John G Hodgson
Affiliation: University of California
- A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletionsClifford L Wang
Department of Microbiology and Immunology, University of California, San Francisco 94143 0414, USA
Retrovirology 1:5. 2004..This provirus can delete its envelope gene by LoxP/Cre mediated recombination and thereby allow superinfection of Cre recombinase expressing cells...
- Mammary carcinoma behavior is programmed in the precancer stem cellPatrizia Damonte
Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, UC Davis, County Road 98 and Hutchison Drive, Davis, California 95616, USA
Breast Cancer Res 10:R50. 2008..Transition to carcinoma has a consistent latency for each line, and three of the lines also exhibit pulmonary metastatic potential...
- miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cellsJoachim Silber
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
BMC Med 6:14. 2008..In this study, we investigated the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells...
- Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenograftsJ Graeme Hodgson
Dept of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA
Neuro Oncol 11:477-87. 2009....
- Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signalingJ Graeme Hodgson
Department of Laboratory Medicine and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA
Cancer Res 65:9695-704. 2005..Our studies highlight loci and genes important in the regulation of tumorigenic RTK signaling in mammary epithelial cells in vivo...
- Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8Chibo Hong
Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143 0875, USA
Cancer Res 65:3617-23. 2005..The shared epigenetic inactivation of mSLC5A8 in mouse gliomas indicates an additional degree of commonality in the origin and/or pathway to tumorigenesis between primary human tumors and these mouse models of gliomas...
- microRNAs in gliomas: small regulators of a big problemJoachim Silber
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 92121, USA
Neuromolecular Med 11:208-22. 2009..This is a rapidly evolving field and it is likely that we have only begun to appreciate the involvement of microRNAs in relation to glioma formation, and the therapeutic potential of microRNAs to improve outcome for glioma patients...
- Glioblastoma multiforme regional genetic and cellular expression patterns: influence on anatomic and physiologic MR imagingRamon F Barajas
Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Long L200B, Box 0628, San Francisco, CA 94143, USA
Radiology 254:564-76. 2010..To determine whether magnetic resonance (MR) imaging is influenced by genetic and cellular features of glioblastoma multiforme (GBM) aggressiveness...
- Oncogene expression and genetic background influence the frequency of DNA copy number abnormalities in mouse pancreatic islet cell carcinomasJeffrey H Hager
Department of Biochemistry, University of California at San Francisco Diabetes and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA
Cancer Res 64:2406-10. 2004..These studies illustrate the utility of transgenic animal models for investigation of factors influencing genomic heterogeneity despite the commonalty of target cell type and initiating oncogene...
- The role of p53 in suppression of KSHV cyclin-induced lymphomagenesisEmmy W Verschuren
Comprehensive Cancer Center and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA
Cancer Res 64:581-9. 2004..Together, our data support a model in which K cyclin-induced genome instability arises early in the pre-tumorigenic lymphocyte population and that loss of p53 licenses subsequent expansion of tumorigenic clones...
- Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumorsChristopher S Hackett
Department of Neurology, University of California, San Francisco, California 94143 0114, USA
Cancer Res 63:5266-73. 2003..These data demonstrate conservation of many genetic changes in murine and human neuroblastoma and suggest that further delineation of genetic abnormalities in murine tumors may identify genes important in human disease...
- Genome amplification of chromosome 20 in breast cancerJ Graeme Hodgson
Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, USA
Breast Cancer Res Treat 78:337-45. 2003....
- Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behaviorAlexander D Borowsky
Department of Medical Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA
Clin Exp Metastasis 22:47-59. 2005..Therefore, these two cell lines provide a stable, reproducible resource for the study of metastasis modulators, AKT molecular pathway interactions, and gene target and marker discovery...
- Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instabilityPeter C Scacheri
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 2152, USA
Cancer Res 64:7039-44. 2004..Thus, the somatic genetic changes that are postulated to lead to tumorigenesis in a mouse model of MEN1 must be unusually subtle, occurring at either the nucleotide level or through epigenetic mechanisms...
- Induction of tumors in mice by genomic hypomethylationFrançois Gaudet
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Science 300:489-92. 2003..These results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability...