HOWARD HODIS

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Postmenopausal oral estrogen therapy and blood pressure in normotensive and hypertensive subjects: the Estrogen in the Prevention of Atherosclerosis Trial
    Anne Z Steiner
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Menopause 12:728-33. 2005
  2. doi request reprint The timing hypothesis and hormone replacement therapy: a paradigm shift in the primary prevention of coronary heart disease in women. Part 2: comparative risks
    Howard N Hodis
    Atherosclerosis Research Unit, University of Southern California, Los Angeles, California 90033, USA
    J Am Geriatr Soc 61:1011-8. 2013
  3. pmc The timing hypothesis and hormone replacement therapy: a paradigm shift in the primary prevention of coronary heart disease in women. Part 1: comparison of therapeutic efficacy
    Howard N Hodis
    Atherosclerosis Research Unit, University of Southern California, Los Angeles, California 90033, USA
    J Am Geriatr Soc 61:1005-10. 2013
  4. pmc Postmenopausal hormone therapy and cardiovascular disease in perspective
    Howard N Hodis
    Harry J Bauer and Dorothy Bauer Rawlins Professor of Cardiology, University of Southern California, Los Angeles, California, USA
    Clin Obstet Gynecol 51:564-80. 2008
  5. pmc Isoflavone soy protein supplementation and atherosclerosis progression in healthy postmenopausal women: a randomized controlled trial
    Howard N Hodis
    USC Keck School of Medicine, Atherosclerosis Research Unit, 2250 Alcazar Street, CSC132, Los Angeles, CA 90033, USA
    Stroke 42:3168-75. 2011
  6. ncbi request reprint Effect of peroxisome proliferator-activated receptor gamma agonist treatment on subclinical atherosclerosis in patients with insulin-requiring type 2 diabetes
    Howard N Hodis
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, 90033, USA
    Diabetes Care 29:1545-53. 2006
  7. ncbi request reprint Assessing benefits and risks of hormone therapy in 2008: new evidence, especially with regard to the heart
    Howard N Hodis
    Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cleve Clin J Med 75:S3-12. 2008
  8. doi request reprint Inflammatory markers and progression of subclinical atherosclerosis in healthy postmenopausal women (from the Estrogen in the Prevention of Atherosclerosis Trial)
    Howard N Hodis
    Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California, USA
    Am J Cardiol 101:1131-3. 2008
  9. ncbi request reprint Postmenopausal hormone therapy in clinical perspective
    Howard N Hodis
    Department of Medicine and the Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Menopause 14:944-57. 2007
  10. pmc High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial
    Howard N Hodis
    Atherosclerosis Research Unit, Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, Calif 90033, USA
    Stroke 40:730-6. 2009

Detail Information

Publications63

  1. ncbi request reprint Postmenopausal oral estrogen therapy and blood pressure in normotensive and hypertensive subjects: the Estrogen in the Prevention of Atherosclerosis Trial
    Anne Z Steiner
    Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Menopause 12:728-33. 2005
    ..To determine if 17beta-estradiol increases blood pressure in postmenopausal women...
  2. doi request reprint The timing hypothesis and hormone replacement therapy: a paradigm shift in the primary prevention of coronary heart disease in women. Part 2: comparative risks
    Howard N Hodis
    Atherosclerosis Research Unit, University of Southern California, Los Angeles, California 90033, USA
    J Am Geriatr Soc 61:1011-8. 2013
    ..In Part 1 of this series, the sex-specificity of statins and aspirin and timing of initiation of HRT as modifiers of efficacy in women were reviewed. Herein, the comparative risks of primary prevention therapies in women are discussed...
  3. pmc The timing hypothesis and hormone replacement therapy: a paradigm shift in the primary prevention of coronary heart disease in women. Part 1: comparison of therapeutic efficacy
    Howard N Hodis
    Atherosclerosis Research Unit, University of Southern California, Los Angeles, California 90033, USA
    J Am Geriatr Soc 61:1005-10. 2013
    ..Herein, the efficacy of the commonly used therapies for the primary prevention of CHD in women, statins, aspirin, and postmenopausal HRT is discussed. The comparative risks of these therapies will be discussed in Part 2 of this series...
  4. pmc Postmenopausal hormone therapy and cardiovascular disease in perspective
    Howard N Hodis
    Harry J Bauer and Dorothy Bauer Rawlins Professor of Cardiology, University of Southern California, Los Angeles, California, USA
    Clin Obstet Gynecol 51:564-80. 2008
    ..These studies showed that young postmenopausal women with menopausal symptoms who use HT for long periods of time have lower rates of mortality and coronary heart disease than comparable postmenopausal women who do not use HT...
  5. pmc Isoflavone soy protein supplementation and atherosclerosis progression in healthy postmenopausal women: a randomized controlled trial
    Howard N Hodis
    USC Keck School of Medicine, Atherosclerosis Research Unit, 2250 Alcazar Street, CSC132, Los Angeles, CA 90033, USA
    Stroke 42:3168-75. 2011
    ..We determined whether ISP reduces subclinical atherosclerosis assessed as carotid artery intima-media thickness progression...
  6. ncbi request reprint Effect of peroxisome proliferator-activated receptor gamma agonist treatment on subclinical atherosclerosis in patients with insulin-requiring type 2 diabetes
    Howard N Hodis
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, 90033, USA
    Diabetes Care 29:1545-53. 2006
    ..To determine the effect of thiazolidinedione treatment on subclinical atherosclerosis progression in insulin-requiring patients with clinical characteristics suggesting type 2 diabetes...
  7. ncbi request reprint Assessing benefits and risks of hormone therapy in 2008: new evidence, especially with regard to the heart
    Howard N Hodis
    Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cleve Clin J Med 75:S3-12. 2008
    ..These data have led to recommendations that the benefits of HT exceed the risks when initiated in menopausal women younger than 60 years...
  8. doi request reprint Inflammatory markers and progression of subclinical atherosclerosis in healthy postmenopausal women (from the Estrogen in the Prevention of Atherosclerosis Trial)
    Howard N Hodis
    Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California, USA
    Am J Cardiol 101:1131-3. 2008
    ..In conclusion, although unopposed 17beta-estradiol significantly altered hs-CRP and sICAM-1, neither marker was associated with progression of subclinical atherosclerosis...
  9. ncbi request reprint Postmenopausal hormone therapy in clinical perspective
    Howard N Hodis
    Department of Medicine and the Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Menopause 14:944-57. 2007
    ....
  10. pmc High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial
    Howard N Hodis
    Atherosclerosis Research Unit, Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, Calif 90033, USA
    Stroke 40:730-6. 2009
    ..We determined whether reduction of tHcy levels with B vitamin supplementation reduces subclinical atherosclerosis progression...
  11. pmc A "window of opportunity:" the reduction of coronary heart disease and total mortality with menopausal therapies is age- and time-dependent
    Howard N Hodis
    Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Brain Res 1379:244-52. 2011
    ....
  12. ncbi request reprint Determinants of the effect of estrogen on the progression of subclinical atherosclerosis: Estrogen in the Prevention of Atherosclerosis Trial
    Roksana Karim
    Department of Preventive Medicine, Keck School of Medicine, Los Angeles, California, USA
    Menopause 12:366-73. 2005
    ....
  13. ncbi request reprint Effect of thiazolidinedione treatment on progression of subclinical atherosclerosis in premenopausal women at high risk for type 2 diabetes
    Anny H Xiang
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Room 6602 GNH, 1200 North State Street, Los Angeles, California 90089 9317, USA
    J Clin Endocrinol Metab 90:1986-91. 2005
    ..Troglitazone reduced the progression of subclinical atherosclerosis via a mechanism that involved unmeasured mediators of atherosclerosis, either in the circulation or directly in the arterial wall...
  14. ncbi request reprint Effect of antihypertensive therapy on progression of carotid intima-media thickness in patients with type 2 diabetes mellitus
    Ling Zheng
    Department of Neurology, Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Cardiol 99:956-60. 2007
    ..The antiatherogenic effect of antihypertensive agents, including BP normalization and possible direct vascular wall protection, can be detected by CIMT progression using B-mode ultrasound in patients with DM...
  15. ncbi request reprint Pharmacological treatment of insulin resistance at two different stages in the evolution of type 2 diabetes: impact on glucose tolerance and beta-cell function
    Anny H Xiang
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 89:2846-51. 2004
    ..These findings highlight the role of insulin resistance in the genesis of progressive beta-cell dysfunction during the evolution of type 2 diabetes...
  16. ncbi request reprint Early onset of subclinical atherosclerosis in young persons with type 1 diabetes
    Jody S Krantz
    Children s Hospital of Orange County, Orange, California, USA
    J Pediatr 145:452-7. 2004
    ..To evaluate the degree of atherosclerosis and its risk factors in adolescents and young adults with type 1 diabetes...
  17. ncbi request reprint Carotid intima-media thickness (cIMT) cosegregates with blood pressure and renal function in hypertensive Hispanic families
    Yi Chun Chen
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Atherosclerosis 198:160-5. 2008
    ..Since cIMT is correlated with hypertension and microalbuminuria, we tested the hypothesis that there is a genetic basis for the observed relationship between cIMT, blood pressure (BP), and renal function within high risk families...
  18. ncbi request reprint Relation of progression of coronary artery atherosclerosis to risk of cardiovascular events (from the Monitored Atherosclerosis Regression Study)
    Cheryl Vigen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Am J Cardiol 95:1277-82. 2005
    ..12) or category 3 (HR 0.81, p = 0.17). These results indicate that quantitative coronary angiographic changes are associated with cardiovascular events and support the long-term benefit of early intervention to decrease atherosclerosis...
  19. ncbi request reprint A genome-wide scan for carotid artery intima-media thickness: the Mexican-American Coronary Artery Disease family study
    Dai Wang
    Medical Genetics Institute, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, 8700 Beverly Blvd, SSB 378, Los Angeles, Calif 90048, USA
    Stroke 36:540-5. 2005
    ..To systematically identify the genetic determinants of CIMT, we performed a genome-wide scan using data from 91 2-generation Mexican American families ascertained via a parent with CAD diagnosed...
  20. pmc Metabolic syndrome and cognitive function in healthy middle-aged and older adults without diabetes
    Nicole M Gatto
    Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90089 9010, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 15:627-41. 2008
    ..We examined the cross-sectional association between MetS and six areas of cognitive function in healthy cognitively intact adults without diabetes (n = 853, mean age 61 years) randomized in two intervention trials...
  21. ncbi request reprint Time from diagnosis of type 2 diabetes to initiation of insulin therapy is related to carotid artery intima-media thickness
    Ling Zheng
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP 218, Los Angeles, CA 90089 9010, USA
    Atherosclerosis 170:293-9. 2003
    ..Longitudinal data are needed to determine the effect of early initiation of insulin therapy on the progression of subclinical atherosclerosis among persons with diabetes...
  22. ncbi request reprint Atherosclerosis imaging methods: assessing cardiovascular disease and evaluating the role of estrogen in the prevention of atherosclerosis
    Howard N Hodis
    Keck School of Medicine, University of Southern California, Los Angeles, Los Angeles, California 90033, USA
    Am J Cardiol 89:19E-27E; discussion 27E. 2002
    ..The results demonstrated that 17beta-estradiol significantly reduces the progression of subclinical atherosclerosis in healthy, postmenopausal women when compared with placebo...
  23. pmc Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study
    Sarah J Lord
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Breast Cancer Res 7:R336-44. 2005
    ..Identifying genetic variants that determine increases in mammographic density in hormone users may be important in understanding hormonal carcinogenesis of the breast...
  24. pmc Brachial artery vasoreactivity is associated with cross-sectional and longitudinal anatomical measures of atherosclerosis in postmenopausal women with coronary artery disease
    Nicole M Gatto
    University of Southern California Keck School of Medicine, Department of Preventive Medicine, Los Angeles, CA 90089 9010, United States
    Atherosclerosis 196:674-81. 2008
    ....
  25. pmc Carotid artery intima-media thickness and HIV infection: traditional risk factors overshadow impact of protease inhibitor exposure
    Judith S Currier
    Center for Clinical AIDS Research and Education, Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    AIDS 19:927-33. 2005
    ..The impact of HIV infection and exposure to antiretroviral therapy on the development of subclinical atherosclerosis is incompletely understood...
  26. pmc Relationship between serum levels of sex hormones and progression of subclinical atherosclerosis in postmenopausal women
    Roksana Karim
    Department of Pediatrics, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP Suite 222R, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 93:131-8. 2008
    ..Postmenopausal hormone therapy has been examined extensively in relation to cardiovascular disease. However, research relating serum levels of sex hormones to cardiovascular disease is sparse, and the results are inconclusive...
  27. ncbi request reprint Carotid artery intima-media thickness after raloxifene treatment
    Wendy J Mack
    Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Womens Health (Larchmt) 16:370-8. 2007
    ....
  28. pmc Effect of pioglitazone on progression of subclinical atherosclerosis in non-diabetic premenopausal Hispanic women with prior gestational diabetes
    Anny H Xiang
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, United States
    Atherosclerosis 199:207-14. 2008
    ..Pioglitazone slows progression of subclinical atherosclerosis in young Hispanic women at increased risk for type 2 diabetes...
  29. ncbi request reprint Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS)
    Howard N Hodis
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, Calif, USA
    Circulation 106:1453-9. 2002
    ..In contrast, randomized controlled trials have reported conflicting results as to whether vitamin E supplementation reduces atherosclerosis progression and CVD events...
  30. ncbi request reprint Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women
    Howard N Hodis
    Atherosclerosis Research Unit, Keck School of Medicine, Los Angeles, CA 90033, USA
    N Engl J Med 349:535-45. 2003
    ..Whether 17beta-estradiol (the endogenous estrogen molecule) alone or administered sequentially with medroxyprogesterone acetate can slow the progression of atherosclerosis is unknown...
  31. pmc Replication of calpain-10 genetic association with carotid intima-media thickness
    Mark O Goodarzi
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Atherosclerosis 205:503-5. 2009
    ..A prior study in Hispanics found association of haplotypes in the diabetes gene calpain-10 (CAPN10) with carotid artery intima-media thickness (CIMT). This study sought to replicate this association in an independent cohort...
  32. ncbi request reprint Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parent
    Anny H Xiang
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    Arterioscler Thromb Vasc Biol 22:843-8. 2002
    ..Heritability is particularly evident in younger family members, suggesting that acquired factors contribute progressively to IMT variability with aging...
  33. pmc Relation of Framingham risk score to subclinical atherosclerosis evaluated across three arterial sites
    Roksana Karim
    Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Am J Cardiol 102:825-30. 2008
    ..Evaluation of subclinical atherosclerosis in different arterial sites in addition to FRS may be useful in targeting subjects for lifestyle and other interventions...
  34. ncbi request reprint Antiatherosclerosis interventions in women
    Howard N Hodis
    Atherosclerosis Research Unit, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Am J Cardiol 90:17F-21F. 2002
    ..Powerful imaging tools for monitoring atherosclerosis progression exist that can be used to help address many questions relating to type, dose, regimen, and timing of HRT...
  35. ncbi request reprint Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women
    Thomas A Buchanan
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Diabetes 51:2796-803. 2002
    ..The protective effect was associated with the preservation of pancreatic beta-cell function and appeared to be mediated by a reduction in the secretory demands placed on beta-cells by chronic insulin resistance...
  36. ncbi request reprint Environmental tobacco smoke and carotid arterial stiffness
    Wendy J Mack
    Department of Preventive Medicine and Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Prev Med 37:148-54. 2003
    ..We used baseline data from the Vitamin E Atherosclerosis Prevention Study to evaluate the association between ETS exposure and arterial stiffness among 227 healthy adult nonsmokers...
  37. ncbi request reprint Elevated subclinical atherosclerosis associated with oophorectomy is related to time since menopause rather than type of menopause
    Wendy J Mack
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Fertil Steril 82:391-7. 2004
    ..To compare common carotid artery intima-media thickness (IMT) between women who had natural menopause with those who had surgical menopause and to correlate IMT with time since menopause...
  38. ncbi request reprint Does elevated body mass modify the influence of postmenopausal estrogen replacement on atherosclerosis progression: results from the estrogen in the prevention of atherosclerosis trial
    Wendy J Mack
    Department of Preventive Medicine, University of Southern California, Los Angeles, USA
    Atherosclerosis 168:91-8. 2003
    ..To determine whether the estrogen-related reduction in atherosclerosis progression demonstrated in the estrogen in the prevention of atherosclerosis trial (EPAT) is modified by body mass index (BMI)...
  39. pmc Ambient air pollution and atherosclerosis in Los Angeles
    Nino Kunzli
    Division of Environmental Health, Department of Preventive Medicine, Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 9013, USA
    Environ Health Perspect 113:201-6. 2005
    ..Given the leading role of cardiovascular disease as a cause of death and the large populations exposed to ambient PM2.5, these findings may be important and need further confirmation...
  40. ncbi request reprint Association of the diabetes gene calpain-10 with subclinical atherosclerosis: the Mexican-American Coronary Artery Disease Study
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diabetes 54:1228-32. 2005
    ..The fact that the diabetes gene CAPN10 also influences the risk for atherosclerosis shows that inherited factors may underlie the frequent co-occurrence of these two conditions...
  41. ncbi request reprint The phytoestrogen equol increases nitric oxide availability by inhibiting superoxide production: an antioxidant mechanism for cell-mediated LDL modification
    Juliana Hwang
    School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Free Radic Biol Med 34:1271-82. 2003
    ..Decreased O(2)(-*) production resulted in increased free NO levels (but not total NO production) indicating that decreased reactions between O(2)(-*) and NO are an outcome of equol's antioxidant activity in cell culture...
  42. pmc Polyunsaturated fatty acids and cardiovascular disease: implications for nutrigenetics
    Hooman Allayee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    J Nutrigenet Nutrigenomics 2:140-8. 2009
    ....
  43. ncbi request reprint Long-term effect of estrogen replacement on plasma nitric oxide levels: results from the estrogen in the prevention of atherosclerosis trial (EPAT)
    Juliana Hwang
    University of Southern California Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Keck School of Medicine, Los Angeles, CA 90033, USA
    Atherosclerosis 181:375-80. 2005
    ..In this study, we found no evidence for an estrogen-induced effect on plasma total NO levels which unlikely accounted for the mechanism underlying the 17beta-estradiol atheroprotective effect on subclinical atherosclerosis progression...
  44. ncbi request reprint Role of annexin II in estrogen-induced macrophage matrix metalloproteinase-9 activity: the modulating effect of statins
    Juliana Hwang
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Atherosclerosis 189:76-82. 2006
    ..Prevention of E(2)-mediated activation of MMP-9 by simvastatin suggests that concurrent statin use may account for early event risk of myocardial infarction seen with hormone therapy in recent clinical trials...
  45. pmc Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women
    Roksana Karim
    Department of Pediatrics and Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Menopause 17:785-90. 2010
    ..It is not known how sex hormone concentrations relate to the markers of inflammation in postmenopausal women taking or not taking hormone therapy...
  46. pmc Influence of age and obesity on serum estradiol, estrone, and sex hormone binding globulin concentrations following oral estrogen administration in postmenopausal women
    Roksana Karim
    Department of Pediatrics, University of Southern California, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 94:4136-43. 2009
    ..Risk of venous thrombosis and stroke is higher in older, overweight, and obese women using HT. However, the impact of age and obesity on estrogen concentrations among HT users is not well defined...
  47. ncbi request reprint Progression of carotid artery intima-media thickening in HIV-infected and uninfected adults
    Judith S Currier
    Center for Clinical AIDS Research and Education, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
    AIDS 21:1137-45. 2007
    ..To compare the rate of change in intima-media thickness (IMT) of the carotid artery among uninfected subjects and HIV-infected subjects receiving or not receiving protease inhibitor (PI) regimens over a 144 week period...
  48. pmc Persistence of the metabolic syndrome and its influence on carotid artery intima media thickness in overweight Latino children
    Claudia M Toledo-Corral
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9073, United States
    Atherosclerosis 206:594-8. 2009
    ..The objective of this study was to examine the influence of persistence of the metabolic syndrome (Mets) and its individual components over a 3-year period on carotid intima media thickness (CIMT) in overweight Latino children...
  49. ncbi request reprint Postmenopausal hormone replacement therapy as antiatherosclerotic therapy
    Howard N Hodis
    Atherosclerosis Research Unit, University of Southern California School of Medicine, 2250 Alcazar Street, CSC 132, Los Angeles, CA 90033, USA
    Curr Atheroscler Rep 4:52-8. 2002
    ....
  50. pmc 17beta-Estradiol reverses shear-stress-mediated low density lipoprotein modifications
    Juliana Hwang
    Department of Biomedical Engineering and Cardiovascular Medicine, Atherosclerosis Research Unit, University of Southern California, Los Angeles, CA 90081, USA
    Free Radic Biol Med 41:568-78. 2006
    ..Thus, E(2) plays an indirect antioxidative role. In addition to upregulation of endothelial (.-)NO synthase and downregulation of Nox4 expression, E(2) influences LDL modifications via lipid peroxidation and protein nitration...
  51. ncbi request reprint Unopposed estradiol therapy in postmenopausal women: results from two randomized trials
    Anne Z Steiner
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Obstet Gynecol 109:581-7. 2007
    ..To estimate the rates of endometrial hyperplasia, bleeding episodes, and interventions among menopausal women receiving unopposed oral estradiol or placebo therapy with ultrasound monitoring over 3 years...
  52. pmc Subclinical atherosclerosis is weakly associated with lower cognitive function in healthy hyperhomocysteinemic adults without clinical cardiovascular disease
    Nicole M Gatto
    Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90089 9010, USA
    Int J Geriatr Psychiatry 24:390-9. 2009
    ..It is not well known whether subclinical atherosclerosis is an independent risk factor for lower cognitive function among individuals without clinically evident CVD...
  53. ncbi request reprint What is the cardioprotective role of hormone replacement therapy?
    Howard N Hodis
    Atherosclerosis Research Unit, University of Southern California, 2250 Alcazar Street, CSC 132, Los Angeles, CA 90033, USA
    Curr Atheroscler Rep 5:56-66. 2003
    ..Observations made from epidemiologic studies will have to be appropriately tested in randomized, controlled trials before any real conclusions can be drawn as to whether hormone replacement is cardioprotective...
  54. pmc Perturbations of circulating levels of RANKL-osteoprotegerin axis in relation to lipids and progression of atherosclerosis in HIV-infected and -uninfected adults: ACTG NWCS 332/A5078 Study
    Theodoros Kelesidis
    Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90035, USA
    AIDS Res Hum Retroviruses 29:938-48. 2013
    ....
  55. pmc Association of hepatitis C virus and HIV infection with subclinical atherosclerosis in the women's interagency HIV study
    Phyllis C Tien
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    AIDS 23:1781-4. 2009
    ..Further follow-up is needed to clarify whether HIV/hepatitis C virus coinfection may be associated with a greater risk of carotid plaque...
  56. ncbi request reprint The ratio of plasminogen activator inhibitor type-1 activity to the concentration of plasminogen activator inhibitor type-1 protein in diabetes: adding insult to injury
    Burton E Sobel
    Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA
    Coron Artery Dis 13:275-81. 2002
    ..This study was performed to delineate the relationship between plasminogen activator inhibitor type-1 (PAI-1) activity and PAI-1 protein to characterize the functional importance of elevated PAI-1 in diabetes...
  57. ncbi request reprint Randomized controlled trial evidence that estrogen replacement therapy reduces the progression of subclinical atherosclerosis in healthy postmenopausal women without preexisting cardiovascular disease
    Howard N Hodis
    Circulation 108:e5; author reply e5. 2003
  58. ncbi request reprint Response to: 'carotid intima-media thickness: assessment of sub-clinical atherosclerosis in HIV-infected patients'
    Judith S Currier
    AIDS 20:311. 2006
  59. ncbi request reprint Putting the latest data into practice: case studies and clinical considerations in menopausal management
    Margaret McKenzie
    Women s Health Center, Ob Gyn and Women s Health Institute, Cleveland, OH 44195, USA
    Cleve Clin J Med 75:S25-33. 2008
  60. pmc Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    AIDS 22:1615-24. 2008
    ..To assess the association of HIV infection, HIV disease parameters (including CD4+ T-cell counts, HIV viral load, and AIDS) and antiretroviral medication use with subclinical carotid artery atherosclerosis...
  61. ncbi request reprint Potential role of platelet FcgammaRIIA in collagen-mediated platelet activation associated with atherothrombosis
    David C Calverley
    Department of Medicine and the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box B171, Denver, CO 80262, USA
    Atherosclerosis 164:261-7. 2002
    ..Increased platelet FcR expression may therefore contribute towards risk for atherothrombotic events...
  62. ncbi request reprint Estrogen therapy and coronary-artery calcification
    Howard N Hodis
    N Engl J Med 357:1252-3; author reply 1254. 2007
  63. pmc Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society
    Wulf H Utian
    Menopause 15:584-602. 2008
    ....

Research Grants18

  1. Phytoestrogens and Progression of Atherosclerosis
    HOWARD HODIS; Fiscal Year: 2007
    ..abstract_text> ..
  2. Biologic Response of Menopausal Women to 17B-Estradiol
    HOWARD HODIS; Fiscal Year: 2007
    ..Treatment duration will average 3 years (,range, 2 to 5 years) and the rate of change _ carotid artery intima-media thickness, a well-established measure of subclinical atherosclerosis, will be the primary trial end point. ..
  3. Biologic Response of Menopausal Women to 17B Estradiol
    HOWARD HODIS; Fiscal Year: 2006
    ..g., menopausal symptoms, prior exposure to hormone therapy, hysterectomy status), and other variables that might confound or modify associations between treatment assignment and cognitive outcomes. ..
  4. B VITAMIN ATHEROSCLEROSIS INTERVENTION TRAIL
    HOWARD HODIS; Fiscal Year: 2004
    ..B-vitamin supplementation may provide a promising approach for reducing the progression of atherosclerosis since it is natural, inexpensive, highly tolerable, and safe. ..
  5. ESTROGEN IN THE PREVENTION OF ATHEROSCLEROSIS TRIAL
    HOWARD HODIS; Fiscal Year: 2004
    ....
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