Research Topics
| Robert J HigginsSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Late-onset progressive spinocerebellar degeneration in Brittany Spaniel dogsR J Higgins
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, 95616, USA
Acta Neuropathol 96:97-101. 1998..There was bilateral sporadic axonal degeneration in the dorsal columns and lateral and ventromedial areas of the spinal cord. The etiology of this syndrome was not determined...- A peripheral primitive neuroectodermal tumor with generalized bone metastases in a puppyH E V De Cock
Department of Pathology, Microbiology and Immunology, One Shields Avenue, Davis, CA 95616, USA
Vet Pathol 41:437-41. 2004.... - Growth inhibition of an orthotopic glioblastoma in immunocompetent mice by cationic lipid-DNA complexesRobert J Higgins
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA
Cancer Immunol Immunother 53:338-44. 2004..The results indicate that an i.v.-administered EV-CLDC can significantly inhibit the growth of a brain tumor in immunocompetent syngeneic mice... 
Necrotizing meningoencephalitis in five Chihuahua dogsR J Higgins
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Vet Pathol 45:336-46. 2008..The clinical signs, distribution pattern, and histologic type of lesions bear close similarities to necrotizing meningoencephalitis as described in series of both Pug and Maltese breed dogs and less commonly in other breeds...- Canine intraneural perineuriomaR J Higgins
Department of Pathology, Immunology and Pathology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Vet Pathol 43:50-4. 2006..These morphologic and immunologic features distinguish this lesion from hypertrophic neuropathy and were consistent with intraneural perineurioma... - Granular cell tumor of the canine central nervous system: two casesR J Higgins
Department of Pathology, Immunology, and Microbiology, School of Veterinary Medicine, University of California, Davis 95616, USA
Vet Pathol 38:620-7. 2001..Although not conclusive, these studies indicated that the granular cells were not of leucocyte origin but may have been derived from the meninges. One dog died 12 months after surgery, and the other was alive 4 months later... - Spontaneous canine gliomas: overexpression of EGFR, PDGFRalpha and IGFBP2 demonstrated by tissue microarray immunophenotypingRobert J Higgins
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
J Neurooncol 98:49-55. 2010..These findings support a role for the spontaneous canine glioma model in directed pathway-targeting therapeutic studies... 
Canine spontaneous glioma: a translational model system for convection-enhanced deliveryPeter J Dickinson
Department of Surgical and Radiological of Sciences, School of Veterinary Medicine, University of California Davis, Davis, California 95616 8745, USA
Neuro Oncol 12:928-40. 2010..Variability in Vd between tumors strongly suggests that real-time imaging should be an essential component of CED therapeutic trials to allow minimization of inappropriate infusions and accurate assessment of clinical outcomes...- Retrospective analysis of spinal arachnoid cysts in 14 dogsHelena Rylander
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California Davis, Davis, CA 95616 8747, USA
J Vet Intern Med 16:690-6. 2002..Furthermore, bilobed or multiple SACs can occur commonly, and myelography effectively localized SACs in dogs. Surgical resection of SACs resulted in improvement in neurological function in the majority of treated dogs... - Glioblastoma multiforme: clinical findings, magnetic resonance imaging, and pathology in five dogsD Lipsitz
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA
Vet Pathol 40:659-69. 2003..These canine GBMs shared many diagnostic neuroimaging, gross, microcopic, and immunoreactivity features similar to those of human GBMs... - Quantitative assessment of blood volume and permeability in cerebral mass lesions using dynamic contrast-enhanced computed tomography in the dogAlexander G MacLeod
Veterinary Medical Teaching Hospital, University of California, Davis, School of Veterinary Medicine, Davis, CA 95616, USA
Acad Radiol 16:1187-95. 2009..To evaluate cerebral blood volume (CBV) and permeability (PS) in spontaneously occurring cerebral neoplastic and non-neoplastic lesions in dogs using dynamic contrast-enhanced computed tomography (DCE-CT)... - Genome-wide association analysis identifies a mutation in the thiamine transporter 2 (SLC19A3) gene associated with Alaskan Husky encephalopathyKaren M Vernau
University of California Davis, Davis, California, United States of America
PLoS ONE 8:e57195. 2013..Furthermore, this mutation was not detected in another 187 dogs of different breeds. These results suggest that this mutation in SLC19A3.1, encoding a thiamine transporter protein, plays a critical role in the pathogenesis of AHE... - Canine model of convection-enhanced delivery of liposomes containing CPT-11 monitored with real-time magnetic resonance imaging: laboratory investigationPeter J Dickinson
Department of Surgical and Radiological Sciences, Tupper Hall, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Neurosurg 108:989-98. 2008..Additionally any possible toxicity of liposomes containing Gd and the chemotherapeutic agent irinotecan (CPT-11) was assessed following direct intraparenchymal delivery... - Magnetic resonance imaging features of canine intracranial neoplasiaErik R Wisner
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Vet Radiol Ultrasound 52:S52-61. 2011..Characterization of neoplasms by histologic type and biological grade is based on the 2007 World Health Organization classification system for CNS tumors in humans... - Magnetic resonance imaging and histological classification of intracranial meningiomas in 112 dogsB K Sturges
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616 87471, USA
J Vet Intern Med 22:586-95. 2008..Classification of meningiomas by tumor grade and subtype has not been reported, and the value of magnetic resonance imaging (MRI) characteristics for predicting tumor subtype and grade has not been investigated... - Ronidazole toxicosis in 3 society finches (Lonchura striata)L W Woods
California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, Davis, CA 95617 1770, USA
Vet Pathol 47:231-5. 2010..Ronidazole was detected in the liver tissue at 2,700 ng/g (wet weight), and 2-hydroxymethyl-1-methyl-5-nitroimidazole was detected at 140 ng/g (wet weight)... - Expression of the tumor suppressor genes NF2, 4.1B, and TSLC1 in canine meningiomasP J Dickinson
Department of Surgical and Radiological Sciences, Tupper Hall, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
Vet Pathol 46:884-92. 2009..In addition, it is likely that other, as yet unidentified, genes play an important role in canine meningioma formation and growth... - Clinical signs, imaging features, neuropathology, and outcome in cats and dogs with central nervous system cryptococcosis from CaliforniaJ E Sykes
Veterinary Medical Teaching Hospital, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Vet Intern Med 24:1427-38. 2010..Cryptococcus spp. is a fungal pathogen with a predilection for the central nervous system (CNS)... - Simultaneously occurring oligodendroglioma and meningioma in a dogB A Stacy
Department of Pathology, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA
J Vet Intern Med 17:357-9. 2003 - Vascular endothelial growth factor mRNA expression and peritumoral edema in canine primary central nervous system tumorsP J Dickinson
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Vet Pathol 45:131-9. 2008..Peritumoral edema was present in all tumor types; however, a significant association between the extent of peritumoral edema and the level of VEGF expression was not apparent... - A grade IV glioblastoma with an oligodendroglial component (GBM-O) in a horseB Gericota
The William R Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, USA
J Comp Pathol 142:332-5. 2010..To our knowledge this is the first report of a GBM-O in the horse... - Intracranial intra-arachnoid cyst with intracystic hemorrhage in two dogsKaren M Vernau
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, 95616, USA
Vet Radiol Ultrasound 43:449-54. 2002..Surgical fenestration and hematoma removal appear to provide a satisfactory treatment for adult dogs with an intracranial intra-arachnoid cyst and intracystic hemorrhage. Persistence of the cyst may occur in some dogs... - Primary canine and feline nervous system tumors: intraoperative diagnosis using the smear techniqueK M Vernau
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis 95616, USA
Vet Pathol 38:47-57. 2001..The distinguishing features of the canine and feline tumors bear a remarkably close resemblance to their human counterparts... - Canine intraspinal meningiomas: imaging features, histopathologic classification, and long-term outcome in 34 dogsS A Petersen
Department of Surgical and Radiological Sciences, University of California, Davis, CA 95616 8747, USA
J Vet Intern Med 22:946-53. 2008.... - Primary intra-axial leiomyosarcoma with obstructive hydrocephalus in a young dogT S Zabka
Pathology Service, Veterinary Medical Teaching Hospital (VMTH, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616-8747, USA
J Comp Pathol 131:334-7. 2004..Leiomyosarcoma should be included in the differential diagnosis for primary brain tumours and hydrocephalus in young dogs... - Evaluation of epidemiological, clinical, and pathological features of neuroaxonal dystrophy in Quarter HorsesMonica Aleman
William R Pritchard Veterinary Medical Teaching Hospital, School of Medicine, University of California Davis, Davis, CA 95616, USA
J Am Vet Med Assoc 239:823-33. 2011..To describe epidemiological, clinical, and pathological features of neuroaxonal dystrophy in Quarter Horses (QHs) on a single farm... - Choroid plexus tumors in 56 dogs (1985-2007)D R Westworth
William R Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California Davis, Davis, CA 95616 8747, USA
J Vet Intern Med 22:1157-65. 2008..The clinical utility of magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, or both in the presumptive diagnosis of CPTs has not been determined... - Spontaneous and nitrosourea-induced primary tumors of the central nervous system in Fischer 344 rats exposed to frequency-modulated microwave fieldsW R Adey
Department of Biochemistry, University of California, Riverside 92521, USA
Cancer Res 60:1857-63. 2000....