M Hochstrasser

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc The Saccharomyces cerevisiae ubiquitin-proteasome system
    M Hochstrasser
    Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637, USA
    Philos Trans R Soc Lond B Biol Sci 354:1513-22. 1999
  2. ncbi request reprint Ubiquitin-dependent protein degradation
    M Hochstrasser
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Genet 30:405-39. 1996
  3. pmc The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein
    S J Li
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 20:2367-77. 2000
  4. pmc A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation
    R Swanson
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 15:2660-74. 2001
  5. pmc The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast
    S Swaminathan
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Biol Cell 10:2583-94. 1999
  6. pmc Eukaryotic 20S proteasome catalytic subunit propeptides prevent active site inactivation by N-terminal acetylation and promote particle assembly
    C S Arendt
    University of Chicago, Department of Biochemistry and Molecular Biology, 920 East 58th Street, Chicago, IL 60637, USA
    EMBO J 18:3575-85. 1999
  7. pmc Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome
    F R Papa
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Biol Cell 10:741-56. 1999
  8. ncbi request reprint A new protease required for cell-cycle progression in yeast
    S J Li
    University of Chicago, Department of Biochemistry and Molecular Biology, Illinois 60637, USA
    Nature 398:246-51. 1999
  9. ncbi request reprint Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway
    P R Johnson
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Cell 94:217-27. 1998
  10. ncbi request reprint Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor
    P Chen
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637
    Cell 74:357-69. 1993

Collaborators

Detail Information

Publications22

  1. pmc The Saccharomyces cerevisiae ubiquitin-proteasome system
    M Hochstrasser
    Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637, USA
    Philos Trans R Soc Lond B Biol Sci 354:1513-22. 1999
    ..Finally, it has become clear that protein (poly) ubiquitination is highly dynamic in vivo, and our studies of yeast de-ubiquitinating enzymes illustrate how such enzymes can facilitate the proteolysis of diverse substrates...
  2. ncbi request reprint Ubiquitin-dependent protein degradation
    M Hochstrasser
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Genet 30:405-39. 1996
    ..This diversity underlies both the high substrate specificity of the ubiquitin system and the variety of regulatory mechanisms that it serves...
  3. pmc The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein
    S J Li
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 20:2367-77. 2000
    ..Our data suggest the existence of a feedback mechanism that limits Smt3-protein ligation when Smt3 deconjugation by both Ulp1 and Ulp2 is compromised, allowing a partial recovery of cell function...
  4. pmc A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation
    R Swanson
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 15:2660-74. 2001
    ..The likely human ortholog of DOA10 is in the cri-du-chat syndrome critical region on chromosome 5p, suggesting that defective ubiquitin ligation might contribute to this common genetic disorder...
  5. pmc The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast
    S Swaminathan
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Biol Cell 10:2583-94. 1999
    ..We propose that Doa4 helps recycle ubiquitin from both proteasome-bound ubiquitinated intermediates and membrane proteins destined for destruction in the vacuole...
  6. pmc Eukaryotic 20S proteasome catalytic subunit propeptides prevent active site inactivation by N-terminal acetylation and promote particle assembly
    C S Arendt
    University of Chicago, Department of Biochemistry and Molecular Biology, 920 East 58th Street, Chicago, IL 60637, USA
    EMBO J 18:3575-85. 1999
    ..In addition to delineating a novel function for proteasome propeptides, these data provide the first biochemical evidence for the postulated participation of the alpha-amino group in the proteasome catalytic mechanism...
  7. pmc Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome
    F R Papa
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Biol Cell 10:741-56. 1999
    ..Together, these data support a model in which Doa4 promotes proteolysis through removal of ubiquitin from proteolytic intermediates on the proteasome before or after initiation of substrate breakdown...
  8. ncbi request reprint A new protease required for cell-cycle progression in yeast
    S J Li
    University of Chicago, Department of Biochemistry and Molecular Biology, Illinois 60637, USA
    Nature 398:246-51. 1999
    ..The pattern of Smt3-coupled proteins in yeast changes markedly throughout the cell cycle, and specific conjugates accumulate in ulp1 mutants. Ulp1 has several functions, including an essential role in the G2/M phase of the cell cycle...
  9. ncbi request reprint Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway
    P R Johnson
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Cell 94:217-27. 1998
    ....
  10. ncbi request reprint Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor
    P Chen
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637
    Cell 74:357-69. 1993
    ..These data reveal an unexpected overlap in substrate specificity among diverse UBC enzymes and suggest a combinatorial mechanism of substrate selection in which UBC enzymes partition into multiple ubiquitination complexes...
  11. ncbi request reprint Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly
    P Chen
    Department of Biochemistry and Molecular Biology, The University of Chicago, Illinois 60637, USA
    Cell 86:961-72. 1996
    ....
  12. pmc Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation
    C S Arendt
    Department of Biochemistry and Molecular Biology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 94:7156-61. 1997
    ....
  13. ncbi request reprint The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene
    F R Papa
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637
    Nature 366:313-9. 1993
    ..The human tre-2 oncogene encodes a deubiquitinating enzyme similar to Doa4, indicating a role for the ubiquitin system in mammalian growth control...
  14. pmc Biogenesis, structure and function of the yeast 20S proteasome
    P Chen
    Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637, USA
    EMBO J 14:2620-30. 1995
    ....
  15. ncbi request reprint Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae
    A Y Amerik
    Yale University, Department of Molecular Biophysics and Biochemistry, New Haven, CT 06520, USA
    Biol Chem 381:981-92. 2000
    ..The data suggest that the DOA4 locus underwent a duplication after the divergence of K. lactis and S. cerevisiae. This information will facilitate fine-structure analysis of the Doa4 protein to help delineate its key functional elements...
  16. pmc The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways
    A Y Amerik
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Mol Biol Cell 11:3365-80. 2000
    ....
  17. pmc The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo
    D J Demarini
    Laboratory of Genetics and Molecular Biology, University of Wisconsin, Madison 53706, USA
    Mol Cell Biol 15:6311-21. 1995
    ....
  18. pmc Molecular organization of the 20S proteasome gene family from Arabidopsis thaliana
    H Fu
    Cellular and Molecular Biology Program and the Department of Horticulture, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 149:677-92. 1998
    ....
  19. ncbi request reprint Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle
    D Finley
    Trends Biochem Sci 23:244-5. 1998
  20. pmc DUB-1, a deubiquitinating enzyme with growth-suppressing activity
    Y Zhu
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 93:3275-9. 1996
    ..Our results suggest that DUB-1 regulates cellular growth by modulating either the ubiquitin-dependent proteolysis or the ubiquitination state of an unknown growth regulatory factor(s)...
  21. ncbi request reprint An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme
    T E Hansen-Hagge
    Department of Pediatrics II, University of Ulm, Germany
    Genomics 49:411-8. 1998
    ..This new deubiquitinating enzyme has been named UBH1, for ubiquitin hydrolyzing enzyme 1...
  22. ncbi request reprint In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor
    M Hochstrasser
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 61:697-708. 1990
    ..This subunit-specific degradation makes possible a novel type of posttranslational remodeling in which a heteromeric protein could be functionally modified by selective, degradation-mediated replacement of its subunits...