Shuk Mei Ho

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling
    Yuet Kin Leung
    Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, College of Medicine, University of Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 103:13162-7. 2006
  2. pmc Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon
    Xiang Zhang
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    PLoS Genet 5:e1000334. 2009
  3. pmc Comprehensive identification and modified-site mapping of S-nitrosylated targets in prostate epithelial cells
    Ying Wai Lam
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e9075. 2010
  4. pmc Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion
    Yuet Kin Leung
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, College of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    Endocr Relat Cancer 17:675-89. 2010
  5. pmc Exposure to bisphenol A correlates with early-onset prostate cancer and promotes centrosome amplification and anchorage-independent growth in vitro
    Pheruza Tarapore
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e90332. 2014
  6. pmc Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma
    Frederica Perera
    The Columbia Center for Children s Environmental Health, Columbia University Mailman School of Public Health, New York, New York, United States of America
    PLoS ONE 4:e4488. 2009
  7. pmc Environmental epigenetics and its implication on disease risk and health outcomes
    Shuk Mei Ho
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    ILAR J 53:289-305. 2012
  8. ncbi request reprint Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancer
    Shuk Mei Ho
    Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Ann N Y Acad Sci 1089:177-93. 2006
  9. pmc Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases
    Shuk Mei Ho
    Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
    Reprod Toxicol 23:267-82. 2007
  10. pmc Environmental epigenetics of asthma: an update
    Shuk Mei Ho
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 126:453-65. 2010

Collaborators

Detail Information

Publications87

  1. pmc Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling
    Yuet Kin Leung
    Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, College of Medicine, University of Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 103:13162-7. 2006
    ..Our findings have provided previously unrecognized directions for studying ER-beta signaling and design of ER-beta-based therapies...
  2. pmc Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon
    Xiang Zhang
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    PLoS Genet 5:e1000334. 2009
    ..Our findings identified key in vivo events and novel transcription factors responsible for AMACR regulation in CCas and suggested these AMACR deletions may have diagnostic/prognostic value for colon carcinogenesis...
  3. pmc Comprehensive identification and modified-site mapping of S-nitrosylated targets in prostate epithelial cells
    Ying Wai Lam
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e9075. 2010
    ..Thus, our primary objective was to identify S-nitrosylated targets in an immortalized normal prostate epithelial cell line, NPrEC...
  4. pmc Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion
    Yuet Kin Leung
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, College of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    Endocr Relat Cancer 17:675-89. 2010
    ..These findings may aid future clinical management of PCa...
  5. pmc Exposure to bisphenol A correlates with early-onset prostate cancer and promotes centrosome amplification and anchorage-independent growth in vitro
    Pheruza Tarapore
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e90332. 2014
    ..Moreover, disruption of the centrosome duplication cycle by low-dose BPA may contribute to neoplastic transformation of the prostate. ..
  6. pmc Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma
    Frederica Perera
    The Columbia Center for Children s Environmental Health, Columbia University Mailman School of Public Health, New York, New York, United States of America
    PLoS ONE 4:e4488. 2009
    ..The results support the emerging theory of early origins of later life disease development...
  7. pmc Environmental epigenetics and its implication on disease risk and health outcomes
    Shuk Mei Ho
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    ILAR J 53:289-305. 2012
    ..Future investigations may focus on their use as readouts or biomarkers of the totality of past exposure for the prediction of future disease risk and the prescription of effective countermeasures...
  8. ncbi request reprint Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancer
    Shuk Mei Ho
    Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Ann N Y Acad Sci 1089:177-93. 2006
    ..These findings open new avenues for drug design that now focuses on developing a new generation of estrogen-based PCa therapies with maximal proapoptotic action but few or no side effects...
  9. pmc Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases
    Shuk Mei Ho
    Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
    Reprod Toxicol 23:267-82. 2007
    ..We believe studies of epigenetic changes such as DNA methylation hold great promise in understanding the early origins of adult diseases and in advancing their diagnosis, prevention, and treatment...
  10. pmc Environmental epigenetics of asthma: an update
    Shuk Mei Ho
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 126:453-65. 2010
    ..The discovery and validation of epigenetic biomarkers linked to exposure, asthma, or both might lead to better epigenotyping of risk, prognosis, treatment prediction, and development of novel therapies...
  11. pmc Estrogens and prostate cancer: etiology, mediators, prevention, and management
    Shuk Mei Ho
    Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Endocrinol Metab Clin North Am 40:591-614, ix. 2011
    ....
  12. pmc α-Methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissues
    Bin Ouyang
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    Urology 77:249.e1-7. 2011
    ..AMACR has been used as a diagnostic biomarker for CaP and is now a standard biomarker for needle biopsy specimens with ambiguous lesions...
  13. pmc Maternal exposure to polycyclic aromatic hydrocarbons and 5'-CpG methylation of interferon-γ in cord white blood cells
    Wan Yee Tang
    Division of Environmental Genetics and Molecular Toxicology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Environ Health Perspect 120:1195-200. 2012
    ..However, it has yet to be established whether maternal exposure to polycyclic aromatic hydrocarbons (PAHs) can alter these gene promoters epigenetically during fetal development...
  14. pmc Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4
    Shuk Mei Ho
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA
    Cancer Res 66:5624-32. 2006
    ..In total, these findings indicate that low-dose exposures to ubiquitous environmental estrogens affect the prostate epigenome during development and, in so doing, promote prostate disease with aging...
  15. pmc Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasion
    Hung Ming Lam
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, United States
    Mol Cell Endocrinol 358:27-35. 2012
    ..These results underscore the functional importance of the first experimentally identified hERβ-phosphorylation site in breast cancer...
  16. pmc Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer
    Xiang Zhang
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Prostate 70:765-76. 2010
    ..We previously demonstrated that a putative anti-tumor gene, peroxisomal membrane protein 4, 24 kDa (PMP24 or PXMP4), is silenced via DNA methylation of a CpG island in its 5' flanking region (5'-CGI) in prostate cancer (PCa) cells...
  17. pmc Estrogen receptor β (ERβ1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner
    Ming Tsung Lee
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 288:25038-52. 2013
    ..Tip60 differentially regulates the endogenous expression of the target genes by modulating the binding of ERβ1 to the cis-regulatory regions. Thus, we have identified Tip60 as the first dual-function coregulator of ERβ1. ..
  18. pmc Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status
    Janet K Hess-Wilson
    Department of Cell and Cancer Biology, University of Cincinnati College of Medicine, Ohio 45267 0521, USA
    Environ Health Perspect 115:1646-53. 2007
    ..In tumors with specific AR mutations, BPA promotes therapeutic bypass, suggesting significant negative impact to the clinical management of prostate cancer...
  19. pmc Research resource: estrogen-driven prolactin-mediated gene-expression networks in hormone-induced prostatic intraepithelial neoplasia
    Neville N C Tam
    Department of Environmental Health, University of Cincinnati Medical Center, Kettering Laboratory, Suite 128, 3223 Eden Avenue, Cincinnati, Ohio 45267 0056, USA
    Mol Endocrinol 24:2207-17. 2010
    ....
  20. pmc Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life
    Wan Yee Tang
    Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Endocrinology 153:42-55. 2012
    ..We speculate that the distinctly different fate of early-life epigenetic marks during adulthood reflects the complex nature of lifelong editing of early-life epigenetic reprogramming...
  21. pmc Sex hormones induce direct epithelial and inflammation-mediated oxidative/nitrosative stress that favors prostatic carcinogenesis in the noble rat
    Neville N C Tam
    Department of Environmental Health, Kettering Complex, Room 130, 3223 Eden Ave, University of Cincinnati Medical Center, PO Box 670056, Cincinnati, OH 45267 0056, USA
    Am J Pathol 171:1334-41. 2007
    ..Thus, we link alterations in the hormonal milieu with oxidative/nitrosative/inflammatory damage to the prostate epithelium that promotes carcinogenesis...
  22. pmc Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium
    Gail S Prins
    Department of Urology G S P, W Y H, G B S, D P H, S M, J L N and Department of Pathology A K B, College of Medicine, and Department of Medicinal Chemistry and Pharmacognosy G L, K H, R B v B, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612 University of Illinois Cancer Center G S P, A K B, R B v B, Chicago, Illinois 60612 Department of Environmental Health S M H, University of Cincinnati, Cincinnati, Ohio 45220 and Center for Translational Cancer Research C L W, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843
    Endocrinology 155:805-17. 2014
    ..Together, the present findings demonstrate that human prostate stem-progenitor cells are direct BPA targets and that developmental exposure to BPA at low doses increases hormone-dependent cancer risk in the human prostate epithelium. ..
  23. doi request reprint Differential expression of estrogen receptor beta isoforms in prostate cancer through interplay between transcriptional and translational regulation
    Ming Tsung Lee
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, Cincinnati, OH, United States
    Mol Cell Endocrinol 376:125-35. 2013
    ..This study reveals that expression of ERβ1 is regulated primarily at the transcriptional level, whereas that of ERβ2 and ERβ5 is controlled by the interplay between transcriptional and post-transcriptional regulation. ..
  24. pmc Gene expression profiling identifies lobe-specific and common disruptions of multiple gene networks in testosterone-supported, 17beta-estradiol- or diethylstilbestrol-induced prostate dysplasia in Noble rats
    Neville N C Tam
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 USA
    Neoplasia 10:20-40. 2008
    ....
  25. pmc The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer
    Lisa M Privette Vinnedge
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e46985. 2012
    ..Together, our data suggest that DEK promotes the pathogenesis of ER+ breast cancer and that the targeted inhibition of DEK may enhance the efficacy of conventional hormone therapies...
  26. pmc Site-specific S-nitrosylation of integrin α6 increases the extent of prostate cancer cell migration by enhancing integrin β1 association and weakening adherence to laminin-1
    Jared Isaac
    Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Biochemistry 51:9689-97. 2012
    ..In conclusion, S-nitrosylation of ITGα6 increased the extent of prostate cancer cell migration, which could be a potential mechanism of NO- and iNOS-induced enhancement of prostate cancer metastasis...
  27. pmc Estrogen receptor-beta and breast cancer: translating biology into clinical practice
    Yuet Kin Leung
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Steroids 77:727-37. 2012
    ..Insights gained from these key questions in ERβ research should help in prevention, diagnosis/prognosis, and treatment of BCa...
  28. pmc Mutually positive regulatory feedback loop between interferons and estrogen receptor-alpha in mice: implications for sex bias in autoimmunity
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e10868. 2010
    ..Here we report that activation of IFN (alpha or gamma)-signaling in immune cells up-regulates expression of estrogen receptor-alpha (ERalpha; encoded by the Esr1 gene) and stimulates expression of target genes...
  29. doi request reprint Estrogen receptor β: switching to a new partner and escaping from estrogen
    Yuet Kin Leung
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati Medical Center, Kettering Complex, Room 128, 3223 Eden Avenue, P O Box 670056, Cincinnati, OH 45267, USA
    Sci Signal 4:pe19. 2011
    ..Future research into ERβ will likely involve this estrogen independency and the preference for binding nonclassical DNA elements through tethering. The development of ERβ-based therapies may lead to improved drug efficacy...
  30. pmc Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: oncogenic and immunomodulations involving the action of tumor necrosis factor
    Shlomo Bakshi
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0056, USA
    Environ Health Perspect 116:769-76. 2008
    ..Cadmium is implicated in prostate carcinogenesis, but its oncogenic action remains unclear...
  31. pmc Environmental epigenetics and asthma: current concepts and call for studies
    Rachel L Miller
    PH8E, 630 W 168th Street, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Respir Crit Care Med 177:567-73. 2008
    ..There is immense promise that the study of environmental epigenetics will help us understand a theoretically preventable environmental disease...
  32. pmc Interferon-γ promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma
    Bin Ouyang
    Department of Environmental Health Sciences, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Toxicol Sci 133:218-24. 2013
    ..Our finding suggests that exposure to occupational chemicals could play a heretofore undefined mechanistic role via epigenetic modification of specific genes in the promoter region...
  33. pmc Epigenetic reprogramming and imprinting in origins of disease
    Wan Yee Tang
    Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
    Rev Endocr Metab Disord 8:173-82. 2007
    ..Improvements in human health could then be redirected from curative care to personalized, preventive medicine based, in part, on epigenetic markings etched in the "margins" of one's genetic make-up...
  34. pmc Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene
    Bin Ouyang
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Cancer Institute, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
    J Occup Environ Med 54:774-80. 2012
    ..This study examined the possibility of an association between PAH-induced epigenetic alterations and occupational firefighting exposure...
  35. doi request reprint A duplex quantitative polymerase chain reaction assay based on quantification of alpha-methylacyl-CoA racemase transcripts and prostate cancer antigen 3 in urine sediments improved diagnostic accuracy for prostate cancer
    Bin Ouyang
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    J Urol 181:2508-13; discussion 2513-4. 2009
    ..In this study we evaluated the diagnostic potential of a duplex assay for prostate cancer by quantifying transcript levels of alpha-methylacyl-CoA racemase and prostate cancer antigen 3 in urine sediments following prostatic massage...
  36. doi request reprint Differential proteomics in the aging Noble rat ventral prostate
    Ying Wai Lam
    Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Proteomics 8:2750-63. 2008
    ..To the best of our knowledge, this is the first study on the proteome of the aging rat prostate...
  37. pmc Epigenetics meets endocrinology
    Xiang Zhang
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Complex Suite 130, Cincinnati, Ohio 45267, USA
    J Mol Endocrinol 46:R11-32. 2011
    ....
  38. pmc Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis
    Chang Jin
    Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Laboratory, Suite 410, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Dev Biol 374:96-107. 2013
    ..Using LCM and expression array, our studies have uncovered novel molecular signatures of MAP3K1 in embryonic eyelid closure...
  39. pmc Enhanced resistance to tamoxifen by the c-ABL proto-oncogene in breast cancer
    Huajun Zhao
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Ave, Cincinnati, OH 45267 0521, USA
    Neoplasia 12:214-23. 2010
    ..This study shows that c-ABL regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-ABL as a therapeutic target and a prognostic tumor marker for breast cancer...
  40. pmc Estrogen receptor β isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12
    Ming Tsung Lee
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH
    Neoplasia 15:1262-71. 2013
    ..In conclusion, ERβ5 interacts with Bcl2L12 and functions in a novel estrogen-independent molecular pathway that promotes chemotherapeutic Agent-Induced in vitro apoptosis of BCa cell lines. ..
  41. ncbi request reprint Interferon-inducible IFI16 protein in human cancers and autoimmune diseases
    Divaker Choubey
    Cincinnati VA Medical Center, OH, USA
    Front Biosci 13:598-608. 2008
    ..In this review, we discuss how our understanding of the regulation of IFI16 expression and its role in cell growth regulation will help elucidate the molecular mechanisms that contribute to the development of various human diseases...
  42. pmc Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein
    Wan Yee Tang
    Department of Environmental Health, Kettering Complex, Room 128, 3223 Eden Avenue, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, Ohio 45267 0056, USA
    Endocrinology 149:5922-31. 2008
    ..Thus, the life reprogramming of uterine Nsbp1 expression by neonatal DES/GEN exposure appears to be mediated by an epigenetic mechanism that interacts with ovarian hormones in adulthood...
  43. pmc Application of phi29 motor pRNA for targeted therapeutic delivery of siRNA silencing metallothionein-IIA and survivin in ovarian cancers
    Pheruza Tarapore
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA
    Mol Ther 19:386-94. 2011
    ..The pRNA system, which has the capability to assemble into multivalent nanoparticles, has immense promise as a highly potent therapeutic agent...
  44. pmc Histone deacetylase 9 is a negative regulator of adipogenic differentiation
    Tapan K Chatterjee
    Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Biol Chem 286:27836-47. 2011
    ..These findings provide new insights into mechanisms of adipogenic differentiation and document a critical regulatory role for HDAC9 in adipogenic differentiation through a deacetylase-independent mechanism...
  45. pmc Plasma levels of nitrate and risk of prostate cancer: a prospective study
    Tianying Wu
    Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Cancer Epidemiol Biomarkers Prev 22:1210-8. 2013
    ..Prospective studies examining the association between plasma nitrate and cancer, especially prostate cancer, are lacking...
  46. ncbi request reprint Hydroxylated polybrominated diphenyl ethers in paired maternal and cord sera
    Aimin Chen
    Division of Epidemiology and Biostatistics, Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    Environ Sci Technol 47:3902-8. 2013
    ..Equal or higher levels of total OH-BDEs and total BDEs in cord serum were observed in 85% and 80% of the mother-neonate pairs, respectively. The study suggests fetuses might receive higher OH-PBDE and PBDE exposure than their mothers...
  47. pmc Hsa-miRNA-765 as a key mediator for inhibiting growth, migration and invasion in fulvestrant-treated prostate cancer
    Yuet Kin Leung
    Department of Environmental Health, Center for Environmental Genetics, and Cancer Institute, University of Cincinnati Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e98037. 2014
    ....
  48. doi request reprint Endocrine disruption of the epigenome: a breast cancer link
    Kevin C Knower
    Cancer Drug Discovery, MIMR PHI Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia Department of Molecular Biology and Biochemistry, Monash University, Clayton, Victoria, Australia Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Endocr Relat Cancer 21:T33-55. 2014
    ..We also highlight the susceptibility of early-life exposure to each EDC to mediate epigenetic alterations, and where possible describe how these epigenome changes influence breast cancer risk. ..
  49. ncbi request reprint Epigenetics meets endocrinology
    Xiang Zhang
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Complex Suite 130, Cincinnati, Ohio 45267, USA
    J Mol Endocrinol 46:R11-32. 2011
    ....
  50. pmc Developmental neurotoxicants in e-waste: an emerging health concern
    Aimin Chen
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Environ Health Perspect 119:431-8. 2011
    ..To provide updated information about the scope of the issue, presence of known and suspected neurotoxicants, toxicologic mechanisms, and current data gaps, we conducted this literature review...
  51. ncbi request reprint Estrogen receptor-beta expression in human testicular germ cell tumors
    Vernon Pais
    Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Clin Cancer Res 9:4475-82. 2003
    ..For completeness, expression of androgen and progesterone receptors was also investigated...
  52. ncbi request reprint Expression study of three secretory proteins (prostatic secretory protein of 94 amino acids, probasin, and seminal vesicle secretion II) in dysplastic and neoplastic rat prostates
    Joseph Kwong
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Prostate 56:81-97. 2003
    ..Among these proteins, rodent PSP94 but not probasin and SVSII has a human homologue and it is also a major secretory protein of the human prostate, in addition to prostatic acid phosphatase and prostate-specific antigen...
  53. ncbi request reprint Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidates
    Shuk Mei Ho
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biochem 91:491-503. 2004
    ..Further advancement of our knowledge of the role of estrogens in prostate carcinogenesis through metabolic activation of estrogens and/or ER-mediated pathways will certainly result in better preventive or therapeutic modalities for PCa...
  54. ncbi request reprint The novel estrogen 17alpha-20Z-21-[(4-amino)phenyl]-19-norpregna-1,3,5(10),20-tetraene-3,17beta-diol induces apoptosis in prostate cancer cell lines at nanomolar concentrations in vitro
    James A Mobley
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester 01605 2324, USA
    Mol Cancer Ther 3:587-95. 2004
    ....
  55. pmc Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis
    Xuegong Zhu
    Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Am J Pathol 164:2003-12. 2004
    ....
  56. ncbi request reprint Expression of estrogen receptor beta in the fetal, neonatal, and prepubertal human prostate
    Jason Y Adams
    Department of Pathology, Schools of Medicine and Veterinary Medicine, Tufts University, Boston, Massachusetts 01655, USA
    Prostate 52:69-81. 2002
    ..Although the fetal rodent prostate has been reported to contain both estrogen receptor alpha (ER-alpha) and beta (ER-beta), there have been no reports as to whether either of the ER subtypes is expressed in the developing human prostate...
  57. ncbi request reprint PMP24, a gene identified by MSRF, undergoes DNA hypermethylation-associated gene silencing during cancer progression in an LNCaP model
    Mengchu Wu
    Division of Urology, Department of Surgery, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Oncogene 23:250-9. 2004
    ....
  58. pmc ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk
    Yuet Kin Leung
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Neoplasia 8:242-9. 2006
    ..Therefore, combined therapies targeting ER-beta and NFkappaB signaling may be synergistic as treatment for PCa...
  59. pmc Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, Chicago, IL, USA
    Basic Clin Pharmacol Toxicol 102:134-8. 2008
    ..In total, these findings indicate that low-dose exposures to ubiquitous environmental oestrogens impact the prostate epigenome during development and in so doing, promote prostate disease with ageing...
  60. ncbi request reprint Profiling estrogen-regulated gene expression changes in normal and malignant human ovarian surface epithelial cells
    Viqar Syed
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Oncogene 24:8128-43. 2005
    ..These findings may explain the paradoxical roles of estrogens in regulating normal and malignant OSE cell functions...
  61. pmc Apigenin suppresses cancer cell growth through ERbeta
    Paul Mak
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Neoplasia 8:896-904. 2006
    ..The differential use of ERalpha and ERbeta signaling for transaction between genistein and apigenin demonstrates the complexity of phytoestrogen action in the context of their anticancer properties...
  62. ncbi request reprint Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells
    Shuk Mei Ho
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Oncogene 22:4243-56. 2003
    ..Specifically, neogenin and restin were found to exhibit proproliferation/survival action on OC cells...
  63. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  64. pmc Expression of androgen receptor is negatively regulated by p53
    Fatouma Alimirah
    Edward Hines Jr VA Hospital, Hines, IL 60141, USA
    Neoplasia 9:1152-9. 2007
    ..Together, our observations provide support for the idea that the loss of p53 function in prostate cancer cells contributes to increased expression of AR...
  65. ncbi request reprint Age-associated changes in histology and gene-expression profile in the rat ventral prostate
    Kin Mang Lau
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Lab Invest 83:743-57. 2003
    ....
  66. ncbi request reprint Alpha-methylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zone
    Irwin Leav
    Department of Pathology, Division of Urology, University of Massachusetts Medical School, Worcester, MA, USA
    Hum Pathol 34:228-33. 2003
    ....
  67. ncbi request reprint Sex hormone-induced alterations in the activities of antioxidant enzymes and lipid peroxidation status in the prostate of Noble rats
    Neville N C Tam
    Division of Urology, Department of Surgery, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Prostate 55:1-8. 2003
    ....
  68. ncbi request reprint DNA microarrays in prostate cancer
    Shuk Mei Ho
    Department of Surgery, University of Massachusetts Medical School, Room S4 746, 55 Lake Avenue North, Worcester, MA 01655, USA
    Curr Urol Rep 3:53-60. 2002
    ..Finally, this review emphasizes existing, but currently underutilized, data-mining tools, such as multivariate statistical analyses, neural networking, and machine learning techniques, to stimulate wider usage...
  69. ncbi request reprint Gene expression profiling of testosterone and estradiol-17 beta-induced prostatic dysplasia in Noble rats and response to the antiestrogen ICI 182,780
    Christopher J Thompson
    Department of Surgery Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Endocrinology 143:2093-105. 2002
    ....
  70. pmc Developmental exposure to bisphenol A increases prostate cancer susceptibility in adult rats: epigenetic mode of action is implicated
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Fertil Steril 89:e41. 2008
  71. pmc Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review
    Ronald Melnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 110:427-31. 2002
    ....
  72. ncbi request reprint Ribozyme-mediated downregulation of human metallothionein II(a) induces apoptosis in human prostate and ovarian cancer cell lines
    Seshadri Tekur
    Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Carcinog 33:44-55. 2002
    ....
  73. ncbi request reprint Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enhanced expression of FasL
    Viqar Syed
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Oncogene 22:6883-90. 2003
    ..They also demonstrate differential P4-regulation of FasL expression between HOSE and OVCA cells...
  74. ncbi request reprint Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants
    Neville N C Tam
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Prostate 66:57-69. 2006
    ..Experimental evidence establishing a causal relationship between oxidative and nitrosative stress (OS/NS) and PCa development and showing its modulation by dietary antioxidants would help justify their usage...
  75. ncbi request reprint Changes in serum proteomic patterns by presurgical alpha-tocopherol and L-selenomethionine supplementation in prostate cancer
    Jeri Kim
    Department of Genitourinary Medical Oncology, University of Massachusetts Medical School, Lazare Research Building, Room 504, 364 Plantation Street, Worcester, MA 01605 2324, USA
    Cancer Epidemiol Biomarkers Prev 14:1697-702. 2005
    ..To determine the effects of selenium and vitamin E in blood and prostate tissue, we undertook a preoperative feasibility study complementary to the currently ongoing Selenium and Vitamin E Cancer Prevention Trial...
  76. ncbi request reprint Mass profiling-directed isolation and identification of a stage-specific serologic protein biomarker of advanced prostate cancer
    Ying Wai Lam
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proteomics 5:2927-38. 2005
    ..With the growing interest in using MP for patient classification and diagnosis, our approach and its variations should be powerful in the separation and characterization of proteins following MP...
  77. ncbi request reprint Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cells
    Kasturi Mukherjee
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Oncogene 24:4388-400. 2005
    ..It also raises the possibility of using progestin and ICI as a combinational therapy for OCa treatment...
  78. ncbi request reprint Androgen action series
    Lucia R Languino
    Department of Cancer Biology and Cell Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biochem 99:331-2. 2006
  79. ncbi request reprint Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling
    Viqar Syed
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 06105, USA
    Oncogene 24:1774-87. 2005
    ..To the best of our knowledge, except for NM23-H2, this is the first report linking P4 to the regulation of these tumor suppressor/proapoptotic genes, which could serve as future therapeutic targets...
  80. ncbi request reprint Human prostate cancer risk factors
    David G Bostwick
    Bostwick Laboratories, Richmond, Virginia 23294, USA
    Cancer 101:2371-490. 2004
    ..An understanding of the risk factors for prostate cancer has practical importance for public health research and policy, genetic and nutritional education and chemoprevention, and prevention strategies...
  81. ncbi request reprint Metastases of prostate cancer express estrogen receptor-beta
    Janice S Lai
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Urology 64:814-20. 2004
    ..It has been proposed that ERbeta may play a role in the growth regulation of prostate cells. The targeting of ERs by selective ER modulators might be an effective method of treating advanced CaP...
  82. ncbi request reprint Human beta-defensin-1, a potential chromosome 8p tumor suppressor: control of transcription and induction of apoptosis in renal cell carcinoma
    Carrie Q Sun
    Department of Urology, Emory University, Atlanta, GA 30322, USA
    Cancer Res 66:8542-9. 2006
    ..These data support the hypothesis that hBD-1 is a potential tumor suppressor gene for urological cancers. Promoter point mutations may be responsible for cancer-specific loss of hDB-1 expression...
  83. pmc Developmental estrogen exposures predispose to prostate carcinogenesis with aging
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, 820 South Wood Street, MC 955, Chicago, IL 60612, United States
    Reprod Toxicol 23:374-82. 2007
    ....
  84. ncbi request reprint Progesterone induces apoptosis in TRAIL-resistant ovarian cancer cells by circumventing c-FLIPL overexpression
    Viqar Syed
    Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Biochem 102:442-52. 2007
    ..Hence, combined progestin regimens, with or without TRAIL, may serve as an effective therapy for OCa by circumventing the anti-apoptotic action of c-FLIP(L)...
  85. pmc Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth
    Neville N C Tam
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Am J Pathol 163:2513-22. 2003
    ..These data might have implications on the use of androgen blockade for prostate cancer prevention and androgen therapy for andropause treatment in elderly men...
  86. pmc Estrogen, progesterone and epithelial ovarian cancer
    Shuk Mei Ho
    Departmens of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Reprod Biol Endocrinol 1:73. 2003
    ..Thus, knowledge of the mechanism of action of steroid hormones on the OSE and OCa is of paramount significance to HRT risk assessment and to the development of novel therapies for the prevention and treatment of OCa...
  87. ncbi request reprint Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro
    James A Mobley
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Epidemiol Biomarkers Prev 12:775-83. 2003
    ..Our findings therefore provide a link between the consumption of dietary fatty acids and the enhanced expression of AMACR, an enzyme that may play an important role in genesis and progression of CaP...

Research Grants36

  1. Metallothionein & Cadmium Carcinogenesis in the Prostate
    Shuk Mei Ho; Fiscal Year: 2006
    ..abstract_text> ..
  2. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2005
    ..Data from these studies are expected to uncover the underlying mechanisms of early prostate carcinogenesis. ..
  3. Metallothionein & Cadmium Carcinogenesis in the Prostate
    Shuk Mei Ho; Fiscal Year: 2005
    ..abstract_text> ..
  4. CYP1A1, estrogen metabolism and ovarian carcinogenesis
    Shuk Mei Ho; Fiscal Year: 2004
    ..abstract_text> ..
  5. Progesterone-mediated protection against ovarian cancer
    Shuk Mei Ho; Fiscal Year: 2005
    ..Results from this proposal have the potential to generate new strategies for the prevention and treatment of OCa. ..
  6. Development Modulation of Mouse Uterine Tumorigenesis
    Shuk Mei Ho; Fiscal Year: 2005
    ..Future studies along this line of investigation will address impacts of other environmental estrogens. ..
  7. Hormone-induced inflammation and prostate cancer
    Shuk Mei Ho; Fiscal Year: 2007
    ..Results from our studies should help explicate the relation between inflammation and carcinogenesis in the human prostate, a topic of intense debate. ..
  8. Progesterone-mediated protection against ovarian cancer
    Shuk Mei Ho; Fiscal Year: 2007
    ..Results from this proposal have the potential to generate new strategies for the prevention and treatment of OCa. ..
  9. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2007
    ..Data from these studies are expected to uncover the underlying mechanisms of early prostate carcinogenesis. ..
  10. Hormone-induced inflammation and prostate cancer
    Shuk Mei Ho; Fiscal Year: 2009
    ..Results from our studies should help explicate the relation between inflammation and carcinogenesis in the human prostate, a topic of intense debate. ..
  11. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2006
    ..Data from these studies are expected to uncover the underlying mechanisms of early prostate carcinogenesis. ..
  12. Hormone-induced inflammation and prostate cancer
    Shuk Mei Ho; Fiscal Year: 2006
    ..Results from our studies should help explicate the relation between inflammation and carcinogenesis in the human prostate, a topic of intense debate. ..
  13. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2000
    ....
  14. CYP1A1, estrogen metabolism and ovarian carcinogenesis
    Shuk Mei Ho; Fiscal Year: 2002
    ..abstract_text> ..
  15. Estrogen Receptor-beta and Prostate Function
    Shuk Mei Ho; Fiscal Year: 2001
    ..They will also identify new ER-beta/antiestrogen regulating genes and illuminate potential roles of ER-beta in prostate carcinogenesis and utility of ER-beta SERMs in prostate cancer treatment. ..
  16. Estrogen Receptor-beta and Prostate Function
    Shuk Mei Ho; Fiscal Year: 2002
    ..They will also identify new ER-beta/antiestrogen regulating genes and illuminate potential roles of ER-beta in prostate carcinogenesis and utility of ER-beta SERMs in prostate cancer treatment. ..
  17. Metallothionein & Cadmium Carcinogenesis in the Prostate
    Shuk Mei Ho; Fiscal Year: 2002
    ..abstract_text> ..
  18. CYP1A1, estrogen metabolism and ovarian carcinogenesis
    Shuk Mei Ho; Fiscal Year: 2003
    ..abstract_text> ..
  19. Metallothionein & Cadmium Carcinogenesis in the Prostate
    Shuk Mei Ho; Fiscal Year: 2003
    ..abstract_text> ..
  20. Estrogen Receptor-beta and Prostate Function
    Shuk Mei Ho; Fiscal Year: 2003
    ..They will also identify new ER-beta/antiestrogen regulating genes and illuminate potential roles of ER-beta in prostate carcinogenesis and utility of ER-beta SERMs in prostate cancer treatment. ..
  21. Estrogen Receptor-beta and Prostate Function
    Shuk Mei Ho; Fiscal Year: 2004
    ..They will also identify new ER-beta/antiestrogen regulating genes and illuminate potential roles of ER-beta in prostate carcinogenesis and utility of ER-beta SERMs in prostate cancer treatment. ..
  22. CYP1A1, estrogen metabolism and ovarian carcinogenesis
    Shuk Mei Ho; Fiscal Year: 2004
    ..abstract_text> ..
  23. Metallothionein & Cadmium Carcinogenesis in the Prostate
    Shuk Mei Ho; Fiscal Year: 2004
    ..abstract_text> ..
  24. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2004
    ..Data from these studies are expected to uncover the underlying mechanisms of early prostate carcinogenesis. ..
  25. Metallothionein & Cadmium Carcinogenesis in the Prostate
    Shuk Mei Ho; Fiscal Year: 2005
    ..abstract_text> ..
  26. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2005
    ..Data from these studies are expected to uncover the underlying mechanisms of early prostate carcinogenesis. ..
  27. Progesterone-mediated protection against ovarian cancer
    Shuk Mei Ho; Fiscal Year: 2005
    ..Results from this proposal have the potential to generate new strategies for the prevention and treatment of OCa. ..
  28. Progesterone-mediated protection against ovarian cancer
    Shuk Mei Ho; Fiscal Year: 2006
    ..Results from this proposal have the potential to generate new strategies for the prevention and treatment of OCa. ..
  29. Progesterone-mediated protection against ovarian cancer
    Shuk Mei Ho; Fiscal Year: 2009
    ..Results from this proposal have the potential to generate new strategies for the prevention and treatment of OCa. ..