Linh Hoang

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Folding units govern the cytochrome c alkaline transition
    Linh Hoang
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    J Mol Biol 331:37-43. 2003
  2. pmc Cytochrome c folding pathway: kinetic native-state hydrogen exchange
    Linh Hoang
    The Johnson Research Foundation, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Proc Natl Acad Sci U S A 99:12173-8. 2002
  3. ncbi request reprint Hydrogen exchange methods to study protein folding
    Mallela M G Krishna
    Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Methods 34:51-64. 2004
  4. ncbi request reprint Recombinant equine cytochrome c in Escherichia coli: high-level expression, characterization, and folding and assembly mutants
    Jon N Rumbley
    The Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6059, USA
    Biochemistry 41:13894-901. 2002
  5. ncbi request reprint Kinetic and stereochemical evidence for the involvement of only one proline molecule in the transition states of proline-catalyzed intra- and intermolecular aldol reactions
    Linh Hoang
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 125:16-7. 2003
  6. pmc New mechanistic studies on the proline-catalyzed aldol reaction
    Benjamin List
    Max Planck Institut fur Kohlenforschung, Kaiser Wilhelm Platz 1, 45470 Mulheim an der Ruhr, Germany
    Proc Natl Acad Sci U S A 101:5839-42. 2004
  7. pmc A nanostructure-initiator mass spectrometry-based enzyme activity assay
    Trent R Northen
    Department of Molecular Biology and Scripps Center for Mass Spectrometry and Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:3678-83. 2008

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Folding units govern the cytochrome c alkaline transition
    Linh Hoang
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    J Mol Biol 331:37-43. 2003
    ..These and other results show that the cooperative folding-unfolding behavior of protein foldons can account for a variety of functional activities in addition to determining folding pathways...
  2. pmc Cytochrome c folding pathway: kinetic native-state hydrogen exchange
    Linh Hoang
    The Johnson Research Foundation, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Proc Natl Acad Sci U S A 99:12173-8. 2002
    ..Four distinct unfolding steps are found to be kinetically ordered in the same pathway sequence inferred before...
  3. ncbi request reprint Hydrogen exchange methods to study protein folding
    Mallela M G Krishna
    Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Methods 34:51-64. 2004
    ..The results obtained in these ways suggest principles that appear to explain the properties of partially folded intermediates and how they are organized into folding pathways. The application of these methods is detailed here...
  4. ncbi request reprint Recombinant equine cytochrome c in Escherichia coli: high-level expression, characterization, and folding and assembly mutants
    Jon N Rumbley
    The Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6059, USA
    Biochemistry 41:13894-901. 2002
    ..In addition, destabilizing glycine mutants in the N-terminal helix are shown to affect the fractional yield of a heme inverted Cyt c isoform...
  5. ncbi request reprint Kinetic and stereochemical evidence for the involvement of only one proline molecule in the transition states of proline-catalyzed intra- and intermolecular aldol reactions
    Linh Hoang
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 125:16-7. 2003
    ..Complementary to recent theoretical studies, our results provide the foundation of a unified enamine catalysis mechanism of proline-catalyzed inter- and intramolecular aldol reactions...
  6. pmc New mechanistic studies on the proline-catalyzed aldol reaction
    Benjamin List
    Max Planck Institut fur Kohlenforschung, Kaiser Wilhelm Platz 1, 45470 Mulheim an der Ruhr, Germany
    Proc Natl Acad Sci U S A 101:5839-42. 2004
    ..Here we summarize our discoveries in this area and provide further evidence for the involvement of enamine intermediates...
  7. pmc A nanostructure-initiator mass spectrometry-based enzyme activity assay
    Trent R Northen
    Department of Molecular Biology and Scripps Center for Mass Spectrometry and Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:3678-83. 2008
    ..More generally, this approach may have important applications for screening both enzymatic and inhibitor libraries, constructing and screening glycan microarrays, and complementing fluorous-phase organic synthesis...