DENISE C contact HOCKING

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Stimulation of integrin-mediated cell contractility by fibronectin polymerization
    D C Hocking
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 275:10673-82. 2000
  2. ncbi Extracellular matrix fibronectin mechanically couples skeletal muscle contraction with local vasodilation
    Denise C Hocking
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    Circ Res 102:372-9. 2008
  3. ncbi Fibronectin matrix polymerization regulates small airway epithelial cell migration
    Denise C Hocking
    Department of Pharmacologyand physiology, University of Rochester Medical Center, 601 Elmwood Ave, Box 711, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 285:L169-79. 2003
  4. ncbi Fibronectin matrix deposition and cell contractility: implications for airway remodeling in asthma
    Denise C Hocking
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Chest 122:275S-278S. 2002
  5. ncbi A cryptic fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility
    Denise C Hocking
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cell Biol 158:175-84. 2002
  6. ncbi Vascularization of three-dimensional collagen hydrogels using ultrasound standing wave fields
    Kelley A Garvin
    Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA
    Ultrasound Med Biol 37:1853-64. 2011
  7. ncbi Fibronectin matrix polymerization increases tensile strength of model tissue
    Candace D Gildner
    Department of Biomedical, University of Rochester Medical Center, 601 Elmwood Ave, PO Box 711, Rochester, NY 14642, USA
    Am J Physiol Heart Circ Physiol 287:H46-53. 2004
  8. ncbi Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions
    Jane Sottile
    Department of Medicine, Center for Cardiovascular Research, Rochester, New York 14642, USA
    Mol Biol Cell 13:3546-59. 2002
  9. ncbi Expression, production, and characterization of full-length vitronectin in Escherichia coli
    Katherine Wojciechowski
    Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Ave, Box 711, NY 14642, USA
    Protein Expr Purif 36:131-8. 2004
  10. ncbi Identification of the heparin-binding determinants within fibronectin repeat III1: role in cell spreading and growth
    Liqiong Gui
    Department of Biomedical Engineering, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 281:34816-25. 2006

Research Grants

  1. Ultrasound Technologies for Tissue Engineering
    DENISE C contact HOCKING; Fiscal Year: 2010
  2. Engineered Matrix Mimetics: Novel Therapies for Wound Repair
    Denise C Hocking; Fiscal Year: 2010
  3. Mechanisms of Tissue Remodeling By Ultrasound
    DENISE HOCKING; Fiscal Year: 2004
  4. Extracellular Matrix Remodeling and Tissue Mechanics
    DENISE HOCKING; Fiscal Year: 2004
  5. FIBRONECTIN DEPOSITION AND PULMONARY FIBROSIS
    DENISE HOCKING; Fiscal Year: 2002
  6. ROLE OF FIBRONECTIN IN AIRWAY REMODELING IN ASTHMA
    DENISE HOCKING; Fiscal Year: 2002
  7. Ultrasound Technologies for Tissue Engineering
    DENISE HOCKING; Fiscal Year: 2009

Collaborators

  • Diane Dalecki
  • J Sottile
  • INGRID SARELIUS
  • Katherine Wojciechowski
  • Candace D Gildner
  • Kelley A Garvin
  • Liqiong Gui
  • Marian Pereira
  • Hristina Nedelkovska
  • Cecilia H Chang
  • Amy L Lerner
  • Patricia J Simpson-Haidaris
  • Tatjana M Odrljin
  • Brain J Rybarczyk

Detail Information

Publications11

  1. ncbi Stimulation of integrin-mediated cell contractility by fibronectin polymerization
    D C Hocking
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 275:10673-82. 2000
    ....
  2. ncbi Extracellular matrix fibronectin mechanically couples skeletal muscle contraction with local vasodilation
    Denise C Hocking
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    Circ Res 102:372-9. 2008
    ..Together, these data provide the first evidence that a matricryptic, heparin-binding site within fibronectin fibrils of adult connective tissue plays a dynamic role in regulating both vascular responses and vascular tone...
  3. ncbi Fibronectin matrix polymerization regulates small airway epithelial cell migration
    Denise C Hocking
    Department of Pharmacologyand physiology, University of Rochester Medical Center, 601 Elmwood Ave, Box 711, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 285:L169-79. 2003
    ..These data indicate that SAEC migration is regulated in a biphasic manner by the polymerization of fibronectin in the extracellular matrix and suggest a stimulatory role for fibronectin's matricryptic III-1 site in cell motility...
  4. ncbi Fibronectin matrix deposition and cell contractility: implications for airway remodeling in asthma
    Denise C Hocking
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Chest 122:275S-278S. 2002
    ..Experimental evidence suggests a model in which fibronectin matrix accumulation contributes to the progression of asthma by altering both the structural properties of the airways and the functional properties of cells of the airway wall...
  5. ncbi A cryptic fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility
    Denise C Hocking
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cell Biol 158:175-84. 2002
    ..These data suggest that a portion of ECM FN partitions into lipid rafts and differentially regulates cytoskeletal organization and growth, in part, through the exposure of a neoepitope within the conformationally labile III1 module...
  6. ncbi Vascularization of three-dimensional collagen hydrogels using ultrasound standing wave fields
    Kelley A Garvin
    Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA
    Ultrasound Med Biol 37:1853-64. 2011
    ..Our results demonstrate that USWF technology leads to rapid and extensive vascularization of 3-D collagen-based engineered tissue and, therefore, provide a new strategy to vascularize engineered tissues in vitro...
  7. ncbi Fibronectin matrix polymerization increases tensile strength of model tissue
    Candace D Gildner
    Department of Biomedical, University of Rochester Medical Center, 601 Elmwood Ave, PO Box 711, Rochester, NY 14642, USA
    Am J Physiol Heart Circ Physiol 287:H46-53. 2004
    ....
  8. ncbi Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions
    Jane Sottile
    Department of Medicine, Center for Cardiovascular Research, Rochester, New York 14642, USA
    Mol Biol Cell 13:3546-59. 2002
    ....
  9. ncbi Expression, production, and characterization of full-length vitronectin in Escherichia coli
    Katherine Wojciechowski
    Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Ave, Box 711, NY 14642, USA
    Protein Expr Purif 36:131-8. 2004
    ..As such, the production of recombinant VN in bacteria represents a rapid and convenient method to produce large quantities of VN for cellular studies...
  10. ncbi Identification of the heparin-binding determinants within fibronectin repeat III1: role in cell spreading and growth
    Liqiong Gui
    Department of Biomedical Engineering, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 281:34816-25. 2006
    ....
  11. ncbi The incorporation of fibrinogen into extracellular matrix is dependent on active assembly of a fibronectin matrix
    Marian Pereira
    Department of Medicine-Vascular Medicine Unit, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Cell Sci 115:609-17. 2002
    ..From these data, we hypothesize that fibrinogen deposition rapidly changes the topology of the extracellular matrix to provide a surface for cell migration and matrix remodeling during tissue repair...

Research Grants19

  1. Ultrasound Technologies for Tissue Engineering
    DENISE C contact HOCKING; Fiscal Year: 2010
    ..End of Abstract) ..
  2. Engineered Matrix Mimetics: Novel Therapies for Wound Repair
    Denise C Hocking; Fiscal Year: 2010
    ..Here, we will develop the use of recombinant extracellular matrix analogs as a novel therapy to rapidly up-regulate cell function and tissue mechanics in chronic, non-healing wounds. ..
  3. Mechanisms of Tissue Remodeling By Ultrasound
    DENISE HOCKING; Fiscal Year: 2004
    ..In Aim 3, we will use optimized acoustic fields to stimulate extracellular matrix organization in order to engineer the biological and material properties of a collagen-based tissue construct. ..
  4. Extracellular Matrix Remodeling and Tissue Mechanics
    DENISE HOCKING; Fiscal Year: 2004
    ....
  5. FIBRONECTIN DEPOSITION AND PULMONARY FIBROSIS
    DENISE HOCKING; Fiscal Year: 2002
    ....
  6. ROLE OF FIBRONECTIN IN AIRWAY REMODELING IN ASTHMA
    DENISE HOCKING; Fiscal Year: 2002
    ..abstract_text> ..
  7. Ultrasound Technologies for Tissue Engineering
    DENISE HOCKING; Fiscal Year: 2009
    ..End of Abstract) ..