Research Topics
Genomes and GenesSpecies | Beng Choon HoSummaryAffiliation: University of Iowa Country: USA Publications
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Publications
MRI brain volume abnormalities in young, nonpsychotic relatives of schizophrenia probands are associated with subsequent prodromal symptomsBeng Choon Ho
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Schizophr Res 96:1-13. 2007..Together with previous genetic high-risk studies of adolescent or young adult relatives, these findings indicate that premorbid MRI brain abnormalities may be of predictive value for the early identification of schizophrenia...
Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flowB C Ho
Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52252, USA
Mol Psychiatry 10:229, 287-98. 2005..Age-related changes and phenotypic heterogeneity of schizophrenia may influence the complex relationships between COMT genotype and cognition...- Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophreniaBeng Choon Ho
Department of Psychiatry, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
Am J Psychiatry 164:1890-9. 2007..Factors underlying progressive brain volume changes in schizophrenia remain poorly understood. The authors investigated whether a gene polymorphism influencing neuroplasticity may contribute to longitudinal brain volume alterations... - Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilitiesBeng Choon Ho
Department of Psychiatry, University of Iowa Carver College of Medicine, USA
Schizophr Res 106:192-9. 2008..rs2344484-C-allele may affect NEUROG1's role in transcription regulation such that brain morphology and cognitive abilities are altered resulting in increased susceptibility to develop schizophrenia... - Secondary prevention of schizophrenia: utility of standardized scholastic tests in early identificationBeng Choon Ho
Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Ann Clin Psychiatry 17:11-8. 2005..Early detection and prompt treatment may improve outcome in schizophrenia. In this study, we examine the value of using pre-morbid cognitive impairment in early detection... - Hippocampal volume deficits and shape deformities in young biological relatives of schizophrenia probandsBeng Choon Ho
Department of Psychiatry, W278 GH, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Neuroimage 49:3385-93. 2010..Other brain maturational anomalies affecting the hippocampus in schizophrenia may manifest closer to illness onset in adolescence/early adulthood... - Validity of symptom assessment in psychotic disorders: information variance across different sources of historyBeng Choon Ho
Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Schizophr Res 68:299-307. 2004..This study was designed to determine the degree to which history provided by such subjects is consistent with that obtained from other sources... - Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophreniaBeng Choon Ho
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 5224, USA
Schizophr Res 128:66-75. 2011..Our findings suggest that heavy cannabis use in the context of specific CNR1 genotypes may contribute to greater WM volume deficits and cognitive impairment, which could in turn increase schizophrenia risk... - Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophreniaBeng Choon Ho
Mental Health Clinical Research Center, Iowa City, Iowa, USA
Arch Gen Psychiatry 60:585-94. 2003..However, whether these abnormalities progressively worsen during the subsequent course of the disorder remains unresolved... - Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophreniaBeng Choon Ho
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine and the University of Iowa College of Public Health, Iowa City, IA 52242, USA
Am J Psychiatry 160:142-8. 2003..This study investigated the relationships between duration of untreated initial psychosis and neurocognitive functioning and high-resolution imaging brain measurements... - Hippocampus volume and treatment delays in first-episode schizophreniaBeng Choon Ho
Center for Bipolar Disorders Research, Department of Psychiatry, 2880 JPP, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
Am J Psychiatry 162:1527-9. 2005..Previous MRI studies have reported no significant correlations between duration of untreated initial psychosis and brain volumes but have not examined specific brain regions that may be most susceptible to neuronal damage... - Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteersBeng Choon Ho
Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
Arch Gen Psychiatry 63:731-40. 2006..Its role in determining cognitive deficits in schizophrenia has also not been systematically studied... 
Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophreniaThomas H Wassink
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Arch Gen Psychiatry 69:885-92. 2012..Our study supports this assertion by finding that specific genotypes of the polymorphism are associated with brain structure volumes in individuals with schizophrenia and healthy volunteers and with symptom severity in schizophrenia...- Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophreniaNancy C Andreasen
Psychiatric Iowa Neuroimaging Consortium, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Biol Psychiatry 70:672-9. 2011..Structural magnetic resonance studies indicate that brain abnormalities are present at onset, but longitudinal studies to assess neuroprogression have been limited by small samples and short or infrequent follow-up intervals... - Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performanceRebecca Fuller
Department of Psychiatry, Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52240, USA
Am J Psychiatry 159:1183-9. 2002..The purpose of this study was to investigate the longitudinal course of premorbid cognitive functioning in individuals with schizophrenia by using prospective data obtained from scholastic test results... - Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-upPeter Milev
Department of Psychiatry, University of Iowa Health Care, Iowa City, USA
Am J Psychiatry 162:495-506. 2005..An additional area of interest was whether the severity of negative symptoms would predict outcome independently from neurocognitive variables or whether there would be an overlap in their predictive power... - Insular cortex abnormalities in schizophrenia: Relationship to symptoms and typical neuroleptic exposureMarcus Pressler
Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Biol Psychiatry 57:394-8. 2005..Previously, we found that neuroleptic-naive subjects had abnormally small insular volumes compared with control subjects, with volume directly related to severity of psychotic symptoms... - Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophreniaBeng Choon Ho
Departments of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Arch Gen Psychiatry 68:128-37. 2011..Because antipsychotics are prescribed for long periods for schizophrenia patients and have increasingly widespread use in other psychiatric disorders, it is imperative to determine their long-term effects on the human brain... - G72 influences longitudinal change in frontal lobe volume in schizophreniaSarah M Hartz
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Am J Med Genet B Neuropsychiatr Genet 153:640-7. 2010..This same haplotype was also associated with more severe psychotic symptoms at the time of the second scan. These data thus suggest that variation in G72 modulates the progressive brain changes that characterize schizophrenia... - Effects of atypical and typical neuroleptics on anterior cingulate volume in schizophreniaLaurie McCormick
The University of Iowa, Carver College of Medicine, Department of Psychiatry, W278 GH, University of Iowa Hospitals and Clinics, Mental Health Clinical Research Center, 200 Hawkins Drive, Iowa City, IA 52242, USA
Schizophr Res 80:73-84. 2005..The increase in anterior cingulate volume with typicals is correlated to improved psychotic symptoms over time... - Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugsNancy C Andreasen
Mental Health Clinical Research Center, Department of Psychiatry, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1057, USA
Biol Psychiatry 67:255-62. 2010..An expert consensus group has published charts of equivalent doses for various antipsychotic medications for first- and second-generation medications. These charts were used in this study... - Magnetic resonance spectroscopy of limbic structures displays metabolite differences in young unaffected relatives of schizophrenia probandsAristides A Capizzano
Department of Radiology, Division of Neuroradiology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
Schizophr Res 131:4-10. 2011.... - Insomnia as a predictor for symptom worsening following antipsychotic withdrawal in schizophreniaEran Chemerinski
Mental Health Clinical Research Center, Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
Compr Psychiatry 43:393-6. 2002..The implications of these findings in research and clinical settings are discussed... - Cerebellar dysfunction in neuroleptic naive schizophrenia patients: clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signsBeng-Choon Ho
Mental Health Clinical Research Center, Department of Psychiatry, Lucille A. Carver College of Medicine, Iowa City, Iowa 52252, USA
Biol Psychiatry 55:1146-53. 2004..CONCLUSIONS: These findings lend further support for cerebellar dysfunction in schizophrenia... - Neuropsychological performance in first-episode adolescents with schizophrenia: a comparison with first-episode adults and adolescent control subjectsTonya White
Division of Child and Adolescent Psychiatry, Center for Neurobehavioral Development, University of Minnesota School of Medicine, Minneapolis, MN 55454, USA
Biol Psychiatry 60:463-71. 2006..The goal of this study was to compare the extent of cognitive deficits between adolescents and adults early in the course of schizophrenia... - Cognitive therapy for persistent psychosis in schizophrenia: a case-controlled clinical trialScott Temple
Department of Psychiatry, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 1911 JPP, Iowa City, IA 52242, USA
Schizophr Res 74:195-9. 2005..Limitations of the study include small sample sizes, lack of randomized assignment, and rater nonblindedness to treatment condition... - Initial magnetic resonance imaging volumetric brain measurements and outcome in schizophrenia: a prospective longitudinal study with 5-year follow-upPeter Milev
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242-1057, USA
Biol Psychiatry 54:608-15. 2003..However, regional brain volumes assessed near illness onset, in general, do not appear to be indicative of subsequent outcome in schizophrenia... - Prism adaptation in schizophreniaNirav O Bigelow
Department of Psychiatry, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, USA
Brain Cogn 61:235-42. 2006..Deficits in prism adaptation among schizophrenia patients may be due to abnormalities in motor programming arising from the disruptions within the neural networks that subserve PL...
Research Grants
- Neuroscience Studies on Early Detection of SchizophreniaBeng Choon Ho; Fiscal Year: 2007..Taken together, the training program and research plan provide the potential for scientific discovery as well as support for the establishment of an independent research career. ..