Genomes and Genes
Affiliation: University of Pittsburgh
- Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse developmentJeffrey D Hildebrand
Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98108, USA
Mol Cell Biol 22:5296-307. 2002..We suggest that the observed phenotypes reflect the large number of transcription factors whose activities are compromised in the absence of CtBP...
- Shroom regulates epithelial cell shape via the apical positioning of an actomyosin networkJeffrey D Hildebrand
Department of Biological Sciences, 4249 Fifth Avenue, Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Cell Sci 118:5191-203. 2005..Thus, Shroom likely facilitates neural tube closure by regulating cell shape changes via the apical positioning of an actomyosin network in the neurepithelium...
- Shroom4 (Kiaa1202) is an actin-associated protein implicated in cytoskeletal organizationMichael Yoder
Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA
Cell Motil Cytoskeleton 64:49-63. 2007..This localization is mediated, at least in part, by the direct interaction of Shroom4 and F-actin. Our results suggest that Shroom4 is a regulator of cytoskeletal architecture that may play an important role in vertebrate development...
- Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteinsMegan L Dietz
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Biol Chem 281:20542-54. 2006..We predict that the ability of Shroom-like proteins to regulate cellular morphology is conserved in evolution and is regulated in part by subcellular localization...
- Specific isoforms of drosophila shroom define spatial requirements for the induction of apical constrictionCory Bolinger
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
Dev Dyn 239:2078-93. 2010..We further hypothesize that differentially positioned contractile arrays have distinct effects on cellular morphologies and behaviors...
- Nucleofection disrupts tight junction fence function to alter membrane polarity of renal epithelial cellsDi Mo
Renal Electrolyte Div, 978 1 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
Am J Physiol Renal Physiol 299:F1178-84. 2010..We conclude that nucleofection selectively hinders development of the tight junction fence function in MDCK cells...
- Shroom induces apical constriction and is required for hingepoint formation during neural tube closureSaori L Haigo
Department of Molecular and Cell Biology, 16 Barker Hall, University of California Berkeley, Berkeley, CA 94720, USA
Curr Biol 13:2125-37. 2003..For example, neural tube closure requires the actin binding protein Shroom, but the cellular basis of Shroom function and how it influences neural tube closure remain to be elucidated...
- Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epitheliumPamela D Fairbank
Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
Development 133:4109-18. 2006..Finally, because the locus encoding human SHROOM2 lies within the critical region for two distinct forms of ocular albinism, it is possible that SHROOM2 mutations may be a contributing factor in these human visual system disorders...
- Epithelial Cell Structure in Vertebrate DevelopmentJeffrey Hildebrand; Fiscal Year: 2006..Together, these avenues of research should shed new light on pathways that control epithelial biology during the course of normal and adult life. ..
- Epithelial Cell Structure in Vertebrate DevelopmentJeffrey Hildebrand; Fiscal Year: 2007..We will continue to use in vivo studies in mice and in vitro studies in cell culture to understand the molecular mechanisms underlying human birth defects. ..
- Epithelial Cell Structure in Vertebrate DevelopmentJeffrey D Hildebrand; Fiscal Year: 2010..We will continue to use in vivo studies in mice and in vitro studies in cell culture to understand the molecular mechanisms underlying human birth defects. ..