Research Topics
| Jane E HittiSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
The vaginal microflora in relation to gingivitisRutger Persson
Department of Periodontology, Div of Oral Microbiology, University of Berne, Berne, Switzerland
BMC Infect Dis 9:6. 2009..Gingivitis has been linked to adverse pregnancy outcome (APO). Bacterial vaginosis (BV) has been associated with APO. We assessed if bacterial counts in BV is associated with gingivitis suggesting a systemic infectious susceptibilty...
Vaginal indicators of amniotic fluid infection in preterm laborJ Hitti
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh Magee Womens Research Institute, Pittsburgh, Pennsylvania, USA
Obstet Gynecol 97:211-9. 2001..To determine whether vaginal interleukin-6, interleukin-8, neutrophils, bacterial vaginosis, and selected vaginal bacteria are predictors of amniotic fluid (AF) infection among women in preterm labor...- Amniotic fluid infection, cytokines, and adverse outcome among infants at 34 weeks' gestation or lessJ Hitti
Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
Obstet Gynecol 98:1080-8. 2001..We examined the hypothesis that amniotic fluid (AF) infection and elevated cytokine concentrations may cause neonatal injury beyond that expected solely from prematurity... - Maternal toxicity with continuous nevirapine in pregnancy: results from PACTG 1022Jane Hitti
University of Washington, Seattle, 98195, USA
J Acquir Immune Defic Syndr 36:772-6. 2004..To compare the safety of nelfinavir and nevirapine-based antiretroviral treatment in HIV-1-infected pregnant women... 
Correlates of cervical Mycoplasma genitalium and risk of preterm birth among Peruvian womenJane Hitti
Department of Obstetrics Gynecology, University of Washington Medical Center, Box 356460, Seattle, WA 98195, USA
Sex Transm Dis 37:81-5. 2010..We investigated associations between cervical M genitalium, demographic and behavioral risk factors for sexually transmitted infection and preterm birth among low-income Peruvian women...- Racial disparity in risk of preterm birth associated with lower genital tract infectionJane Hitti
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
Paediatr Perinat Epidemiol 21:330-7. 2007.... - Inadequate prenatal care and risk of preterm delivery among adolescents: a retrospective study over 10 yearsKatherine E Debiec
Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA
Am J Obstet Gynecol 203:122.e1-6. 2010..The aim of this study was to determine whether inadequate prenatal care is associated with increased risk of preterm birth among adolescents... - Partner- and partnership-related risk factors for preterm birth among low-income women in Lima, PeruKathleen Paul
Department of Obstetrics and Gynecology, University of Washington, Seattle, USA
Soc Sci Med 68:1535-40. 2009..Further research could clarify the specific mechanisms through which these partner and partnership characteristics may increase the risk of preterm birth... - Adherence to antiretrovirals among US women during and after pregnancyArlene D Bardeguez
Department of Obstetrics, Gynecology and Women s Health, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103 1709, USA
J Acquir Immune Defic Syndr 48:408-17. 2008..Antiretrovirals (ARVs) are recommended for maternal health and to reduce HIV-1 mother-to-child transmission, but suboptimal adherence can counteract its benefits... - Comparison of oral and vaginal metronidazole for treatment of bacterial vaginosis in pregnancy: impact on fastidious bacteriaCaroline M Mitchell
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
BMC Infect Dis 9:89. 2009..Both oral and intravaginal metronidazole can be used to treat bacterial vaginosis in pregnancy, but little is known about the impact of different routes of antibiotic administration on concentrations of fastidious vaginal bacteria... - Generation C: prevalence of and risk factors for chlamydia trachomatis among adolescents and young women in Lima, PeruKathleen J Paul
Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
J Womens Health (Larchmt) 18:1419-24. 2009..We assessed associations of Chlamydia trachomatis (CT) infection with both traditional STI risk factors, and partner and partnership-related factors among low-income women in Lima, Peru, by age group... - Bacterial vaginosis, not HIV, is primarily responsible for increased vaginal concentrations of proinflammatory cytokinesCaroline M Mitchell
Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
AIDS Res Hum Retroviruses 24:667-71. 2008..005). Neither HIV nor BV was associated with changes in IL-6 or IL-8. HIV does not have a major impact on vaginal concentrations of proinflammatory cytokines when controlling for the presence of bacterial vaginosis... - Effect of semen on vaginal fluid cytokines and secretory leukocyte protease inhibitorKathy J Agnew
Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific Street, Box 356460, Seattle, WA 98195, USA
Infect Dis Obstet Gynecol 2008:820845. 2008..The presence of semen in vaginal fluid, as identified by an acid phosphatase spot test, does not influence vaginal proinflammatory cytokine concentrations... - Compartmentalization of HIV-1 within the female genital tract is due to monotypic and low-diversity variants not distinct viral populationsMarta Bull
Seattle Children s Hospital Research Institute, Seattle, Washington, USA
PLoS ONE 4:e7122. 2009.... - Changes in the vaginal microenvironment with metronidazole treatment for bacterial vaginosis in early pregnancyCaroline Mitchell
Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
J Womens Health (Larchmt) 18:1817-24. 2009..We examined whether oral or vaginal metronidazole treatment for BV in early pregnancy was more effective in restoring the normal vaginal environment... - Racial disparity in bacterial vaginosis: the role of socioeconomic status, psychosocial stress, and neighborhood characteristics, and possible implications for preterm birthKathleen Paul
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
Soc Sci Med 67:824-33. 2008..These results suggest that both the effects of individual- and neighborhood-level risk factors for BV may differ importantly by racial group, and stressful life events may have physiological effects independent of perceived stress... - Estimating volume of cervicovaginal secretions in cervicovaginal lavage fluid collected for measurement of genital HIV-1 RNA levels in womenCaroline Mitchell
University of Washington, Department of Obstetrics and Gynecology, Harborview Medical Center, 325 9th Ave, Box 359865, Seattle, WA 98104, USA
J Clin Microbiol 49:735-6. 2011..Thirty-eight women provided 275 cervicovaginal specimens. The estimated median volume of cervicovaginal fluid was 0.51 ml (interquartile range, 0.33, 0.69)... - The relationship between racial identity, income, stress and C-reactive protein among parous women: implications for preterm birth disparity researchKathleen Paul
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
J Natl Med Assoc 100:540-6. 2008..Objective life event stressors may be important to consider in future studies investigating a potential inflammatory etiology for preterm birth... - HIV type 1 zidovudine (ZDV) resistance in blood and uterine cervical secretions of pregnant womenLisa M Frenkel
University of Washington, Seattle, Washington 98109, Children s Hospital and Medical Center of Seattle, Seattle, Washington 98105, USA
AIDS Res Hum Retroviruses 22:870-3. 2006..However, in only 1 (1.8%) of 57 pregnancies evaluated was resistant virus limited to the cervical secretions. ZDV-resistant virus is rarely limited to the female genital tract... - A case report of dengue virus infection and acalculous cholecystitis in a pregnant returning travelerWilliam R Berrington
Department of Medicine, Division of Allergy and Infectious Disease, University of Washington, Seattle, WA 98195, USA
Travel Med Infect Dis 5:251-3. 2007..Travel during pregnancy to dengue-endemic areas poses a risk to both mother and fetus. Pregnancies complicated by dengue infection require close monitoring for potential maternal and fetal complications... - Increased tumor necrosis factor-alpha in whole blood during the luteal phase of ovulatory cyclesJosephine H Amory
Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA
J Reprod Med 49:678-82. 2004..To evaluate whether the fact that blood from premenopausal, ovulatory women shows a significant fluctuation in tumor necrosis factor-alpha (TNF-alpha) levels when tested randomly over time is related to the hormonal cycle... - Infectious correlates of HIV-1 shedding in the female upper and lower genital tractsJenell S Coleman
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94105, USA
AIDS 21:755-9. 2007..To determine the effects of vaginal, cervical, and endometrial infections on shedding of HIV-1 RNA in the female genital tract... - Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084Jane Hitti
University of Washington, Seattle, WA, USA
Am J Obstet Gynecol 196:331.e1-7. 2007..The objective of the study was to determine whether protease inhibitors increase glucose intolerance and insulin resistance in pregnancy... - Increased risk of adverse pregnancy outcome among Somali immigrants in Washington stateE Blair Johnson
Department of Obstetrics and Gynecology, University of Washington Medical Center, Harborview Medical Center, Seattle, USA
Am J Obstet Gynecol 193:475-82. 2005..CONCLUSION: Pregnancy outcomes should be evaluated within ethnically and culturally unique groups; Somali immigrants are a high-risk subpopulation... - Monotypic human immunodeficiency virus type 1 genotypes across the uterine cervix and in blood suggest proliferation of cells with provirusMarta E Bull
Seattle Children s Hospital Research Institute, University of Washington, Seattle, Washington 98101 1304, USA
J Virol 83:6020-8. 2009..Further studies are warranted to investigate mechanisms producing monotypic viruses across tissues and, importantly, to determine whether the proliferation of cells with provirus sustain HIV-1 persistence in spite of effective ART... - Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluidJane Hitti
Department of Obstetrics Gynecology, University of Washington, Seattle, WA, USA
Am J Obstet Gynecol 203:32.e1-8. 2010..We analyzed the vaginal fluid proteome to identify biomarkers of intraamniotic infection among women in preterm labor... - Agricultural-related chemical exposures, season of conception, and risk of gastroschisis in Washington StateSarah A Waller
Department of Obstetrics and Gynecology, University of Washington School of Medicine, 1959 NE Pacific St, Box 356460, Seattle, WA 98195, USA
Am J Obstet Gynecol 202:241.e1-6. 2010..We sought to determine if periconceptional exposure to agrichemicals was associated with the development of gastroschisis... - Adverse outcomes after preterm labor are associated with tumor necrosis factor-alpha polymorphism -863, but not -308, in mother-infant pairsJosephine H Amory
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
Am J Obstet Gynecol 191:1362-7. 2004..TNF-alpha genotypes were tested for association with adverse outcomes in mother-infant pairs with preterm labor... - Cord blood lipids in infants born to HIV-1-infected women treated with combination antiretroviral therapyAnn J Melvin
Department of Pediatrics, University of Washington, Seattle, WA, USA
Antivir Ther 13:349-55. 2008.... - Contemporary management of preterm premature rupture of membranes: determinants of latency and neonatal outcomeSameer Gopalani
Departments of Obstetrics, Gynecology, and Reproductive of Sciences, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Perinatol 21:183-90. 2004..001), and amniotic fluid index ( p = 0.02) were independently predictive of latency. Histopathologic funisitis increased with pregnancy length. There were no fetal deaths or significant intraventricular hemorrhage past 28 weeks... - Identification and sequencing of bacterial rDNAs in culture-negative amniotic fluid from women in premature laborCarolyn Gardella
Department of Obstetrics and Gynecology, University of Washington, and VA Medical Center, Seattle, Washington 98195, USA
Am J Perinatol 21:319-23. 2004.... - Increasing rates of preterm twin births coincide with improving twin pair survivalRebecca S Hartley
Department of Biology, Seattle University, Seattle, WA 98122, USA
J Perinat Med 38:297-303. 2010..To examine trends in twin gestational age over time, with adjustment for potential confounding factors, and to assess twin pair mortality and respiratory support over time... - P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational agesAnita A Mathias
Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
Am J Physiol Regul Integr Comp Physiol 289:R963-9. 2005..The placental P-gp expression appears to be upregulated in early pregnancy to protect the fetus from xenobiotic toxicity at a time when it is most vulnerable to such toxicity... - Birth order and delivery interval: analysis of twin pair perinatal outcomesRebecca S Hartley
Biology Department, Seattle University, Seattle, Washington 98122, USA
J Matern Fetal Neonatal Med 17:375-80. 2005..To determine whether second-born twins (B) have higher morbidity and mortality than first-born twins (A), using a paired analysis... - Increasing rates of sex-discordant twins no longer correspond to decreasing perinatal mortality ratesRebecca S Hartley
Department of Biology, Seattle University, Seattle, WA 98122, USA
J Perinat Med 36:228-34. 2008..To analyze dizygotic twinning rates and outcomes over a 25-year period... - Antiretroviral pharmacokinetic profile: a review of sex differencesIghovwerha Ofotokun
Department of Internal Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30303, USA
Gend Med 4:106-19. 2007..Although the mechanisms of sex-related antiretroviral pharmacodynamic differences remain poorly understood and may be multifactorial, they appear to be mediated through a common pathway of pharmacokinetic variability between the sexes...
Research Grants
- Mechanisms for Racial Disparity in Preterm BirthJane Hitti; Fiscal Year: 2006....