Research Topics
| C H HinkinSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Verbal and spatial working memory performance among HIV-infected adultsCharles H Hinkin
Department of Psychiatry and Behavioral Sciences, UCLA School of Medicine, Los Angeles, CA 90024, USA
J Int Neuropsychol Soc 8:532-8. 2002..These findings implicate central executive dysfunction as a likely substrate and provide the basis for hypothesizing that decline in working memory may contribute to other HIV-associated neuropsychological deficits...
The Item-Specific Deficit Approach to evaluating verbal memory dysfunction: rationale, psychometrics, and applicationMatthew J Wright
Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
J Clin Exp Neuropsychol 31:790-802. 2009..Currently, the ISDA is intended for experimental use, although further research may support its utility for characterizing memory impairments in clinical assessments...- Neurocognition in individuals co-infected with HIV and hepatitis CCharles H Hinkin
David Geffen School of Medicine, University of California, Los Angeles, 760 Westwood Plaza, Room C8 747, Los Angeles, CA 90024, USA
J Addict Dis 27:11-7. 2008..Finally, we discuss implications of these findings and potential future directions for research in this area... - Medication adherence among HIV+ adults: effects of cognitive dysfunction and regimen complexityC H Hinkin
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA 90024, USA
Neurology 59:1944-50. 2002..e., at least 90 to 95% of doses taken), viral replication may ensue and drug-resistant strains of the virus may emerge... - Screening for drug and alcohol abuse among older adults using a modified version of the CAGEC H Hinkin
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA 90024, USA
Am J Addict 10:319-26. 2001..Given the ease of administration and sensitivity to both alcohol and drug abuse, these data suggest that the modified CAGE is well suited as a screening instrument for geriatric drug and alcohol abuse... - Neuropsychiatric aspects of HIV infection among older adultsC H Hinkin
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, 760 Westwood Plaza, Room C8 747, Los Angeles, CA 90024, USA
J Clin Epidemiol 54:S44-52. 2001.... - Medication adherence in HIV-infected adults: effect of patient age, cognitive status, and substance abuseCharles H Hinkin
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, and Psychology Service, VA Greater Los Angeles Health Care System, 90024, USA
AIDS 18:S19-25. 2004..To examine the predictors of antiretroviral adherence among HIV-infected adults, with a particular focus on advancing age, neuropsychological dysfunction, and substance abuse... - Methylphenidate improves HIV-1-associated cognitive slowingC H Hinkin
Department of Psychiatry and Behavioral Sciences, UCLA School of Medicine, Los Angeles 90024, USA
J Neuropsychiatry Clin Neurosci 13:248-54. 2001..However, results suggest clinicians should consider reserving the use of MPH for patients with more pronounced cognitive and affective deficits... - Drug use and medication adherence among HIV-1 infected individualsCharles H Hinkin
David Geffen School of Medicine, University of California at Los Angeles, 760 Westwood Plaza, Room C8 747, Los Angeles, CA 90024, USA
AIDS Behav 11:185-94. 2007..These data suggest that it is the acute effects of intoxication, rather than stable features that may be characteristic of the drug-using populace, which leads to difficulties with medication adherence... - Dual task performance in HIV-1 infectionC H Hinkin
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, CA 90024, USA
J Clin Exp Neuropsychol 22:16-24. 2000..These results suggest that HIV-1 infection leads to deficits in divided attention and the simultaneous processing of competing stimuli, deficits which have been linked to disruption of the anterior attentional system... - Computerized and traditional stroop task dysfunction in HIV-1 infectionC H Hinkin
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles UCLA School of Medicine and VA Los Angeles Health Care System, 90024, USA
Neuropsychology 13:306-16. 1999..These data suggest that HIV infection may result in deficient response inhibition, possibly secondary to frontostriatal dysfunction and dopaminergic alterations... - Depression predicts procedural but not episodic memory in HIV-1 infectionA D Kalechstein
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles Neuropsychiatric Institute and Hospital, USA
J Clin Exp Neuropsychol 20:529-35. 1998..These findings underscore the complex interplay between neuropsychiatric and neuropsychological symptomatology in HIV-1 infection... - Neuropsychiatric disturbance is associated with executive dysfunction in HIV-1 infectionS A Castellon
Department of Psychiatry, UCLA School of Medicine, USA
J Int Neuropsychol Soc 6:336-47. 2000..In HIV/AIDS, the disruption of frontal-subcortical circuits may be a common mechanism causing both executive dysfunction and NP disturbance... - Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: results of a randomized, double-blind, placebo-controlled investigationA M Llorente
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, 90024, USA
J Int Neuropsychol Soc 7:27-32. 2001..The results suggest that, although AZT may afford patients prophylactic benefits, protracted high-dose AZT treatment does not improve NP functioning in mildly symptomatic HIV-positive individuals... - Reciprocal prediction of medication adherence and neurocognition in HIV/AIDSMark L Ettenhofer
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, CA, USA
Neurology 74:1217-22. 2010..However, little is known about the predictive pathways linking medication adherence with cognitive ability... - Base rate of a WMS-R malingering index in a sample of non-compensation-seeking men infected with HIV-1D J Slick
UCLA Neuropsychiatric Institute and Hospital, Los Angeles, California, USA
Appl Neuropsychol 8:185-9. 2001..These findings suggest a cautious approach to application of the GMI-ACI Malingering Index, particularly among patients who obtain above-average GMI scores... - Apathy, depression, and cognitive performance in HIV-1 infectionS A Castellon
Department of Psychology, University of California Los Angeles 90024, USA
J Neuropsychiatry Clin Neurosci 10:320-9. 1998..Total BDI scores showed a less consistent relationship with neurocognitive performance, suggesting that somatic symptomatology is diagnostically ambiguous among HIV-infected subjects... - Pedophilia and temporal lobe disturbancesM F Mendez
Department of Neurology, University of California at Los Angeles, USA
J Neuropsychiatry Clin Neurosci 12:71-6. 2000..A predisposition to pedophilia may be unmasked by hypersexuality from brain disease. These observations have potential implications for all neurologically based paraphilias... - Aging, neurocognition, and medication adherence in HIV infectionMark L Ettenhofer
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Am J Geriatr Psychiatry 17:281-90. 2009..To evaluate the hypothesis that poor adherence to highly active antiretroviral treatment (HAART) would be more strongly related to cognitive impairment among older than among younger HIV-seropositive adults... - Age-associated predictors of medication adherence in HIV-positive adults: health beliefs, self-efficacy, and neurocognitive statusTerry R Barclay
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA
Health Psychol 26:40-9. 2007..In this study, a theoretical framework encompassing demographic characteristics, health beliefs/attitudes, treatment self-efficacy, and neurocognitive status was examined in relationship to highly active antiretroviral therapy adherence... - Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individualsMichael A Cole
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
J Int Neuropsychol Soc 13:549-54. 2007..Thus, these findings suggest that apathy and irritability, but not depression and anxiety, are likely associated with the effects of HIV on frontal-subcortical circuitry... - The generalizability of neurocognitive test/retest data derived from a nonclinical sample for detecting change among two HIV+ cohortsAndrew J Levine
Department of Neurology, National Neurological AIDS Bank, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
J Clin Exp Neuropsychol 29:669-78. 2007..Thus, the accuracy of the two methods examined for determining clinically significant change among HIV+ cohorts differs depending upon their similarity with the normative sample... - Neurocognitive functioning in HIV-1 infection: effects of cerebrovascular risk factors and ageJessica Foley
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095 8353, USA
Clin Neuropsychol 24:265-85. 2010..The cognitive impact of risk appears to be more pronounced in the absence of adequate pharmacological treatment... - Elements of attention in HIV-infected adults: evaluation of an existing modelAndrew J Levine
University of California, Los Angeles National Neurological AIDS Bank, Los Angeles, CA 90025, USA
J Clin Exp Neuropsychol 30:53-62. 2008..Suggestions for further research in this important area are discussed... - An exploratory study of long-term neurocognitive outcomes following recovery from opportunistic brain infections in HIV+ adultsAndrew J Levine
Los Angeles National Neurological AIDS Bank, University of California, Los Angeles, CA 90025, USA
J Clin Exp Neuropsychol 30:836-43. 2008.... - Adherence to antiretroviral medications in HIV: differences in data collected via self-report and electronic monitoringAndrew J Levine
Neuropsychiatric Institute, University of California, Los Angeles, CA, USA
Health Psychol 25:329-35. 2006..These findings lend support for using both EM and SR methods; however, study design (e.g., length) and other factors (e.g., cognitive status, cost) should be considered... - Components of depression in HIV-1 infection: their differential relationship to neurocognitive performanceSteven A Castellon
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA
J Clin Exp Neuropsychol 28:420-37. 2006..The association between disturbance in mood and motivation and neurocognitive compromise may suggest that each are sequelae of disease specific mechanisms... - The effect of recent stimulant use on sustained attention in HIV-infected adultsAndrew J Levine
University of California, Los Angeles, Neuropsychiatric Institute, USA
J Clin Exp Neuropsychol 28:29-42. 2006..The results indicate that recent stimulant use among HIV-infected adults adversely affects sustained attention... - Subcortical hyperintensities in Alzheimer's disease: associated clinical and metabolic findingsDavid L Sultzer
Departments of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, USA
J Neuropsychiatry Clin Neurosci 14:262-9. 2002..These preliminary findings indicate that subcortical MRI hyperintensities may play a role in the pathophysiology and clinical expression of Alzheimer's disease... - Stability of human immunodeficiency virus type 1 RNA in cerebrospinal fluid determined with the AMPLICOR HIV-1 MONITOR test, version 1.5 (ultrasensitive)Elyse J Singer
Department of Neurology, School of Medicine, University of California at Los Angeles, 11645 Wilshire Boulevard, Suite 770, Los Angeles, CA 90025, USA
J Clin Microbiol 40:3863-4. 2002..5 (ultrasensitive). While a statistically significant decrease from the baseline was observed at 24 h, but not at 6 or 12 h, and with one freeze-thaw cycle, all changes were within the range of intra-assay variability... - Reaction time slowing in adults with HIV: results of a meta-analysis using brinley plotsDavid J Hardy
University of California, Los Angeles, CA, USA
Brain Cogn 50:25-34. 2002..97 and.90 respectively), with slopes of 1.034 and 1.117 respectively. Only the slope for symptomatic HIV+ groups was significantly larger than b = 1.00, suggesting a modest generalized slowing of cognition in these adults... - Reaction time performance in adults with HIV/AIDSDavid J Hardy
Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA 90024, USA
J Clin Exp Neuropsychol 24:912-29. 2002..Given the demonstrated sensitivity of RT tasks to the neuropsychological effects of HIV infection, it is recommended that RT tasks be included whenever possible in the routine clinical evaluation of HIV-infected patients... - Perceptual span deficits in adults with HIVDavid J Hardy
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024, USA
J Int Neuropsychol Soc 10:135-40. 2004..The present results illustrate a new type of attentional deficit in HIV and show the impact of HIV on cognition at an earlier point in information processing than has been previously reported... - Variations in patterns of highly active antiretroviral therapy (HAART) adherenceAndrew J Levine
Neuropsychiatric Institute, University of California, Los Angeles, California 90024 1759, USA
AIDS Behav 9:355-62. 2005..The results of the current study indicate that distinct subgroups of adherers may exist, and suggest that interventions designed to improve adherence can be designed to accommodate this variability in behavior... 
Depression, cognition, and self-appraisal of functional abilities in HIV: an examination of subjective appraisal versus objective performanceApril D Thames
Semel Institute for Neuroscience and Human Behavior, School of Medicine, University of California Los Angeles, CA 90095, USA
Clin Neuropsychol 25:224-43. 2011..Together, these results suggest that over-reliance on self-reported functional status poses risk for error when diagnoses require documentation of both cognitive impairment and associated functional disability in everyday life...- Medication and finance management among HIV-infected adults: the impact of age and cognitionApril D Thames
UCLA School of Medicine, Los Angeles, CA 90024
J Clin Exp Neuropsychol 33:200-9. 2011.... - Executive dysfunction in Alzheimer's disease: association with neuropsychiatric symptoms and functional impairmentS T Chen
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, USA
J Neuropsychiatry Clin Neurosci 10:426-32. 1998..Executive skills deficits, neuropsychiatric symptoms, and functional disability may emerge from shared neurobiological mechanisms... - Aging and neuro-AIDS conditions and the changing spectrum of HIV-1-associated morbidity and mortalityK Goodkin
Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, 803 A, Miami, FL 33136, USA
J Clin Epidemiol 54:S35-43. 2001..Age associations with incidence of these disorders and with treatment foci are specified. Implications for future changes in management are discussed... - Interrater reliability of clinical ratings and neurocognitive diagnoses in HIVSteven Paul Woods
University of California, San Diego, CA 92103, USA
J Clin Exp Neuropsychol 26:759-78. 2004..Not surprisingly, most diagnostic disagreements concerned the etiology of impairments in persons with medical and neuropsychiatric risk factors in addition to HIV... - Emerging issues in the neuropsychology of HIV infectionJessica Foley
David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Room C8 747, Los Angeles, CA 90024, USA
Curr HIV/AIDS Rep 5:204-11. 2008.... - Sensation seeking and visual selective attention in adults with HIV/AIDSDavid J Hardy
Department of Psychology, Loyola Marymount University, Los Angeles, CA 90045, USA
AIDS Behav 12:930-4. 2008..Furthermore, sensation seeking differences might explain certain inconsistencies in the HIV neuropsychology literature... - Two-dimensional MR spectroscopy of minimal hepatic encephalopathy and neuropsychological correlates in vivoAparna Singhal
Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1721, USA
J Magn Reson Imaging 32:35-43. 2010.... - Risky decision making assessed with the gambling task in adults with HIVDavid J Hardy
Department of Psychology, Loyola Marymount University, and the VA Greater Los Angeles Health Care System, CA 90045 2659, USA
Neuropsychology 20:355-60. 2006..These findings indicate the usefulness of the gambling task as a laboratory tool to examine risky decision making and cognition in the HIV population... - Triple trouble: cognitive deficits from hepatitis C, HIV, and methamphetamineWilfred G van Gorp
Neurology 64:1328-9. 2005 - Neuropsychological aspects of coinfection with HIV and hepatitis C virusRobin C Hilsabeck
Psychology Service, South Texas Veterans Health Care System, San Antonio, TX 78229 4404, USA
Clin Infect Dis 41:S38-44. 2005..This review summarizes what is known about neuropsychological aspects of monoinfection with HIV and HCV, as well as coinfection, discusses implications of these findings, and suggests future directions for this research area... - Neuropsychological exploration of alleged mold neurotoxicityMatthew J Reinhard
University of California Los Angeles, Semel Institute of Neuroscience and Human Behavior, United States
Arch Clin Neuropsychol 22:533-43. 2007..A potential subgroup of cognitively impaired outliers within mold exposure litigants is explored. Limitations of self-reported and objective measurements for mold exposure and exploratory statistical methodology are discussed...
Research Grants
- Neurobehavioral Deficits in HIV/HCV Infection Pre/Post Anti-HCV TherapyCharles Hinkin; Fiscal Year: 2009..Of particular interest is how HIV co-infection affects response to treatment. ..
- COGNITIVE DEFICITS AND MEDICATION ADHERENCE IN HIV/AIDSCharles Hinkin; Fiscal Year: 2002..Increased understanding as to how neuropsychological dysfunction impacts on treatment adherence, particularly among older HIV+ patients, is of critical importance given the personal and public health consequences of non-adherence. ..
- Neurobehavioral Deficits in HIV/HCV Infection Pre/Post Anti-HCV TherapyCharles H Hinkin; Fiscal Year: 2010..Of particular interest is how HIV co-infection affects response to treatment. ..
- NEUROPSYCHOLOGY AIDS FELLOWSHIPCharles Hinkin; Fiscal Year: 2007....
- Predictors: Medication Adherence in HIV+ Cocaine AbusersCharles Hinkin; Fiscal Year: 2004..abstract_text> ..