Beng Choon Ho

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc MRI brain volume abnormalities in young, nonpsychotic relatives of schizophrenia probands are associated with subsequent prodromal symptoms
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Schizophr Res 96:1-13. 2007
  2. ncbi request reprint Hippocampus volume and treatment delays in first-episode schizophrenia
    Beng Choon Ho
    Center for Bipolar Disorders Research, Department of Psychiatry, 2880 JPP, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Am J Psychiatry 162:1527-9. 2005
  3. pmc Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 5224, USA
    Schizophr Res 128:66-75. 2011
  4. ncbi request reprint Secondary prevention of schizophrenia: utility of standardized scholastic tests in early identification
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Ann Clin Psychiatry 17:11-8. 2005
  5. ncbi request reprint Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow
    B C Ho
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52252, USA
    Mol Psychiatry 10:229, 287-98. 2005
  6. pmc Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Psychiatry 164:1890-9. 2007
  7. ncbi request reprint Validity of symptom assessment in psychotic disorders: information variance across different sources of history
    Beng Choon Ho
    Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Schizophr Res 68:299-307. 2004
  8. pmc Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilities
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, USA
    Schizophr Res 106:192-9. 2008
  9. ncbi request reprint Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia
    Beng Choon Ho
    Mental Health Clinical Research Center, Iowa City, Iowa, USA
    Arch Gen Psychiatry 60:585-94. 2003
  10. ncbi request reprint Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia
    Beng Choon Ho
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine and the University of Iowa College of Public Health, Iowa City, IA 52242, USA
    Am J Psychiatry 160:142-8. 2003

Research Grants

Detail Information

Publications29

  1. pmc MRI brain volume abnormalities in young, nonpsychotic relatives of schizophrenia probands are associated with subsequent prodromal symptoms
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Schizophr Res 96:1-13. 2007
    ..Together with previous genetic high-risk studies of adolescent or young adult relatives, these findings indicate that premorbid MRI brain abnormalities may be of predictive value for the early identification of schizophrenia...
  2. ncbi request reprint Hippocampus volume and treatment delays in first-episode schizophrenia
    Beng Choon Ho
    Center for Bipolar Disorders Research, Department of Psychiatry, 2880 JPP, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Am J Psychiatry 162:1527-9. 2005
    ..Previous MRI studies have reported no significant correlations between duration of untreated initial psychosis and brain volumes but have not examined specific brain regions that may be most susceptible to neuronal damage...
  3. pmc Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 5224, USA
    Schizophr Res 128:66-75. 2011
    ..Our findings suggest that heavy cannabis use in the context of specific CNR1 genotypes may contribute to greater WM volume deficits and cognitive impairment, which could in turn increase schizophrenia risk...
  4. ncbi request reprint Secondary prevention of schizophrenia: utility of standardized scholastic tests in early identification
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Ann Clin Psychiatry 17:11-8. 2005
    ..Early detection and prompt treatment may improve outcome in schizophrenia. In this study, we examine the value of using pre-morbid cognitive impairment in early detection...
  5. ncbi request reprint Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow
    B C Ho
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52252, USA
    Mol Psychiatry 10:229, 287-98. 2005
    ..Age-related changes and phenotypic heterogeneity of schizophrenia may influence the complex relationships between COMT genotype and cognition...
  6. pmc Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Psychiatry 164:1890-9. 2007
    ..Factors underlying progressive brain volume changes in schizophrenia remain poorly understood. The authors investigated whether a gene polymorphism influencing neuroplasticity may contribute to longitudinal brain volume alterations...
  7. ncbi request reprint Validity of symptom assessment in psychotic disorders: information variance across different sources of history
    Beng Choon Ho
    Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Schizophr Res 68:299-307. 2004
    ..This study was designed to determine the degree to which history provided by such subjects is consistent with that obtained from other sources...
  8. pmc Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilities
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, USA
    Schizophr Res 106:192-9. 2008
    ..rs2344484-C-allele may affect NEUROG1's role in transcription regulation such that brain morphology and cognitive abilities are altered resulting in increased susceptibility to develop schizophrenia...
  9. ncbi request reprint Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia
    Beng Choon Ho
    Mental Health Clinical Research Center, Iowa City, Iowa, USA
    Arch Gen Psychiatry 60:585-94. 2003
    ..However, whether these abnormalities progressively worsen during the subsequent course of the disorder remains unresolved...
  10. ncbi request reprint Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia
    Beng Choon Ho
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine and the University of Iowa College of Public Health, Iowa City, IA 52242, USA
    Am J Psychiatry 160:142-8. 2003
    ..This study investigated the relationships between duration of untreated initial psychosis and neurocognitive functioning and high-resolution imaging brain measurements...
  11. pmc Hippocampal volume deficits and shape deformities in young biological relatives of schizophrenia probands
    Beng Choon Ho
    Department of Psychiatry, W278 GH, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Neuroimage 49:3385-93. 2010
    ..Other brain maturational anomalies affecting the hippocampus in schizophrenia may manifest closer to illness onset in adolescence/early adulthood...
  12. pmc Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers
    Beng Choon Ho
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
    Arch Gen Psychiatry 63:731-40. 2006
    ..Its role in determining cognitive deficits in schizophrenia has also not been systematically studied...
  13. doi request reprint Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Gen Psychiatry 69:885-92. 2012
    ..Our study supports this assertion by finding that specific genotypes of the polymorphism are associated with brain structure volumes in individuals with schizophrenia and healthy volunteers and with symptom severity in schizophrenia...
  14. pmc Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia
    Nancy C Andreasen
    Psychiatric Iowa Neuroimaging Consortium, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Biol Psychiatry 70:672-9. 2011
    ..Structural magnetic resonance studies indicate that brain abnormalities are present at onset, but longitudinal studies to assess neuroprogression have been limited by small samples and short or infrequent follow-up intervals...
  15. ncbi request reprint Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up
    Peter Milev
    Department of Psychiatry, University of Iowa Health Care, Iowa City, USA
    Am J Psychiatry 162:495-506. 2005
    ..An additional area of interest was whether the severity of negative symptoms would predict outcome independently from neurocognitive variables or whether there would be an overlap in their predictive power...
  16. ncbi request reprint Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance
    Rebecca Fuller
    Department of Psychiatry, Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52240, USA
    Am J Psychiatry 159:1183-9. 2002
    ..The purpose of this study was to investigate the longitudinal course of premorbid cognitive functioning in individuals with schizophrenia by using prospective data obtained from scholastic test results...
  17. pmc Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia
    Beng Choon Ho
    Departments of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Gen Psychiatry 68:128-37. 2011
    ..Because antipsychotics are prescribed for long periods for schizophrenia patients and have increasingly widespread use in other psychiatric disorders, it is imperative to determine their long-term effects on the human brain...
  18. ncbi request reprint Insular cortex abnormalities in schizophrenia: Relationship to symptoms and typical neuroleptic exposure
    Marcus Pressler
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Biol Psychiatry 57:394-8. 2005
    ..Previously, we found that neuroleptic-naive subjects had abnormally small insular volumes compared with control subjects, with volume directly related to severity of psychotic symptoms...
  19. ncbi request reprint Cerebellar dysfunction in neuroleptic naive schizophrenia patients: clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs
    Beng Choon Ho
    Mental Health Clinical Research Center, Department of Psychiatry, Lucille A Carver College of Medicine, Iowa City, Iowa 52252, USA
    Biol Psychiatry 55:1146-53. 2004
    ..The goal of this study was to investigate cerebellar dysfunction in schizophrenia by examining the clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs in schizophrenia patients...
  20. pmc G72 influences longitudinal change in frontal lobe volume in schizophrenia
    Sarah M Hartz
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 153:640-7. 2010
    ..This same haplotype was also associated with more severe psychotic symptoms at the time of the second scan. These data thus suggest that variation in G72 modulates the progressive brain changes that characterize schizophrenia...
  21. ncbi request reprint Insomnia as a predictor for symptom worsening following antipsychotic withdrawal in schizophrenia
    Eran Chemerinski
    Mental Health Clinical Research Center, Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Compr Psychiatry 43:393-6. 2002
    ..The implications of these findings in research and clinical settings are discussed...
  22. ncbi request reprint Effects of atypical and typical neuroleptics on anterior cingulate volume in schizophrenia
    Laurie McCormick
    The University of Iowa, Carver College of Medicine, Department of Psychiatry, W278 GH, University of Iowa Hospitals and Clinics, Mental Health Clinical Research Center, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Schizophr Res 80:73-84. 2005
    ..The increase in anterior cingulate volume with typicals is correlated to improved psychotic symptoms over time...
  23. ncbi request reprint Initial magnetic resonance imaging volumetric brain measurements and outcome in schizophrenia: a prospective longitudinal study with 5-year follow-up
    Peter Milev
    Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242 1057, USA
    Biol Psychiatry 54:608-15. 2003
    ..Far fewer studies have examined the relationships between brain morphology assessed at illness onset and subsequent outcome, and their results have been contradictory...
  24. pmc Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs
    Nancy C Andreasen
    Mental Health Clinical Research Center, Department of Psychiatry, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1057, USA
    Biol Psychiatry 67:255-62. 2010
    ..An expert consensus group has published charts of equivalent doses for various antipsychotic medications for first- and second-generation medications. These charts were used in this study...
  25. ncbi request reprint Prism adaptation in schizophrenia
    Nirav O Bigelow
    Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, USA
    Brain Cogn 61:235-42. 2006
    ..Deficits in prism adaptation among schizophrenia patients may be due to abnormalities in motor programming arising from the disruptions within the neural networks that subserve PL...
  26. doi request reprint Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study
    Nancy C Andreasen
    Psychiatric Iowa Neuroimaging Consortium, University ofIowa Carver College of Medicine, Iowa City, USA
    Am J Psychiatry 170:609-15. 2013
    ..Recurrent relapses are believed to play a role in this loss, but the relationship between relapse and structural MRI measures has not been rigorously assessed. The authors analyzed longitudinal data to examine this question...
  27. ncbi request reprint Cognitive therapy for persistent psychosis in schizophrenia: a case-controlled clinical trial
    Scott Temple
    Department of Psychiatry, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 1911 JPP, Iowa City, IA 52242, USA
    Schizophr Res 74:195-9. 2005
    ..Limitations of the study include small sample sizes, lack of randomized assignment, and rater nonblindedness to treatment condition...
  28. pmc Magnetic resonance spectroscopy of limbic structures displays metabolite differences in young unaffected relatives of schizophrenia probands
    Aristides A Capizzano
    Department of Radiology, Division of Neuroradiology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Schizophr Res 131:4-10. 2011
    ....
  29. ncbi request reprint Neuropsychological performance in first-episode adolescents with schizophrenia: a comparison with first-episode adults and adolescent control subjects
    Tonya White
    Division of Child and Adolescent Psychiatry, Center for Neurobehavioral Development, University of Minnesota School of Medicine, Minneapolis, MN 55454, USA
    Biol Psychiatry 60:463-71. 2006
    ..The goal of this study was to compare the extent of cognitive deficits between adolescents and adults early in the course of schizophrenia...

Research Grants2

  1. Neuroscience Studies on Early Detection of Schizophrenia
    Beng Choon Ho; Fiscal Year: 2007
    ..Taken together, the training program and research plan provide the potential for scientific discovery as well as support for the establishment of an independent research career. ..