Jane E Hitti

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Effects of pregnancy and bacterial vaginosis on proinflammatory cytokine and secretory leukocyte protease inhibitor concentrations in vaginal secretions
    Jennifer Balkus
    Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA
    J Pregnancy 2010:385981. 2010
  2. pmc Detection of hydrogen peroxide-producing Lactobacillus species in the vagina: a comparison of culture and quantitative PCR among HIV-1 seropositive women
    Jennifer E Balkus
    Department of Epidemiology, University of Washington, Box 359909, 325 9th Avenue, Seattle, WA 98104, USA
    BMC Infect Dis 12:188. 2012
  3. pmc The vaginal microflora in relation to gingivitis
    Rutger Persson
    Department of Periodontology, Div of Oral Microbiology, University of Berne, Berne, Switzerland
    BMC Infect Dis 9:6. 2009
  4. ncbi request reprint Racial disparity in risk of preterm birth associated with lower genital tract infection
    Jane Hitti
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
    Paediatr Perinat Epidemiol 21:330-7. 2007
  5. ncbi request reprint Correlates of cervical Mycoplasma genitalium and risk of preterm birth among Peruvian women
    Jane Hitti
    Department of Obstetrics Gynecology, University of Washington Medical Center, Box 356460, Seattle, WA 98195, USA
    Sex Transm Dis 37:81-5. 2010
  6. ncbi request reprint Vaginal indicators of amniotic fluid infection in preterm labor
    J Hitti
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh Magee Womens Research Institute, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol 97:211-9. 2001
  7. ncbi request reprint Maternal toxicity with continuous nevirapine in pregnancy: results from PACTG 1022
    Jane Hitti
    University of Washington, Seattle, 98195, USA
    J Acquir Immune Defic Syndr 36:772-6. 2004
  8. ncbi request reprint Amniotic fluid infection, cytokines, and adverse outcome among infants at 34 weeks' gestation or less
    J Hitti
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
    Obstet Gynecol 98:1080-8. 2001
  9. ncbi request reprint Inadequate prenatal care and risk of preterm delivery among adolescents: a retrospective study over 10 years
    Katherine E Debiec
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA
    Am J Obstet Gynecol 203:122.e1-6. 2010
  10. doi request reprint Partner- and partnership-related risk factors for preterm birth among low-income women in Lima, Peru
    Kathleen Paul
    Department of Obstetrics and Gynecology, University of Washington, Seattle, USA
    Soc Sci Med 68:1535-40. 2009

Research Grants

Collaborators

Detail Information

Publications39

  1. pmc Effects of pregnancy and bacterial vaginosis on proinflammatory cytokine and secretory leukocyte protease inhibitor concentrations in vaginal secretions
    Jennifer Balkus
    Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA
    J Pregnancy 2010:385981. 2010
    ..Pregnancy and BV were both independently associated with increased vaginal concentrations of IL-1β and IL-8; pregnant women had increased concentrations of SLPI, while women with BV had decreased SLPI concentrations...
  2. pmc Detection of hydrogen peroxide-producing Lactobacillus species in the vagina: a comparison of culture and quantitative PCR among HIV-1 seropositive women
    Jennifer E Balkus
    Department of Epidemiology, University of Washington, Box 359909, 325 9th Avenue, Seattle, WA 98104, USA
    BMC Infect Dis 12:188. 2012
    ..We assessed the concordance of H(2)O(2)-producing Lactobacillus detected by culture with quantitative PCR (qPCR) detection of Lactobacillus species commonly assumed to be H(2)O(2)-producers...
  3. pmc The vaginal microflora in relation to gingivitis
    Rutger Persson
    Department of Periodontology, Div of Oral Microbiology, University of Berne, Berne, Switzerland
    BMC Infect Dis 9:6. 2009
    ..Gingivitis has been linked to adverse pregnancy outcome (APO). Bacterial vaginosis (BV) has been associated with APO. We assessed if bacterial counts in BV is associated with gingivitis suggesting a systemic infectious susceptibilty...
  4. ncbi request reprint Racial disparity in risk of preterm birth associated with lower genital tract infection
    Jane Hitti
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
    Paediatr Perinat Epidemiol 21:330-7. 2007
    ....
  5. ncbi request reprint Correlates of cervical Mycoplasma genitalium and risk of preterm birth among Peruvian women
    Jane Hitti
    Department of Obstetrics Gynecology, University of Washington Medical Center, Box 356460, Seattle, WA 98195, USA
    Sex Transm Dis 37:81-5. 2010
    ..We investigated associations between cervical M genitalium, demographic and behavioral risk factors for sexually transmitted infection and preterm birth among low-income Peruvian women...
  6. ncbi request reprint Vaginal indicators of amniotic fluid infection in preterm labor
    J Hitti
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh Magee Womens Research Institute, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol 97:211-9. 2001
    ..To determine whether vaginal interleukin-6, interleukin-8, neutrophils, bacterial vaginosis, and selected vaginal bacteria are predictors of amniotic fluid (AF) infection among women in preterm labor...
  7. ncbi request reprint Maternal toxicity with continuous nevirapine in pregnancy: results from PACTG 1022
    Jane Hitti
    University of Washington, Seattle, 98195, USA
    J Acquir Immune Defic Syndr 36:772-6. 2004
    ..To compare the safety of nelfinavir and nevirapine-based antiretroviral treatment in HIV-1-infected pregnant women...
  8. ncbi request reprint Amniotic fluid infection, cytokines, and adverse outcome among infants at 34 weeks' gestation or less
    J Hitti
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
    Obstet Gynecol 98:1080-8. 2001
    ..We examined the hypothesis that amniotic fluid (AF) infection and elevated cytokine concentrations may cause neonatal injury beyond that expected solely from prematurity...
  9. ncbi request reprint Inadequate prenatal care and risk of preterm delivery among adolescents: a retrospective study over 10 years
    Katherine E Debiec
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA
    Am J Obstet Gynecol 203:122.e1-6. 2010
    ..The aim of this study was to determine whether inadequate prenatal care is associated with increased risk of preterm birth among adolescents...
  10. doi request reprint Partner- and partnership-related risk factors for preterm birth among low-income women in Lima, Peru
    Kathleen Paul
    Department of Obstetrics and Gynecology, University of Washington, Seattle, USA
    Soc Sci Med 68:1535-40. 2009
    ..Further research could clarify the specific mechanisms through which these partner and partnership characteristics may increase the risk of preterm birth...
  11. doi request reprint Bacterial vaginosis, not HIV, is primarily responsible for increased vaginal concentrations of proinflammatory cytokines
    Caroline M Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
    AIDS Res Hum Retroviruses 24:667-71. 2008
    ..005). Neither HIV nor BV was associated with changes in IL-6 or IL-8. HIV does not have a major impact on vaginal concentrations of proinflammatory cytokines when controlling for the presence of bacterial vaginosis...
  12. pmc Adherence to antiretrovirals among US women during and after pregnancy
    Arlene D Bardeguez
    Department of Obstetrics, Gynecology and Women s Health, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103 1709, USA
    J Acquir Immune Defic Syndr 48:408-17. 2008
    ..Antiretrovirals (ARVs) are recommended for maternal health and to reduce HIV-1 mother-to-child transmission, but suboptimal adherence can counteract its benefits...
  13. pmc Comparison of oral and vaginal metronidazole for treatment of bacterial vaginosis in pregnancy: impact on fastidious bacteria
    Caroline M Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    BMC Infect Dis 9:89. 2009
    ..Both oral and intravaginal metronidazole can be used to treat bacterial vaginosis in pregnancy, but little is known about the impact of different routes of antibiotic administration on concentrations of fastidious vaginal bacteria...
  14. pmc Generation C: prevalence of and risk factors for chlamydia trachomatis among adolescents and young women in Lima, Peru
    Kathleen J Paul
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
    J Womens Health (Larchmt) 18:1419-24. 2009
    ..We assessed associations of Chlamydia trachomatis (CT) infection with both traditional STI risk factors, and partner and partnership-related factors among low-income women in Lima, Peru, by age group...
  15. pmc Effect of semen on vaginal fluid cytokines and secretory leukocyte protease inhibitor
    Kathy J Agnew
    Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific Street, Box 356460, Seattle, WA 98195, USA
    Infect Dis Obstet Gynecol 2008:820845. 2008
    ..The presence of semen in vaginal fluid, as identified by an acid phosphatase spot test, does not influence vaginal proinflammatory cytokine concentrations...
  16. pmc Compartmentalization of HIV-1 within the female genital tract is due to monotypic and low-diversity variants not distinct viral populations
    Marta Bull
    Seattle Children s Hospital Research Institute, Seattle, Washington, USA
    PLoS ONE 4:e7122. 2009
    ....
  17. pmc Changes in the vaginal microenvironment with metronidazole treatment for bacterial vaginosis in early pregnancy
    Caroline Mitchell
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
    J Womens Health (Larchmt) 18:1817-24. 2009
    ..We examined whether oral or vaginal metronidazole treatment for BV in early pregnancy was more effective in restoring the normal vaginal environment...
  18. pmc Estimating volume of cervicovaginal secretions in cervicovaginal lavage fluid collected for measurement of genital HIV-1 RNA levels in women
    Caroline Mitchell
    University of Washington, Department of Obstetrics and Gynecology, Harborview Medical Center, 325 9th Ave, Box 359865, Seattle, WA 98104, USA
    J Clin Microbiol 49:735-6. 2011
    ..Thirty-eight women provided 275 cervicovaginal specimens. The estimated median volume of cervicovaginal fluid was 0.51 ml (interquartile range, 0.33, 0.69)...
  19. ncbi request reprint Racial disparity in bacterial vaginosis: the role of socioeconomic status, psychosocial stress, and neighborhood characteristics, and possible implications for preterm birth
    Kathleen Paul
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    Soc Sci Med 67:824-33. 2008
    ..These results suggest that both the effects of individual- and neighborhood-level risk factors for BV may differ importantly by racial group, and stressful life events may have physiological effects independent of perceived stress...
  20. ncbi request reprint Increased tumor necrosis factor-alpha in whole blood during the luteal phase of ovulatory cycles
    Josephine H Amory
    Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA
    J Reprod Med 49:678-82. 2004
    ..To evaluate whether the fact that blood from premenopausal, ovulatory women shows a significant fluctuation in tumor necrosis factor-alpha (TNF-alpha) levels when tested randomly over time is related to the hormonal cycle...
  21. ncbi request reprint The relationship between racial identity, income, stress and C-reactive protein among parous women: implications for preterm birth disparity research
    Kathleen Paul
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    J Natl Med Assoc 100:540-6. 2008
    ..Objective life event stressors may be important to consider in future studies investigating a potential inflammatory etiology for preterm birth...
  22. ncbi request reprint Increased risk of adverse pregnancy outcome among Somali immigrants in Washington state
    E Blair Johnson
    Department of Obstetrics and Gynecology, University of Washington Medical Center, Harborview Medical Center, Seattle, USA
    Am J Obstet Gynecol 193:475-82. 2005
    ..The purpose of this study was to compare maternal and neonatal morbidity among Somali immigrants, US-born blacks and whites in Washington state...
  23. pmc A case report of dengue virus infection and acalculous cholecystitis in a pregnant returning traveler
    William R Berrington
    Department of Medicine, Division of Allergy and Infectious Disease, University of Washington, Seattle, WA 98195, USA
    Travel Med Infect Dis 5:251-3. 2007
    ..Travel during pregnancy to dengue-endemic areas poses a risk to both mother and fetus. Pregnancies complicated by dengue infection require close monitoring for potential maternal and fetal complications...
  24. ncbi request reprint Infectious correlates of HIV-1 shedding in the female upper and lower genital tracts
    Jenell S Coleman
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94105, USA
    AIDS 21:755-9. 2007
    ..To determine the effects of vaginal, cervical, and endometrial infections on shedding of HIV-1 RNA in the female genital tract...
  25. ncbi request reprint HIV type 1 zidovudine (ZDV) resistance in blood and uterine cervical secretions of pregnant women
    Lisa M Frenkel
    University of Washington, Seattle, Washington 98109, Children s Hospital and Medical Center of Seattle, Seattle, Washington 98105, USA
    AIDS Res Hum Retroviruses 22:870-3. 2006
    ..However, in only 1 (1.8%) of 57 pregnancies evaluated was resistant virus limited to the cervical secretions. ZDV-resistant virus is rarely limited to the female genital tract...
  26. ncbi request reprint Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084
    Jane Hitti
    University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 196:331.e1-7. 2007
    ..The objective of the study was to determine whether protease inhibitors increase glucose intolerance and insulin resistance in pregnancy...
  27. doi request reprint Agricultural-related chemical exposures, season of conception, and risk of gastroschisis in Washington State
    Sarah A Waller
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, 1959 NE Pacific St, Box 356460, Seattle, WA 98195, USA
    Am J Obstet Gynecol 202:241.e1-6. 2010
    ..We sought to determine if periconceptional exposure to agrichemicals was associated with the development of gastroschisis...
  28. pmc Monotypic human immunodeficiency virus type 1 genotypes across the uterine cervix and in blood suggest proliferation of cells with provirus
    Marta E Bull
    Seattle Children s Hospital Research Institute, University of Washington, Seattle, Washington 98101 1304, USA
    J Virol 83:6020-8. 2009
    ..Further studies are warranted to investigate mechanisms producing monotypic viruses across tissues and, importantly, to determine whether the proliferation of cells with provirus sustain HIV-1 persistence in spite of effective ART...
  29. pmc Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluid
    Jane Hitti
    Department of Obstetrics Gynecology, University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 203:32.e1-8. 2010
    ..We analyzed the vaginal fluid proteome to identify biomarkers of intraamniotic infection among women in preterm labor...
  30. ncbi request reprint Adverse outcomes after preterm labor are associated with tumor necrosis factor-alpha polymorphism -863, but not -308, in mother-infant pairs
    Josephine H Amory
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 191:1362-7. 2004
    ..TNF-alpha genotypes were tested for association with adverse outcomes in mother-infant pairs with preterm labor...
  31. ncbi request reprint Cord blood lipids in infants born to HIV-1-infected women treated with combination antiretroviral therapy
    Ann J Melvin
    Department of Pediatrics, University of Washington, Seattle, WA, USA
    Antivir Ther 13:349-55. 2008
    ....
  32. pmc Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses but genital lineages do not persist over time
    Marta E Bull
    Department of Pediatrics University of Washington, Seattle, WA 98101, USA
    J Infect Dis 207:1206-15. 2013
    ....
  33. doi request reprint Increasing rates of preterm twin births coincide with improving twin pair survival
    Rebecca S Hartley
    Department of Biology, Seattle University, Seattle, WA 98122, USA
    J Perinat Med 38:297-303. 2010
    ..To examine trends in twin gestational age over time, with adjustment for potential confounding factors, and to assess twin pair mortality and respiratory support over time...
  34. ncbi request reprint Identification and sequencing of bacterial rDNAs in culture-negative amniotic fluid from women in premature labor
    Carolyn Gardella
    Department of Obstetrics and Gynecology, University of Washington, and VA Medical Center, Seattle, Washington 98195, USA
    Am J Perinatol 21:319-23. 2004
    ....
  35. ncbi request reprint Contemporary management of preterm premature rupture of membranes: determinants of latency and neonatal outcome
    Sameer Gopalani
    Departments of Obstetrics, Gynecology, and Reproductive of Sciences, Magee Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Perinatol 21:183-90. 2004
    ..001), and amniotic fluid index ( p = 0.02) were independently predictive of latency. Histopathologic funisitis increased with pregnancy length. There were no fetal deaths or significant intraventricular hemorrhage past 28 weeks...
  36. ncbi request reprint P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages
    Anita A Mathias
    Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
    Am J Physiol Regul Integr Comp Physiol 289:R963-9. 2005
    ..The placental P-gp expression appears to be upregulated in early pregnancy to protect the fetus from xenobiotic toxicity at a time when it is most vulnerable to such toxicity...
  37. doi request reprint Increasing rates of sex-discordant twins no longer correspond to decreasing perinatal mortality rates
    Rebecca S Hartley
    Department of Biology, Seattle University, Seattle, WA 98122, USA
    J Perinat Med 36:228-34. 2008
    ..To analyze dizygotic twinning rates and outcomes over a 25-year period...
  38. ncbi request reprint Birth order and delivery interval: analysis of twin pair perinatal outcomes
    Rebecca S Hartley
    Biology Department, Seattle University, Seattle, Washington 98122, USA
    J Matern Fetal Neonatal Med 17:375-80. 2005
    ..To determine whether second-born twins (B) have higher morbidity and mortality than first-born twins (A), using a paired analysis...
  39. ncbi request reprint Antiretroviral pharmacokinetic profile: a review of sex differences
    Ighovwerha Ofotokun
    Department of Internal Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Gend Med 4:106-19. 2007
    ..Although the mechanisms of sex-related antiretroviral pharmacodynamic differences remain poorly understood and may be multifactorial, they appear to be mediated through a common pathway of pharmacokinetic variability between the sexes...

Research Grants6

  1. Mechanisms for Racial Disparity in Preterm Birth
    Jane Hitti; Fiscal Year: 2002
    ....
  2. Mechanisms for Racial Disparity in Preterm Birth
    Jane Hitti; Fiscal Year: 2003
    ....
  3. Mechanisms for Racial Disparity in Preterm Birth
    Jane Hitti; Fiscal Year: 2004
    ....
  4. Mechanisms for Racial Disparity in Preterm Birth
    Jane Hitti; Fiscal Year: 2006
    ....
  5. Mechanisms for Racial Disparity in Preterm Birth
    Jane Hitti; Fiscal Year: 2001
    ....