Aram F Hezel
Affiliation: University of Rochester
- Diabetes mellitus impacts risk of macrovascular invasion in patients undergoing transplantation for hepatocellular carcinomaGregory C Connolly
The Department of Medicine, James P, Wilmot Cancer Center, and, University of Rochester, Rochester, NY, USA
BMC Gastroenterol 13:9. 2013..Diabetes mellitus (DM) is identified as a negative prognostic indicator in hepatocellular carcinoma (HCC), though the basis for this is unknown...
- Mutational profiling reveals PIK3CA mutations in gallbladder carcinomaVikram Deshpande
Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
BMC Cancer 11:60. 2011..The genetics of advanced biliary tract cancers (BTC), which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined...
- Genetics of biliary tract cancers and emerging targeted therapiesAram F Hezel
James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, NY 14642, USA
J Clin Oncol 28:3531-40. 2010..Here, we summarize the molecular pathogenesis and genetics of BTCs and animal modeling and relate these to recent and ongoing clinical trials with targeted agents...
- Autophagy in intra-hepatic cholangiocarcinomaJing Li Huang
James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, NY, USA
Autophagy 8:1148-9. 2012..A basic understanding of the disease has long been hampered by limited tumor cell lines and good model systems. Similarly, such limitations have obstructed new therapeutic inroads...
- Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinomaMichael R O'Dell
James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, New York 14642, USA
Cancer Res 72:1557-67. 2012..These findings establish a new genetically and histopathologically faithful model of IHCC and lend experimental support to the hypothesis that IPBN and VMC are precursors to invasive cancers...