Shawn D Hingtgen
Affiliation: University of North Carolina
Sheets K, Bagó J, Hingtgen S. Delivery of Cytotoxic Mesenchymal Stem Cells with Biodegradable Scaffolds for Treatment of Postoperative Brain Cancer. Methods Mol Biol. 2018;1831:49-58 pubmed publisher
..Here, we describe a method for the delivery of therapeutic MSCs on biodegradable fibrin scaffolds into the resection cavity to treat postoperative brain cancer. ..
Sheets K, Bagó J, Paulk I, Hingtgen S. Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds. J Vis Exp. 2018;: pubmed publisher
..While currently used for investigating stem cell mediated delivery of therapeutics, this protocol could be modified to investigate the impact of surgical resection on other GBM interventions. ..
BagÃ³ J, Sheets K, Hingtgen S. Neural stem cell therapy for cancer. Methods. 2016;99:37-43 pubmed publisher
..With the recent launch of new clinical trials, the potential to successfully manage cancer in human patients with cytotoxic NSC therapy is moving closer to becoming a reality. ..
BagÃ³ J, Pegna G, Okolie O, Hingtgen S. Fibrin matrices enhance the transplant and efficacy of cytotoxic stem cell therapy for post-surgical cancer. Biomaterials. 2016;84:42-53 pubmed publisher
..Fibrin-based SC therapy could represent a clinically compatible, viable treatment to suppress recurrence of post-surgical GBM and other lethal cancer types. ..
Bagó J, Pegna G, Okolie O, Mohiti Asli M, Loboa E, Hingtgen S. Electrospun nanofibrous scaffolds increase the efficacy of stem cell-mediated therapy of surgically resected glioblastoma. Biomaterials. 2016;90:116-25 pubmed publisher
..5 to 31 days in mice. These results suggest that nanofibrous-based SC therapies could be an innovative new approach to improve the outcomes of patients suffering from terminal brain cancer. ..
BagÃ³ J, Okolie O, Dumitru R, Ewend M, Parker J, Werff R, et al
. Tumor-homing cytotoxic human induced neural stem cells for cancer therapy. Sci Transl Med. 2017;9: pubmed publisher