Charlotte Hobbs

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Cheek swabs, SNP chips, and CNVs: assessing the quality of copy number variant calls generated with subject-collected mail-in buccal brush DNA samples on a high-density genotyping microarray
    Stephen W Erickson
    Department of Biostatistics, College of Medicine, University of Arkansas for Medical Science, 4301 W, Markham Street, Mail Slot 781, Little Rock, AR 72205 7199, USA
    BMC Med Genet 13:51. 2012
  2. pmc Maternal folate-related gene environment interactions and congenital heart defects
    Charlotte A Hobbs
    Department of Pediatrics, Birth Defects Research Section, Arkansas Children s Hospital Research Institute, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, Arkansas, USA
    Obstet Gynecol 116:316-22. 2010
  3. ncbi request reprint Genetic epidemiology and congenital malformations: from the chromosome to the crib
    Charlotte A Hobbs
    Department of Pediatrics, Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences, 11219 Financial Centre Pkwy, Suite 250, Little Rock, AR 72211, USA
    Arch Pediatr Adolesc Med 156:315-20. 2002
  4. ncbi request reprint Congenital heart defects and maternal biomarkers of oxidative stress
    Charlotte A Hobbs
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72211, USA
    Am J Clin Nutr 82:598-604. 2005
  5. ncbi request reprint Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism
    Charlotte A Hobbs
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, AR 72211, USA
    Am J Clin Nutr 81:147-53. 2005
  6. pmc Neural tube defects and maternal biomarkers of folate, homocysteine, and glutathione metabolism
    Weizhi Zhao
    Section of Birth Defects Research, Department of Pediatrics, Arkansas Children s Hospital Research Institute, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, 72211, USA
    Birth Defects Res A Clin Mol Teratol 76:230-6. 2006
  7. ncbi request reprint Birth defects in Arkansas: is folic acid fortification making a difference?
    Caroline J Simmons
    Arkansas Center for Birth Defects Research and Prevention, College of Medicine, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72211, USA
    Birth Defects Res A Clin Mol Teratol 70:559-64. 2004
  8. ncbi request reprint Awareness and use of folic acid among women in the lower Mississippi Delta
    James M Robbins
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Rural Health 22:196-203. 2006
  9. ncbi request reprint Regional bias in birth defect prevalence rates for Arkansas: influence of incomplete ascertainment along surveillance system borders
    Bridget S Mosley
    Arkansas Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, 11219 Financial Center Parkway, Suite 250, Little Rock, AR 72211, USA
    Teratology 66:S36-40. 2002
  10. ncbi request reprint Hospitalizations of newborns with folate-sensitive birth defects before and after fortification of foods with folic acid
    James M Robbins
    Arkansas Center for Birth Defects Research and Prevention, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Pediatrics 118:906-15. 2006

Detail Information

Publications38

  1. pmc Cheek swabs, SNP chips, and CNVs: assessing the quality of copy number variant calls generated with subject-collected mail-in buccal brush DNA samples on a high-density genotyping microarray
    Stephen W Erickson
    Department of Biostatistics, College of Medicine, University of Arkansas for Medical Science, 4301 W, Markham Street, Mail Slot 781, Little Rock, AR 72205 7199, USA
    BMC Med Genet 13:51. 2012
    ..Regardless of the source of DNA, it is more difficult to detect CNVs than to genotype SNPs using these microarrays, and it therefore remains an open question whether buccal brush samples provide enough high-quality DNA for this purpose...
  2. pmc Maternal folate-related gene environment interactions and congenital heart defects
    Charlotte A Hobbs
    Department of Pediatrics, Birth Defects Research Section, Arkansas Children s Hospital Research Institute, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, Arkansas, USA
    Obstet Gynecol 116:316-22. 2010
    ..To investigate whether women with congenital heart defect (CHD)-affected pregnancies were more likely to have functional single-nucleotide polymorphisms in genes encoding enzymes in folate-dependent pathways...
  3. ncbi request reprint Genetic epidemiology and congenital malformations: from the chromosome to the crib
    Charlotte A Hobbs
    Department of Pediatrics, Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences, 11219 Financial Centre Pkwy, Suite 250, Little Rock, AR 72211, USA
    Arch Pediatr Adolesc Med 156:315-20. 2002
  4. ncbi request reprint Congenital heart defects and maternal biomarkers of oxidative stress
    Charlotte A Hobbs
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72211, USA
    Am J Clin Nutr 82:598-604. 2005
    ....
  5. ncbi request reprint Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism
    Charlotte A Hobbs
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, AR 72211, USA
    Am J Clin Nutr 81:147-53. 2005
    ..It is well established that folic acid prevents neural tube defects. Although the mechanisms remain unclear, multivitamins containing folic acid may also protect against other birth defects, including congenital heart defects...
  6. pmc Neural tube defects and maternal biomarkers of folate, homocysteine, and glutathione metabolism
    Weizhi Zhao
    Section of Birth Defects Research, Department of Pediatrics, Arkansas Children s Hospital Research Institute, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, 72211, USA
    Birth Defects Res A Clin Mol Teratol 76:230-6. 2006
    ..Alterations in maternal folate and homocysteine metabolism are associated with neural tube defects (NTDs). The role played by specific micronutrients and metabolites in the causal pathway leading to NTDs is not fully understood...
  7. ncbi request reprint Birth defects in Arkansas: is folic acid fortification making a difference?
    Caroline J Simmons
    Arkansas Center for Birth Defects Research and Prevention, College of Medicine, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72211, USA
    Birth Defects Res A Clin Mol Teratol 70:559-64. 2004
    ..This study was performed to determine if fortification has reduced the prevalence of NTDs and other birth defects in Arkansas...
  8. ncbi request reprint Awareness and use of folic acid among women in the lower Mississippi Delta
    James M Robbins
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Rural Health 22:196-203. 2006
    ..National and state efforts to increase folic acid awareness and use may not be reaching large segments of the population...
  9. ncbi request reprint Regional bias in birth defect prevalence rates for Arkansas: influence of incomplete ascertainment along surveillance system borders
    Bridget S Mosley
    Arkansas Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, 11219 Financial Center Parkway, Suite 250, Little Rock, AR 72211, USA
    Teratology 66:S36-40. 2002
    ..As part of the continuing evaluation of the Arkansas Reproductive Health Monitoring System (ARHMS), we assessed the effects on birth defect prevalence rates introduced by incomplete case ascertainment along surveillance boundaries...
  10. ncbi request reprint Hospitalizations of newborns with folate-sensitive birth defects before and after fortification of foods with folic acid
    James M Robbins
    Arkansas Center for Birth Defects Research and Prevention, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Pediatrics 118:906-15. 2006
    ..Since 1998, grain products in the United States have been fortified with folic acid. Fortification may have additional benefits by reducing the national prevalence of newborn hospitalizations for other folate-sensitive birth defects...
  11. ncbi request reprint Reduction in newborns with discharge coding of in utero alcohol effects in the United States, 1993 to 2002
    James M Robbins
    Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Arch Pediatr Adolesc Med 160:1224-31. 2006
    ....
  12. ncbi request reprint Association between congenital heart defects and small for gestational age
    Sadia Malik
    Arkansas Center for Birth Defects Research and Prevention, Little Rock, AR, USA
    Pediatrics 119:e976-82. 2007
    ....
  13. ncbi request reprint Congenital defects among liveborn infants with Down syndrome
    Mario A Cleves
    Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, and Arkansas Children s Hospital, Little Rock, Arkansas 72202, USA
    Birth Defects Res A Clin Mol Teratol 79:657-63. 2007
    ..This article uses a unique national hospital discharge dataset to identify the rate at which structural birth defects are identified among liveborn infants with DS...
  14. doi request reprint Maternal smoking and congenital heart defects
    Sadia Malik
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, 1120 Marshall St, Little Rock, AR 72202, USA
    Pediatrics 121:e810-6. 2008
    ..In a population-based case-control study, we investigated the association between congenital heart defects and maternal smoking...
  15. doi request reprint Maternal urinary tract infections and selected cardiovascular malformations
    Mario A Cleves
    Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, University of Arkansas for Medical Sciences, and Arkansas Children s Hospital, Little Rock, Arkansas 72202, USA
    Birth Defects Res A Clin Mol Teratol 82:464-73. 2008
    ..In a population-based case-control study, we investigated the association between congenital cardiovascular malformations (CVMs) and maternal urinary tract infections (UTIs)...
  16. pmc Association between selected folate pathway polymorphisms and nonsyndromic limb reduction defects: a case-parental analysis
    Mario A Cleves
    Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, University of Arkansas for Medical Sciences, and Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Paediatr Perinat Epidemiol 25:124-34. 2011
    ....
  17. pmc Maternal genome-wide DNA methylation patterns and congenital heart defects
    Shimul Chowdhury
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas, United States of America
    PLoS ONE 6:e16506. 2011
    ..Our results suggest that further studies involving maternal epigenetic patterns and CHDs are warranted. Multiple candidate processes and pathways for future study have been identified...
  18. ncbi request reprint First-year survival of infants born with congenital heart defects in Arkansas (1993-1998): a survival analysis using registry data
    Mario A Cleves
    Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, University of Arkansas for Medical Sciences, College of Medicine, Arkansas Children s Hospital, Little Rock, Arkansas 72211, USA
    Birth Defects Res A Clin Mol Teratol 67:662-8. 2003
    ..Congenital heart defects (CHDs) are among the most prevalent and fatal of all birth defects. Here we report the survival probability of infants born with CHDs in Arkansas and examine the impact of multiple malformations on survival...
  19. ncbi request reprint Health state preference scores of children with spina bifida and their caregivers
    John M Tilford
    Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Little Rock, AR 72202 3591, USA
    Qual Life Res 14:1087-98. 2005
    ..A more modest association was found for caregiver health preference scores by lesion location. The findings can inform cost-effectiveness evaluations of interventions to treat or prevent spina bifida...
  20. ncbi request reprint Folic acid use by women receiving routine gynecologic care
    Mario A Cleves
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Little Rock, Arkansas 72202 3591, USA
    Obstet Gynecol 103:746-53. 2004
    ..Many health professional groups recommend folic acid supplementation for all women able to become pregnant. In this study, we document folic acid supplement use among a sample of women receiving routine gynecologic care...
  21. ncbi request reprint Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene: evaluating gene-environment interactions
    Charlotte A Hobbs
    Department of Pediatrics, Arkansas Children s Hospital Research Institute, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, AR, USA
    Am J Obstet Gynecol 194:218-24. 2006
    ..This study was undertaken to investigate the association between congenital heart defects (CHD), and maternal homocysteine, smoking, and the MTHFR 677 C>T polymorphism...
  22. ncbi request reprint Randomized trial of a physician-based intervention to increase the use of folic acid supplements among women
    James M Robbins
    Department of Pediatrics, Arkansas Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences College of Medicine, and Arkansas Children s Hospital, Little Rock, AR, USA
    Am J Obstet Gynecol 192:1126-32. 2005
    ..This study determined the impact of a physician intervention during routine gynecologic visits on folic acid supplementation...
  23. pmc Neural tube defects and maternal folate intake among pregnancies conceived after folic acid fortification in the United States
    Bridget S Mosley
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Am J Epidemiol 169:9-17. 2009
    ..Further investigation is warranted to possibly identify women who remain at increased risk of preventable neural tube defects...
  24. ncbi request reprint National rates of birth defects among hospitalized newborns
    T M Bird
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Birth Defects Res A Clin Mol Teratol 76:762-9. 2006
    ..This report estimates national hospital admissions for newborn infants diagnosed with birth defects computed from HCUP and compares them to pooled prevalence figures computed from state birth defect surveillance systems...
  25. ncbi request reprint Preferential transmission of the MTHFR 677 T allele to infants with Down syndrome: implications for a survival advantage
    Charlotte A Hobbs
    Arkansas Center for Birth Defects Research and Prevention, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Am J Med Genet 113:9-14. 2002
    ..Published 2002 Wiley-Liss, Inc...
  26. ncbi request reprint Prevention of neural tube defects: the importance of folic acid counseling
    Charlotte A Hobbs
    Arkansas Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences, College of Medicine, Arkansas Children s Hospital, USA
    J Ark Med Soc 102:89-90. 2005
  27. doi request reprint Demographic and environmental risk factors for gastroschisis and omphalocele in the National Birth Defects Prevention Study
    T Mac Bird
    Department of Pediatrics, Center for Applied Research and Evaluation, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72202 3591, USA
    J Pediatr Surg 44:1546-51. 2009
    ....
  28. ncbi request reprint Maternal use of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs), and muscular ventricular septal defects
    Mario A Cleves
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Arkansas Center for Birth Defects Research and Prevention, 11219 Financial Centre Parkway, Little Rock, AR 72211, USA
    Birth Defects Res A Clin Mol Teratol 70:107-13. 2004
    ..We evaluated the association between mVSDs and maternal use of acetaminophen or NSAIDs adjusting for fever...
  29. ncbi request reprint Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States
    Laura J Williams
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Teratology 66:33-9. 2002
    ..We sought to determine the prevalences of spina bifida and anencephaly during the transition to mandatory folic acid fortification...
  30. doi request reprint Diabetes mellitus and birth defects
    Adolfo Correa
    Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Obstet Gynecol 199:237.e1-9. 2008
    ..The purpose of this study was to examine associations between diabetes mellitus and 39 birth defects...
  31. ncbi request reprint Prevalence of birth defects among infants of Gulf War veterans in Arkansas, Arizona, California, Georgia, Hawaii, and Iowa, 1989-1993
    Maria Rosario G Araneta
    Department of Defense Center for Deployment Health Research, Naval Health Research, Center, San Diego, California, USA
    Birth Defects Res A Clin Mol Teratol 67:246-60. 2003
    ..This study was conducted to measure the prevalence of birth defects among infants of GWVs and nondeployed veterans (NDV) in states that conducted active case ascertainment of birth defects between 1989-93...
  32. ncbi request reprint Maternal homocysteine and congenital heart defects
    Charlotte A Hobbs
    J Am Coll Cardiol 47:683-5. 2006
  33. ncbi request reprint Prepregnancy obesity as a risk factor for structural birth defects
    D Kim Waller
    School of Public Health, The University of Texas at Houston, Houston, TX 77030, USA
    Arch Pediatr Adolesc Med 161:745-50. 2007
    ..To describe the relation between maternal obesity, overweight and underweight status, and 16 categories of structural birth defects...
  34. ncbi request reprint Folic acid and the decline in neural tube defects in Arkansas
    Bridget S Mosley
    J Ark Med Soc 103:247-50. 2007
    ....
  35. ncbi request reprint National estimates and race/ethnic-specific variation of selected birth defects in the United States, 1999-2001
    Mark A Canfield
    Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas 78756, USA
    Birth Defects Res A Clin Mol Teratol 76:747-56. 2006
    ..In the United States, birth defects affect approximately 3% of all births, are a leading cause of infant mortality, and contribute substantially to childhood morbidity...
  36. ncbi request reprint NKX2.5 and congenital heart defects: A population-based study
    Charlotte A Hobbs
    Am J Med Genet A 134:223-5. 2005
  37. pmc The National Down Syndrome Project: design and implementation
    Sallie B Freeman
    Department of Human Genetics, Emory University, Atlanta, GA, USA
    Public Health Rep 122:62-72. 2007
    ....
  38. doi request reprint Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project
    Sallie B Freeman
    Department of Human Genetics, Emory University, Atlanta, Georgia 30033, USA
    Genet Med 10:173-80. 2008
    ..The population-based National Down Syndrome Project combined epidemiological and molecular methods to study congenital heart defects in Down syndrome...

Research Grants10

  1. Genetic and Metabolic Determinants of Congenital Heart Defect Risk
    Charlotte Hobbs; Fiscal Year: 2009
    ..Successful completion of the proposed studies will advance translational research targeting these costly and devastating birth defects. ..
  2. GENES, MICRONUTRIENTS AND HOMEOBOX RELATED MALFORMATIONS
    Charlotte Hobbs; Fiscal Year: 2004
    ....
  3. Genetic and Metabolic Determinants of Congenital Heart Defect Risk
    Charlotte A Hobbs; Fiscal Year: 2010
    ..Successful completion of the proposed studies will advance translational research targeting these costly and devastating birth defects. ..