Jeffrey Hildebrand

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology
    Swarna Mohan
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e81075. 2013
  2. pmc Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development
    Jeffrey D Hildebrand
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98108, USA
    Mol Cell Biol 22:5296-307. 2002
  3. ncbi request reprint Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network
    Jeffrey D Hildebrand
    Department of Biological Sciences, 4249 Fifth Avenue, Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Cell Sci 118:5191-203. 2005
  4. ncbi request reprint Shroom4 (Kiaa1202) is an actin-associated protein implicated in cytoskeletal organization
    Michael Yoder
    Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA
    Cell Motil Cytoskeleton 64:49-63. 2007
  5. ncbi request reprint Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins
    Megan L Dietz
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 281:20542-54. 2006
  6. pmc Specific isoforms of drosophila shroom define spatial requirements for the induction of apical constriction
    Cory Bolinger
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Dev Dyn 239:2078-93. 2010
  7. pmc Nucleofection disrupts tight junction fence function to alter membrane polarity of renal epithelial cells
    Di Mo
    Renal Electrolyte Div, 978 1 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 299:F1178-84. 2010
  8. ncbi request reprint Shroom induces apical constriction and is required for hingepoint formation during neural tube closure
    Saori L Haigo
    Department of Molecular and Cell Biology, 16 Barker Hall, University of California Berkeley, Berkeley, CA 94720, USA
    Curr Biol 13:2125-37. 2003
  9. ncbi request reprint Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium
    Pamela D Fairbank
    Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
    Development 133:4109-18. 2006

Research Grants

  1. Epithelial Cell Structure in Vertebrate Development
    Jeffrey Hildebrand; Fiscal Year: 2006
  2. Epithelial Cell Structure in Vertebrate Development
    Jeffrey Hildebrand; Fiscal Year: 2007
  3. Epithelial Cell Structure in Vertebrate Development
    Jeffrey D Hildebrand; Fiscal Year: 2010

Collaborators

  • Ora A Weisz
  • Carol A Bertrand
  • Jeffrey M Gross
  • John B Wallingford
  • Swarna Mohan
  • Cory Bolinger
  • Di Mo
  • Michael Yoder
  • Megan L Dietz
  • Pamela D Fairbank
  • Saori L Haigo
  • Robert J Bauer
  • Debamitra Das
  • Andrew P VanDemark
  • Jenna K Zalewski
  • Atinuke M Dosunmu-Ogunbi
  • Simone Heber
  • Annie Heroux
  • Michael A Trakselis
  • Ryan Rizaldy
  • Jennifer R Bruns
  • Beth A Potter
  • Lauren Zasadil
  • Avegiyel Ellis
  • Chanjae Lee
  • Joseph M Kielec
  • Teresa M Bernaciak
  • Frank Vendetti
  • Richard M Harland

Detail Information

Publications9

  1. pmc Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology
    Swarna Mohan
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e81075. 2013
    ..Finally, we show that the binding surface is essential for Rock colocalization with Shroom and for Shroom-mediated changes in cell morphology. ..
  2. pmc Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development
    Jeffrey D Hildebrand
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98108, USA
    Mol Cell Biol 22:5296-307. 2002
    ..We suggest that the observed phenotypes reflect the large number of transcription factors whose activities are compromised in the absence of CtBP...
  3. ncbi request reprint Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network
    Jeffrey D Hildebrand
    Department of Biological Sciences, 4249 Fifth Avenue, Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Cell Sci 118:5191-203. 2005
    ..Thus, Shroom likely facilitates neural tube closure by regulating cell shape changes via the apical positioning of an actomyosin network in the neurepithelium...
  4. ncbi request reprint Shroom4 (Kiaa1202) is an actin-associated protein implicated in cytoskeletal organization
    Michael Yoder
    Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA
    Cell Motil Cytoskeleton 64:49-63. 2007
    ..This localization is mediated, at least in part, by the direct interaction of Shroom4 and F-actin. Our results suggest that Shroom4 is a regulator of cytoskeletal architecture that may play an important role in vertebrate development...
  5. ncbi request reprint Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins
    Megan L Dietz
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 281:20542-54. 2006
    ..We predict that the ability of Shroom-like proteins to regulate cellular morphology is conserved in evolution and is regulated in part by subcellular localization...
  6. pmc Specific isoforms of drosophila shroom define spatial requirements for the induction of apical constriction
    Cory Bolinger
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Dev Dyn 239:2078-93. 2010
    ..We further hypothesize that differentially positioned contractile arrays have distinct effects on cellular morphologies and behaviors...
  7. pmc Nucleofection disrupts tight junction fence function to alter membrane polarity of renal epithelial cells
    Di Mo
    Renal Electrolyte Div, 978 1 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 299:F1178-84. 2010
    ..We conclude that nucleofection selectively hinders development of the tight junction fence function in MDCK cells...
  8. ncbi request reprint Shroom induces apical constriction and is required for hingepoint formation during neural tube closure
    Saori L Haigo
    Department of Molecular and Cell Biology, 16 Barker Hall, University of California Berkeley, Berkeley, CA 94720, USA
    Curr Biol 13:2125-37. 2003
    ..For example, neural tube closure requires the actin binding protein Shroom, but the cellular basis of Shroom function and how it influences neural tube closure remain to be elucidated...
  9. ncbi request reprint Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium
    Pamela D Fairbank
    Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
    Development 133:4109-18. 2006
    ..Finally, because the locus encoding human SHROOM2 lies within the critical region for two distinct forms of ocular albinism, it is possible that SHROOM2 mutations may be a contributing factor in these human visual system disorders...

Research Grants9

  1. Epithelial Cell Structure in Vertebrate Development
    Jeffrey Hildebrand; Fiscal Year: 2006
    ..Together, these avenues of research should shed new light on pathways that control epithelial biology during the course of normal and adult life. ..
  2. Epithelial Cell Structure in Vertebrate Development
    Jeffrey Hildebrand; Fiscal Year: 2007
    ..We will continue to use in vivo studies in mice and in vitro studies in cell culture to understand the molecular mechanisms underlying human birth defects. ..
  3. Epithelial Cell Structure in Vertebrate Development
    Jeffrey D Hildebrand; Fiscal Year: 2010
    ..We will continue to use in vivo studies in mice and in vitro studies in cell culture to understand the molecular mechanisms underlying human birth defects. ..