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Genomes and Genes | M M HobbsSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Vaginal swab specimen processing methods influence performance of rapid semen detection tests: a cautionary taleMarcia M Hobbs
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Contraception 82:291-5. 2010..Quantitative tests for detection of prostate-specific antigen (PSA) perform well, but are expensive and require specialized equipment. We assessed two rapid immunochromatographic strip tests for identification of semen in vaginal swabs...- Haemophilus ducreyi infection causes basal keratinocyte cytotoxicity and elicits a unique cytokine induction pattern in an In vitro human skin modelM M Hobbs
Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Infect Immun 66:2914-21. 1998..IL-8 produced in response to H. ducreyi infection may be involved in recruiting polymorphonuclear leukocytes and other inflammatory cells, thereby contributing to the tissue necrosis and ulcer formation characteristic of chancroid... 
Molecular typing of Neisseria gonorrhoeae causing repeated infections: evolution of porin during passage within a communityM M Hobbs
Division of Infectious Diseases, Department of Medicine and Epidemiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
J Infect Dis 179:371-81. 1999..Sequence analysis of por genes revealed evidence of horizontal genetic exchange and point mutations in potential surface-exposed regions during passage in the community...
Good performance of rapid prostate-specific antigen test for detection of semen exposure in women: implications for qualitative researchMarcia M Hobbs
Department of Medicine, University of North Carolina at Chapel Hill, CB 7031, Chapel Hill, North Carolina 27599, USA
Sex Transm Dis 36:501-6. 2009..This study evaluated the performance of a rapid PSA test compared with a quantitative assay to identify semen in vaginal swab specimens...- From the NIH: proceedings of a workshop on the importance of self-obtained vaginal specimens for detection of sexually transmitted infectionsMarcia M Hobbs
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Sex Transm Dis 35:8-13. 2008..Similarly, SOVs should be explored for use in the diagnosis of other sexually transmitted pathogens... - Methods for detection of Trichomonas vaginalis in the male partners of infected women: implications for control of trichomoniasisMarcia M Hobbs
Department of Medicine, University of North Carolina at Chapel Hill, 27599, USA
J Clin Microbiol 44:3994-9. 2006..vaginalis in male partners required multiple specimens. The majority of male sexual partners in this study were infected, emphasizing the importance of partner evaluation and treatment... - The transferrin receptor expressed by gonococcal strain FA1090 is required for the experimental infection of human male volunteersC N Cornelissen
Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, USA
Mol Microbiol 27:611-6. 1998..To our knowledge, this is the first experimental demonstration that a bacterial iron acquisition system is an essential virulence factor for human infection... - Development and validation of a PCR-based enzyme-linked immunosorbent assay with urine for use in clinical research settings to detect Trichomonas vaginalis in womenS Cornelia Kaydos
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
J Clin Microbiol 40:89-95. 2002..For clinical research settings in which vaginal specimens are not available and culture conditions are not feasible, urine-based PCR-ELISA may be useful for the detection of trichomoniasis in women... - Improving the accuracy of syndromic diagnosis of genital ulcer disease in MalawiCathrine Hoyo
Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Sex Transm Dis 32:231-7. 2005..However, the etiologic pathogens of GUD vary temporally and geographically, and current criteria may not reflect changes in the prevalence of specific pathogens... - Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and preventionArlene C Sena
Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Clin Infect Dis 44:13-22. 2007..Nucleic acid amplification tests can increase detection of T. vaginalis in men compared with culture... - The association between Trichomonas vaginalis infection and level of vaginal lactobacilli, in nonpregnant womenMichelle R Torok
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Infect Dis 196:1102-7. 2007..6 [95% CI, 2.2-9.5]) but not in women with a lower educational level (OR, 1.6 [95% CI, 0.7-3.4]). Vaginal lactobacilli may be associated with trichomoniasis in women with higher levels of education or a related behavioral factor... - Targeted screening for Trichomonas vaginalis with culture using a two-step method in women presenting for STD evaluationHeidi Swygard
Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, 27599 7030, USA
Sex Transm Dis 31:659-64. 2004..Trichomonas vaginalis is the most common nonviral sexually transmitted pathogen. Wet mount microscopy performs poorly compared with culture; however, universal screening using culture would be cost-prohibitive... - Prevalence of chlamydial and gonococcal infections among young adults in the United StatesWilliam C Miller
Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill 27599 7435, USA
JAMA 291:2229-36. 2004..Although screening for Chlamydia trachomatis is widely recommended among young adult women, little information is available regarding the prevalence of chlamydial and gonococcal infections in the general young adult population... - The use of specimens from various genitourinary sites in men, to detect Trichomonas vaginalis infectionS Cornelia Kaydos-Daniels
Department of Epidemiology, University of North Carolina School of Public Health, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
J Infect Dis 189:1926-31. 2004..Semen was the most sensitive single specimen, and, in 25.6% of cases, only semen specimens tested positive. Thus, prevalence of T. vaginalis infection in men is underestimated if only 1 specimen is tested... - The association between oral contraceptives, depot-medroxyprogesterone acetate, and trichomoniasisMichelle R Torok
Department of Epidemiology, University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, NC, USA
Sex Transm Dis 36:336-40. 2009..We explored the effect of hormonal contraceptive use, specifically oral contraception (OC), and depot-medroxyprogesterone acetate (DMPA) on Trichomonas vaginalis infections in women... - The prevalence of trichomoniasis in young adults in the United StatesWilliam C Miller
Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
Sex Transm Dis 32:593-8. 2005..The prevalence of trichomoniasis in the general population of the United States is unknown. This study provides the first population-based prevalence estimates of trichomoniasis among young adults in the United States... - Selection for expression of the gonococcal hemoglobin receptor during mensesJ E Anderson
University of North Carolina School of Medicine, Dept of Medicine, Div of Infectious Diseases, Chapel Hill, NC 27599 7030, USA
J Infect Dis 184:1621-3. 2001..031, Wilcoxon rank-sum test). Thus, there may be a selective advantage to expression of the gonococcal Hgb receptor during infection of women in the early phases of their menstrual cycles... - Addition of treatment for trichomoniasis to syndromic management of urethritis in Malawi: a randomized clinical trialMatthew A Price
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Sex Transm Dis 30:516-22. 2003..Such treatment should be strongly considered as part of empirical therapy for urethritis in men in Malawi and places where T vaginalis infection in men is common... - Opposing selective forces for expression of the gonococcal lactoferrin receptorJames E Anderson
Department of Medicine, School of Medicine, University of North Carolina, 521 Burnett Womack Building, CB 7030, Chapel Hill 27599, USA
Mol Microbiol 48:1325-37. 2003..Thus, there are apparently selective pressures for expression of the Lf receptor in the male urethra that are balanced by others against expression of the Lf receptor in niches other than the male urethra... - Validation of a urine-based PCR-enzyme-linked immunosorbent assay for use in clinical research settings to detect Trichomonas vaginalis in menS Cornelia Kaydos-Daniels
Departments of Epidemiology. Medicine. Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. UNC Project, Lilongwe, Malawi
J Clin Microbiol 41:318-23. 2003..For clinical research settings in which urethral swabs are not available and culture is not feasible, the urine-based PCR-ELISA may be useful for detection of trichomoniasis in men... - Immunogenicity of gonococcal transferrin binding proteins during natural infectionsGregory A Price
Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0678, USA
Infect Immun 72:277-83. 2004.... - Trichomoniasis: clinical manifestations, diagnosis and managementH Swygard
The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
Sex Transm Infect 80:91-5. 2004..Metronidazole resistance is an emerging problem, but its clinical importance is not yet clear. Concomitant treatment of sexual partners is recommended... - Quantification of Chlamydia trachomatis elementary bodies in urine by ligase chain reactionMichael E Blocker
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Clin Microbiol 40:3631-4. 2002..qLCR will be useful for studies of chlamydial infection aimed at understanding the associations of organism burden with clinical manifestations and transmission... - Does a choice of condoms impact sexually transmitted infection incidence? A randomized, controlled trialMarkus J Steiner
Family Health International, Research Triangle Park, North Carolina 27707, USA
Sex Transm Dis 33:31-5. 2006..The objective of this study was to assess whether providing a choice of condoms would increase condom acceptability, increase self-reported use, and decrease incident sexually transmitted infection... - Mycoplasma genitalium detected by transcription-mediated amplification is associated with Chlamydia trachomatis in adolescent womenJill S Huppert
Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center Cincinnati, Ohio 45229 3039, USA
Sex Transm Dis 35:250-4. 2008.... - Genetic typing of the porin protein of Neisseria gonorrhoeae from clinical noncultured samples for strain characterization and identification of mixed gonococcal infectionsFreyja Lynn
Division of Bacterial, Allergenic, and Parasitic Products, Center for Biologics Evaluation and Research, Bethesda, Maryland, USA
J Clin Microbiol 43:368-75. 2005..Methods that utilize direct clinical samples and can identify mixed infections may contribute significantly to studies of host immunity, gonococcal epidemiology, and pathogenesis... - Self-reported condom use is associated with reduced risk of chlamydia, gonorrhea, and trichomoniasisMaria F Gallo
Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
Sex Transm Dis 34:829-33. 2007..To evaluate the association between self-reported condom use and prevalent and incident chlamydia, gonorrhea, and trichomoniasis... - Rapid antigen testing compares favorably with transcription-mediated amplification assay for the detection of Trichomonas vaginalis in young womenJill S Huppert
Division of Adoeslecent Medicine, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Clin Infect Dis 45:194-8. 2007..We assessed the sensitivity and specificity of 4 tests for the identification of TV using 3 statistical approaches... - Use of an immunochromatographic assay for rapid detection of Trichomonas vaginalis in vaginal specimensJill S Huppert
Division of Adolescent Medicine ML 4000, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
J Clin Microbiol 43:684-7. 2005..The OSOM Trichomonas Rapid Test is a simple, objective test that can be expected to improve the diagnosis of T. vaginalis, especially where microscopy and culture are unavailable... - Prostate-specific antigen to ascertain reliability of self-reported coital exposure to semenMaria F Gallo
Family Health International FHI, Research Triangle Park, North Carolina, USA
Sex Transm Dis 33:476-9. 2006..The objective of this study was to assess the validity of women's reports of recent unprotected sex by testing for prostate-specific antigen (PSA) in vaginal samples... - Randomised controlled trial on whether advance knowledge of prostate-specific antigen testing improves participant reporting of unprotected sexSarah C Thomsen
Centers for Disease Control and Prevention, Division of Reproductive Health, Atlanta, GA 30341, USA
Sex Transm Infect 83:419-20. 2007..To determine whether the process of informing research participants that they would be tested for the presence of a biological marker of semen exposure would reduce bias in their reports of unprotected sex... - Prevalence of HIV infection among young adults in the United States: results from the Add Health studyMartina Morris
Department of Sociology, University of Washington, Seattle, WA 98125, USA
Am J Public Health 96:1091-7. 2006..We estimated HIV prevalence rates among young adults in the United States...