Research Topics
Genomes and Genes | Shuk Mei HoSummaryAffiliation: University of Cincinnati Country: USA Publications
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Publications
Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signalingYuet Kin Leung
Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, College of Medicine, University of Cincinnati, OH 45267, USA
Proc Natl Acad Sci U S A 103:13162-7. 2006..Our findings have provided previously unrecognized directions for studying ER-beta signaling and design of ER-beta-based therapies...- Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseasesShuk Mei Ho
Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
Reprod Toxicol 23:267-82. 2007..We believe studies of epigenetic changes such as DNA methylation hold great promise in understanding the early origins of adult diseases and in advancing their diagnosis, prevention, and treatment... 
Environmental epigenetics of asthma: an updateShuk Mei Ho
Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Allergy Clin Immunol 126:453-65. 2010..The discovery and validation of epigenetic biomarkers linked to exposure, asthma, or both might lead to better epigenotyping of risk, prognosis, treatment prediction, and development of novel therapies...
Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancerShuk Mei Ho
Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
Ann N Y Acad Sci 1089:177-93. 2006..These findings open new avenues for drug design that now focuses on developing a new generation of estrogen-based PCa therapies with maximal proapoptotic action but few or no side effects...- Estrogens and prostate cancer: etiology, mediators, prevention, and managementShuk Mei Ho
Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
Endocrinol Metab Clin North Am 40:591-614, ix. 2011.... - Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasionHung Ming Lam
Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, United States
Mol Cell Endocrinol 358:27-35. 2012..These results underscore the functional importance of the first experimentally identified hERβ-phosphorylation site in breast cancer... - Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation statusJanet K Hess-Wilson
Department of Cell and Cancer Biology, University of Cincinnati College of Medicine, Ohio 45267 0521, USA
Environ Health Perspect 115:1646-53. 2007..In tumors with specific AR mutations, BPA promotes therapeutic bypass, suggesting significant negative impact to the clinical management of prostate cancer... - Research resource: estrogen-driven prolactin-mediated gene-expression networks in hormone-induced prostatic intraepithelial neoplasiaNeville N C Tam
Department of Environmental Health, University of Cincinnati Medical Center, Kettering Laboratory, Suite 128, 3223 Eden Avenue, Cincinnati, Ohio 45267 0056, USA
Mol Endocrinol 24:2207-17. 2010.... - α-Methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissuesBin Ouyang
Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
Urology 77:249.e1-7. 2011..AMACR has been used as a diagnostic biomarker for CaP and is now a standard biomarker for needle biopsy specimens with ambiguous lesions... - Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancerXiang Zhang
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
Prostate 70:765-76. 2010..We previously demonstrated that a putative anti-tumor gene, peroxisomal membrane protein 4, 24 kDa (PMP24 or PXMP4), is silenced via DNA methylation of a CpG island in its 5' flanking region (5'-CGI) in prostate cancer (PCa) cells... - Sex hormones induce direct epithelial and inflammation-mediated oxidative/nitrosative stress that favors prostatic carcinogenesis in the noble ratNeville N C Tam
Department of Environmental Health, Kettering Complex, Room 130, 3223 Eden Ave, University of Cincinnati Medical Center, PO Box 670056, Cincinnati, OH 45267 0056, USA
Am J Pathol 171:1334-41. 2007..Thus, we link alterations in the hormonal milieu with oxidative/nitrosative/inflammatory damage to the prostate epithelium that promotes carcinogenesis... - Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasionYuet Kin Leung
Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, College of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
Endocr Relat Cancer 17:675-89. 2010..These findings may aid future clinical management of PCa... - Gene expression profiling identifies lobe-specific and common disruptions of multiple gene networks in testosterone-supported, 17beta-estradiol- or diethylstilbestrol-induced prostate dysplasia in Noble ratsNeville N C Tam
Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 USA
Neoplasia 10:20-40. 2008.... - Estrogen receptor-beta and breast cancer: translating biology into clinical practiceYuet Kin Leung
Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
Steroids 77:727-37. 2012..Insights gained from these key questions in ERβ research should help in prevention, diagnosis/prognosis, and treatment of BCa... - Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout lifeWan Yee Tang
Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
Endocrinology 153:42-55. 2012..We speculate that the distinctly different fate of early-life epigenetic marks during adulthood reflects the complex nature of lifelong editing of early-life epigenetic reprogramming... - Estrogen receptor β: switching to a new partner and escaping from estrogenYuet Kin Leung
Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati Medical Center, Kettering Complex, Room 128, 3223 Eden Avenue, P O Box 670056, Cincinnati, OH 45267, USA
Sci Signal 4:pe19. 2011..Future research into ERβ will likely involve this estrogen independency and the preference for binding nonclassical DNA elements through tethering. The development of ERβ-based therapies may lead to improved drug efficacy... - Comprehensive identification and modified-site mapping of S-nitrosylated targets in prostate epithelial cellsYing Wai Lam
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
PLoS ONE 5:e9075. 2010..Thus, our primary objective was to identify S-nitrosylated targets in an immortalized normal prostate epithelial cell line, NPrEC... - Epigenetic reprogramming and imprinting in origins of diseaseWan Yee Tang
Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
Rev Endocr Metab Disord 8:173-82. 2007..Improvements in human health could then be redirected from curative care to personalized, preventive medicine based, in part, on epigenetic markings etched in the "margins" of one's genetic make-up... - Mutually positive regulatory feedback loop between interferons and estrogen receptor-alpha in mice: implications for sex bias in autoimmunityRavichandran Panchanathan
Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
PLoS ONE 5:e10868. 2010..Here we report that activation of IFN (alpha or gamma)-signaling in immune cells up-regulates expression of estrogen receptor-alpha (ERalpha; encoded by the Esr1 gene) and stimulates expression of target genes... - Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyreneBin Ouyang
Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Cancer Institute, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
J Occup Environ Med 54:774-80. 2012..This study examined the possibility of an association between PAH-induced epigenetic alterations and occupational firefighting exposure... - Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: oncogenic and immunomodulations involving the action of tumor necrosis factorShlomo Bakshi
Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0056, USA
Environ Health Perspect 116:769-76. 2008..Cadmium is implicated in prostate carcinogenesis, but its oncogenic action remains unclear... - Interferon-inducible IFI16 protein in human cancers and autoimmune diseasesDivaker Choubey
Cincinnati VA Medical Center, OH, USA
Front Biosci 13:598-608. 2008..In this review, we discuss how our understanding of the regulation of IFI16 expression and its role in cell growth regulation will help elucidate the molecular mechanisms that contribute to the development of various human diseases... - Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4Shuk-Mei Ho
Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA
Cancer Res 66:5624-32. 2006..In total, these findings indicate that low-dose exposures to ubiquitous environmental estrogens affect the prostate epigenome during development and, in so doing, promote prostate disease with aging... - Site-Specific S-Nitrosylation of Integrin α6 Increases the Extent of Prostate Cancer Cell Migration by Enhancing Integrin β1 Association and Weakening Adherence to Laminin-1Jared Isaac
Cancer and Cell Biology, Department of Environmental Health, Center for Environmental Genetics, and Cancer Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, United States
Biochemistry 51:9689-97. 2012..In conclusion, S-nitrosylation of ITGα6 increased the extent of prostate cancer cell migration, which could be a potential mechanism of NO- and iNOS-induced enhancement of prostate cancer metastasis... - Epigenetics meets endocrinologyXiang Zhang
Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Complex Suite 130, Cincinnati, Ohio 45267, USA
J Mol Endocrinol 46:R11-32. 2011.... - Enhanced resistance to tamoxifen by the c-ABL proto-oncogene in breast cancerHuajun Zhao
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Ave, Cincinnati, OH 45267 0521, USA
Neoplasia 12:214-23. 2010..This study shows that c-ABL regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-ABL as a therapeutic target and a prognostic tumor marker for breast cancer... - Differential proteomics in the aging Noble rat ventral prostateYing Wai Lam
Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Proteomics 8:2750-63. 2008..To the best of our knowledge, this is the first study on the proteome of the aging rat prostate... - Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesisChang Jin
Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Laboratory, Suite 410, P O Box 670056, Cincinnati, OH 45267 0056, USA
Dev Biol 374:96-107. 2013..Using LCM and expression array, our studies have uncovered novel molecular signatures of MAP3K1 in embryonic eyelid closure... - Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colonXiang Zhang
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA
PLoS Genet 5:e1000334. 2009..Our findings identified key in vivo events and novel transcription factors responsible for AMACR regulation in CCas and suggested these AMACR deletions may have diagnostic/prognostic value for colon carcinogenesis... - Application of phi29 motor pRNA for targeted therapeutic delivery of siRNA silencing metallothionein-IIA and survivin in ovarian cancersPheruza Tarapore
Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA
Mol Ther 19:386-94. 2011..The pRNA system, which has the capability to assemble into multivalent nanoparticles, has immense promise as a highly potent therapeutic agent... - Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genisteinWan Yee Tang
Department of Environmental Health, Kettering Complex, Room 128, 3223 Eden Avenue, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, Ohio 45267 0056, USA
Endocrinology 149:5922-31. 2008..Thus, the life reprogramming of uterine Nsbp1 expression by neonatal DES/GEN exposure appears to be mediated by an epigenetic mechanism that interacts with ovarian hormones in adulthood... - Developmental neurotoxicants in e-waste: an emerging health concernAimin Chen
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
Environ Health Perspect 119:431-8. 2011..To provide updated information about the scope of the issue, presence of known and suspected neurotoxicants, toxicologic mechanisms, and current data gaps, we conducted this literature review... - Epigenetics meets endocrinologyXiang Zhang
Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Complex Suite 130, Cincinnati, Ohio 45267, USA
J Mol Endocrinol 46:R11-32. 2011.... - Histone deacetylase 9 is a negative regulator of adipogenic differentiationTapan K Chatterjee
Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Biol Chem 286:27836-47. 2011..These findings provide new insights into mechanisms of adipogenic differentiation and document a critical regulatory role for HDAC9 in adipogenic differentiation through a deacetylase-independent mechanism... - A duplex quantitative polymerase chain reaction assay based on quantification of alpha-methylacyl-CoA racemase transcripts and prostate cancer antigen 3 in urine sediments improved diagnostic accuracy for prostate cancerBin Ouyang
Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
J Urol 181:2508-13; discussion 2513-4. 2009..In this study we evaluated the diagnostic potential of a duplex assay for prostate cancer by quantifying transcript levels of alpha-methylacyl-CoA racemase and prostate cancer antigen 3 in urine sediments following prostatic massage... - The novel estrogen 17alpha-20Z-21-[(4-amino)phenyl]-19-norpregna-1,3,5(10),20-tetraene-3,17beta-diol induces apoptosis in prostate cancer cell lines at nanomolar concentrations in vitroJames A Mobley
Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester 01605-2324, USA
Mol Cancer Ther 3:587-95. 2004.... - Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidatesShuk Mei Ho
Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Cell Biochem 91:491-503. 2004..Further advancement of our knowledge of the role of estrogens in prostate carcinogenesis through metabolic activation of estrogens and/or ER-mediated pathways will certainly result in better preventive or therapeutic modalities for PCa... - Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasisXuegong Zhu
Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
Am J Pathol 164:2003-12. 2004.... - Estrogen receptor-beta expression in human testicular germ cell tumorsVernon Pais
Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Clin Cancer Res 9:4475-82. 2003..For completeness, expression of androgen and progesterone receptors was also investigated... - PMP24, a gene identified by MSRF, undergoes DNA hypermethylation-associated gene silencing during cancer progression in an LNCaP modelMengchu Wu
Division of Urology, Department of Surgery, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Oncogene 23:250-9. 2004.... - Expression study of three secretory proteins (prostatic secretory protein of 94 amino acids, probasin, and seminal vesicle secretion II) in dysplastic and neoplastic rat prostatesJoseph Kwong
Department of Anatomy, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Prostate 56:81-97. 2003.... - Expression of estrogen receptor beta in the fetal, neonatal, and prepubertal human prostateJason Y Adams
Department of Pathology, Schools of Medicine and Veterinary Medicine, Tufts University, Boston, Massachusetts 01655, USA
Prostate 52:69-81. 2002..Although the fetal rodent prostate has been reported to contain both estrogen receptor alpha (ER-alpha) and beta (ER-beta), there have been no reports as to whether either of the ER subtypes is expressed in the developing human prostate... - Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesisGail S Prins
Department of Urology, University of Illinois at Chicago, Chicago, IL, USA
Basic Clin Pharmacol Toxicol 102:134-8. 2008..In total, these findings indicate that low-dose exposures to ubiquitous environmental oestrogens impact the prostate epigenome during development and in so doing, promote prostate disease with ageing... - Environmental epigenetics and asthma: current concepts and call for studiesRachel L Miller
PH8E, 630 W 168th Street, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am J Respir Crit Care Med 177:567-73. 2008..There is immense promise that the study of environmental epigenetics will help us understand a theoretically preventable environmental disease... - Profiling estrogen-regulated gene expression changes in normal and malignant human ovarian surface epithelial cellsViqar Syed
Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
Oncogene 24:8128-43. 2005..These findings may explain the paradoxical roles of estrogens in regulating normal and malignant OSE cell functions... - Apigenin suppresses cancer cell growth through ERbetaPaul Mak
Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
Neoplasia 8:896-904. 2006..The differential use of ERalpha and ERbeta signaling for transaction between genistein and apigenin demonstrates the complexity of phytoestrogen action in the context of their anticancer properties... - ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalkYuet Kin Leung
Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
Neoplasia 8:242-9. 2006..Therefore, combined therapies targeting ER-beta and NFkappaB signaling may be synergistic as treatment for PCa... - Expression of androgen receptor is negatively regulated by p53Fatouma Alimirah
Edward Hines Jr VA Hospital, Hines, IL 60141, USA
Neoplasia 9:1152-9. 2007..Together, our observations provide support for the idea that the loss of p53 function in prostate cancer cells contributes to increased expression of AR... - Developmental estrogen exposures predispose to prostate carcinogenesis with agingGail S Prins
Department of Urology, University of Illinois at Chicago, 820 South Wood Street, MC 955, Chicago, IL 60612, United States
Reprod Toxicol 23:374-82. 2007.... - Human beta-defensin-1, a potential chromosome 8p tumor suppressor: control of transcription and induction of apoptosis in renal cell carcinomaCarrie Q Sun
Department of Urology, Emory University, Atlanta, GA 30322, USA
Cancer Res 66:8542-9. 2006..These data support the hypothesis that hBD-1 is a potential tumor suppressor gene for urological cancers. Promoter point mutations may be responsible for cancer-specific loss of hDB-1 expression... - Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cellsShuk Mei Ho
Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
Oncogene 22:4243-56. 2003..Specifically, neogenin and restin were found to exhibit proproliferation/survival action on OC cells... - Alpha-methylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zoneIrwin Leav
Department of Pathology, Division of Urology, University of Massachusetts Medical School, Worcester, MA, USA
Hum Pathol 34:228-33. 2003.... - Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidantsNeville N C Tam
Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Prostate 66:57-69. 2006..CONCLUSIONS: Our data indicate that in TRAMP mice, OS/NS injuries are likely involved in early prostatic tumorigenesis and can be modulated by various antioxidants... - Sex hormone-induced alterations in the activities of antioxidant enzymes and lipid peroxidation status in the prostate of Noble ratsNeville N C Tam
Division of Urology, Department of Surgery, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Prostate 55:1-8. 2003.... - DNA microarrays in prostate cancerShuk Mei Ho
Department of Surgery, University of Massachusetts Medical School, Room S4 746, 55 Lake Avenue North, Worcester, MA 01655, USA
Curr Urol Rep 3:53-60. 2002..Finally, this review emphasizes existing, but currently underutilized, data-mining tools, such as multivariate statistical analyses, neural networking, and machine learning techniques, to stimulate wider usage... - Gene expression profiling of testosterone and estradiol-17 beta-induced prostatic dysplasia in Noble rats and response to the antiestrogen ICI 182,780Christopher J Thompson
Department of Surgery Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Endocrinology 143:2093-105. 2002.... - Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer reviewRonald Melnick
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 110:427-31. 2002.... - Changes in serum proteomic patterns by presurgical alpha-tocopherol and L-selenomethionine supplementation in prostate cancerJeri Kim
Department of Genitourinary Medical Oncology, University of Massachusetts Medical School, Lazare Research Building, Room 504, 364 Plantation Street, Worcester, MA 01605-2324, USA
Cancer Epidemiol Biomarkers Prev 14:1697-702. 2005..CONCLUSION: In sera from patients with prostate cancer, selenium and vitamin E combined induced statistically significant proteomic pattern changes associated with prostate cancer-free status... - Mass profiling-directed isolation and identification of a stage-specific serologic protein biomarker of advanced prostate cancerYing Wai Lam
Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proteomics 5:2927-38. 2005..With the growing interest in using MP for patient classification and diagnosis, our approach and its variations should be powerful in the separation and characterization of proteins following MP... - Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitroJames A Mobley
Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Cancer Epidemiol Biomarkers Prev 12:775-83. 2003..Our findings therefore provide a link between the consumption of dietary fatty acids and the enhanced expression of AMACR, an enzyme that may play an important role in genesis and progression of CaP... - Ribozyme-mediated downregulation of human metallothionein II(a) induces apoptosis in human prostate and ovarian cancer cell linesSeshadri Tekur
Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Mol Carcinog 33:44-55. 2002.... - Developmental exposure to bisphenol A increases prostate cancer susceptibility in adult rats: epigenetic mode of action is implicatedGail S Prins
Department of Urology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Fertil Steril 89:e41. 2008 - Metastases of prostate cancer express estrogen receptor-betaJanice S Lai
Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
Urology 64:814-20. 2004..05) was detected. CONCLUSIONS: Our data have shown that ERbeta is expressed in CaP metastases, validating the initiation of studies to evaluate selective ER modulators for treatment of advanced CaP... - Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposureFrederick S vom Saal
Reprod Toxicol 24:131-8. 2007 - Human prostate cancer risk factorsDavid G Bostwick
Bostwick Laboratories, Richmond, Virginia 23294, USA
Cancer 101:2371-490. 2004..An understanding of the risk factors for prostate cancer has practical importance for public health research and policy, genetic and nutritional education and chemoprevention, and prevention strategies... - Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profilingViqar Syed
Department of Surgery, University of Massachusetts Medical School, Worcester, MA 06105, USA
Oncogene 24:1774-87. 2005..To the best of our knowledge, except for NM23-H2, this is the first report linking P4 to the regulation of these tumor suppressor/proapoptotic genes, which could serve as future therapeutic targets... - Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cellsKasturi Mukherjee
Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
Oncogene 24:4388-400. 2005..It also raises the possibility of using progestin and ICI as a combinational therapy for OCa treatment... - Progesterone induces apoptosis in TRAIL-resistant ovarian cancer cells by circumventing c-FLIPL overexpressionViqar Syed
Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Cell Biochem 102:442-52. 2007..Hence, combined progestin regimens, with or without TRAIL, may serve as an effective therapy for OCa by circumventing the anti-apoptotic action of c-FLIP(L)... - Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowthNeville N C Tam
Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Am J Pathol 163:2513-22. 2003..These data might have implications on the use of androgen blockade for prostate cancer prevention and androgen therapy for andropause treatment in elderly men... - Estrogen, progesterone and epithelial ovarian cancerShuk Mei Ho
Departmens of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Reprod Biol Endocrinol 1:73. 2003..Thus, knowledge of the mechanism of action of steroid hormones on the OSE and OCa is of paramount significance to HRT risk assessment and to the development of novel therapies for the prevention and treatment of OCa... - Androgen action seriesLucia R Languino
Department of Cancer Biology and Cell Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Cell Biochem 99:331-2. 2006 - Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enhanced expression of FasLViqar Syed
Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
Oncogene 22:6883-90. 2003..They also demonstrate differential P4-regulation of FasL expression between HOSE and OVCA cells... - Age-associated changes in histology and gene-expression profile in the rat ventral prostateKin Mang Lau
Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Lab Invest 83:743-57. 2003....
Research Grants
- Metallothionein & Cadmium Carcinogenesis in the ProstateShuk Mei Ho; Fiscal Year: 2006..abstract_text> ..
- CYP1A1, estrogen metabolism and ovarian carcinogenesisShuk Mei Ho; Fiscal Year: 2004..abstract_text> ..
- Development Modulation of Mouse Uterine TumorigenesisShuk Mei Ho; Fiscal Year: 2005..Future studies along this line of investigation will address impacts of other environmental estrogens. ..
- Hormone-induced inflammation and prostate cancerShuk Mei Ho; Fiscal Year: 2007..Results from our studies should help explicate the relation between inflammation and carcinogenesis in the human prostate, a topic of intense debate. ..
- Progesterone-mediated protection against ovarian cancerShuk Mei Ho; Fiscal Year: 2007..Results from this proposal have the potential to generate new strategies for the prevention and treatment of OCa. ..
- PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISMShuk Mei Ho; Fiscal Year: 2007..Data from these studies are expected to uncover the underlying mechanisms of early prostate carcinogenesis. ..
- Hormone-induced inflammation and prostate cancerShuk Mei Ho; Fiscal Year: 2009..Results from our studies should help explicate the relation between inflammation and carcinogenesis in the human prostate, a topic of intense debate. ..
- PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISMShuk Mei Ho; Fiscal Year: 2000....
- Estrogen Receptor-beta and Prostate FunctionShuk Mei Ho; Fiscal Year: 2004..They will also identify new ER-beta/antiestrogen regulating genes and illuminate potential roles of ER-beta in prostate carcinogenesis and utility of ER-beta SERMs in prostate cancer treatment. ..
- Progesterone-mediated protection against ovarian cancerShuk Mei Ho; Fiscal Year: 2009..Results from this proposal have the potential to generate new strategies for the prevention and treatment of OCa. ..