M Hoenig

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. pmc The cat as a model for human obesity and diabetes
    Margarethe Hoenig
    College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802, USA
    J Diabetes Sci Technol 6:525-33. 2012
  2. doi request reprint Evaluation of long-term glucose homeostasis in lean and obese cats by use of continuous glucose monitoring
    Margarethe Hoenig
    Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana Champaign, IL 61802, USA
    Am J Vet Res 73:1100-6. 2012
  3. ncbi request reprint Effect of macronutrients, age, and obesity on 6- and 24-h postprandial glucose metabolism in cats
    Margarethe Hoenig
    Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1798-807. 2011
  4. doi request reprint Oral glucose leads to a differential response in glucose, insulin, and GLP-1 in lean versus obese cats
    M Hoenig
    Department of Veterinary Clinical Medicine and College of Veterinary Medicine, University of Illinois, Urbana, IL, USA
    Domest Anim Endocrinol 38:95-102. 2010
  5. ncbi request reprint Insulin sensitivity, fat distribution, and adipocytokine response to different diets in lean and obese cats before and after weight loss
    M Hoenig
    Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA 30602, USA
    Am J Physiol Regul Integr Comp Physiol 292:R227-34. 2007
  6. ncbi request reprint Triiodothyronine differentially regulates key metabolic factors in lean and obese cats
    M Hoenig
    Department of Physiology and Pharmacology, College of Veterinary Medicine, 501 DW Brooks Drive, University of Georgia, Athens, GA 30602, United States
    Domest Anim Endocrinol 34:229-37. 2008
  7. ncbi request reprint Diagnostic utility of glycosylated hemoglobin concentrations in the cat
    M Hoenig
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602 7389, USA
    Domest Anim Endocrinol 16:11-7. 1999
  8. ncbi request reprint Development of a feline proinsulin immunoradiometric assay and a feline proinsulin enzyme-linked immunosorbent assay (ELISA): a novel application to examine beta cell function in cats
    S Kley
    Department of Physiology and Pharmacology, University of Georgia, College of Veterinary Medicine, Athens, GA, United States
    Domest Anim Endocrinol 34:311-8. 2008
  9. ncbi request reprint Obesity increases free thyroxine proportionally to nonesterified fatty acid concentrations in adult neutered female cats
    D C Ferguson
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    J Endocrinol 194:267-73. 2007
  10. ncbi request reprint Assessment and mathematical modeling of glucose turnover and insulin sensitivity in lean and obese cats
    M Hoenig
    Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA, USA
    Domest Anim Endocrinol 31:373-89. 2006

Collaborators

Detail Information

Publications26

  1. pmc The cat as a model for human obesity and diabetes
    Margarethe Hoenig
    College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802, USA
    J Diabetes Sci Technol 6:525-33. 2012
    ..In addition, amyloid, demonstrated to be deposited in islet of chronically obese cats, may contribute to a reduction in insulin secretion by reducing functional β-cell mass...
  2. doi request reprint Evaluation of long-term glucose homeostasis in lean and obese cats by use of continuous glucose monitoring
    Margarethe Hoenig
    Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana Champaign, IL 61802, USA
    Am J Vet Res 73:1100-6. 2012
    ..To evaluate intraday and interday variations in glucose concentrations in cats and to test the utility of a continuous glucose monitoring system (CGMS)...
  3. ncbi request reprint Effect of macronutrients, age, and obesity on 6- and 24-h postprandial glucose metabolism in cats
    Margarethe Hoenig
    Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1798-807. 2011
    ..Aging may predispose to insulin resistance, which is a risk factor for diabetes in cats. Mechanisms underlying the high adiponectin of healthy old lean cats need to be further explored...
  4. doi request reprint Oral glucose leads to a differential response in glucose, insulin, and GLP-1 in lean versus obese cats
    M Hoenig
    Department of Veterinary Clinical Medicine and College of Veterinary Medicine, University of Illinois, Urbana, IL, USA
    Domest Anim Endocrinol 38:95-102. 2010
    ..The low GLP-1 concentrations in obese cats might indicate a contribution of GLP-1 to the lower insulin sensitivity of obese cats, but this hypothesis needs to be further investigated...
  5. ncbi request reprint Insulin sensitivity, fat distribution, and adipocytokine response to different diets in lean and obese cats before and after weight loss
    M Hoenig
    Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA 30602, USA
    Am J Physiol Regul Integr Comp Physiol 292:R227-34. 2007
    ..These data also show that insulin sensitivity of glucose and fat metabolism can be differentially regulated in cats...
  6. ncbi request reprint Triiodothyronine differentially regulates key metabolic factors in lean and obese cats
    M Hoenig
    Department of Physiology and Pharmacology, College of Veterinary Medicine, 501 DW Brooks Drive, University of Georgia, Athens, GA 30602, United States
    Domest Anim Endocrinol 34:229-37. 2008
    ..No effect was seen on leptin, or UCP2 and 3. This shows that T3 regulates thermogenesis but not through changes in uncoupling protein expression. It also indicates that PPARs have an important role in the pathogenesis of obesity in cats...
  7. ncbi request reprint Diagnostic utility of glycosylated hemoglobin concentrations in the cat
    M Hoenig
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602 7389, USA
    Domest Anim Endocrinol 16:11-7. 1999
    ..53; P < 0.001). It is concluded that GHb measurements are a simple and reliable way to monitor changes in glucose control in the diabetic cat over a prolonged period...
  8. ncbi request reprint Development of a feline proinsulin immunoradiometric assay and a feline proinsulin enzyme-linked immunosorbent assay (ELISA): a novel application to examine beta cell function in cats
    S Kley
    Department of Physiology and Pharmacology, University of Georgia, College of Veterinary Medicine, Athens, GA, United States
    Domest Anim Endocrinol 34:311-8. 2008
    ..In conclusion, we report the development and validation of an IRMA and an ELISA for FPI. This novel assay is useful to elucidate FPI secretion and can be used similar to a C-petide assay to evaluate residual beta cell function in cats...
  9. ncbi request reprint Obesity increases free thyroxine proportionally to nonesterified fatty acid concentrations in adult neutered female cats
    D C Ferguson
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    J Endocrinol 194:267-73. 2007
    ..In conclusion, feline obesity is associated with a significant increase in FT(4) within the normal range; future investigation into the cellular thyroid status will be necessary to establish cause and effect in this obesity model...
  10. ncbi request reprint Assessment and mathematical modeling of glucose turnover and insulin sensitivity in lean and obese cats
    M Hoenig
    Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA, USA
    Domest Anim Endocrinol 31:373-89. 2006
    ..Finally, glucose disposal at basal insulin appears to occur entirely through glycolysis, whereas significant amounts of glucose are sequestrated from oxidation during EHC...
  11. ncbi request reprint GLUT4 but not GLUT1 expression decreases early in the development of feline obesity
    C L Brennan
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
    Domest Anim Endocrinol 26:291-301. 2004
    ..040, respectively). GLUT1 expression showed no significant change in the obese cats in either tissue. It is concluded that the changes in GLUT4 are early derangements in obesity and occur before glucose intolerance is clinically evident...
  12. ncbi request reprint Expression and purification of feline thyrotropin (fTSH): immunological detection and bioactivity of heterodimeric and yoked glycoproteins
    S Rayalam
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Domest Anim Endocrinol 30:185-202. 2006
    ....
  13. doi request reprint Dyslipidemia in obese cats
    E Jordan
    Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA 30602, United States
    Domest Anim Endocrinol 35:290-9. 2008
    ..This suggests that dyslipidemia alone is not sufficient to induce hypertension and atherosclerosis. Other anti-atherogenic factors may be present in the obese, dyslipidemic cat...
  14. ncbi request reprint Fatty acid turnover, substrate oxidation, and heat production in lean and obese cats during the euglycemic hyperinsulinemic clamp
    M Hoenig
    Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA, United States
    Domest Anim Endocrinol 32:329-38. 2007
    ..Further studies are needed to investigate if the different response to insulin of male cats is involved in their higher risk to develop diabetes...
  15. ncbi request reprint Influence of glucose dosage on interpretation of intravenous glucose tolerance tests in lean and obese cats
    M Hoenig
    College of Veterinary Medicine, University of Georgia, Athens 30602, USA
    J Vet Intern Med 16:529-32. 2002
    ..Obese cats showed an abnormal insulin secretion pattern, indicating a defect in insulin secretion with obesity and insulin resistance...
  16. doi request reprint Investigation of 1H MRS for quantification of hepatic triglyceride in lean and obese cats
    M H Clark
    Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
    Res Vet Sci 95:678-80. 2013
    ..This report should provide a foundation for the further development of spectroscopic techniques for studying hepatic lipid accumulation in cats...
  17. doi request reprint Pharmacokinetics of pioglitazone in lean and obese cats
    M H Clark
    Department of Comparative Biosciences Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
    J Vet Pharmacol Ther 35:428-36. 2012
    ..Systemic exposure to pioglitazone in cats after a 3 mg/kg oral dose approximates that observed in humans with therapeutic doses...
  18. ncbi request reprint Activity and tissue-specific expression of lipases and tumor-necrosis factor alpha in lean and obese cats
    M Hoenig
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Domest Anim Endocrinol 30:333-44. 2006
    ..Tumor necrosis factor alpha may regulate this repartitioning process through suppression of adipocyte LPL...
  19. ncbi request reprint Cloning and sequencing of feline thyrotropin (fTSH): heterodimeric and yoked constructs
    S Rayalam
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA
    Domest Anim Endocrinol 30:203-17. 2006
    ..The resulting DNA sequence was cloned, sequenced, ligated and recloned into expression vector PEAK. This report constitutes the first cloning and sequencing of the genes encoding the subunits of feline thyrotropin...
  20. ncbi request reprint Beta cell and insulin antibodies in treated and untreated diabetic cats
    M Hoenig
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30622, USA
    Vet Immunol Immunopathol 77:93-102. 2000
    ..It is concluded that immune-mediated processes are not causing diabetes in the cat. Further studies are needed to evaluate if antibodies directed against exogenous insulin alter the response of diabetic cats to insulin...
  21. doi request reprint Molecular and histological evidence of brown adipose tissue in adult cats
    M H Clark
    Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
    Vet J 195:66-72. 2013
    ..It is possible that dietary components or pharmacological agents that influence brown fat activity could exert a relevant biological effect in cats...
  22. ncbi request reprint Comparative aspects of diabetes mellitus in dogs and cats
    M Hoenig
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Mol Cell Endocrinol 197:221-9. 2002
    ..The diabetic cat, however, resembles type 2 diabetic human patients more closely. The clinical presentation, pathophysiology, and histologic findings are described for both dog and cat and possible etiological mechanisms are discussed...
  23. doi request reprint Pharmacokinetics and pharmacodynamics of protamine zinc recombinant human insulin in healthy dogs
    M Clark
    Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
    J Vet Pharmacol Ther 35:342-50. 2012
    ..Results confirm the tendency toward a late onset and long duration of action for PZIR in dogs. This insulin may be an alternative treatment option for diabetic dogs...
  24. pmc A feline model of experimentally induced islet amyloidosis
    M Hoenig
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
    Am J Pathol 157:2143-50. 2000
    ..Blood-glycosylated hemoglobin concentrations were not significantly different between the two treatment groups. This study documents for the first time an inducible model of islet amyloidosis in a nontransgenic animal...
  25. ncbi request reprint Feline hyperadrenocorticism--where are we now?
    M Hoenig
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602, USA
    J Feline Med Surg 4:171-4. 2002
  26. ncbi request reprint Cloning, expression and purification of feline proinsulin
    M Hoenig
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
    Domest Anim Endocrinol 30:28-37. 2006
    ..RP-HPLC and mass spectrometric analysis indicated that the proinsulin contained the correct disulfide bridging pattern. This proinsulin can be used for therapeutic and diagnostic purposes...