Research Topics
| J W HicksSummaryAffiliation: University of California Country: USA Publications
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Publications
Time domains of the hypoxic ventilatory response in ectothermic vertebratesCosima Porteus
Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
J Comp Physiol B 181:311-33. 2011..If we are to distinguish between the genetic, developmental and environmental influences underlying the various ventilatory responses to hypoxia, however, we must design future experiments with time domains in mind...
Eat and run: prioritization of oxygen delivery during elevated metabolic statesJames W Hicks
Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
Respir Physiol Neurobiol 144:215-24. 2004....- Hypometabolism in reptiles: behavioural and physiological mechanisms that reduce aerobic demandsJames W Hicks
Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
Respir Physiol Neurobiol 141:261-71. 2004..Below we review these two different strategies and discuss their possible mechanisms and physiological significance... - Patterns of cardiovascular and ventilatory response to elevated metabolic states in the lizard Varanus exanthematicusJ W Hicks
Department of Ecology and Evolutionary Biology, University of California at Irvine, Irvine, CA 92697, USA
J Exp Biol 203:2437-45. 2000..In contrast, the ventilatory response is flexible and state-dependent, not only in pattern but also in its frequency and volume components... - Gas exchange potential in reptilian lungs: implications for the dinosaur-avian connectionJ W Hicks
Department of Ecology and Evolutionary Biology, University of California, Irvine 92697, USA
Respir Physiol 117:73-83. 1999..Furthermore, our analysis suggests that factors besides diffusive gas exchange were important in the evolution of the distinct morphology of the highly effective avian and mammalian lungs. reserved... - Hypoxic hypometabolism in the anesthetized turtle, Trachemys scriptaJ W Hicks
Department of Ecology and Evolutionary Biology, University of California, Irvine, California, USA
Am J Physiol 277:R18-23. 1999..Finally, we hypothesize that hypoxemia induced by the right-to-left cardiac shunt often associated with diving may trigger the development of a hypometabolic state and therefore contribute to the prolongation of aerobic dive times... - Cardiovascular regulation during anoxia in the turtle: an in vivo studyJ W Hicks
Department of Ecology and Evolutionary Biology, University of California, Irvine 92697, USA
Physiol Zool 71:1-14. 1998..In contrast, injection of atropine during anoxia resulted in an increase in the heart rate and systemic blood flow, suggesting that the anoxic cardiac response is partially mediated through cholinergic mechanisms... - Reductions in systemic oxygen delivery induce a hypometabolic state in the turtle Trachemys scriptaB Platzack
Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697 2525, USA
Am J Physiol Regul Integr Comp Physiol 281:R1295-301. 2001.... - Metabolic and blood gas dependence on digestive state in the Savannah monitor lizard Varanus exanthematicus: an assessment of the alkaline tideL K Hartzler
Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
J Exp Biol 209:1052-7. 2006..Collectively the data indicate that the metabolic alkalosis associated with H+ secretion (as indicated by increased plasma bicarbonate) is partially compensated by a respiratory acidosis... - An experimental test of the thermoregulatory hypothesis for the evolution of endothermyA F Bennett
Department of Ecology and Evolutionary Biology, University of California Irvine 92697, USA
Evolution 54:1768-73. 2000..Thus, increasing the visceral metabolic rate of this ectothermic lizard established neither consequential endothermy nor homeothermy. These results are inconsistent with a thermoregulatory explanation for the evolution of endothermy... - Postprandial exercise: prioritization or additivity of the metabolic responses?A F Bennett
Department of Ecology and Evolutionary Biology, University of California at Irvine, Irvine, CA 92697, USA
J Exp Biol 204:2127-32. 2001..It is clear that fasting exercise did not elicit truly maximal levels of cardiopulmonary oxygen transport in these animals, indicating problems for design models that make this assumption... - The interaction of pulmonary ventilation and the right-left shunt on arterial oxygen levelsT Wang
Department of Ecology and Evolutionary Biology, University of California at Irvine 92717, USA
J Exp Biol 199:2121-9. 1996.... - The effect of altering pulmonary blood flow on pulmonary gas exchange in the turtle Trachemys (Pseudemys) scriptaS R Hopkins
Department of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
J Exp Biol 199:2207-14. 1996..These findings suggest that increased pulmonary blood flow during a ventilatory period results in both temporal and spatial matching of ventilation and perfusion, without altering pulmonary diffusion limitation... - Terrestrial locomotion does not constrain venous return in the American alligator, Alligator mississippiensisSuzanne L Munns
Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA 92697, USA
J Exp Biol 208:3331-9. 2005..These results suggest that, while tonically elevated intra-abdominal pressure induced by exercise does not inhibit venous return, phasic fluctuations during each breath cycle may contribute to venous flow limitation during exercise... - The energetic consequences of dietary specialization in populations of the garter snake, Thamnophis elegansE J Britt
Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
J Exp Biol 209:3164-9. 2006..However, there was no apparent trade-off on the more generalized diet that was associated with this specialization... - Recovery from an activity-induced metabolic acidosis in the American alligator, Alligator mississippiensisL K Hartzler
Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697 2525, USA
Comp Biochem Physiol A Mol Integr Physiol 143:368-74. 2006..Compensation during recovery of acid-base balance was achieved by altering ventilation: following the initial metabolic acidosis and titration of bicarbonate, a relative hyperventilation prevented a further decrease in pH... - Cardiorespiratory synchrony in turtlesT Wang
Department of Ecology and Evolutionary Biology, University of California at Irvine 92717, USA
J Exp Biol 199:1791-800. 1996..80 during lung ventilation. This study confirms cardiorespiratory synchrony in the turtle Trachemys scripta but, in contrast to earlier studies, a net right-to-left cardiac shunt prevailed regardless of ventilatory state... - Ventilation and gas exchange in lizards during treadmill exerciseT Wang
Department of Ecology, University of California at Irvine, Irvine, CA 92717, USA
J Exp Biol 200:2629-39. 1997..Iguana iguana, therefore, appears to be unable to match the increased oxygen demand with adequate ventilation at moderate and higher speeds... - Physiology: postprandial cardiac hypertrophy in pythonsJohnnie B Andersen
Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA
Nature 434:37-8. 2005..As this fully reversible hypertrophy occurs naturally, it could provide a useful model for investigating the mechanisms that lead to cardiac growth in other animals... - Atmospheric oxygen level affects growth trajectory, cardiopulmonary allometry and metabolic rate in the American alligator (Alligator mississippiensis)Tomasz Owerkowicz
Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
J Exp Biol 212:1237-47. 2009..This suggests that growth and metabolic patterns of extinct vertebrates would have been significantly affected by changes in the atmospheric oxygen level... - The physiological and evolutionary significance of cardiovascular shunting patterns in reptilesJames W Hicks
Department of Ecology and Evolutionary Biology, University of California at Irvine, 92697, USA
News Physiol Sci 17:241-5. 2002..Alternative views are advanced suggesting that, in reptiles, cardiac shunts represent either an ancestral condition or an embryonic trait... - Exhaustive exercise training enhances aerobic capacity in American alligator (Alligator mississippiensis)John Eme
Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, CA 92697 2525, USA
J Comp Physiol B 179:921-31. 2009..Unlike mammals, but similar to squamate reptiles, alligators do not also increase citrate synthase activity of the skeletal muscles in response to exercise... - Surgical removal of right-to-left cardiac shunt in the American alligator (Alligator mississippiensis) causes ventricular enlargement but does not alter apnoea or metabolism during divingJohn Eme
Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, CA 92697 2525, USA
J Exp Biol 212:3553-63. 2009..It appears probable that the low metabolic rate of reptiles, rather than pulmonary circulatory bypass, allows for normal aerobic dives... - Ontogeny of baroreflex control in the American alligator Alligator mississippiensisDane A Crossley
Department of Ecology and Evolutionary Biology, University of California at Irvine, CA 92697, USA
J Exp Biol 206:2895-902. 2003.... - Turning crocodilian hearts into bird hearts: growth rates are similar for alligators with and without right-to-left cardiac shuntJohn Eme
University of California, Irvine, Ecology and Evolutionary Biology, 321 Steinhaus Hall, Irvine, CA 92697 2525, USA
J Exp Biol 213:2673-80. 2010..This study suggests that crocodilian R-L cardiac shunt does not provide an adaptive advantage for juvenile alligator growth and supports the logic that cardiac shunts persist in crocodilians because they have not been selected against... - Elevated intra-abdominal pressure limits venous return during exercise in Varanus exanthematicusSuzanne L Munns
Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA 92697, USA
J Exp Biol 207:4111-20. 2004..During locomotion, the physical compression of the large abdominal veins may represent a significant limitation to cardiac output and maximal oxygen consumption in lizards... - Characterization and cardiovascular actions of endothelin-1 and endothelin-3 from the American alligatorBjörn Platzack
Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA
Am J Physiol Regul Integr Comp Physiol 282:R594-602. 2002.... - Circulatory impairment induced by exercise in the lizard Iguana iguanaC G Farmer
Department of Ecology and Evolutionary Biology, University of California at Irvine, Irvine, CA 92697, USA
J Exp Biol 203:2691-7. 2000..We suggest that mechanical coupling of the pulmonary and cardiac pumps may have been important for the evolution of high-speed locomotor stamina in terrestrial vertebrates... - The effect of meal composition on specific dynamic action in burmese pythons (Python molurus)M D McCue
Department of Ecology and Evolutionary Biology, University of California, Irvine, 92697 2525, USA
Physiol Biochem Zool 78:182-92. 2005..Stomach distension and mechanical digestion of intact prey did not cause measurable SDA... - The siphon controversy counterpoint: the brain need not be "baffling"James W Hicks
Department of Ecology and Evolutionary Biology, University of California-Irvine, Irvine, CA, USA
Am J Physiol Regul Integr Comp Physiol 289:R629-32. 2005 - Cardiac output and shunt during voluntary activity at different temperatures in the turtle, Trachemys scriptaEgle H Krosniunas
Department of Ecology and Evolutionary Biology, University of California, Irvine, CA, 92697, USA
Physiol Biochem Zool 76:679-94. 2003.... 
Phylogeny, ecology, and heart position in snakesGabriel E A Gartner
Department of Biology, University of California, Riverside, California 92521, USA
Physiol Biochem Zool 83:43-54. 2010..Our results suggest that overcoming gravitational pressure gradients in snakes most likely involves the combined action of several cardiovascular and behavioral adaptations in addition to alterations in relative heart location...- Why savannah monitor lizards hyperventilate during activity: a comparison of model predictions and experimental dataTobias Wang
Department of Zoophysiology, Aarhus University, Aarhus, Denmark
Respir Physiol Neurobiol 144:251-61. 2004..We conclude from both our theoretical and experimental analyses that V. exanthematicus operates near the functional limits of its lung...