Peter D R Higgins

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint The quantitative validation of non-endoscopic disease activity indices in ulcerative colitis
    P D R Higgins
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Aliment Pharmacol Ther 25:333-42. 2007
  2. doi request reprint Systematic review: impact of non-adherence to 5-aminosalicylic acid products on the frequency and cost of ulcerative colitis flares
    P D R Higgins
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Aliment Pharmacol Ther 29:247-57. 2009
  3. pmc Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestine
    Peter D R Higgins
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan Hospitals, Ann Arbor, Michigan 48109, USA
    Inflamm Bowel Dis 17:1398-408. 2011
  4. ncbi request reprint Computed tomographic enterography adds information to clinical management in small bowel Crohn's disease
    Peter D R Higgins
    Department of Internal Medicine, University of Michigan, University of Michigan, Ann Arbor, Michigan 48109, USA
    Inflamm Bowel Dis 13:262-8. 2007
  5. pmc New keys to maintenance treatment in ulcerative colitis
    Peter D R Higgins
    University of Michigan, West Medical Center, Ann Arbor, MI 48109, USA
    Dig Dis 28:483-9. 2010
  6. pmc Patient defined dichotomous end points for remission and clinical improvement in ulcerative colitis
    P D R Higgins
    6510 MSRB I, Box 0682, University of Michigan, Ann Arbor, MI, 48109, USA
    Gut 54:782-8. 2005
  7. doi request reprint Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with Crohn's disease
    Ryan W Stidham
    Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 141:819-826.e1. 2011
  8. pmc Spironolactone and colitis: increased mortality in rodents and in humans
    Laura A Johnson
    University of Michigan, Department of Internal Medicine, Ann Arbor, Michigan 48109 0682, USA
    Inflamm Bowel Dis 18:1315-24. 2012
  9. doi request reprint Does rectal indomethacin eliminate the need for prophylactic pancreatic stent placement in patients undergoing high-risk ERCP? Post hoc efficacy and cost-benefit analyses using prospective clinical trial data
    B Joseph Elmunzer
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 108:410-5. 2013
  10. pmc Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: impact of a "Top-Down" approach to intestinal fibrosis in mice
    Laura A Johnson
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan Hospitals, Ann Arbor, MI 48109, USA
    Inflamm Bowel Dis 18:460-71. 2012

Collaborators

Detail Information

Publications46

  1. ncbi request reprint The quantitative validation of non-endoscopic disease activity indices in ulcerative colitis
    P D R Higgins
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Aliment Pharmacol Ther 25:333-42. 2007
    ..Ulcerative colitis disease activity indices have not been formally validated...
  2. doi request reprint Systematic review: impact of non-adherence to 5-aminosalicylic acid products on the frequency and cost of ulcerative colitis flares
    P D R Higgins
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Aliment Pharmacol Ther 29:247-57. 2009
    ..Ulcerative colitis (UC) can be maintained in remission with 5-aminosalicylic acid (5-ASA) medications, but frequent non-adherence by patients who are feeling well has been associated with more frequent flares of colitis...
  3. pmc Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestine
    Peter D R Higgins
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan Hospitals, Ann Arbor, Michigan 48109, USA
    Inflamm Bowel Dis 17:1398-408. 2011
    ..The aim of this study was to determine whether prior H. pylori infection acts at a distance to modulate the immune response of S.typhimurium-induced colitis...
  4. ncbi request reprint Computed tomographic enterography adds information to clinical management in small bowel Crohn's disease
    Peter D R Higgins
    Department of Internal Medicine, University of Michigan, University of Michigan, Ann Arbor, Michigan 48109, USA
    Inflamm Bowel Dis 13:262-8. 2007
    ..However, the clinical relevance of these images is unknown. It is also not known if these radiologic findings correlate with objective biomarkers of inflammation...
  5. pmc New keys to maintenance treatment in ulcerative colitis
    Peter D R Higgins
    University of Michigan, West Medical Center, Ann Arbor, MI 48109, USA
    Dig Dis 28:483-9. 2010
    ..Combination therapy with immunomodulators improves trough levels in Crohn's, and may prove to have benefits for the maintenance of biologic efficacy in ulcerative colitis...
  6. pmc Patient defined dichotomous end points for remission and clinical improvement in ulcerative colitis
    P D R Higgins
    6510 MSRB I, Box 0682, University of Michigan, Ann Arbor, MI, 48109, USA
    Gut 54:782-8. 2005
    ..The use of clinically important end points would strengthen the validity of study outcomes. Our aims were to identify objective end points in standard disease activity indices for remission and for improvement in ulcerative colitis...
  7. doi request reprint Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with Crohn's disease
    Ryan W Stidham
    Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 141:819-826.e1. 2011
    ..We hypothesized that UEI could differentiate inflammatory from fibrotic bowel wall changes in both animal models of colitis and humans with CD...
  8. pmc Spironolactone and colitis: increased mortality in rodents and in humans
    Laura A Johnson
    University of Michigan, Department of Internal Medicine, Ann Arbor, Michigan 48109 0682, USA
    Inflamm Bowel Dis 18:1315-24. 2012
    ..Spironolactone is an antifibrotic medication commonly used in heart failure to reduce mortality. We examined whether spironolactone is antifibrotic in the context of intestinal inflammation...
  9. doi request reprint Does rectal indomethacin eliminate the need for prophylactic pancreatic stent placement in patients undergoing high-risk ERCP? Post hoc efficacy and cost-benefit analyses using prospective clinical trial data
    B Joseph Elmunzer
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 108:410-5. 2013
    ..We performed a post hoc analysis of this RCT to explore whether rectal indomethacin can replace PSP in the prevention of PEP and to estimate the potential cost savings of such an approach...
  10. pmc Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: impact of a "Top-Down" approach to intestinal fibrosis in mice
    Laura A Johnson
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan Hospitals, Ann Arbor, MI 48109, USA
    Inflamm Bowel Dis 18:460-71. 2012
    ..The aim of this study was to determine the relationship between intestinal inflammation and fibrogenesis and the impact of a very early "top-down" interventional approach on fibrosis in vivo...
  11. pmc Patient reported symptoms during an ulcerative colitis flare: a Qualitative Focus Group Study
    Akbar K Waljee
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Eur J Gastroenterol Hepatol 21:558-64. 2009
    ..It has been assumed that the symptoms measured in disease activity indices for ulcerative colitis reflect those symptoms that patients find useful in evaluating the severity of a disease flare...
  12. pmc Cost effectiveness of ulcerative colitis surveillance in the setting of 5-aminosalicylates
    Joel H Rubenstein
    The Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Am J Gastroenterol 104:2222-32. 2009
    ..Therefore, in patients prescribed 5-ASAs for maintenance of remission, annual surveillance might be overly burdensome and inefficient. We aimed to determine the ideal frequency of surveillance in patients with UC maintained on 5-ASAs...
  13. doi request reprint Individual health discount rate in patients with ulcerative colitis
    Akbar K Waljee
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Inflamm Bowel Dis 17:1328-32. 2011
    ..In this study we aimed to measure the discount rate in UC patients and identify variables associated with the discount rate...
  14. ncbi request reprint How early to take arms against a sea of troubles? The case for aggressive early therapy in Crohn's disease to prevent fibrotic intestinal strictures
    Shail M Govani
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, United States
    J Crohns Colitis 7:923-7. 2013
    ..With increased early use of biologics and better control of inflammation, we hope to see a global reduction in intestinal fibrosis and related complications of Crohn's disease. ..
  15. doi request reprint US elastography-derived shear wave velocity helps distinguish acutely inflamed from fibrotic bowel in a Crohn disease animal model
    Jonathan R Dillman
    Department of Radiology, Section of Pediatric Radiology, University of Michigan Health System, C S Mott Children s Hospital, 1540 E Hospital Dr, Ann Arbor, MI 48109 4252, USA
    Radiology 267:757-66. 2013
    ..To determine if acoustic radiation force impulse elastography-derived bowel wall shear wave velocity (SWV) allows distinction of acutely inflamed from fibrotic intestine in a Crohn disease animal model...
  16. doi request reprint Association between Helicobacter pylori infection and inflammatory bowel disease: a meta-analysis and systematic review of the literature
    Jay Luther
    University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Inflamm Bowel Dis 16:1077-84. 2010
    ..Numerous observational studies have investigated the association between H. pylori infection and inflammatory bowel disease (IBD). Our aim was to perform a systematic review and meta-analysis of this association...
  17. doi request reprint Proximity to disease and perception of utility: physicians' vs patients' assessment of treatment options for ulcerative colitis
    Lindsay Kennedy Brown
    University of Michigan Medical School, Ann Arbor, Michigan, USA
    Dis Colon Rectum 54:1529-36. 2011
    ..If physicians perceive these states differently than patients, their therapeutic recommendations may not align with patient values...
  18. pmc Transient or persistent norovirus infection does not alter the pathology of Salmonella typhimurium induced intestinal inflammation and fibrosis in mice
    Peter D R Higgins
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan Medical Center, Medical Science Research Building One, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, United States
    Comp Immunol Microbiol Infect Dis 34:247-57. 2011
    ..We hypothesize that this is particularly important in cases of research models that use immunocompromised mice, which could be more sensitive to MNV infection-induced changes...
  19. doi request reprint A randomised trial of sheathed versus standard forceps for obtaining uncontaminated biopsy specimens of microbiota from the terminal ileum
    Maneesh Dave
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan Medical Center, Medical Science Research Ann Arbor, MI 48109 0682, USA
    Gut 60:1043-9. 2011
    ....
  20. doi request reprint CARD-024, a vitamin D analog, attenuates the pro-fibrotic response to substrate stiffness in colonic myofibroblasts
    Laura A Johnson
    University of Michigan, Department of Internal Medicine, Ann Arbor, MI 48109 0682, United States
    Exp Mol Pathol 93:91-8. 2012
    ..In summary, CARD-024 attenuated the pro-fibrotic response of colonic myofibroblasts to high matrix stiffness, suggesting that vitamin D analogs such as CARD-024 may ameliorate intestinal fibrosis...
  21. doi request reprint Voting With their Feet (VWF) endpoint: a meta-analysis of an alternative endpoint in clinical trials, using 5-ASA induction studies in ulcerative colitis
    Sujal C Rangwalla
    Division of Gastroenterology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
    Inflamm Bowel Dis 15:422-8. 2009
    ....
  22. doi request reprint The prognostic power of the NOD2 genotype for complicated Crohn's disease: a meta-analysis
    Jeremy Adler
    Department of Pediatrics and Communicable Diseases, University of Michigan Health System, Ann Arbor, MI, USA
    Am J Gastroenterol 106:699-712. 2011
    ..We performed a systematic review and meta-analysis to obtain accurate estimates of the predictive power of the identified mutations (such as p.R702W, P.G908R, and p.Leu1007fsX1008) in NOD2 for the risk of complicated disease...
  23. doi request reprint Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines
    Akbar K Waljee
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Gastroenterol Hepatol 8:143-50. 2010
    ....
  24. doi request reprint Anti-adhesion therapies and the rule of 3 for rare events
    Shail M Govani
    Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA
    Am J Gastroenterol 108:1831-2. 2013
    ..So, going forward, how do we quantify the risk of this serious adverse event? This review details how we define the maximum risk when no (or very few) events have occurred with an easy-to-use equation. ..
  25. pmc Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity
    Joel C Joyce
    Medical School, University of Michigan, Ann Arbor, MI, USA
    Health Qual Life Outcomes 6:69. 2008
    ....
  26. pmc Magnetization transfer helps detect intestinal fibrosis in an animal model of Crohn disease
    Jeremy Adler
    Department of Pediatrics, Division of Gastroenterology, University of Michigan Medical Center, 1150 W Medical Center Dr, A520B MSRB I, Box 5658, Ann Arbor, MI 48109, USA
    Radiology 259:127-35. 2011
    ..To determine the utility of magnetization transfer (MT) in the identification and quantification of intestinal fibrosis in a rat model of Crohn disease...
  27. ncbi request reprint Is endoscopy necessary for the measurement of disease activity in ulcerative colitis?
    Peter D R Higgins
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Gastroenterol 100:355-61. 2005
    ..However, invasive indices are commonly used in clinical research. Our objective was to determine whether endoscopy is necessary for the assessment of disease activity in patients with ulcerative colitis...
  28. doi request reprint Empiric quadruple vs. triple therapy for primary treatment of Helicobacter pylori infection: Systematic review and meta-analysis of efficacy and tolerability
    Jay Luther
    University of Michigan Medical Center, Ann Arbor, USA
    Am J Gastroenterol 105:65-73. 2010
    ..We performed a systematic review and meta-analysis to compare the efficacy and tolerability of these regimens as first-line treatment of H. pylori...
  29. ncbi request reprint Jumbo forceps are superior to standard large-capacity forceps in obtaining diagnostically adequate inflammatory bowel disease surveillance biopsy specimens
    B Joseph Elmunzer
    Division of Gastroenterology Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Gastrointest Endosc 68:273-8; quiz 334, 336. 2008
    ..In inflammatory bowel disease (IBD) surveillance colonoscopy, an increased number of biopsy specimens correlates with a higher dysplasia detection rate. Larger biopsy specimens may also increase the diagnostic yield...
  30. ncbi request reprint Massive lower gastrointestinal bleeding after rejection of pancreatic transplants
    Peter D R Higgins
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Nat Clin Pract Gastroenterol Hepatol 2:240-4; quiz 1 p following 244. 2005
    ..He presented in late 2003 with a single episode of coffee-ground emesis and two episodes of brisk hematochezia...
  31. ncbi request reprint A meta-analysis of rectal NSAIDs in the prevention of post-ERCP pancreatitis
    B J Elmunzer
    Division of Gastroenterology, Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Gut 57:1262-7. 2008
    ..Clinical trials evaluating the protective effect of non-steroidal anti-inflammatory drugs (NSAIDs) have yielded inconclusive results...
  32. pmc X-linked inhibitor of apoptosis regulates lung fibroblast resistance to Fas-mediated apoptosis
    Iyabode O Ajayi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Am J Respir Cell Mol Biol 49:86-95. 2013
    ..Collectively, these findings support a mechanistic role for XIAP in the apoptosis-resistant phenotype of IPF fibroblasts...
  33. pmc Cost utility of inflammation-targeted therapy for patients with ulcerative colitis
    Sameer D Saini
    Veterans Affairs Center for Clinical Management Research, Ann Arbor, MI 48105, USA
    Clin Gastroenterol Hepatol 10:1143-51. 2012
    ..We compared the cost utility of inflammation-targeted, intermittent therapy with that of universal, continuous maintenance therapy with mesalamine agents for patients with mild-to-moderate UC...
  34. pmc Noninvasive ultrasound elasticity imaging (UEI) of Crohn's disease: animal model
    Kang Kim
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Ultrasound Med Biol 34:902-12. 2008
    ..The preliminary results on an animal model also suggest the feasibility of translating this imaging technique directly to human subjects for both diagnosis and monitoring...
  35. ncbi request reprint Drug insight: statins and gastrointestinal cancer
    Taft P Bhuket
    University of Michigan, Ann Arbor, MI, USA
    Nat Clin Pract Gastroenterol Hepatol 3:552-62. 2006
    ..This review critically evaluates the current body of literature on the role of statins in the treatment and prevention of gastrointestinal cancers, with particular focus on clinical and observational studies...
  36. doi request reprint Perceived and actual quality of life with ulcerative colitis: a comparison of medically and surgically treated patients
    Akbar K Waljee
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Am J Gastroenterol 106:794-9. 2011
    ..Our aims were to compare the perceived utility assigned by UC patients with and without a colectomy to standardized chronic UC and post-colectomy scenarios, and to compare the utility of actual health states among groups...
  37. doi request reprint Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts
    Laura A Johnson
    Department of Internal Medicine, Department of Pharmacology, and Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, Michigan
    Inflamm Bowel Dis 20:154-65. 2014
    ..Recent recognition of the role of Rho-regulated gene transcription by serum response factor (SRF) and its transcriptional cofactor myocardin-related transcription factor A (MRTF-A) suggest a novel locus for pharmacological intervention...
  38. pmc A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis
    B Joseph Elmunzer
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    N Engl J Med 366:1414-22. 2012
    ..Preliminary research suggests that rectally administered nonsteroidal antiinflammatory drugs may reduce the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP)...
  39. pmc Combination of thiopurines and allopurinol: adverse events and clinical benefit in IBD
    Shail M Govani
    University of Michigan, Department of Internal Medicine, Division of General Medicine, United States
    J Crohns Colitis 4:444-9. 2010
    ..Additionally we aimed to identify which variables predict complications...
  40. ncbi request reprint Primary sclerosing cholangitis: meta-analysis of diagnostic performance of MR cholangiopancreatography
    Maneesh Dave
    Department of Internal Medicine, Wayne State University, Detroit, Mich, USA
    Radiology 256:387-96. 2010
    ..To determine the diagnostic accuracy of magnetic resonance cholangiopancreatography (MRCP) for detection of primary sclerosing cholangitis (PSC) in patients with biochemical cholestasis...
  41. ncbi request reprint Value of mucosal assessment and biomarkers in inflammatory bowel disease
    Ryan W Stidham
    University of Michigan Medical Center, Division of Gastroenterology and Hepatology, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0682, USA
    Expert Rev Gastroenterol Hepatol 4:285-91. 2010
    ....
  42. ncbi request reprint Statins and the risk of colorectal cancer
    Jenny N Poynter
    Department of Epidemiology, University of Michigan, Ann Arbor 48109 0638, USA
    N Engl J Med 352:2184-92. 2005
    ..Statins inhibit the growth of colon-cancer cell lines, and secondary analyses of some, but not all, clinical trials suggest that they reduce the risk of colorectal cancer...
  43. ncbi request reprint Epidemiology of constipation in North America: a systematic review
    Peter D R Higgins
    Department of Internal Medicine, University of Michigan Division of Gastroenterology, Ann Arbor, Michigan, USA
    Am J Gastroenterol 99:750-9. 2004
    ..The aim of this study was to systematically review the published literature regarding prevalence, risk factors, incidence, natural history, and the effect on quality of life of constipation in North America...
  44. pmc Threefold increased risk of infertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis
    A Waljee
    Division of Gastroenterology, University of Michigan, 6520 MSRB I, Box 0682, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Gut 55:1575-80. 2006
    ..Increased infertility in women has been reported after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis but reported infertility rates vary substantially...
  45. ncbi request reprint Liver transplantation in acute liver failure
    P D R Higgins
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA
    Panminerva Med 45:85-94. 2003
    ..In the meanwhile, it is recommended that acute liver failure patients be managed in experienced centers with ready access to liver transplantation to optimize outcomes in this rare but frequently fatal illness...
  46. ncbi request reprint Statins and cancer prevention
    Marie France Demierre
    Department of Dermatology, Boston University School of Medicine, 720 Harrison Avenue DOB 801A, Boston, MA 02118, USA
    Nat Rev Cancer 5:930-42. 2005
    ..This understanding might also help the development of drugs for other ageing-related diseases with interrelated molecular pathways...