Erik Hewlett

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Clinical practice. Pertussis--not just for kids
    Erik L Hewlett
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA
    N Engl J Med 352:1215-22. 2005
  2. pmc Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control
    Kevin M D'Auria
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    BMC Syst Biol 6:2. 2012
  3. pmc Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis
    Joshua C Eby
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Infect Immun 80:850-9. 2012
  4. ncbi request reprint Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: more than just making cyclic AMP!
    Erik L Hewlett
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Box 800419, Charlottesville, 22908, USA
    Mol Microbiol 59:447-59. 2006
  5. ncbi request reprint Adenylate cyclase toxin from Bordetella pertussis: current concepts and problems in the study of toxin functions
    E L Hewlett
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, USA
    Int J Med Microbiol 290:333-5. 2000
  6. ncbi request reprint A commentary on the pathogenesis of pertussis
    E L Hewlett
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA
    Clin Infect Dis 28:S94-8. 1999
  7. pmc Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis
    Gina M Donato
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, 22908, USA
    J Bacteriol 187:7579-88. 2005
  8. pmc Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells
    Joshua C Eby
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 285:10662-70. 2010
  9. ncbi request reprint Mechanism of association of adenylate cyclase toxin with the surface of Bordetella pertussis: a role for toxin-filamentous haemagglutinin interaction
    Franca R Zaretzky
    University of Virginia School of Medicine, Department of Internal Medicine, Charlottesville, Virginia 22908, USA
    Mol Microbiol 45:1589-98. 2002
  10. ncbi request reprint Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1)
    Darren J Perkins
    Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, School of Medicine, 660 W Baltimore Street, Suite 324, Baltimore, MD 21201, USA
    Mol Microbiol 66:1003-15. 2007

Collaborators

  • Mary C Gray
  • Gina M Donato
  • Kathryn Edwards
  • LISA MEHLMANN
  • Darren J Perkins
  • Joshua C Eby
  • Kevin M D'Auria
  • Franca R Zaretzky
  • Zhiyong Gao
  • Jason A Papin
  • Annabelle R Mangan
  • Joanne A Lannigan
  • Michael D Solga
  • Cirle A Warren
  • Lauren M Cave
  • Glynis L Kolling
  • William P Ciesla
  • Wendy Hamman
  • Raymond J Pickles
  • Wayne I Lencer
  • Robert A Young
  • Franz M Matschinsky
  • Matteo M Trucco
  • Bryan A Wolf
  • Scott R Greene

Detail Information

Publications12

  1. ncbi request reprint Clinical practice. Pertussis--not just for kids
    Erik L Hewlett
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA
    N Engl J Med 352:1215-22. 2005
  2. pmc Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control
    Kevin M D'Auria
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    BMC Syst Biol 6:2. 2012
    ..To better understand their effects in a susceptible cell line, we analyzed the transciptome-wide gene expression response of human ileocecal epithelial cells (HCT-8) after 2, 6, and 24 hr of toxin exposure...
  3. pmc Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis
    Joshua C Eby
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Infect Immun 80:850-9. 2012
    ..In addition to characterizing the effects of CR3 on the actions of ACT, these data show that ATP consumption is yet another concentration-dependent activity of ACT that must be considered when studying how ACT affects target cells...
  4. ncbi request reprint Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: more than just making cyclic AMP!
    Erik L Hewlett
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Box 800419, Charlottesville, 22908, USA
    Mol Microbiol 59:447-59. 2006
    ....
  5. ncbi request reprint Adenylate cyclase toxin from Bordetella pertussis: current concepts and problems in the study of toxin functions
    E L Hewlett
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, USA
    Int J Med Microbiol 290:333-5. 2000
    ..The current issues in understanding AC toxin, which will be discussed here, include the role of acylation in its various activities and the relationship among those several toxin functions...
  6. ncbi request reprint A commentary on the pathogenesis of pertussis
    E L Hewlett
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA
    Clin Infect Dis 28:S94-8. 1999
    ..pertussis in humans, and such data are necessary for adequate understanding and treatment of this novel infectious disease...
  7. pmc Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis
    Gina M Donato
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, 22908, USA
    J Bacteriol 187:7579-88. 2005
    ..pertussis ACT. These results demonstrate the expression of ACT by B. hinzii and represent the first characterization of a potential virulence factor of this organism...
  8. pmc Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells
    Joshua C Eby
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 285:10662-70. 2010
    ..Thus, elements of the basolateral membrane render epithelial cells highly sensitive to the entry of ACT in the absence of a specific receptor for toxin binding...
  9. ncbi request reprint Mechanism of association of adenylate cyclase toxin with the surface of Bordetella pertussis: a role for toxin-filamentous haemagglutinin interaction
    Franca R Zaretzky
    University of Virginia School of Medicine, Department of Internal Medicine, Charlottesville, Virginia 22908, USA
    Mol Microbiol 45:1589-98. 2002
    ..pertussis and raise the possibility of an involvement of adherence mediated by FHA in delivery of AC toxin from the bacterium to the target cell...
  10. ncbi request reprint Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1)
    Darren J Perkins
    Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, School of Medicine, 660 W Baltimore Street, Suite 324, Baltimore, MD 21201, USA
    Mol Microbiol 66:1003-15. 2007
    ..pertussis infection by augmenting COX-2 expression and provides evidence against the concept that ACT functions exclusively via its inhibitory effects on phagocytic leucocytes...
  11. pmc Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis
    Zhiyong Gao
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, 5135 Main Building, 34th Street and Civic Center Blvd, Philadelphia, PA 19104 4399, U S A
    Biochem J 368:397-404. 2002
    ..In conclusion, glucose and GLP-1 amplify insulin secretion via cAMP production and PKAbeta activation...
  12. pmc Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte
    Lisa M Mehlmann
    Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06032, USA
    Dev Biol 299:345-55. 2006
    ..Thus, neither of these well-known mechanisms of cAMP regulation can account for LH signaling to the oocyte in the mouse ovary...

Research Grants32

  1. BORDETELLA CYCLASE--STRUCTURE AND BIOLOGICAL ACTIVITIES
    Erik Hewlett; Fiscal Year: 2000
    ..Additional structural data will be collected with CD spectroscopy an x-ray diffraction studies to develop a better understanding of the actions of AC toxin. ..
  2. Seventh International Symposium on Pertussis
    Erik Hewlett; Fiscal Year: 2002
    ..This meeting will lead to a greater scientific understanding of the biology of this organism, and the promise for developing a more effective means to control this disease. ..
  3. BORDETELLA CYCLASE-STRUCTURE AND BIOLOGICAL ACTIVITIES
    Erik Hewlett; Fiscal Year: 2005
    ....
  4. 8th International Symposium - Saga of the Genus Bordetella, 1906-2006
    Erik Hewlett; Fiscal Year: 2006
    ..The bordetella community is an especially open and collaborative collection of scientists and it is important to assure and support attendance of trainees at meetings such as this. ..
  5. Bordetella cyclase toxin: effects on leukocytes and respiratory epithelial cells
    Erik Hewlett; Fiscal Year: 2009
    ..The objective is to apply the information on AC toxin and on other bordetellae virulence factors, to a more focused study of how AC toxin contributes to infections and diseases caused by this genus. ..
  6. BORDETELLA CYCLASE: STRUCTURE AND BIOLOGICAL ACTIVITY
    Erik Hewlett; Fiscal Year: 1993
    ....
  7. BORDETELLA CYCLASE: STRUCTURE AND BIOLOGICAL ACTIVITY
    Erik Hewlett; Fiscal Year: 1991
    ..The work proposed in this application and ongoing at present will provide information of use in vaccine development and of importance to the understanding of bacterial toxins and their roles in pathogenesis of bacterial disease...
  8. Bordetella cyclase toxin: effects on leukocytes and respiratory epithelial cells
    Erik L Hewlett; Fiscal Year: 2010
    ..The objective is to apply the information on AC toxin and on other bordetellae virulence factors, to a more focused study of how AC toxin contributes to infections and diseases caused by this genus. ..