Shirley Hill

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc White matter microstructure, alcohol exposure, and familial risk for alcohol dependence
    Shirley Y Hill
    University of Pittsburgh Medical Center, Department of Psychiatry, 3811 O Hara St, Pittsburgh, PA 15213 2593, United States
    Psychiatry Res 212:43-53. 2013
  2. pmc ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 159:445-55. 2012
  3. pmc Cerebellum volume in high-risk offspring from multiplex alcohol dependence families: association with allelic variation in GABRA2 and BDNF
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh Scholl of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 194:304-13. 2011
  4. pmc Psychopathology in offspring from families of alcohol dependent female probands: a prospective study
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    J Psychiatr Res 45:285-94. 2011
  5. pmc Temperament at 5 years of age predicts amygdala and orbitofrontal volume in the right hemisphere in adolescence
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychiatry Res 182:14-21. 2010
  6. pmc Childhood risk factors for young adult substance dependence outcome in offspring from multiplex alcohol dependence families: a prospective study
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 66:750-7. 2009
  7. pmc Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Biol Psychiatry 65:129-36. 2009
  8. pmc Psychopathology in offspring from multiplex alcohol dependence families with and without parental alcohol dependence: a prospective study during childhood and adolescence
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychiatry Res 160:155-66. 2008
  9. pmc fMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Alcohol Clin Exp Res 31:2028-35. 2007
  10. pmc A genome wide search for alcoholism susceptibility genes
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 128:102-13. 2004

Detail Information

Publications18

  1. pmc White matter microstructure, alcohol exposure, and familial risk for alcohol dependence
    Shirley Y Hill
    University of Pittsburgh Medical Center, Department of Psychiatry, 3811 O Hara St, Pittsburgh, PA 15213 2593, United States
    Psychiatry Res 212:43-53. 2013
    ..Only one tract showed a significant difference for exposure alone, the anterior thalamic radiation...
  2. pmc ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 159:445-55. 2012
    ..Family-based association analysis shows the ASTN1 gene significantly associated with alcohol dependence. The potential importance of the ASTN1 gene for AD risk may be related its role in glial-guided neuronal migration...
  3. pmc Cerebellum volume in high-risk offspring from multiplex alcohol dependence families: association with allelic variation in GABRA2 and BDNF
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh Scholl of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 194:304-13. 2011
    ..An interaction between allelic variation in GABRA2 and BDNF genes was associated with GM volumes, suggesting that inherited variation in these genes may promote early developmental differences in neuronal proliferation of the cerebellum...
  4. pmc Psychopathology in offspring from families of alcohol dependent female probands: a prospective study
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    J Psychiatr Res 45:285-94. 2011
    ..Multiplex AD families in which multiple cases of AD are present provide an ideal setting for understanding developmental variants of the adult phenotype...
  5. pmc Temperament at 5 years of age predicts amygdala and orbitofrontal volume in the right hemisphere in adolescence
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychiatry Res 182:14-21. 2010
    ..Behavioral control, including both over- and under-control, is likely to be subserved by neural circuitry associated with emotion regulation including the right OFC and the amygdala...
  6. pmc Childhood risk factors for young adult substance dependence outcome in offspring from multiplex alcohol dependence families: a prospective study
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 66:750-7. 2009
    ..A longitudinal study spanning childhood to young adulthood provided the opportunity to determine if these same factors would predict the presence and onset of substance use disorders (SUD)...
  7. pmc Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Biol Psychiatry 65:129-36. 2009
    ..The role of the orbitofrontal cortex (OFC) in regulating emotional processing is increasingly being recognized along with its association with impulsive behavior...
  8. pmc Psychopathology in offspring from multiplex alcohol dependence families with and without parental alcohol dependence: a prospective study during childhood and adolescence
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychiatry Res 160:155-66. 2008
    ....
  9. pmc fMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Alcohol Clin Exp Res 31:2028-35. 2007
    ..These characteristics may be related to inherited differences in the neuroanatomical network that comprises the social brain...
  10. pmc A genome wide search for alcoholism susceptibility genes
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 128:102-13. 2004
    ..Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17...
  11. ncbi request reprint Trajectories of alcohol use and electrophysiological and morphological indices of brain development: distinguishing causes from consequences
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1021:245-59. 2004
    ..Finally, differences seen in amygdala volume between high- and low-risk adolescents suggest that functional differences seen in electrophysiological responding or neuropsychological test performance may have anatomical correlates...
  12. pmc Offspring from families at high risk for alcohol dependence: increased body mass index in association with prenatal exposure to cigarettes but not alcohol
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychiatry Res 135:203-16. 2005
    ....
  13. pmc Cerebellar volume in offspring from multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 61:41-7. 2007
    ..Additionally, developmental changes in cerebellar volume during adolescence have been reported...
  14. pmc The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses
    Abigail G Matthews
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
    J Stud Alcohol Drugs 68:625-33. 2007
    ..Results were confirmed in three case-control studies. The objective of this study was to investigate the GABRA2 gene in another collection of multiplex families...
  15. pmc Dopaminergic mutations: within-family association and linkage in multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 147:517-26. 2008
    ..062), but was consistent with the family data results. These results support a role for DRD2 as a susceptibility gene for alcohol dependence within multiplex families at high risk for developing alcohol dependence...
  16. pmc Neurodevelopmental patterns of visual P3b in association with familial risk for alcohol dependence and childhood diagnosis
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Biol Psychiatry 51:621-31. 2002
    ..P300 amplitude changes during development for all children. Previously it has been shown that high-risk offspring display a pattern in which the amplitude is lower at age 8 with a smaller rate of change during adolescence...
  17. pmc Neural circuitry associated with risk for alcohol use disorders
    Kevin D Tessner
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuropsychol Rev 20:1-20. 2010
    ..This review proposes several neurobehavioral mechanisms of genetic vulnerability that may account for phenotypic characteristics in individuals at risk for AUD...
  18. pmc Neural plasticity, human genetics, and risk for alcohol dependence
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int Rev Neurobiol 91:53-94. 2010
    ..Finally, a review of studies showing associations between brain structural and functional characteristics and specific genes will be offered...

Research Grants53

  1. BIOLOGICAL RISK FACTORS IN RELATIVES OF ALCOHOLIC WOMEN
    Shirley Y Hill; Fiscal Year: 2010
    ....
  2. BIOLOGICAL RISK FACTORS IN RELATIVES OF ALCOHOLIC WOMEN
    Shirley Hill; Fiscal Year: 2002
    ..The possible interplay between environmental variation and the neurobiological factors associated with high-risk status also suggests the need to assess this variation in the context of a longitudinal follow-up. ..
  3. MOLECULAR GENETICS ANALYSES OF MULTIPLEX FAMILIES
    Shirley Hill; Fiscal Year: 2001
    ..The combined resources of our research team will situate us to initiate positional cloning of a gene, should significant positive linkages be found with our Stage I and Stage 11 genotyping endeavors. ..
  4. COGNITIVE/PERSONALITY FACTORS IN RELATIVES OF ALCOHOLICS
    Shirley Hill; Fiscal Year: 2000
    ..Little is known about the factors that discourage continued heavy drinking in young adulthood for individuals from multigenerational alcohol dependent families in which a high density of individuals are dependent on alcohol. ..
  5. Longitudinal Predictors of Alcohol Dependence in Offspring from Multiplex Familie
    Shirley Y Hill; Fiscal Year: 2010
    ....
  6. Alcoholism Susceptibility Genes in High Density Families
    Shirley Hill; Fiscal Year: 2009
    ..4 cm intervals for all three generations would be combined and linkage analyses performed using the well validated alcoholism phenotype and the well validated childhood diagnoses obtained from the K-SADS. ..
  7. BIOLOGICAL RISK FACTORS IN RELATIVES OF ALCOHOLIC WOMEN
    Shirley Hill; Fiscal Year: 2007
    ..g., marriage, first career-related job) during this period as they relate to risk status and its interaction with other familial/genetic and other environmental factors. ..
  8. COGNITIVE/PERSONALITY FACTORS IN RELATIVES OF ALCOHOLICS
    Shirley Hill; Fiscal Year: 2006
    ..New measures will be added to explore non-shared environmental effects in these families where sibling pairs are available for study (N=346 sib pairs). ..
  9. BIOLOGICAL RISK FACTORS IN RELATIVES OF ALCOHOLIC WOMEN
    Shirley Hill; Fiscal Year: 1993
  10. COGNITIVE/PERSONALITY FACTORS IN RELATIVES OF ALCOHOLICS
    Shirley Hill; Fiscal Year: 1993
    ..Third, we plan to build the foundation for a comprehensive prospective longitudinal follow-up of children between the ages of 8-13 years...
  11. COGNITIVE/PERSONALITY FACTORS IN RELATIVES OF ALCOHOLICS
    Shirley Hill; Fiscal Year: 1990
    ..Also, we will begin to explore the nature of the neurobehavioral deficits reported in the literature for children of alcoholics utilizing measures of vigilance, iconic memory, and neurological functioning including static ataxia...