Joseph A Hill

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy
    Dian J Cao
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    J Am Heart Assoc 2:e000016. 2013
  2. pmc Pathological ventricular remodeling: mechanisms: part 1 of 2
    Jana S Burchfield
    Texas Heart Institute, Houston, TX, USA
    Circulation 128:388-400. 2013
  3. pmc Hypertrophic reprogramming of the left ventricle: translation to the ECG
    Joseph A Hill
    Department of Internal Medicine, Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    J Electrocardiol 45:624-9. 2012
  4. ncbi request reprint In vino veritas: alcohol and heart disease
    Joseph A Hill
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Med Sci 329:124-35. 2005
  5. pmc Autophagy in cardiac plasticity and disease
    Joseph A Hill
    Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, NB11 200, 6000 Harry Hines Blvd, Dallas, TX 75390 8573, USA
    Pediatr Cardiol 32:282-9. 2011
  6. ncbi request reprint Electrical remodeling in cardiac hypertrophy
    Joseph A Hill
    Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Trends Cardiovasc Med 13:316-22. 2003
  7. doi request reprint Cardiac plasticity
    Joseph A Hill
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    N Engl J Med 358:1370-80. 2008
  8. pmc Requirement of protein kinase D1 for pathological cardiac remodeling
    Jens Fielitz
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 105:3059-63. 2008
  9. pmc C/EBP transcription factors mediate epicardial activation during heart development and injury
    Guo N Huang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 338:1599-603. 2012
  10. ncbi request reprint Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure
    Beverly A Rothermel
    Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    Physiol Genomics 23:18-27. 2005

Collaborators

Detail Information

Publications84

  1. pmc Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy
    Dian J Cao
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    J Am Heart Assoc 2:e000016. 2013
    ..However, mechanisms underlying this benefit are unclear...
  2. pmc Pathological ventricular remodeling: mechanisms: part 1 of 2
    Jana S Burchfield
    Texas Heart Institute, Houston, TX, USA
    Circulation 128:388-400. 2013
    ..Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling. ..
  3. pmc Hypertrophic reprogramming of the left ventricle: translation to the ECG
    Joseph A Hill
    Department of Internal Medicine, Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    J Electrocardiol 45:624-9. 2012
    ..Here, I present an overview of the complex biology of left ventricular hypertrophy with an eye toward enhancing our understanding of its ECG manifestations...
  4. ncbi request reprint In vino veritas: alcohol and heart disease
    Joseph A Hill
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Med Sci 329:124-35. 2005
    ..Here, I review the association between alcohol use and CHD risk, explore putative mechanisms, and make recommendations...
  5. pmc Autophagy in cardiac plasticity and disease
    Joseph A Hill
    Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, NB11 200, 6000 Harry Hines Blvd, Dallas, TX 75390 8573, USA
    Pediatr Cardiol 32:282-9. 2011
    ..Together, these observations raise the intriguing prospect of targeting maladaptive autophagy and advancing cell survival-promoting, adaptive autophagy to benefit patients with heart disease...
  6. ncbi request reprint Electrical remodeling in cardiac hypertrophy
    Joseph A Hill
    Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Trends Cardiovasc Med 13:316-22. 2003
    ..Where information is available, the remodeling of hypertrophy is contrasted with what is known about heart failure...
  7. doi request reprint Cardiac plasticity
    Joseph A Hill
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    N Engl J Med 358:1370-80. 2008
  8. pmc Requirement of protein kinase D1 for pathological cardiac remodeling
    Jens Fielitz
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 105:3059-63. 2008
    ..We conclude that PKD1 functions as a key transducer of stress stimuli involved in pathological cardiac remodeling in vivo...
  9. pmc C/EBP transcription factors mediate epicardial activation during heart development and injury
    Guo N Huang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 338:1599-603. 2012
    ..These findings reveal a transcriptional basis for epicardial activation and heart injury, providing a platform for enhancing cardiac regeneration...
  10. ncbi request reprint Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure
    Beverly A Rothermel
    Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    Physiol Genomics 23:18-27. 2005
    ..This information may be useful in identifying novel targets of therapy in chronic disease...
  11. pmc Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy
    Paul Tannous
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 8573, USA
    Circulation 117:3070-8. 2008
    ..Because autophagy is a highly conserved process through which damaged proteins and organelles can be degraded, we hypothesized that stress-induced protein aggregation is a proximal trigger of cardiomyocyte autophagy...
  12. pmc MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²⁺ overload and cell death
    Arin B Aurora
    Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Clin Invest 122:1222-32. 2012
    ..These findings reveal a pivotal role for miR-214 as a regulator of cardiomyocyte Ca²⁺ homeostasis and survival during cardiac injury...
  13. pmc TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
    Koichiro Kuwahara
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9148, USA
    J Clin Invest 116:3114-26. 2006
    ..These findings implicate TRPC6 as a positive regulator of calcineurin-NFAT signaling and a key component of a calcium-dependent regulatory loop that drives pathologic cardiac remodeling...
  14. pmc The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice
    Yuri Kim
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Clin Invest 118:124-32. 2008
    ..These results reveal a unique and important function for MEF2D in stress-dependent cardiac growth and reprogramming of gene expression in the adult heart...
  15. pmc Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice
    Pavan K Battiprolu
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    J Clin Invest 122:1109-18. 2012
    ..Together, these data suggest that activation of FoxO1 is an important mediator of diabetic cardiomyopathy and is a promising therapeutic target for the disease...
  16. pmc Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility
    Rusty L Montgomery
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Genes Dev 21:1790-802. 2007
    ....
  17. ncbi request reprint Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy
    Yongli Kong
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Circulation 113:2579-88. 2006
    ..Thus, HDAC inhibitors hold promise as potential therapeutic agents in hypertrophic heart disease...
  18. pmc Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor
    Eva van Rooij
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Circ Res 106:155-65. 2010
    ..Although it is proposed that HDACs additionally influence nuclear receptor signaling, the effect of class II HDACs on gender differences in cardiovascular disease remains unstudied...
  19. pmc Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development
    Shurong Chang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Mol Cell Biol 24:8467-76. 2004
    ..These findings reveal central roles for HDACs 5 and 9 in the suppression of a subset of cardiac stress signals as well as redundant functions in the control of cardiac development...
  20. ncbi request reprint Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling
    Yan G Ni
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Circulation 114:1159-68. 2006
    ..In cultured neonatal cardiomyocytes, Foxo transcription factors trigger an atrophy-related gene program that counters hypertrophic growth. However, downstream molecular events are not yet well defined...
  21. pmc Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel
    Samvit Tandan
    Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390 8573, USA
    Circ Res 105:51-60. 2009
    ..Furthermore, they demonstrate that calcineurin induces robust increases in I(Ca,L) and highlight calcineurin as a key modulator of pathological electrical remodeling in cardiac hypertrophy...
  22. ncbi request reprint Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress
    Norbert Frey
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nat Med 10:1336-43. 2004
    ..These findings show important roles for calsarcins as modulators of calcineurin signaling and the transmission of a specific subset of stress signals leading to cardiac remodeling in vivo...
  23. ncbi request reprint The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases
    Kunhua Song
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Cell 125:453-66. 2006
    ..These findings reveal a transcriptional regulatory mechanism that modulates cardiac growth and gene expression by linking hypertrophic signals to the cardiac genome...
  24. pmc Diminished cardiac fibrosis in heart failure is associated with altered ventricular arrhythmia phenotype
    Jorge Massare
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    J Cardiovasc Electrophysiol 21:1031-7. 2010
    ..We sought to define the role of interstitial fibrosis in the proarrhythmic phenotype of failing ventricular myocardium...
  25. pmc Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart
    Nita Sachan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Circ Res 108:437-45. 2011
    ..Despite overwhelming evidence of the importance of circadian rhythms in cardiovascular health and disease, little is known regarding the circadian regulation of intracellular signaling pathways controlling cardiac function and remodeling...
  26. pmc Reversibility of adverse, calcineurin-dependent cardiac remodeling
    JEFF M BERRY
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390 8573, USA
    Circ Res 109:407-17. 2011
    ..Finally, even though therapeutic interventions in adults are designed to slow, arrest, or reverse disease pathogenesis, little is known about the capacity for spontaneous reversibility of calcineurin-dependent pathological remodeling...
  27. pmc Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay
    Nikhil V Munshi
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Development 136:2665-74. 2009
    ..Thus, our results implicate Gata4 in conduction system function and provide a clearer understanding of the transcriptional pathways that impact normal AV delay...
  28. pmc FHL2 binds calcineurin and represses pathological cardiac growth
    Berdymammet Hojayev
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Mol Cell Biol 32:4025-34. 2012
    ..FHL2 is an endogenous, agonist-dependent suppressor of calcineurin...
  29. pmc Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure
    Yanggan Wang
    Department of Internal Medicine Cardiology and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    J Biol Chem 283:25524-32. 2008
    ..I(Ca) density manifests a significant transmural gradient, and this gradient is preserved in heart failure. Activation of CaMKII, a known pro-arrhythmic molecule, is a major contributor to I(Ca) remodeling in load-induced heart failure...
  30. pmc Autophagy is an adaptive response in desmin-related cardiomyopathy
    Paul Tannous
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:9745-50. 2008
    ..This study reports activation of autophagy in DRCM. Further, our findings point to autophagy as an adaptive response in this proteotoxic form of heart disease...
  31. pmc Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity
    Koichiro Kuwahara
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Clin Invest 117:1324-34. 2007
    ..These findings suggest that STARS modulates the responsiveness of the heart to stress signaling by functioning as a cytoskeletal intermediary between MEF2 and SRF...
  32. pmc Transient regenerative potential of the neonatal mouse heart
    Enzo R Porrello
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 331:1078-80. 2011
    ..Echocardiography performed 2 months after surgery revealed that the regenerated ventricular apex had normal systolic function. Thus, for a brief period after birth, the mammalian heart appears to have the capacity to regenerate...
  33. pmc FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases
    Yan G Ni
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Proc Natl Acad Sci U S A 104:20517-22. 2007
    ....
  34. pmc Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy
    Dian J Cao
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:4123-8. 2011
    ..Together, these data implicate autophagy as an obligatory element in pathological cardiac remodeling and point to HDAC1/2 as required effectors. Also, these data reveal autophagy as a previously unknown target of HDAC inhibitor therapy...
  35. pmc The CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4
    Misook Oh
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 285:16623-31. 2010
    ....
  36. pmc Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice
    David M Patrick
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Clin Invest 120:3912-6. 2010
    ..We therefore conclude that miR-21 is not essential for pathological cardiac remodeling...
  37. pmc Cardiac autophagy is a maladaptive response to hemodynamic stress
    Hongxin Zhu
    Department of Internal Medicine and Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    J Clin Invest 117:1782-93. 2007
    ..Taken together, these findings implicate autophagy in the pathogenesis of load-induced heart failure and suggest it may be a target for novel therapeutic intervention...
  38. pmc Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers
    Misook Oh
    University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Mol Cell Biol 25:6629-38. 2005
    ..These results demonstrate that developmental patterning of slow fibers is independent of calcineurin, while the maintenance of the slow-fiber phenotype in the adult requires calcineurin activity...
  39. pmc Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein
    Igor I Rybkin
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    J Cell Biol 179:527-37. 2007
    ..These findings identify RRP17 as a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues...
  40. pmc Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway
    Zhao V Wang
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 156:1179-92. 2014
    ..Collectively, these studies reveal that Xbp1s couples the UPR to the HBP to protect cells under stress...
  41. pmc Reprogramming of human fibroblasts toward a cardiac fate
    Young Jae Nam
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 110:5588-93. 2013
    ....
  42. pmc Heart repair by reprogramming non-myocytes with cardiac transcription factors
    Kunhua Song
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Nature 485:599-604. 2012
    ..Our results suggest a strategy for cardiac repair through reprogramming fibroblasts resident in the heart with cardiogenic transcription factors or other molecules...
  43. pmc STIM1-dependent store-operated Ca²⁺ entry is required for pathological cardiac hypertrophy
    Xiang Luo
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    J Mol Cell Cardiol 52:136-47. 2012
    ..Stress-triggered STIM1 re-expression, and consequent SOCE activation, are critical elements in the upstream, Ca(2+)-dependent control of pathological cardiac hypertrophy...
  44. pmc Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
    Eva van Rooij
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 105:13027-32. 2008
    ..We conclude that miR-29 acts as a regulator of cardiac fibrosis and represents a potential therapeutic target for tissue fibrosis in general...
  45. pmc The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
    Shusheng Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Dev Cell 15:261-71. 2008
    ..These findings have important therapeutic implications for a variety of disorders involving abnormal angiogenesis and vascular leakage...
  46. ncbi request reprint Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
    Chun Li Zhang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas 75390, USA
    Cell 110:479-88. 2002
    ..Thus, class II HDACs act as signal-responsive suppressors of the transcriptional program governing cardiac hypertrophy and heart failure...
  47. pmc The effects of neuregulin on cardiac Myosin light chain kinase gene-ablated hearts
    Audrey N Chang
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e66720. 2013
    ..We generated a cMLCK knockout mouse to test the hypothesis that cMLCK is necessary for neuregulin-induced improvement in cardiac function by increasing RLC phosphorylation...
  48. pmc Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo
    Peiguo Ding
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 285:40819-29. 2010
    ..Thus, cMLCK appears to be the predominant protein kinase that maintains basal RLC phosphorylation that is required for normal physiological cardiac performance in vivo...
  49. pmc The heart of autophagy: deconstructing cardiac proteotoxicity
    Beverly A Rothermel
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Autophagy 4:932-5. 2008
    ..Our findings situate heart disease stemming from environmental stress in the category of proteinopathy and raise important new questions regarding molecular events that elicit adaptive and maladaptive autophagy...
  50. ncbi request reprint Myocyte autophagy in heart disease: friend or foe?
    Beverly A Rothermel
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    Autophagy 3:632-4. 2007
    ..Here, we discuss recent studies that both answer some questions and pose new ones...
  51. ncbi request reprint Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor
    Francisco J Naya
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Nat Med 8:1303-9. 2002
    ..These findings reveal specific roles for MEF2A in maintaining appropriate mitochondrial content and cyto-architectural integrity in the post-natal heart and show that other MEF2 isoforms cannot support these activities...
  52. pmc HDAC-dependent ventricular remodeling
    Min Xie
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Trends Cardiovasc Med 23:229-35. 2013
    ..Looking to the future, HDAC inhibitor therapy may emerge as a novel means of arresting the untoward consequences of pathological cardiac stress, conferring clinical benefit to millions of patients with heart failure. ..
  53. pmc Effect of spironolactone on patients with atrial fibrillation and structural heart disease
    Ryan S Williams
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Clin Cardiol 34:415-9. 2011
    ..The aim of this study was to determine if spironolactone, a mineralocorticoid receptor blocker with potent antifibrotic properties, has beneficial effects on AF...
  54. pmc Autophagy as a therapeutic target in cardiovascular disease
    Andriy Nemchenko
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Mol Cell Cardiol 51:584-93. 2011
    ..This article is part of a special issue entitled ''Key Signaling Molecules in Hypertrophy and Heart Failure.''..
  55. pmc Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo
    Anwarul Ferdous
    Department of Internal Medicine, Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Proc Natl Acad Sci U S A 108:16307-12. 2011
    ..Collectively, our findings provide critical molecular insight into a unique FoxO1-VCAM1 axis that governs placental morphogenesis, a process that is essential for subsequent normal cardiovascular development and fetal life...
  56. pmc Dual control of cardiac Na+ Ca2+ exchange by PIP(2): analysis of the surface membrane fraction by extracellular cysteine PEGylation
    Chengcheng Shen
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9040, USA
    J Physiol 582:1011-26. 2007
    ....
  57. pmc The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice
    Qing Jun Zhang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Clin Invest 121:2447-56. 2011
    ..Our studies reveal that JMJD2A promotes cardiac hypertrophy under pathological conditions and suggest what we believe to be a novel mechanism for JMJD2A in reprogramming of gene expression involved in cardiac hypertrophy...
  58. pmc FoxO, autophagy, and cardiac remodeling
    Anwarul Ferdous
    Department of Internal Medicine Division of Cardiology, University of Texas Southwestern Medical Center, NB11 200, 6000 Harry Hines Boulevard, Dallas, TX 75390 8573, USA
    J Cardiovasc Transl Res 3:355-64. 2010
    ..Here, we discuss recent advances in our understanding of cardiomyocyte autophagy, its governance by FoxO, and the roles each of these plays in cardiac remodeling...
  59. ncbi request reprint Remodeling of outward K+ currents in pressure-overload heart failure
    Yanggan Wang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    J Cardiovasc Electrophysiol 18:869-75. 2007
    ..Here, we investigated the native transmural gradient of outward K+ currents in murine left ventricle (LV) and delineated disease-related remodeling of these currents in heart failure (HF)...
  60. pmc Diabetic cardiomyopathy and metabolic remodeling of the heart
    Pavan K Battiprolu
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Life Sci 92:609-15. 2013
    ..Here, we review recently unveiled insights into the pathogenesis of diabetic cardiomyopathy and associated metabolic remodeling with an eye toward identifying novel targets with therapeutic potential...
  61. pmc Autophagy in load-induced heart disease
    Hongxin Zhu
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Methods Enzymol 453:343-63. 2009
    ..We then outline methods available for monitoring autophagic activity in the heart, providing detailed protocols for several techniques unique to working with heart and other striated muscles...
  62. pmc A dynamic notch injury response activates epicardium and contributes to fibrosis repair
    Jamie L Russell
    Department of Internal Medicine Cardiology, UT Southwestern Medical Center, Dallas, 75390 8573, USA
    Circ Res 108:51-9. 2011
    ....
  63. ncbi request reprint Histone deacetylase inhibition in the treatment of heart disease
    JEFF M BERRY
    University of Texas Southwestern Medical Center, Donald W Reynolds Cardiovascular Clinical Research Center, Dallas, Texas, USA
    Expert Opin Drug Saf 7:53-67. 2008
    ..This paper reviews understanding of the mechanisms of action of HDAC inhibitors in the heart and summarizes emerging data regarding their effects on disease-related cardiac remodeling and function...
  64. ncbi request reprint Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function
    Joseph A Hill
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242 1081, USA
    J Biol Chem 277:10251-5. 2002
    ..Finally, they demonstrate that ventricular performance is preserved despite attenuation of compensatory hypertrophy...
  65. pmc Autophagy in hypertensive heart disease
    Zhao V Wang
    Department of Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    J Biol Chem 285:8509-14. 2010
    ..Excessive autophagy eliminates, however, essential cellular elements and possibly provokes cell death, which together contribute to hypertension-related heart disease...
  66. pmc Mitochondrial fission and autophagy in the normal and diseased heart
    Myriam Iglewski
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Curr Hypertens Rep 12:418-25. 2010
    ..Furthermore, it examines recent studies revealing the importance of these processes in normal and diseased heart...
  67. ncbi request reprint Doxycycline attenuates isoproterenol- and transverse aortic banding-induced cardiac hypertrophy in mice
    Mounir Errami
    Division of Translational Research, University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390 9185, USA
    J Pharmacol Exp Ther 324:1196-203. 2008
    ..These results suggest that DOX might be evaluated as a potential CH therapeutic and also provide potential signaling mechanisms to investigate in the context of CH phenotype development and regression...
  68. ncbi request reprint Transient-outward K+ channel inhibition facilitates L-type Ca2+ current in heart
    Yanggan Wang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Cardiovasc Electrophysiol 17:298-304. 2006
    ..Here, we investigated the effects of I(to) channel blockers, 4-aminopyridine (4-AP) and heteropodatoxin-2 (HpTx2), on I(Ca) in cardiac ventricular myocytes...
  69. pmc Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury
    Xiucui Ma
    Division of Cardiology, Washington University School of Medicine, 4940 Parkview, CSRB 827 NTA, St Louis, MO 63110, USA
    Circulation 125:3170-81. 2012
    ..We examined flux through the macroautophagy pathway as a determinant of the discrepant outcomes in cardiomyocyte cell death in this setting...
  70. pmc Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
    Congcong He
    Center for Autophagy Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nature 481:511-5. 2012
    ..Thus, exercise induces autophagy, BCL2 is a crucial regulator of exercise- (and starvation)-induced autophagy in vivo, and autophagy induction may contribute to the beneficial metabolic effects of exercise...
  71. pmc Autophagy in load-induced heart disease
    Beverly A Rothermel
    Departments of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Circ Res 103:1363-9. 2008
    ..Here, we review recent studies of cardiomyocyte autophagy in load-induced disease and address molecular mechanisms and unanswered questions...
  72. pmc Tuning flux: autophagy as a target of heart disease therapy
    Min Xie
    Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Curr Opin Cardiol 26:216-22. 2011
    ..Here, we review current understanding of the role of autophagy in the pathogenesis of heart failure and explore this pathway as a target of therapeutic intervention...
  73. pmc Remodeling of early-phase repolarization: a mechanism of abnormal impulse conduction in heart failure
    Yanggan Wang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Circulation 113:1849-56. 2006
    ..In the present study we tested the impact of heart failure-associated electrical remodeling on AP propagation...
  74. pmc Spironolactone therapy is associated with reduced ventricular tachycardia rate in patients with cardiomyopathy
    Vassilis Dimas
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    Pacing Clin Electrophysiol 34:309-14. 2011
    ..However, the effect of these medications on the ventricular arrhythmia phenotype is currently unknown. Therefore, we set out to define the ventricular arrhythmia rates in patients actively treated with such therapies...
  75. ncbi request reprint Does load-induced ventricular hypertrophy progress to systolic heart failure?
    Kambeez Berenji
    Div of Cardiology, Dept of Internal Medicine, Univ of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Am J Physiol Heart Circ Physiol 289:H8-H16. 2005
    ..In this review, we summarize findings from epidemiologic studies, preclinical experiments in animals, and clinical trials to lay out what is known-and not known-about this important question...
  76. pmc Titrating autophagy in cardiac plasticity
    Dian J Cao
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Autophagy 7:1078-9. 2011
    ..Our work went on to decipher the role of histone deacetylases in this biology...
  77. pmc Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo
    Christopher L Antos
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 99:907-12. 2002
    ....
  78. pmc Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy
    Aslan T Turer
    Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 106:360-8. 2010
    ....
  79. ncbi request reprint Guanosine triphosphatase activation occurs downstream of calcineurin in cardiac hypertrophy*
    Kenneth E Richardson
    Molecular Biology Interdisciplinary Program, Univerity of Iowa Carver College of Medicine, Iwoa City, IA, USA
    J Investig Med 53:414-24. 2005
    ..Importantly, despite significant suppression of hypertrophy, clinical and hemodynamic markers remained compensated, suggesting that the hypertrophic growth induced by this pathway is not required to maintain circulatory performance...
  80. ncbi request reprint Hypertrophy of the heart: a new therapeutic target?
    Norbert Frey
    Department of Cardiology, University of Heidelberg N F, H A K, Heidelberg, Germany
    Circulation 109:1580-9. 2004
    ..We also summarize observations from animal models and clinical trials that suggest benefit from an antihypertrophic strategy...
  81. ncbi request reprint Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels
    Chien Chang Chen
    Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    Science 302:1416-8. 2003
    ..Furthermore, acute blockade of T-channels with Ni2+ prevented relaxation of wild-type coronary arteries. Thus, Ca2+ influx through alpha1H T-type Ca2+ channels is essential for normal relaxation of coronary arteries...
  82. ncbi request reprint Human atrial chloride channels: swelling with pride
    Yanggan Wang
    J Cardiovasc Electrophysiol 17:69-71. 2006
  83. ncbi request reprint Expression of membrane-bound HLA-G at the maternal-fetal interface is not associated with pregnancy maintenance among patients with idiopathic recurrent pregnancy loss
    Radhika N Patel
    Fearing Laboratory and The Center for Reproductive Medicine, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Mol Hum Reprod 9:551-7. 2003
    ..Within the limitations of this study, we conclude that HLA-G expression is not a major immunological determinant of pregnancy maintenance among patients with idiopathic RPL...
  84. ncbi request reprint In-vitro adhesion of endometrium to autologous peritoneal membranes: effect of the cycle phase and the stage of endometriosis
    Sophie Debrock
    Leuven University Fertility Center and Department of Pathology, UZ Gasthuisberg, Belgium
    Hum Reprod 17:2523-8. 2002
    ..Endometrium can adhere to autologous peritoneum. This study was undertaken to determine the effect of the menstrual cycle phase and the presence and stage of endometriosis on in-vitro adhesion of endometrium onto autologous peritoneum...

Research Grants14

  1. VOLTAGE DEPENDENT K+ CHANNELS IN HEAT--KV15 ALPHA SUBUNI
    Joseph Hill; Fiscal Year: 2002
    ..5. The methods to be used are biochemical and immunological (Western blots, immunoprecipitation) and electrophysiological (patch clamping, ambulatory electrocardiography). ..
  2. HDAC Inhibition in Cardiac Hypertrophy and Failure
    Joseph A Hill; Fiscal Year: 2010
    ..Together, these studies will provide important insights regarding the utility of HDACi pharmacotherapy as a novel antihypertrophic strategy. ..
  3. Foxo: Negative Regulator of Cardiac Hypertrophy
    Joseph Hill; Fiscal Year: 2009
    ..By determining their role in pathological cardiac growth and atrophy, we will take steps that may lead to novel strategies to prevent heart failure in humans. ..
  4. Calcineurin-Mediated Regulation of Cardiac Ca2+ Channel
    Joseph Hill; Fiscal Year: 2009
    ..In Aim 4, we will determine whether the mechanisms of calcineurin regulation of Ca2+ channel expression and function examined in Aims 1-3 occur in a clinically relevant, in vivo model of hypertrophy. ..
  5. HDAC Inhibition in Cardiac Hypertrophy and Failure
    Joseph Hill; Fiscal Year: 2009
    ..Together, these studies will provide important insights regarding the utility of HDACi pharmacotherapy as a novel antihypertrophic strategy. ..
  6. Calcineurin-Mediated Regulation of Cardiac Ca2+ Channel
    Joseph Hill; Fiscal Year: 2007
    ..In Aim 4, we will determine whether the mechanisms of calcineurin regulation of Ca2+ channel expression and function examined in Aims 1-3 occur in a clinically relevant, in vivo model of hypertrophy. ..
  7. TRAINING IN CARDIOVASCULAR RESEARCH
    Joseph Hill; Fiscal Year: 2007
    ..abstract_text> ..
  8. HDAC Inhibition in Cardiac Hypertrophy and Failure
    Joseph Hill; Fiscal Year: 2007
    ..Together, these studies will provide important insights regarding the utility of HDACi pharmacotherapy as a novel antihypertrophic strategy. ..
  9. Calcineurin-Mediated Regulation of Cardiac Ca2+ Channel
    Joseph Hill; Fiscal Year: 2006
    ..In Aim 4, we will determine whether the mechanisms of calcineurin regulation of Ca2+ channel expression and function examined in Aims 1-3 occur in a clinically relevant, in vivo model of hypertrophy. ..
  10. Calcineurin-Mediated Regulation of Cardiac Ca2+ Channel
    Joseph Hill; Fiscal Year: 2005
    ..In Aim 4, we will determine whether the mechanisms of calcineurin regulation of Ca2+ channel expression and function examined in Aims 1-3 occur in a clinically relevant, in vivo model of hypertrophy. ..
  11. Foxo: Negative Regulator of Cardiac Hypertrophy
    Joseph A Hill; Fiscal Year: 2010
    ..By determining their role in pathological cardiac growth and atrophy, we will take steps that may lead to novel strategies to prevent heart failure in humans. ..