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Genomes and GenesSpecies | Alan L HinderliterSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Assessing endothelial function as a risk factor for cardiovascular diseaseAlan L Hinderliter
Division of Cardiology, University of North Carolina, 130 Mason Farm Road, Chapel Hill, NC 27599 7075, USA
Curr Atheroscler Rep 5:506-13. 2003..Additional research is needed to define the impact of complex, long-term dietary patterns on the vascular endothelium...
Independent prognostic value of echocardiography and N-terminal pro-B-type natriuretic peptide in patients with heart failureAlan L Hinderliter
Division of Cardiology, University of North Carolina, Chapel Hill, NC 27559 7075, USA
Am Heart J 156:1191-5. 2008..Whether cardiac ultrasound and natriuretic peptides provide independent prognostic information is uncertain...
Ethnic differences in left ventricular structure: relations to hemodynamics and diurnal blood pressure variationAlan L Hinderliter
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Am J Hypertens 17:43-9. 2004....
The DASH diet and insulin sensitivityAlan L Hinderliter
Department of Medicine, Division of Cardiology, University of North Carolina, Chapel Hill, NC 27599 7075, USA
Curr Hypertens Rep 13:67-73. 2011....
Frequency and severity of tricuspid regurgitation determined by Doppler echocardiography in primary pulmonary hypertensionAlan L Hinderliter
Department of Medicine, University of North Carolina, CB 7075, Chapel Hill, NC 27599, USA
Am J Cardiol 91:1033-7, A9. 2003
Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertensionAlan Hinderliter
Department of Medicine, University of North Carolina, CB 7075, 338 Burnett Womack, Chapel Hill, NC 27599 7075, USA
Arch Intern Med 162:1333-9. 2002..Although lifestyle interventions are efficacious in lowering blood pressure, evidence that they have a beneficial effect on target organs has been lacking...
Changes in hemodynamics and left ventricular structure after menopauseAlan L Hinderliter
University of North Carolina, Chapel Hill, North Carolina 27599 7075, USA
Am J Cardiol 89:830-3. 2002..These results suggest that menopause is associated with hemodynamic changes and left ventricular remodeling, which may contribute to the enhanced cardiovascular risk observed in postmenopausal women...
Histories of sexual abuse are associated with differential effects of clonidine on autonomic function in women with premenstrual dysphoric disorderRobertas Bunevicius
Department of Psychiatry, University of North Carolina at Chapel Hill, CB# 7175, Medical Research Bldg A, Chapel Hill, NC 27599-7175, USA
Biol Psychol 69:281-96. 2005....
Lifestyle modifications to lower or control high blood pressure: is advice associated with action? The behavioral risk factor surveillance surveyAnthony J Viera
Department of Family Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7595, USA
J Clin Hypertens (Greenwich) 10:105-11. 2008..62; 95% confidence interval [CI], 1.56-1.67), reduce salt (PR, 1.53; 95% CI, 1.48-1.58), exercise (PR, 1.41; 95% CI, 1.36-1.47), and reduce alcohol consumption (PR, 1.78; 95% CI, 1.70-1.87)...
Nighttime blood pressure dipping in young adults and coronary artery calcium 10-15 years later: the coronary artery risk development in young adults studyAnthony J Viera
Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Hypertension 59:1157-63. 2012..001 for quadratic term). Both failure of systolic BP to dip sufficiently and "overdipping" during nighttime may be associated with future subclinical coronary atherosclerosis...
Echocardiographic predictors of adverse outcomes in primary pulmonary hypertensionRonald J Raymond
University of North Carolina, Chapel Hill, North Carolina 27599-7075, USA
J Am Coll Cardiol 39:1214-9. 2002..These characteristics may help identify patients appropriate for more intensive medical therapy or earlier transplantation...
Low-glycemic load decreases postprandial insulin and glucose and increases postprandial ghrelin in white but not black womenKimberly A Brownley
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
J Nutr 142:1240-5. 2012..If reproducible, these findings have implications for individualized diet prescription for the purposes of glucose or weight control in women...
Postprandial ghrelin is elevated in black compared with white womenKimberly A Brownley
Department of Psychiatry, CB 7175, University of North Carolina, Chapel Hill, North Carolina 27599 7175, USA
J Clin Endocrinol Metab 89:4457-63. 2004..These findings suggest subnormal postprandial ghrelin suppression (or faster ghrelin rebound) in black women, especially the obese, that might play a role in their increased prevalence of obesity and cardiovascular disorders...
Cytochrome P450-derived eicosanoids and vascular dysfunction in coronary artery disease patientsRobert N Schuck
Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA
Atherosclerosis 227:442-8. 2013....
Lifestyle modification advice for lowering or controlling high blood pressure: who's getting it?Anthony J Viera
Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7595, USA
J Clin Hypertens (Greenwich) 9:850-8. 2007..35; 95% CI, 1.98-2.81). This study demonstrates that older persons, persons not taking antihypertensive medication, and individuals who are not overweight or obese are less likely to report receiving LSM advice...
Sympathoadrenergic mechanisms in reduced hemodynamic stress responses after exerciseKimberly A Brownley
Department of Psychiatry, University of North Carolina, Chapel Hill 27599, USA
Med Sci Sports Exerc 35:978-86. 2003..This study examines the acute effects of moderate aerobic exercise on 1) hemodynamic and sympathetic activity during behavioral stress and 2) beta-adrenergic receptor responsivity in a biracial sample of 24 sedentary adults...
Cost-effectiveness of electrocardiography vs. electrocardiography plus limited echocardiography to diagnose LVH in young, newly identified, hypertensivesPeter J Leese
Department of Health Policy and Management, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Hypertens 23:592-8. 2010..However, the introduction of limited echo within the past decade has made sonographic imaging of the heart less expensive and more available for routine screening...
Cardiovascular effects of 6 months of hormone replacement therapy versus placebo: differences associated with years since menopauseKimberly A Brownley
Department of Psychiatry, University of North Carolina, Chapel Hill, 27599 7175, USA
Am J Obstet Gynecol 190:1052-8. 2004....
Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trialGary N Asher
Department of Family Medicine, University of North Carolina, Chapel Hill, USA
BMC Complement Altern Med 12:26. 2012..The aim of this study was to investigate the relationship between hawthorn extract dose and brachial artery flow mediated dilation (FMD), an indirect measure of nitric oxide release...
Tolerability of the Oscar 2 ambulatory blood pressure monitor among research participants: a cross-sectional repeated measures studyAnthony J Viera
Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
BMC Med Res Methodol 11:59. 2011....
Effect of glycemic load on peptide-YY levels in a biracial sample of obese and normal weight womenKimberly A Brownley
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Obesity (Silver Spring) 18:1297-303. 2010....
Influence of sex on the accuracy of oscillometric-derived blood pressuresSkand D Bhatt
Department of Medicine, University of Washington, Seattle, WA, USA
J Clin Hypertens (Greenwich) 13:112-9. 2011..Sex is an important determinant of the accuracy of oscillometric BP...
Diurnal blood pressure pattern and development of prehypertension or hypertension in young adults: the CARDIA studyAnthony J Viera
Department of Family Medicine, University of North Carolina, Chapel Hill, NC, USA
J Am Soc Hypertens 5:48-55. 2011..Nondipping might predate a meaningful clinically detected increase in BP in some people, but more research in larger study samples is needed...
Lack of beneficial effects of clonidine in the treatment of premenstrual dysphoric disorder: results of a double-blind, randomized studyRobertas Bunevicius
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Hum Psychopharmacol 20:33-9. 2005..CONCLUSION: Compared with an active placebo clonidine demonstrated no beneficial changes in mood and premenstrual symptoms in women with PMDD...
Evaluation and management of the patient with difficult-to-control or resistant hypertensionAnthony J Viera
Department of Family Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599 7595, USA
Am Fam Physician 79:863-9. 2009..Obesity, heavy alcohol intake, high levels of dietary sodium, and interfering substances (especially nonsteroidal anti-inflammatory drugs) contribute to hypertension that is resistant or difficult to control...
Validation of the HEM-780REL with easy wrap cuff for self-measurement of blood pressure according to the European Society of Hypertension International ProtocolAnthony J Viera
Department of Family Medicine, Division of Cardiology, University of North Carolina at Chapel Hill, North Carolina 27599 7595, USA
Blood Press Monit 12:335-8. 2007..We tested the accuracy of the HEM-780REL automatic blood pressure monitor with Easy Wrap Cuff...
Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypesCraig R Lee
Division of Pharmacotherapy, University of North Carolina at Chapel Hill, NC 27599 7360, Chapel Hill, USA
Eur J Clin Pharmacol 58:791-4. 2003..This study was conducted to examine differences in flurbiprofen metabolism among individuals with the CYP2C9*1/*1, *1/*2, and *1/*3 genotypes...
Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controlsSusan S Girdler
Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
Psychosom Med 65:849-56. 2003..To examine the biological correlates associated with histories of sexual or physical abuse in women meeting DSM criteria for premenstrual dysphoric disorder (PMDD) and in healthy, non-PMDD controls...
Losartan and E3174 pharmacokinetics in cytochrome P450 2C9*1/*1, *1/*2, and *1/*3 individualsCraig R Lee
Division of Pharmacotherapy, University of North Carolina at Chapel Hill, 27599 7360, USA
Pharmacotherapy 23:720-5. 2003..To determine if differences in the pharmacokinetics of losartan and its pharmacologically active E3174 metabolite exist among individuals expressing the cytochrome P450 (CYP) 2C9*1/*1, *1/*2, and *1/*3 genotypes...
Reproducibility of masked hypertension in adults with untreated borderline office blood pressure: comparison of ambulatory and home monitoringAnthony J Viera
Department of Family Medicine, University of North Carolina at Chapel Hill, USA
Am J Hypertens 23:1190-7. 2010....
Dietary sodium restriction alters postprandial ghrelin: implications for race differences in obesityKimberly A Brownley
Department of Psychiatry, University of North Carolina at Chapel Hill 27599 7175, USA
Ethn Dis 16:844-51. 2006..To examine the effect of sodium restriction on the appetite-stimulating hormone, ghrelin, as a function of race, salt sensitivity, and obesity...
Depression and thyroid axis function in coronary artery disease: impact of cardiac impairment and genderRobertas Bunevicius
Institute of Psychophysiology and Rehabilitation, Kaunas University of Medicine, Palanga, Lithuania
Clin Cardiol 29:170-4. 2006..Increased rates of depression are reported in coronary artery disease (CAD). In heart disease, depression increases disability, reduces quality of life, and increases mortality...
Oxytocinergic activity is linked to lower blood pressure and vascular resistance during stress in postmenopausal women on estrogen replacementKathleen C Light
School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7175, USA
Horm Behav 47:540-8. 2005..The findings suggest that enhanced oxytocinergic activity may contribute to BP decreases associated with ERT in more responsive postmenopausal women...
Transdermal versus oral estrogen therapy in postmenopausal smokers: hemodynamic and endothelial effectsSusan S Girdler
Departments of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
Obstet Gynecol 103:169-80. 2004....
Changes in plasma volume associated with mental stress ischemia in patients with coronary artery diseaseSimon L Bacon
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Int J Psychophysiol 61:143-8. 2006..Reduced plasma volume may be one mechanism by which mental stress may increase the risk for acute coronary events...
Association of leukocyte count with progression of aortic atheroma in stroke/transient ischemic attack patientsSouvik Sen
Department of Neurology, University of North Carolina, Chapel Hill, NC, USA
Stroke 38:2900-5. 2007..Leukocyte count is an independent predictor of stroke. We investigated the association between leukocyte count and progression of aortic atheroma over 12 months in stroke/transient ischemic attack (TIA) patients...
Pulmonary hypertension in patients with sickle cell disease: a longitudinal studyKenneth I Ataga
Division of Hematology Oncology and Comprehensive Sickle Cell Program, University of North Carolina, Chapel Hill, NC, USA
Br J Haematol 134:109-15. 2006....
Depressive symptoms are related to higher ambulatory blood pressure in people with a family history of hypertensionKaren M Grewen
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
Psychosom Med 66:9-16. 2004..We investigated whether parental history of hypertension (FH+) enhances the impact of depressed mood, indexed by Beck Depression Inventory (BDI), on ambulatory blood pressure (ABP)...
Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertensionKenneth I Ataga
Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, CB 7305, 3009 Old Clinic Bldg Chapel Hill, NC 27599 7305, USA
Haematologica 93:20-6. 2008..Pulmonary hypertension (PHT) is common in sickle cell disease (SCD). The purpose of this study was to determine whether markers of coagulation activation and inflammation are associated with PHT in SCD...
Clinical predictors and characteristics of patients with chronic liver disease and intrapulmonary shuntsRichard A Santa-Cruz
Division of Cardiology, University of North Carolina, Chapel Hill, NC 27599 7075, USA
Clin Cardiol 28:437-41. 2005..Intrapulmonary shunting (IPS) is a well-described phenomenon in chronic liver disease but its significance is not known...
Aortic arch atheroma progression and recurrent vascular events in patients with stroke or transient ischemic attackSouvik Sen
Department of Neurology, University of North Carolina, Chapel Hill, USA
Circulation 116:928-35. 2007..It is not known whether progression of aortic arch (AA) atheroma is associated with vascular events in patients with stroke or transient ischemic attack (TIA)...
Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular diseaseKatherine N Theken
Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA
Atherosclerosis 222:530-6. 2012..Therefore, the primary objective was to identify clinical factors that influence CYP epoxygenase, soluble epoxide hydrolase (sEH), and CYP ω-hydroxylase metabolism in patients with established CAD...
Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humansCraig R Lee
Divisions of Pharmacotherapy, CB# 7360, Beard Hall, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA
J Clin Pharmacol 43:84-91. 2003..Tolbutamide is a better CYP2C9 probe than flurbiprofen and losartan, and the 0- to 12-hour amount of 4'-hydroxytolbutamide and carboxytolbutamide is the best urinary measure of its metabolism...
Relationship of depression to death or hospitalization in patients with heart failureAndrew Sherwood
Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
Arch Intern Med 167:367-73. 2007..However, patients with heart failure (HF) have been less frequently studied, and the effect of depression on prognosis, independent of disease severity, is uncertain...
Placenta growth factor in sickle cell disease: association with hemolysis and inflammationJulia E Brittain
Department of Biochemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7305, USA
Blood 115:2014-20. 2010..Prospective studies are required to conclusively define the contribution of PlGF to the pathogenesis of PHT and other hemolytic complications in SCD...
Sex differences in the endothelial function of untreated hypertensionFaye S Routledge
Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA
J Clin Hypertens (Greenwich) 14:228-35. 2012..These findings raise the possibility that female sex may impart a greater risk of CV events in patients with untreated stage 1 hypertension potentially due to poorer endothelial function...
Relation between digital peripheral arterial tonometry and brachial artery ultrasound measures of vascular function in patients with coronary artery disease and in healthy volunteersCraig R Lee
Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA
Am J Cardiol 109:651-7. 2012....
A 38-year-old Hispanic woman with paradoxical embolism and Libman-Sacks endocarditis involving the tricuspid valveAndrew O Zurick
Department of Internal Medicine, Division of Cardiology, University of North Carolina Hospitals, Chapel Hill, North Carolina 27599, USA
J Am Soc Echocardiogr 20:1316.e5-7. 2007..A review of the literature on Libman-Sacks endocarditis and patent foramen ovale closure is presented...
The effects of periodontal therapy on vascular endothelial function: a pilot trialJohn R Elter
SciMetrika, LLC, Research Triangle Park, NC, USA
Am Heart J 151:47. 2006....
Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C91 heterozygotesCraig R Lee
Divisions of Pharmacotherapy and Cardiology, University of North Carolina at Chapel Hill, USA
Clin Pharmacol Ther 72:562-71. 2002..Multiple single-nucleotide polymorphisms in the gene encoding cytochrome P450 (CYP) 2C9 have been identified, but the functional significance of the various putative defective genotypes in humans merits further study...
Relationship of clinic, ambulatory, and laboratory stress blood pressure to left ventricular mass in overweight men and women with high blood pressureAndrew Sherwood
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 64:247-57. 2002....
Hostility is related to blunted beta-adrenergic receptor responsiveness among middle-aged womenAndrew Sherwood
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 66:507-13. 2004..The roles of the sympathetic nervous system and of social support in this putative relationship were also evaluated...
Relationship between exercise systolic blood pressure and left ventricular geometry in overweight, mildly hypertensive patientsLee M Pierson
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J Hypertens 22:399-405. 2004..These results suggest that RWT is an important determinant of the association between cardiac mass and exercise SBP response...
Association between exercise capacity and left ventricular geometry in overweight patients with mild systemic hypertensionLee M Pierson
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
Am J Cardiol 94:1322-5. 2004..1 +/- 1.2) and normal (27.3 +/- 0.6) geometries. The LV geometric pattern was found to be associated with exercise capacity in unmedicated, hypertensive patients, such that patients with concentric hypertrophy showed reduced capacity...
Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertensionNazzareno Galie
Institute of Cardiology, University of Bologna, Italy
J Am Coll Cardiol 41:1380-6. 2003..The purpose of this study was to investigate the effects of bosentan (125 or 250 mg twice daily) on echocardiographic and Doppler variables in 85 patients with World Health Organization class III or IV pulmonary arterial hypertension (PAH)...
Age moderates the short-term effects of transdermal 17beta-estradiol on endothelium-dependent vascular function in postmenopausal womenAndrew Sherwood
Duke University Medical Center, Durham, NC 27710, USA
Arterioscler Thromb Vasc Biol 27:1782-7. 2007..We evaluated age and coronary heart disease (CHD) as potential moderators of the effects of 17beta-estradiol on vascular endothelial function in postmenopausal women...
Hostility, social support, and adrenergic receptor responsiveness among African-American and white men and womenJoel W Hughes
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 65:582-7. 2003..Impaired beta-adrenergic receptor function, which is a common characteristic of cardiovascular disease, may be a marker of increased cardiovascular disease risk among individuals high in hostility and low in social support...
Nighttime blood pressure dipping: the role of the sympathetic nervous systemAndrew Sherwood
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Hypertens 15:111-8. 2002..05). These data suggest that the SNS may contribute to individual differences in nighttime BP dipping, and appears to account in part for blunted BP dipping in African Americans...
Effects of daily stress on autonomic cardiac control in patients with coronary artery diseaseSimon L Bacon
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3119, Durham, NC 27710, USA
Am J Cardiol 93:1292-4. 2004..g., anger, stress, sadness) with decreases in high- and low-frequency power, whereas higher levels of positive emotion were related to an increase in low-frequency power, independent of age, posture, and medications...
Prevalence and predictors of cardiovascular calcium in chronic kidney disease (from the Prospective Longitudinal RRI-CKD Study)Santo Dellegrottaglie
Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, New York, New York, USA
Am J Cardiol 98:571-6. 2006..The extent of cardiovascular calcium in patients with predialysis CKD is related to some of the traditional risk factors for atherosclerosis but not to indexes of abnormal renal function or progression in renal dysfunction...
Impaired endothelial function in coronary heart disease patients with depressive symptomatologyAndrew Sherwood
Duke University Medical Center, Durham, North Carolina 27710, USA
J Am Coll Cardiol 46:656-9. 2005..The purpose of this study was to assess whether depressive symptomatology was associated with vascular endothelial dysfunction in patients with coronary heart disease (CHD)...
