Kyle L Hoehn

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Insulin resistance is a cellular antioxidant defense mechanism
    Kyle L Hoehn
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Proc Natl Acad Sci U S A 106:17787-92. 2009
  2. pmc IRS1-independent defects define major nodes of insulin resistance
    Kyle L Hoehn
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Cell Metab 7:421-33. 2008
  3. pmc Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3
    Mark Larance
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    Mol Cell Proteomics 9:682-94. 2010
  4. pmc Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity
    Kyle L Hoehn
    Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Cell Metab 11:70-6. 2010
  5. doi request reprint CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes
    Ming Fai Yip
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Cell Metab 8:384-98. 2008
  6. ncbi request reprint Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
    Nigel Turner
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Diabetes 56:2085-92. 2007

Detail Information

Publications6

  1. pmc Insulin resistance is a cellular antioxidant defense mechanism
    Kyle L Hoehn
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Proc Natl Acad Sci U S A 106:17787-92. 2009
    ..These data place mitochondrial superoxide at the nexus between intracellular metabolism and the control of insulin action potentially defining this as a metabolic sensor of energy excess...
  2. pmc IRS1-independent defects define major nodes of insulin resistance
    Kyle L Hoehn
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Cell Metab 7:421-33. 2008
    ..These findings indicate that while insulin resistance is associated with multiple deficiencies, the most deleterious defects and the origin of insulin resistance occur independently of IRS...
  3. pmc Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3
    Mark Larance
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    Mol Cell Proteomics 9:682-94. 2010
    ..These data highlight an important new arm of the insulin signaling cascade in the regulation of mRNA utilization...
  4. pmc Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity
    Kyle L Hoehn
    Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Cell Metab 11:70-6. 2010
    ..We conclude that negative energy balance is a prerequisite for weight reduction, and increased fatty acid oxidation per se has little, if any, effect to reduce adiposity...
  5. doi request reprint CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes
    Ming Fai Yip
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Cell Metab 8:384-98. 2008
    ..These data suggest that insulin regulates Myo1c function via CaMKII-dependent phosphorylation, and these events play a role in insulin-regulated GLUT4 trafficking in adipocytes likely involving Myo1c motor activity...
  6. ncbi request reprint Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
    Nigel Turner
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Diabetes 56:2085-92. 2007
    ..These findings suggest that high lipid availability does not lead to intramuscular lipid accumulation and insulin resistance in rodents by decreasing muscle mitochondrial fatty acid oxidative capacity...