Israel Hodish

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Location of ectopic adrenocortical hormone-secreting tumors causing Cushing's syndrome in the paranasal sinuses
    Israel Hodish
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA
    Head Neck 31:699-706. 2009
  2. pmc In vivo misfolding of proinsulin below the threshold of frank diabetes
    Israel Hodish
    Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Diabetes 60:2092-101. 2011
  3. pmc Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
    Israel Hodish
    Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0678, USA
    J Biol Chem 285:685-94. 2010
  4. pmc Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth
    Ming Liu
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, MI, USA
    Trends Endocrinol Metab 21:652-9. 2010
  5. pmc Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding
    Afaf Absood
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS ONE 8:e54351. 2013
  6. doi request reprint Frequent insulin dosage adjustments based on glucose readings alone are sufficient for a safe and effective therapy
    Eran Bashan
    Hygieia, Inc, Ann Arbor, MI, USA
    J Diabetes Complications 26:230-6. 2012
  7. doi request reprint The effort required to achieve and maintain optimal glycemic control
    Elyse S Rosenthal
    University of Michigan, College of Literature, Arts and Sciences, Ann Arbor, MI, USA
    J Diabetes Complications 25:283-8. 2011
  8. pmc Proinsulin maturation, misfolding, and proteotoxicity
    Ming Liu
    Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 104:15841-6. 2007
  9. doi request reprint Are glucose readings sufficient to adjust insulin dosage?
    Eran Bashan
    Hygieia, Inc, Ann Arbor, Michigan, USA
    Diabetes Technol Ther 13:85-92. 2011

Collaborators

  • Peter Arvan
  • William H Herman
  • David E Schteingart
  • Eran Bashan
  • Ming Liu
  • Afaf Absood
  • Elyse S Rosenthal
  • Andrew Michail
  • Peter M W Habib
  • Anthony Zaki
  • Vlad Nasta
  • Benjamin Gandomani
  • Leena Haataja
  • Jordan Wright
  • Gautam Rajpal
  • Roberto Lara-Lemus
  • Christopher J Rhodes

Detail Information

Publications9

  1. doi request reprint Location of ectopic adrenocortical hormone-secreting tumors causing Cushing's syndrome in the paranasal sinuses
    Israel Hodish
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA
    Head Neck 31:699-706. 2009
    ..The majority of ectopic adrenocorticotropic hormone (ACTH)-secreting tumors are localized in the chest or abdomen. Occasionally, these tumors are found in the paranasal sinuses...
  2. pmc In vivo misfolding of proinsulin below the threshold of frank diabetes
    Israel Hodish
    Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Diabetes 60:2092-101. 2011
    ..Herein we have compared two mouse models expressing equally small amounts of transgenic proinsulin in pancreatic β-cells...
  3. pmc Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
    Israel Hodish
    Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0678, USA
    J Biol Chem 285:685-94. 2010
    ..The data support that misfolded proinsulin perturbs bystander proinsulin in the endoplasmic reticulum, leading to beta-cell failure...
  4. pmc Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth
    Ming Liu
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, MI, USA
    Trends Endocrinol Metab 21:652-9. 2010
    ..Accumulated evidence indicates that, in the molecular pathogenesis of the disease, misfolded proinsulin exerts dominant effects that initially inhibit insulin production, progressing to beta cell demise with diabetes...
  5. pmc Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding
    Afaf Absood
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS ONE 8:e54351. 2013
    ..Our observations suggest that alleviation of pre-diabetic ER-crowding using a treat-to-target insulin therapy may improve β-cell function and may prevent further metabolic deterioration...
  6. doi request reprint Frequent insulin dosage adjustments based on glucose readings alone are sufficient for a safe and effective therapy
    Eran Bashan
    Hygieia, Inc, Ann Arbor, MI, USA
    J Diabetes Complications 26:230-6. 2012
    ..We hypothesize that glucose readings are sufficient to adjust insulin dosage provided that it is done on a weekly basis...
  7. doi request reprint The effort required to achieve and maintain optimal glycemic control
    Elyse S Rosenthal
    University of Michigan, College of Literature, Arts and Sciences, Ann Arbor, MI, USA
    J Diabetes Complications 25:283-8. 2011
    ..Insulin therapy is most effective when dosage is frequently adjusted. We sought to evaluate the effort required to maintain A1C below 7% once attained in older patients with type 2 diabetes...
  8. pmc Proinsulin maturation, misfolding, and proteotoxicity
    Ming Liu
    Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 104:15841-6. 2007
    ..The data imply that PI misfolding leading to impaired endoplasmic reticulum exit of nonmutant PI may be a key early step in a chain reaction of beta cell dysfunction and demise leading to onset and progression of diabetes...
  9. doi request reprint Are glucose readings sufficient to adjust insulin dosage?
    Eran Bashan
    Hygieia, Inc, Ann Arbor, Michigan, USA
    Diabetes Technol Ther 13:85-92. 2011
    ..We hypothesize that glucose readings are sufficient to adjust insulin dosage provided that dosage is adjusted every 1-4 weeks...

Research Grants2

  1. A Novel Tool to Understand Insulin Production and Failure in Pancreatic beta-Cell
    Israel Hodish; Fiscal Year: 2007
    ..The model presented opens new avenues to the development and testing of potential therapeutic interventions that may ultimately help preserve insulin secretory function in humans with diabetes mellitus. ..