M M Hobbs

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Vaginal swab specimen processing methods influence performance of rapid semen detection tests: a cautionary tale
    Marcia M Hobbs
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Contraception 82:291-5. 2010
  2. pmc Haemophilus ducreyi infection causes basal keratinocyte cytotoxicity and elicits a unique cytokine induction pattern in an In vitro human skin model
    M M Hobbs
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Infect Immun 66:2914-21. 1998
  3. ncbi request reprint Molecular typing of Neisseria gonorrhoeae causing repeated infections: evolution of porin during passage within a community
    M M Hobbs
    Division of Infectious Diseases, Department of Medicine and Epidemiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    J Infect Dis 179:371-81. 1999
  4. pmc Good performance of rapid prostate-specific antigen test for detection of semen exposure in women: implications for qualitative research
    Marcia M Hobbs
    Department of Medicine, University of North Carolina at Chapel Hill, CB 7031, Chapel Hill, North Carolina 27599, USA
    Sex Transm Dis 36:501-6. 2009
  5. ncbi request reprint From the NIH: proceedings of a workshop on the importance of self-obtained vaginal specimens for detection of sexually transmitted infections
    Marcia M Hobbs
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Sex Transm Dis 35:8-13. 2008
  6. pmc Methods for detection of Trichomonas vaginalis in the male partners of infected women: implications for control of trichomoniasis
    Marcia M Hobbs
    Department of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    J Clin Microbiol 44:3994-9. 2006
  7. ncbi request reprint The transferrin receptor expressed by gonococcal strain FA1090 is required for the experimental infection of human male volunteers
    C N Cornelissen
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, USA
    Mol Microbiol 27:611-6. 1998
  8. pmc Development and validation of a PCR-based enzyme-linked immunosorbent assay with urine for use in clinical research settings to detect Trichomonas vaginalis in women
    S Cornelia Kaydos
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Microbiol 40:89-95. 2002
  9. ncbi request reprint Improving the accuracy of syndromic diagnosis of genital ulcer disease in Malawi
    Cathrine Hoyo
    Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Sex Transm Dis 32:231-7. 2005
  10. ncbi request reprint Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention
    Arlene C Sena
    Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Clin Infect Dis 44:13-22. 2007

Detail Information

Publications32

  1. pmc Vaginal swab specimen processing methods influence performance of rapid semen detection tests: a cautionary tale
    Marcia M Hobbs
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Contraception 82:291-5. 2010
    ..Quantitative tests for detection of prostate-specific antigen (PSA) perform well, but are expensive and require specialized equipment. We assessed two rapid immunochromatographic strip tests for identification of semen in vaginal swabs...
  2. pmc Haemophilus ducreyi infection causes basal keratinocyte cytotoxicity and elicits a unique cytokine induction pattern in an In vitro human skin model
    M M Hobbs
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Infect Immun 66:2914-21. 1998
    ..IL-8 produced in response to H. ducreyi infection may be involved in recruiting polymorphonuclear leukocytes and other inflammatory cells, thereby contributing to the tissue necrosis and ulcer formation characteristic of chancroid...
  3. ncbi request reprint Molecular typing of Neisseria gonorrhoeae causing repeated infections: evolution of porin during passage within a community
    M M Hobbs
    Division of Infectious Diseases, Department of Medicine and Epidemiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    J Infect Dis 179:371-81. 1999
    ..Sequence analysis of por genes revealed evidence of horizontal genetic exchange and point mutations in potential surface-exposed regions during passage in the community...
  4. pmc Good performance of rapid prostate-specific antigen test for detection of semen exposure in women: implications for qualitative research
    Marcia M Hobbs
    Department of Medicine, University of North Carolina at Chapel Hill, CB 7031, Chapel Hill, North Carolina 27599, USA
    Sex Transm Dis 36:501-6. 2009
    ..This study evaluated the performance of a rapid PSA test compared with a quantitative assay to identify semen in vaginal swab specimens...
  5. ncbi request reprint From the NIH: proceedings of a workshop on the importance of self-obtained vaginal specimens for detection of sexually transmitted infections
    Marcia M Hobbs
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Sex Transm Dis 35:8-13. 2008
    ..Similarly, SOVs should be explored for use in the diagnosis of other sexually transmitted pathogens...
  6. pmc Methods for detection of Trichomonas vaginalis in the male partners of infected women: implications for control of trichomoniasis
    Marcia M Hobbs
    Department of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    J Clin Microbiol 44:3994-9. 2006
    ..vaginalis in male partners required multiple specimens. The majority of male sexual partners in this study were infected, emphasizing the importance of partner evaluation and treatment...
  7. ncbi request reprint The transferrin receptor expressed by gonococcal strain FA1090 is required for the experimental infection of human male volunteers
    C N Cornelissen
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, USA
    Mol Microbiol 27:611-6. 1998
    ..To our knowledge, this is the first experimental demonstration that a bacterial iron acquisition system is an essential virulence factor for human infection...
  8. pmc Development and validation of a PCR-based enzyme-linked immunosorbent assay with urine for use in clinical research settings to detect Trichomonas vaginalis in women
    S Cornelia Kaydos
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Microbiol 40:89-95. 2002
    ..For clinical research settings in which vaginal specimens are not available and culture conditions are not feasible, urine-based PCR-ELISA may be useful for the detection of trichomoniasis in women...
  9. ncbi request reprint Improving the accuracy of syndromic diagnosis of genital ulcer disease in Malawi
    Cathrine Hoyo
    Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Sex Transm Dis 32:231-7. 2005
    ..However, the etiologic pathogens of GUD vary temporally and geographically, and current criteria may not reflect changes in the prevalence of specific pathogens...
  10. ncbi request reprint Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention
    Arlene C Sena
    Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Clin Infect Dis 44:13-22. 2007
    ..Nucleic acid amplification tests can increase detection of T. vaginalis in men compared with culture...
  11. ncbi request reprint The association between Trichomonas vaginalis infection and level of vaginal lactobacilli, in nonpregnant women
    Michelle R Torok
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Infect Dis 196:1102-7. 2007
    ..6 [95% CI, 2.2-9.5]) but not in women with a lower educational level (OR, 1.6 [95% CI, 0.7-3.4]). Vaginal lactobacilli may be associated with trichomoniasis in women with higher levels of education or a related behavioral factor...
  12. ncbi request reprint Targeted screening for Trichomonas vaginalis with culture using a two-step method in women presenting for STD evaluation
    Heidi Swygard
    Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, 27599 7030, USA
    Sex Transm Dis 31:659-64. 2004
    ..Trichomonas vaginalis is the most common nonviral sexually transmitted pathogen. Wet mount microscopy performs poorly compared with culture; however, universal screening using culture would be cost-prohibitive...
  13. ncbi request reprint Prevalence of chlamydial and gonococcal infections among young adults in the United States
    William C Miller
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill 27599 7435, USA
    JAMA 291:2229-36. 2004
    ..Although screening for Chlamydia trachomatis is widely recommended among young adult women, little information is available regarding the prevalence of chlamydial and gonococcal infections in the general young adult population...
  14. ncbi request reprint The use of specimens from various genitourinary sites in men, to detect Trichomonas vaginalis infection
    S Cornelia Kaydos-Daniels
    Department of Epidemiology, University of North Carolina School of Public Health, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    J Infect Dis 189:1926-31. 2004
    ..Semen was the most sensitive single specimen, and, in 25.6% of cases, only semen specimens tested positive. Thus, prevalence of T. vaginalis infection in men is underestimated if only 1 specimen is tested...
  15. pmc The association between oral contraceptives, depot-medroxyprogesterone acetate, and trichomoniasis
    Michelle R Torok
    Department of Epidemiology, University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, NC, USA
    Sex Transm Dis 36:336-40. 2009
    ..We explored the effect of hormonal contraceptive use, specifically oral contraception (OC), and depot-medroxyprogesterone acetate (DMPA) on Trichomonas vaginalis infections in women...
  16. ncbi request reprint The prevalence of trichomoniasis in young adults in the United States
    William C Miller
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    Sex Transm Dis 32:593-8. 2005
    ..The prevalence of trichomoniasis in the general population of the United States is unknown. This study provides the first population-based prevalence estimates of trichomoniasis among young adults in the United States...
  17. ncbi request reprint Selection for expression of the gonococcal hemoglobin receptor during menses
    J E Anderson
    University of North Carolina School of Medicine, Dept of Medicine, Div of Infectious Diseases, Chapel Hill, NC 27599 7030, USA
    J Infect Dis 184:1621-3. 2001
    ..031, Wilcoxon rank-sum test). Thus, there may be a selective advantage to expression of the gonococcal Hgb receptor during infection of women in the early phases of their menstrual cycles...
  18. ncbi request reprint Addition of treatment for trichomoniasis to syndromic management of urethritis in Malawi: a randomized clinical trial
    Matthew A Price
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Sex Transm Dis 30:516-22. 2003
    ..Male urethritis is generally treated syndromically, but failure of empirical treatment is common...
  19. ncbi request reprint Opposing selective forces for expression of the gonococcal lactoferrin receptor
    James E Anderson
    Department of Medicine, School of Medicine, University of North Carolina, 521 Burnett Womack Building, CB 7030, Chapel Hill 27599, USA
    Mol Microbiol 48:1325-37. 2003
    ..Thus, there are apparently selective pressures for expression of the Lf receptor in the male urethra that are balanced by others against expression of the Lf receptor in niches other than the male urethra...
  20. pmc Validation of a urine-based PCR-enzyme-linked immunosorbent assay for use in clinical research settings to detect Trichomonas vaginalis in men
    S Cornelia Kaydos-Daniels
    Departments of Epidemiology Medicine Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina UNC Project, Lilongwe, Malawi
    J Clin Microbiol 41:318-23. 2003
    ..For clinical research settings in which urethral swabs are not available and culture is not feasible, the urine-based PCR-ELISA may be useful for detection of trichomoniasis in men...
  21. pmc Immunogenicity of gonococcal transferrin binding proteins during natural infections
    Gregory A Price
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0678, USA
    Infect Immun 72:277-83. 2004
    ....
  22. pmc Trichomoniasis: clinical manifestations, diagnosis and management
    H Swygard
    The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    Sex Transm Infect 80:91-5. 2004
    ..Metronidazole resistance is an emerging problem, but its clinical importance is not yet clear. Concomitant treatment of sexual partners is recommended...
  23. pmc Quantification of Chlamydia trachomatis elementary bodies in urine by ligase chain reaction
    Michael E Blocker
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Clin Microbiol 40:3631-4. 2002
    ..qLCR will be useful for studies of chlamydial infection aimed at understanding the associations of organism burden with clinical manifestations and transmission...
  24. ncbi request reprint Does a choice of condoms impact sexually transmitted infection incidence? A randomized, controlled trial
    Markus J Steiner
    Family Health International, Research Triangle Park, North Carolina 27707, USA
    Sex Transm Dis 33:31-5. 2006
    ..The objective of this study was to assess whether providing a choice of condoms would increase condom acceptability, increase self-reported use, and decrease incident sexually transmitted infection...
  25. doi request reprint Mycoplasma genitalium detected by transcription-mediated amplification is associated with Chlamydia trachomatis in adolescent women
    Jill S Huppert
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center Cincinnati, Ohio 45229 3039, USA
    Sex Transm Dis 35:250-4. 2008
    ....
  26. pmc Genetic typing of the porin protein of Neisseria gonorrhoeae from clinical noncultured samples for strain characterization and identification of mixed gonococcal infections
    Freyja Lynn
    Division of Bacterial, Allergenic, and Parasitic Products, Center for Biologics Evaluation and Research, Bethesda, Maryland, USA
    J Clin Microbiol 43:368-75. 2005
    ..Methods that utilize direct clinical samples and can identify mixed infections may contribute significantly to studies of host immunity, gonococcal epidemiology, and pathogenesis...
  27. ncbi request reprint Self-reported condom use is associated with reduced risk of chlamydia, gonorrhea, and trichomoniasis
    Maria F Gallo
    Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    Sex Transm Dis 34:829-33. 2007
    ..To evaluate the association between self-reported condom use and prevalent and incident chlamydia, gonorrhea, and trichomoniasis...
  28. ncbi request reprint Rapid antigen testing compares favorably with transcription-mediated amplification assay for the detection of Trichomonas vaginalis in young women
    Jill S Huppert
    Division of Adoeslecent Medicine, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Clin Infect Dis 45:194-8. 2007
    ..We assessed the sensitivity and specificity of 4 tests for the identification of TV using 3 statistical approaches...
  29. pmc Use of an immunochromatographic assay for rapid detection of Trichomonas vaginalis in vaginal specimens
    Jill S Huppert
    Division of Adolescent Medicine ML 4000, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    J Clin Microbiol 43:684-7. 2005
    ..The OSOM Trichomonas Rapid Test is a simple, objective test that can be expected to improve the diagnosis of T. vaginalis, especially where microscopy and culture are unavailable...
  30. ncbi request reprint Prostate-specific antigen to ascertain reliability of self-reported coital exposure to semen
    Maria F Gallo
    Family Health International FHI, Research Triangle Park, North Carolina, USA
    Sex Transm Dis 33:476-9. 2006
    ..The objective of this study was to assess the validity of women's reports of recent unprotected sex by testing for prostate-specific antigen (PSA) in vaginal samples...
  31. pmc Randomised controlled trial on whether advance knowledge of prostate-specific antigen testing improves participant reporting of unprotected sex
    Sarah C Thomsen
    Centers for Disease Control and Prevention, Division of Reproductive Health, Atlanta, GA 30341, USA
    Sex Transm Infect 83:419-20. 2007
    ..To determine whether the process of informing research participants that they would be tested for the presence of a biological marker of semen exposure would reduce bias in their reports of unprotected sex...
  32. pmc Prevalence of HIV infection among young adults in the United States: results from the Add Health study
    Martina Morris
    Department of Sociology, University of Washington, Seattle, WA 98125, USA
    Am J Public Health 96:1091-7. 2006
    ..We estimated HIV prevalence rates among young adults in the United States...