Keli L Hippen

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
    Claudio G Brunstein
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA
    Blood 117:1061-70. 2011
  2. pmc Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes
    Keli L Hippen
    Department of Pediatrics, Division of Hematology Oncology and Blood and Marrow Transplantation, University of Minnesota, Minneapolis, 55455, USA
    Blood 119:619-28. 2012
  3. pmc Clinical perspectives for regulatory T cells in transplantation tolerance
    Keli L Hippen
    University of Minnesota Cancer Center, Division of Bone Marrow Transplantation, Minneapolis, MN, USA
    Semin Immunol 23:462-8. 2011
  4. pmc Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity
    Keli L Hippen
    Division of Bone Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Sci Transl Med 3:83ra41. 2011
  5. pmc Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease
    K L Hippen
    Department of Pediatrics, Division of Hematology Oncology and Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, MN, USA
    Am J Transplant 11:1148-57. 2011
  6. pmc Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells
    Keli L Hippen
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone, Blood and Marrow Transplantation, Minneapolis, USA
    Blood 112:2847-57. 2008
  7. ncbi Late immature B cells (IgMhighIgDneg) undergo a light chain receptor editing response to soluble self-antigen
    Lina E Tze
    Center for Immunology and Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 171:678-82. 2003
  8. ncbi B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements
    Brian R Schram
    Center for Immunology, Department of Medicine, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 180:4728-41. 2008
  9. ncbi In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance
    Keli L Hippen
    Departments of Medicine and Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 175:909-16. 2005
  10. pmc Visualization of the genesis and fate of isotype-switched B cells during a primary immune response
    Kathryn A Pape
    Department of Microbiology and Center for Immunology, University of Minnesota Medical School, MMC334, 420 Delaware St S E, Minneapolis, MN 55455, USA
    J Exp Med 197:1677-87. 2003

Collaborators

Detail Information

Publications14

  1. pmc Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
    Claudio G Brunstein
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA
    Blood 117:1061-70. 2011
    ..These results set the stage for a definitive study of UCB Treg to determine its potency in preventing allogeneic aGVHD. This study is registered at http://www.clinicaltrials.gov as NCT00602693...
  2. pmc Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes
    Keli L Hippen
    Department of Pediatrics, Division of Hematology Oncology and Blood and Marrow Transplantation, University of Minnesota, Minneapolis, 55455, USA
    Blood 119:619-28. 2012
    ..Based on these findings, anti-IL-21 mAb could be considered for GVHD prevention in the clinic...
  3. pmc Clinical perspectives for regulatory T cells in transplantation tolerance
    Keli L Hippen
    University of Minnesota Cancer Center, Division of Bone Marrow Transplantation, Minneapolis, MN, USA
    Semin Immunol 23:462-8. 2011
    ..This review will summarize the clinical trials conducted to date that have employed Tregs to prevent GVHD following HSCT and discuss recent advances in Treg cellular therapy...
  4. pmc Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity
    Keli L Hippen
    Division of Bone Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Sci Transl Med 3:83ra41. 2011
    ..The capability to efficiently produce donor cell banks of functional nT(regs) could transform the treatment of GVHD and autoimmunity by providing an off-the-shelf, cost-effective, and proven cellular therapy...
  5. pmc Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease
    K L Hippen
    Department of Pediatrics, Division of Hematology Oncology and Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, MN, USA
    Am J Transplant 11:1148-57. 2011
    ..Most importantly, Rapa/TGFß iTregs suppress disease in a xenogeneic model of GVHD. This study opens the door for iTreg cellular therapy for human diseases...
  6. pmc Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells
    Keli L Hippen
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone, Blood and Marrow Transplantation, Minneapolis, USA
    Blood 112:2847-57. 2008
    ..These data offer a novel approach for UCB Treg expansion using aAPCs, including those coexpressing OX40L or 4-1BBL...
  7. ncbi Late immature B cells (IgMhighIgDneg) undergo a light chain receptor editing response to soluble self-antigen
    Lina E Tze
    Center for Immunology and Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 171:678-82. 2003
    ..These studies suggest that the developmental window available for immature B cells to edit their Ig receptors, at least in response to certain soluble Ags, extends through the IgM(high) late immature B cell stage...
  8. ncbi B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements
    Brian R Schram
    Center for Immunology, Department of Medicine, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 180:4728-41. 2008
    ..These findings support a model whereby Ag-induced receptor editing is inhibited by BCR basal signaling on developing B cells; BCR down-regulation removes this basal signal, thereby initiating receptor editing...
  9. ncbi In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance
    Keli L Hippen
    Departments of Medicine and Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 175:909-16. 2005
    ..These data identify receptor editing as a major physiologic mechanism by which highly self-reactive B cells are tolerized to membrane and soluble self-Ags...
  10. pmc Visualization of the genesis and fate of isotype-switched B cells during a primary immune response
    Kathryn A Pape
    Department of Microbiology and Center for Immunology, University of Minnesota Medical School, MMC334, 420 Delaware St S E, Minneapolis, MN 55455, USA
    J Exp Med 197:1677-87. 2003
    ..Antigen-experienced IgM B cells were rarely found in GCs, indicating that these cells switched rapidly after entering GCs or did not persist in this environment...
  11. pmc Basal immunoglobulin signaling actively maintains developmental stage in immature B cells
    Lina E Tze
    Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    PLoS Biol 3:e82. 2005
    ..These studies identify a previously unappreciated level of plasticity in the B cell developmental program, and have important implications for our understanding of central tolerance mechanisms...
  12. pmc Immune regulatory cells in umbilical cord blood: T regulatory cells and mesenchymal stromal cells
    Jakub Tolar
    Blood and Marrow Transplant Program, Department of Pediatrics and Center for Translational Medicine, University of Minnesota, MMC 366, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Br J Haematol 147:200-6. 2009
    ..More recent studies have indicated that umbilical cord blood (UCB) is a rich source of both cell types. We will review the current data on UCB-derived Tregs and MSCs and their therapeutic implications...
  13. ncbi Attenuation of IL-7 receptor signaling is not required for allelic exclusion
    Wynette M Will
    Department of Laboratory Medicine and Pathology, The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 176:3350-5. 2006
    ..Thus, attenuation of IL-7R/STAT5 signaling is not required for allelic exclusion...
  14. ncbi Fatal acute lymphoblastic leukemia in mice transgenic for B cell-restricted bcl-xL and c-myc
    Penelope J Swanson
    Department of Medicine, Cancer Center, and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 172:6684-91. 2004
    ..Tumors in these animals target an early stage in B cell development characterized by the expression of both B lineage and stem cell genes...