Aram F Hezel

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Diabetes mellitus impacts risk of macrovascular invasion in patients undergoing transplantation for hepatocellular carcinoma
    Gregory C Connolly
    The Department of Medicine, James P, Wilmot Cancer Center, and, University of Rochester, Rochester, NY, USA
    BMC Gastroenterol 13:9. 2013
  2. pmc Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma
    Vikram Deshpande
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    BMC Cancer 11:60. 2011
  3. pmc Genetics of biliary tract cancers and emerging targeted therapies
    Aram F Hezel
    James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Clin Oncol 28:3531-40. 2010
  4. ncbi request reprint Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression
    Conan Kinsey
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cell Rep 7:1143-55. 2014
  5. pmc Autophagy in intra-hepatic cholangiocarcinoma
    Jing Li Huang
    James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, NY, USA
    Autophagy 8:1148-9. 2012
  6. pmc Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma
    Michael R O'Dell
    James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Cancer Res 72:1557-67. 2012

Collaborators

  • Vikram Deshpande
  • Andrew X Zhu
  • Nabeel Bardeesy
  • Jing Li Huang
  • Michael R O'Dell
  • Conan Kinsey
  • Hartmut Land
  • Christa L Whitney-Miller
  • Gregory C Connolly
  • Vijaya Balakrishnan
  • Laurel Newman
  • Rui Chen
  • Randeep Kashyap
  • Saman Safadjou
  • Mark S Orloff
  • Randall M Rossi
  • Paul Rothberg
  • Valerie Grose

Detail Information

Publications7

  1. pmc Diabetes mellitus impacts risk of macrovascular invasion in patients undergoing transplantation for hepatocellular carcinoma
    Gregory C Connolly
    The Department of Medicine, James P, Wilmot Cancer Center, and, University of Rochester, Rochester, NY, USA
    BMC Gastroenterol 13:9. 2013
    ..Diabetes mellitus (DM) is identified as a negative prognostic indicator in hepatocellular carcinoma (HCC), though the basis for this is unknown...
  2. pmc Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma
    Vikram Deshpande
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    BMC Cancer 11:60. 2011
    ..The genetics of advanced biliary tract cancers (BTC), which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined...
  3. pmc Genetics of biliary tract cancers and emerging targeted therapies
    Aram F Hezel
    James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Clin Oncol 28:3531-40. 2010
    ..Here, we summarize the molecular pathogenesis and genetics of BTCs and animal modeling and relate these to recent and ongoing clinical trials with targeted agents...
  4. ncbi request reprint Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression
    Conan Kinsey
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cell Rep 7:1143-55. 2014
    ..Plac8 thus provides a mechanistic link between primary oncogenic mutations and the induction of autophagy, a central mechanism of metabolic reprogramming, during PDA progression...
  5. pmc Autophagy in intra-hepatic cholangiocarcinoma
    Jing Li Huang
    James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, NY, USA
    Autophagy 8:1148-9. 2012
    ..A basic understanding of the disease has long been hampered by limited tumor cell lines and good model systems. Similarly, such limitations have obstructed new therapeutic inroads...
  6. pmc Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma
    Michael R O'Dell
    James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Cancer Res 72:1557-67. 2012
    ..These findings establish a new genetically and histopathologically faithful model of IHCC and lend experimental support to the hypothesis that IPBN and VMC are precursors to invasive cancers...