated by the inflammasome and interleukin-1beta, providing additional targets in the future...
  4. doi request reprint Therapy of autoinflammatory syndromes
    Hal M Hoffman
    Department of Pediatrics and Medicine, Division of Allergy, Immunology, and Rheumatology, University of California at San Diego, School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 124:1129-38; quiz 1139-40. 2009
    ..This article reviews the general approach to the therapy of autoinflammatory diseases, focusing on current approved therapies and novel approaches that might be used in the future...
  5. doi request reprint Recurrent febrile syndromes: what a rheumatologist needs to know
    Hal M Hoffman
    University of California at San Diego, La Jolla, CA 92093, USA
    Nat Rev Rheumatol 5:249-56. 2009
    ..NSAIDs, colchicine and corticosteroids have roles in the treatment of some of these disorders, but biologic drugs that target interleukin-1beta are emerging as consistently effective therapies...
  6. ncbi request reprint Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS)
    Hal M Hoffman
    University of California at San Diego, Division of Rheumatology and Allergy Immunology, Mail Code 0635, 9500 Gilman Drive, La Jolla, CA 92093 0635, USA
    Expert Opin Biol Ther 9:519-31. 2009
    ..Until recently, there was no effective treatment for CAPS, but identification of the genetic basis of CAPS highlighted the pathogenic role of IL-1beta...
  7. ncbi request reprint Cryopyrin-associated periodic syndromes: development of a patient-reported outcomes instrument to assess the pattern and severity of clinical disease activity
    Hal M Hoffman
    University of California at San Diego, La Jolla, CA 92093 0635, USA
    Curr Med Res Opin 24:2531-43. 2008
    ..Development of an instrument for characterization of symptom patterns and severity in patients with cryopyrin-associated periodic syndromes (CAPS)...
  8. ncbi request reprint Hereditary immunologic disorders caused by pyrin and cryopyrin
    Hal M Hoffman
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego Medical School, 9500 Gilman Drive, La Jolla, CA 92093 0635, USA
    Curr Allergy Asthma Rep 7:323-30. 2007
    ..These advances have also resulted in direct improvement in diagnosis and therapy for autoinflammatory disorders such as the cryopyrinopathies and familial Mediterranean fever and have implications for more common inflammatory diseases...
  9. ncbi request reprint Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
    Hal M Hoffman
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego School of Medicine, La Jolla, CA 92093 0635, USA
    Lancet 364:1779-85. 2004
    ..The genetic basis of this disease has been elucidated. Cryopyrin, the protein that is altered in FCAS, is one of the adaptor proteins that activate caspase 1, resulting in release of interleukin 1...
  10. ncbi request reprint Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P
    Hal M Hoffman
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0635, USA
    Hum Genet 112:209-16. 2003
    ..We also report a comprehensive list of intragenic single nucleotide polymorphisms. The data provided here will assist others researching the 1q44 region and will aid clinicians in the diagnosis of FCAS...
  11. ncbi request reprint Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
    H M Hoffman
    Ludwig Institute for Cancer Research, University of California School of Medicine, San Diego, California, USA
    Nat Genet 29:301-5. 2001
    ....
  12. ncbi request reprint Humoral immunodeficiency with facial dysmorphology and limb anomalies: a new syndrome
    H M Hoffman
    Division of Rheumatology, Allergy and Immunology, University of California at San Diego, 92093 0635, USA
    Clin Dysmorphol 10:1-8. 2001
    ..A review of the literature and the London Dysmorphology Database did not produce any recognizable syndromes that match her constellation of findings. She may represent a unique syndrome of unknown etiology...
  13. pmc Identification of a locus on chromosome 1q44 for familial cold urticaria
    H M Hoffman
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Am J Hum Genet 66:1693-8. 2000
    ..5-cM region between markers D1S423 and D1S2682. Muckle-Wells syndrome was recently linked to chromosome 1q44, which suggests that the two disorders may be linked to the same locus...
  14. ncbi request reprint Development of an experimental paradigm in which to examine human learning using two computer-based formats
    H M Hoffman
    Learning Resources Center, 9500 Gilman Drive, La Jolla CA 92093 0661, USA
    Stud Health Technol Inform 81:187-91. 2001
    ..The results of the pilot study will be used to refine and improve the design of the remainder of studies planned in this experimental series...
  15. pmc Expression and regulation of cryopyrin and related proteins in rheumatoid arthritis synovium
    S Rosengren
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, UCSD School of Medicine, 0656, 9500 Gilman Drive, La Jolla California 92093 0656, USA
    Ann Rheum Dis 64:708-14. 2005
    ..Rheumatoid arthritis (RA) synovium is characterised by enhanced NF-kappaB activity and proinflammatory cytokines. Cryopyrin (CIAS-1, NALP-3, PYPAF-1) has been shown to regulate NF-kappaB and caspase-1 activation...
  16. pmc Autoinflammation: translating mechanism to therapy
    Taylor A Doherty
    Division of Allergy, Immunology, and Rheumatology, University of California at San Diego, School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0635, USA
    J Leukoc Biol 90:37-47. 2011
    ..Here, we review current treatment strategies of autoinflammatory diseases with a focus on IL-1 antagonism...

Research Grants11

  1. GENETIC AND MOLECULAR BASIS OF FAMILIAL COLD URTICARIA
    Harold Hoffman; Fiscal Year: 2002
    ..The achievement of these goals will result in identification of the gene responsible for familial cold urticaria which will ultimately lead to an understanding of the mechanism of the inflammatory response to a physical stimulus. ..
  2. The role of cryopyrin in autoinflammatory diseases
    Harold Hoffman; Fiscal Year: 2009
    ....
  3. The role of cryopyrin in autoinflammatory diseases
    Harold Hoffman; Fiscal Year: 2007
    ....
  4. The role of cryopyrin in autoinflammatory diseases
    Harold Hoffman; Fiscal Year: 2006
    ..The achievement of these goals will improve our understanding of inflammation in FCAS as well as other inflammatory disorders. ..
  5. Novel regulatory role of cryopyrin in inflammation
    Harold Hoffman; Fiscal Year: 2005
    ..abstract_text> ..
  6. The role of cryopyrin in autoinflammatory diseases
    HAROLD M HOFFMAN; Fiscal Year: 2010
    ....