M Hochstrasser

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc The Saccharomyces cerevisiae ubiquitin-proteasome system
    M Hochstrasser
    Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637, USA
    Philos Trans R Soc Lond B Biol Sci 354:1513-22. 1999
  2. ncbi request reprint Ubiquitin-dependent protein degradation
    M Hochstrasser
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Genet 30:405-39. 1996
  3. pmc A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation
    R Swanson
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 15:2660-74. 2001
  4. pmc The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein
    S J Li
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 20:2367-77. 2000
  5. pmc Eukaryotic 20S proteasome catalytic subunit propeptides prevent active site inactivation by N-terminal acetylation and promote particle assembly
    C S Arendt
    University of Chicago, Department of Biochemistry and Molecular Biology, 920 East 58th Street, Chicago, IL 60637, USA
    EMBO J 18:3575-85. 1999
  6. pmc The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast
    S Swaminathan
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Biol Cell 10:2583-94. 1999
  7. ncbi request reprint Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor
    P Chen
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637
    Cell 74:357-69. 1993
  8. pmc Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome
    F R Papa
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Biol Cell 10:741-56. 1999
  9. ncbi request reprint A new protease required for cell-cycle progression in yeast
    S J Li
    University of Chicago, Department of Biochemistry and Molecular Biology, Illinois 60637, USA
    Nature 398:246-51. 1999
  10. ncbi request reprint Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway
    P R Johnson
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Cell 94:217-27. 1998

Collaborators

  • S J Li
  • S Swaminathan
  • J Nowak
  • R D Vierstra
  • A Varshavsky
  • D Ursic
  • Keiji Tanaka
  • A Y Amerik
  • F R Papa
  • C S Arendt
  • R Swanson
  • P Chen
  • D Finley
  • T E Hansen-Hagge
  • H Fu
  • P R Johnson
  • Y Zhu
  • M Locher
  • T Sommer
  • S Jentsch
  • D J Demarini
  • V Fried
  • W Baumeister
  • J W Janssen
  • C Mann
  • P Silver
  • J Haber
  • R Hampton
  • S Johnston
  • J McCusker
  • J H Doelling
  • S I Reed
  • D Becke
  • L Frontali
  • H Hameister
  • A Goldberg
  • P Thorsness
  • C R Bartram
  • D M Rubin
  • K Madura
  • T Seriu
  • H Feldmann
  • A Toh-e
  • U Zechner
  • D Wolf
  • A Jauch
  • B Byers
  • L Rakhilina
  • A D D'Andrea
  • M Carroll
  • T P Rasmussen
  • M R Culbertson
  • P Johnson

Detail Information

Publications22

  1. pmc The Saccharomyces cerevisiae ubiquitin-proteasome system
    M Hochstrasser
    Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637, USA
    Philos Trans R Soc Lond B Biol Sci 354:1513-22. 1999
    ..Finally, it has become clear that protein (poly) ubiquitination is highly dynamic in vivo, and our studies of yeast de-ubiquitinating enzymes illustrate how such enzymes can facilitate the proteolysis of diverse substrates...
  2. ncbi request reprint Ubiquitin-dependent protein degradation
    M Hochstrasser
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Genet 30:405-39. 1996
    ..This diversity underlies both the high substrate specificity of the ubiquitin system and the variety of regulatory mechanisms that it serves...
  3. pmc A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation
    R Swanson
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 15:2660-74. 2001
    ..The likely human ortholog of DOA10 is in the cri-du-chat syndrome critical region on chromosome 5p, suggesting that defective ubiquitin ligation might contribute to this common genetic disorder...
  4. pmc The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein
    S J Li
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 20:2367-77. 2000
    ..Our data suggest the existence of a feedback mechanism that limits Smt3-protein ligation when Smt3 deconjugation by both Ulp1 and Ulp2 is compromised, allowing a partial recovery of cell function...
  5. pmc Eukaryotic 20S proteasome catalytic subunit propeptides prevent active site inactivation by N-terminal acetylation and promote particle assembly
    C S Arendt
    University of Chicago, Department of Biochemistry and Molecular Biology, 920 East 58th Street, Chicago, IL 60637, USA
    EMBO J 18:3575-85. 1999
    ..In addition to delineating a novel function for proteasome propeptides, these data provide the first biochemical evidence for the postulated participation of the alpha-amino group in the proteasome catalytic mechanism...
  6. pmc The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast
    S Swaminathan
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Biol Cell 10:2583-94. 1999
    ..We propose that Doa4 helps recycle ubiquitin from both proteasome-bound ubiquitinated intermediates and membrane proteins destined for destruction in the vacuole...
  7. ncbi request reprint Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor
    P Chen
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637
    Cell 74:357-69. 1993
    ..These data reveal an unexpected overlap in substrate specificity among diverse UBC enzymes and suggest a combinatorial mechanism of substrate selection in which UBC enzymes partition into multiple ubiquitination complexes...
  8. pmc Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome
    F R Papa
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Biol Cell 10:741-56. 1999
    ..Together, these data support a model in which Doa4 promotes proteolysis through removal of ubiquitin from proteolytic intermediates on the proteasome before or after initiation of substrate breakdown...
  9. ncbi request reprint A new protease required for cell-cycle progression in yeast
    S J Li
    University of Chicago, Department of Biochemistry and Molecular Biology, Illinois 60637, USA
    Nature 398:246-51. 1999
    ..The pattern of Smt3-coupled proteins in yeast changes markedly throughout the cell cycle, and specific conjugates accumulate in ulp1 mutants. Ulp1 has several functions, including an essential role in the G2/M phase of the cell cycle...
  10. ncbi request reprint Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway
    P R Johnson
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Cell 94:217-27. 1998
    ....
  11. ncbi request reprint Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly
    P Chen
    Department of Biochemistry and Molecular Biology, The University of Chicago, Illinois 60637, USA
    Cell 86:961-72. 1996
    ....
  12. pmc Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation
    C S Arendt
    Department of Biochemistry and Molecular Biology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 94:7156-61. 1997
    ....
  13. ncbi request reprint The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene
    F R Papa
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637
    Nature 366:313-9. 1993
    ..The human tre-2 oncogene encodes a deubiquitinating enzyme similar to Doa4, indicating a role for the ubiquitin system in mammalian growth control...
  14. pmc Biogenesis, structure and function of the yeast 20S proteasome
    P Chen
    Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637, USA
    EMBO J 14:2620-30. 1995
    ....
  15. pmc Molecular organization of the 20S proteasome gene family from Arabidopsis thaliana
    H Fu
    Cellular and Molecular Biology Program and the Department of Horticulture, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 149:677-92. 1998
    ....
  16. ncbi request reprint Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle
    D Finley
    Trends Biochem Sci 23:244-5. 1998
  17. ncbi request reprint Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae
    A Y Amerik
    Yale University, Department of Molecular Biophysics and Biochemistry, New Haven, CT 06520, USA
    Biol Chem 381:981-92. 2000
    ..The data suggest that the DOA4 locus underwent a duplication after the divergence of K. lactis and S. cerevisiae. This information will facilitate fine-structure analysis of the Doa4 protein to help delineate its key functional elements...
  18. pmc The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways
    A Y Amerik
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Mol Biol Cell 11:3365-80. 2000
    ....
  19. pmc The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo
    D J Demarini
    Laboratory of Genetics and Molecular Biology, University of Wisconsin, Madison 53706, USA
    Mol Cell Biol 15:6311-21. 1995
    ....
  20. ncbi request reprint An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme
    T E Hansen-Hagge
    Department of Pediatrics II, University of Ulm, Germany
    Genomics 49:411-8. 1998
    ..This new deubiquitinating enzyme has been named UBH1, for ubiquitin hydrolyzing enzyme 1...
  21. pmc DUB-1, a deubiquitinating enzyme with growth-suppressing activity
    Y Zhu
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 93:3275-9. 1996
    ..Our results suggest that DUB-1 regulates cellular growth by modulating either the ubiquitin-dependent proteolysis or the ubiquitination state of an unknown growth regulatory factor(s)...
  22. ncbi request reprint In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor
    M Hochstrasser
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 61:697-708. 1990
    ..This subunit-specific degradation makes possible a novel type of posttranslational remodeling in which a heteromeric protein could be functionally modified by selective, degradation-mediated replacement of its subunits...