Research Topics
| R M HirschfeldSummaryAffiliation: University of Texas Medical Branch Country: USA Publications
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Detail Information
Publications
History and evolution of the monoamine hypothesis of depressionR M Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
J Clin Psychiatry 61:4-6. 2000....
The epidemiology of depression and the evolution of treatmentRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA
J Clin Psychiatry 73:5-9. 2012....- Defining the clinical course of bipolar disorder: response, remission, relapse, recurrence, and rougheningRobert Ma Hirschfeld
Psychiatry and Behavioral Sciences, The University of Texas Medical Branch, Galveston, TX, USA
Psychopharmacol Bull 40:7-14. 2007..This manuscript presents working definitions for key clinical course indicators for bipolar disorder, including response, remission, relapse, recurrence, and roughening... - A randomized, placebo-controlled, multicenter study of divalproex sodium extended-release in the acute treatment of maniaRobert M A Hirschfeld
The University of Texas Medical Branch, Department of Psychiatry, 301 University Blvd, Galveston, TX 77555, USA
J Clin Psychiatry 71:426-32. 2010..One study demonstrated statistically significant improvements in mania symptoms compared to placebo, while an earlier study did not. Results of the earlier study are presented here... - Perceptions and impact of bipolar disorder: how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorderRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555, USA
J Clin Psychiatry 64:161-74. 2003..To assess the experience of selected individuals living with bipolar disorder and compare this experience with that of a similar group of individuals sampled in 1992... - The efficacy of atypical antipsychotics in bipolar disordersRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, USA
J Clin Psychiatry 64:15-21. 2003.... - The safety and early efficacy of oral-loaded divalproex versus standard-titration divalproex, lithium, olanzapine, and placebo in the treatment of acute mania associated with bipolar disorderRobert M A Hirschfeld
University of Texas Medical Branch at Galveston, Galveston, USA
J Clin Psychiatry 64:841-6. 2003..The purpose of this study was to evaluate the early efficacy of oral-loaded divalproex... - Long-term side effects of SSRIs: sexual dysfunction and weight gainRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 1 302 Rebecca Sealy Building, 301 University Boulevard, Galveston, TX 77555 0188, USA
J Clin Psychiatry 64:20-4. 2003..Side effects that emerge or persist after 1 month of treatment include sexual dysfunction and weight gain. Although these adverse events are serious, they can be managed successfully if recognized early... - Newer antidepressants: review of efficacy and safety of escitalopram and duloxetineRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
J Clin Psychiatry 65:46-52. 2004..This article reviews the available controlled data on these agents with regard to efficacy, safety, and tolerability... - Bipolar depression: the real challengeRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 301 University Blvd, 1 302 Rebbecca Sealy, Galveston, TX 77555 0188, USA
Eur Neuropsychopharmacol 14:S83-8. 2004..These facts emphasise the importance of improving the diagnosis and treatment of bipolar depression... - Rapid antimanic effect of risperidone monotherapy: a 3-week multicenter, double-blind, placebo-controlled trialRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA
Am J Psychiatry 161:1057-65. 2004..This study evaluated the efficacy and safety of risperidone monotherapy in the treatment of acute bipolar mania... - A review of the evidence for carbamazepine and oxcarbazepine in the treatment of bipolar disorderRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch at Galveston, TX 77555 0188, USA
Int J Neuropsychopharmacol 7:507-22. 2004..This review presents a balanced selection of the key studies on carbamazepine and oxcarbazepine in bipolar disorder... - Quetiapine in the treatment of anxiety in patients with bipolar I or II depression: a secondary analysis from a randomized, double-blind, placebo-controlled studyRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, USA
J Clin Psychiatry 67:355-62. 2006..The analyses in this multicenter, double-blind, randomized, fixed-dose, placebo-controlled study evaluated effects of quetiapine monotherapy on anxiety symptoms in bipolar depression... - Time course of depression-symptom improvement during treatment with duloxetineRobert M A Hirschfeld
University of Texas Medical Branch, Galveston, TX 77555 0188, USA
Depress Anxiety 21:170-7. 2005..These results may help clinicians establish more accurate expectations regarding treatment with duloxetine... - An open-label extension trial of risperidone monotherapy in the treatment of bipolar I disorderRobert M A Hirschfeld
University of Texas Medical Branch at Galveston, Texas 77555, USA
Int Clin Psychopharmacol 21:11-20. 2006..Patients switched from placebo to risperidone improved markedly. Risperidone treatment did not induce depression... - Introduction: an overview of the issues surrounding the recognition and management of bipolar disorder and comorbid anxietyRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555-0188, USA
J Clin Psychiatry 67:3-4. 2006 - Screening for bipolar disorderRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 1 302 Rebecca Sealy, 301 University Blvd, Galveston, TX 77555 0188, USA
Am J Manag Care 13:S164-9. 2007..The most widely used screening tool is the Mood Disorder Questionnaire. This screening tool will be discussed in this article regarding its use in outpatient clinics and the community... - Screening for bipolar disorder in the communityRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, 77555 188, USA
J Clin Psychiatry 64:53-9. 2003..Our goal was to estimate the rate of positive screens for bipolar I and bipolar II disorders in the general population of the United States... - Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder QuestionnaireR M Hirschfeld
Department of Psychiatry and Behavioral Sciences, Medical Branch, the University of Texas at Galveston 77555 01888, USA
Am J Psychiatry 157:1873-5. 2000..This report describes the validation of a new brief self-report screening instrument for bipolar spectrum disorders called the Mood Disorder Questionnaire... - Validity of the mood disorder questionnaire: a general population studyRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 1 302 Rebecca Sealy, 301 University Blvd, Galveston, TX 77555 0188, USA
Am J Psychiatry 160:178-80. 2003..The Mood Disorder Questionnaire has been validated in a psychiatric outpatient study group... - Bipolar spectrum disorder: improving its recognition and diagnosisR M Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
J Clin Psychiatry 62:5-9. 2001..One way to increase recognition of bipolar spectrum disorder is to screen for it. A recently introduced screening instrument for bipolar spectrum disorder, the Mood Disorder Questionnaire, is described... - Clinical importance of long-term antidepressant treatmentR M Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch at Galveston, 1 302 Rebecca Sealy, 301 University Blvd, Galveston, TX 77555 0188, USA
Br J Psychiatry Suppl 42:S4-8. 2001..Depression, which only a few decades ago was considered to be a short-term illness requiring short-term treatment, is now recognised as a recurrent, sometimes chronic, long-term illness... - Partial response and nonresponse to antidepressant therapy: current approaches and treatment optionsRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
J Clin Psychiatry 63:826-37. 2002..Switching to an agent of a different class is probably optimal for those patients who fail to respond to first-line therapy... - The use of mirtazapine in difficult-to-treat patient populationsRobert M A Hirschfeld
University of Texas, Galveston, Texas, USA
Hum Psychopharmacol 17:S33-6. 2002..Mirtazapine has also proved effective in elderly depressed patients and again showed a faster onset of action than another of the SSRIs, paroxetine... - A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study GroupC L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78284 7792, USA
Arch Gen Psychiatry 57:481-9. 2000..This study compared the efficacy of divalproex, lithium, and placebo as prophylactic therapy... - Effect of concurrent anxiety on response to sertraline and imipramine in patients with chronic depressionJ M Russell
University of Texas Medical Branch at Galveston, 301 University Boulevard, Department of Psychiatry and Behavioral Sciences, Route 0197, Galveston, TX 77555, USA
Depress Anxiety 13:18-27. 2001..High baseline levels of anxiety did not reduce overall antidepressant response but did somewhat delay the onset of response to sertraline or imipramine in patients with chronic depression... - Maintenance efficacy of divalproex in the prevention of bipolar depressionLaszlo Gyulai
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 28:1374-82. 2003.... - The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorderTrisha Suppes
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9121, USA
J Clin Psychiatry 66:870-86. 2005..The guidelines for evaluating possible medications, the criteria for selection and ranking, and the updated algorithms are described... 
Bipolar disorder with frequent mood episodes in the national comorbidity survey replication (NCS-R)A A Nierenberg
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Mol Psychiatry 15:1075-87. 2010..Whether these indicators of severity merely reflect attenuated effects of rapid cycling or independent effects of sub-threshold rapid cycling warrants further study given the high proportion of lifetime cases who met criteria for FME...- Citalopram as adjunctive therapy in bipolar depressionD J Kupfer
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
J Clin Psychiatry 62:985-90. 2001..The treatment of bipolar depression remains a major clinical challenge. The effectiveness and safety of adjunctive citalopram were evaluated in DSM-IV-diagnosed bipolar depressed patients in a 5-site study... - Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, psychotherapy, and their combinationJohn Zajecka
Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, 1725 W. Harrison Street, Suite 955, Chicago, IL 60612, USA
J Clin Psychiatry 63:709-16. 2002..Treatment with nefazodone, CBASP, and combined treatment improved sexual interest/satisfaction, with greatest improvement observed with combined treatment... - Intravenous antidepressants: a reviewNidal J Moukaddam
University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA
Depress Anxiety 19:1-9. 2004..v. over p.o.administration but there are suggestions of a faster onset of action. In one study i.v. citalopram showed superior response rates over p.o. citalopram (79% vs. 63%) in severely depressed patients at 8 weeks... - Validation of the Mood Disorder Questionnaire for bipolar disorders in adolescentsKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
J Clin Psychiatry 67:827-30. 2006.... - Impact of bipolar disorder on a U.S. community sampleJoseph R Calabrese
Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
J Clin Psychiatry 64:425-32. 2003..Bipolar symptoms have been associated with significant functional impairment. We conducted a study to determine the psychosocial impact of bipolar disorder in a U.S. community sample... - Screening for bipolar disorder in patients treated for depression in a family medicine clinicRobert M A Hirschfeld
Department of Psychiatry, University of Texas Medical Branch at Galveston, TX 77555 0188, USA
J Am Board Fam Pract 18:233-9. 2005..The prevalence of bipolar disorder in patients being treated for depression with antidepressants in a family medicine clinic was investigated in this study... - Predictors of bipolar disorder risk among patients currently treated for major depressionJoseph R Calabrese
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
MedGenMed 8:38. 2006..PATIENTS, DESIGN, AND SETTING: Psychiatrists from community and private practice settings sequentially selected patients with unipolar depression who exhibited nonresponse to at least 1 antidepressant (AD) trial... - Recognition and diagnosis of bipolar disorderRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77550-0188, USA
J Clin Psychiatry 65:5-9. 2004..The rate of recognition may be improved by asking patients about bipolar symptoms and by screening for bipolar disorder using the Mood Disorder Questionnaire... - Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT StudyJames H Kocsis
Department of Psychiatry, Weill Cornell Medical College, New York, NY 10012, USA
J Clin Psychiatry 68:1014-23. 2007..To test the long-term efficacy and safety of venlafaxine extended-release (ER) in preventing recurrence in patients with major depression... - Chronic depression and comorbid personality disorders: response to sertraline versus imipramineJames M Russell
Department of Psychiatry and Behavioral Sciences, The University of Texas Medical Branch at Galveston, 77555, USA
J Clin Psychiatry 64:554-61. 2003..Few studies, though, have systematically examined the clinical correlates of Axis II personality disorder comorbidity or its effect on treatment response or time to response... - Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depressionAlan J Gelenberg
Department of Psychiatry, Health Sciences Center, University of Arizona, PO Box 245002, Tucson, AZ 85724-5002, USA
Biol Psychiatry 54:806-17. 2003..8%). Somnolence was significantly greater among the patients taking active medication (15.4%), compared with placebo (4.6%). CONCLUSIONS: Nefazodone is well-tolerated and is an effective maintenance therapy for chronic forms of MDD... - Double-blind switch study of imipramine or sertraline treatment of antidepressant-resistant chronic depressionMichael E Thase
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 59:233-9. 2002..Although various strategies have been proposed to treat antidepressant nonresponders, little controlled research has been published that examines prospectively the use of switching to an alternate antidepressant... - Screening for bipolar disorder in a county jail at the time of criminal arrestDavid E Kemp
Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA
J Psychiatr Res 42:778-86. 2008..This study assessed the operating characteristics of the mood disorder questionnaire (MDQ) among offenders arrested and detained at a county jail... - New developments in the neurobiological basis of anxiety disordersJack M Gorman
Department of Psychiatry, Columbia University, New York, New York 10032, USA
Psychopharmacol Bull 36:49-67. 2002.... - Bipolar disorder: quality of life and the impact of atypical antipsychoticsLana A Vornik
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Calveston, Texas, USA
Am J Manag Care 11:S275-80. 2005..Among atypical antipsychotics, olanzapine has been studied most with regard to quality of life. In general, symptomatic improvements have been associated with improvements in quality of life... - A randomized, double-blind, active-control study of sertraline versus venlafaxine XR in major depressive disorderRichard C Shelton
Department of Psychiatry, Vanderbilt University Medical Center, Nashville, Tenn, USA
J Clin Psychiatry 67:1674-81. 2006..The objective of the current multisite study was to compare relatively higher doses of sertraline (i.e., 150 mg/day) and venlafaxine extended release (XR) (225 mg/day) in outpatients with major depressive disorder... - Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combinationRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555 0188, USA
Biol Psychiatry 51:123-33. 2002..This study compared efficacy of nefazodone, psychotherapy, and their combination in improving psychosocial functioning in chronically depressed outpatients... - Bipolar disorder--costs and comorbidityRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, USA
Am J Manag Care 11:S85-90. 2005..In addition, bipolar disorder has been associated with a variety of general medical conditions, which further complicate management of the psychiatric disorder... - Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force ReportS Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
Bipolar Disord 10:117-28. 2008.... - Diagnostic guidelines for bipolar depression: a probabilistic approachPhilip B Mitchell
School of Psychiatry, University of New South Wales, Sydney, Australia
Bipolar Disord 10:144-52. 2008..There are currently no accepted diagnostic criteria for bipolar depression for either research or clinical purposes. This paper aimed to develop recommendations for diagnostic criteria for bipolar I depression... - Long-term treatment strategies in anxiety disordersChrister Allgulander
Karolinska Institute, Neurotec Department, Huddinge University Hospital, Stockholm
Psychopharmacol Bull 36:79-92. 2002.... - Report of the Texas Consensus Conference Panel on medication treatment of bipolar disorder 2000Trisha Suppes
Department of Psychiatry The University of Texas Southwestern Medical Center Dallas, 75390 9070, USA
J Clin Psychiatry 63:288-99. 2002.... - Can we distinguish anxiety from depression?David S Baldwin
Department of Psychiatry, University of Southampton, Hampshire, United Kingdom
Psychopharmacol Bull 36:158-65. 2002..There is still uncertainty regarding the neurobiological cause, but it is probably linked to dysregulation in the serotonergic and noradrenergic systems... - The effectiveness of St. John's Wort in major depressive disorder: a naturalistic phase 2 follow-up in which nonresponders were provided alternate medicationAlan J Gelenberg
University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
J Clin Psychiatry 65:1114-9. 2004..A continuation study of an extract of St. John's wort (Hypericum perforatum) for depression was performed in follow-up to an acute study that found no significant difference between St. John's wort extract and placebo... - Impact of depressive symptoms compared with manic symptoms in bipolar disorder: results of a U.S. community-based sampleJoseph R Calabrese
University Hospitals of Cleveland Case Western Reserve School of Medicine, Cleveland, Ohio, USA
J Clin Psychiatry 65:1499-504. 2004..In the present study, we assessed the functional impact of depressive versus manic symptoms in bipolar disorder... - Prevalence of bipolar symptoms in epilepsy vs other chronic health disordersAlan B Ettinger
Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
Neurology 65:535-40. 2005..To estimate the comparative prevalence of bipolar symptoms in respondents with epilepsy vs other chronic medical conditions... - Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replicationKathleen R Merikangas
Intramural Research Program, Section on Developmental Genetic Epidemiology, National Institute of Mental Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 64:543-52. 2007..There is growing recognition that bipolar disorder (BPD) has a spectrum of expression that is substantially more common than the 1% BP-I prevalence traditionally found in population surveys... - Use of health care services among persons who screen positive for bipolar disorderMark A Frye
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, California 90095, USA
Psychiatr Serv 56:1529-33. 2005..This study examined patterns of diagnosis, consultation, and treatment of persons who screened positive for bipolar disorder... - The distinct temperament profiles of bipolar I, bipolar II and unipolar patientsHagop S Akiskal
National Institute of Mental Health Collaborative Program on the Psychobiology of Depression, Clinical Studies, Rockville, MD, USA
J Affect Disord 92:19-33. 2006.... - Antidepressants for bipolar depressionRobert M A Hirschfeld
Am J Psychiatry 162:1546-7; author reply 1547-8. 2005 - Atypical antipsychotics in the treatment of mania: a meta-analysis of randomized, placebo-controlled trialsRoy H Perlis
Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 67:509-16. 2006..However, there are no published comparisons of individual atypical antipsychotics for mania... - Reassessing carbamazepine in the treatment of bipolar disorder: clinical implications of new dataHagop S Akiskal
University of California, San Diego, USA
CNS Spectr 10:suppl 1-11; discuss 12-3; quiz 14-5. 2005..Further efforts are needed to update physicians on the use of carbamazepine relative to other medications in the treatment of bipolar disorder... - Validity of the assessment of bipolar spectrum disorders in the WHO CIDI 3.0Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
J Affect Disord 96:259-69. 2006..CIDI BPD screening scales were also evaluated... - Are depression and bipolar disorder the same illness?Robert M A Hirschfeld
Am J Psychiatry 162:1241-2. 2005 - Effectiveness and medical costs of divalproex versus lithium in the treatment of bipolar disorder: results of a naturalistic clinical trialDennis A Revicki
Center for Health Outcomes Research, MEDTAP International, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
J Affect Disord 86:183-93. 2005..The clinical, quality of life (QOL), and medical cost outcomes of treatment with divalproex were compared with lithium in patients with bipolar I disorder over 1 year... - The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the 2-year and combined maintenance phasesMartin B Keller
Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
J Clin Psychiatry 68:1246-56. 2007..To report second-year results from the 2-year maintenance phase of a long-term study to evaluate the efficacy and safety of venlafaxine extended release (ER) in preventing recurrence of depression...