Research Topics
Genomes and Genes | Martin HewisonSummaryAffiliation: University of California Country: USA Publications
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Publications
Vitamin D and immune function: autocrine, paracrine or endocrine?Martin Hewison
UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and Orthopaedic Hospital Research Center, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
Scand J Clin Lab Invest Suppl 243:92-102. 2012..The current review will discuss this by comparing the intracrine, paracrine and endocrine metabolic systems that influence the interaction between vitamin D and the immune system...- An update on vitamin D and human immunityMartin Hewison
Department of Orthopaedic Surgery and Molecular Biology Institute, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
Clin Endocrinol (Oxf) 76:315-25. 2012..The current review summarizes these developments, with specific reference to the newly identified effects of vitamin D on the immune system, but also highlights the challenges in translating these observations to clinical practice... 
Vitamin D and the immune system: new perspectives on an old themeMartin Hewison
Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Rheum Dis Clin North Am 38:125-39. 2012..Future studies now need to focus on the clinical implications of vitamin D–mediated immunity and, in particular, the possible beneficial effects of supplementary vitamin D with respect to infectious and autoimmune diseases...- Vitamin D and immune function: an overviewMartin Hewison
UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, David Geffen School of Medicine at UCLA, 615 Charles E Young, Los Angeles, CA 90095, USA
Proc Nutr Soc 71:50-61. 2012..Collectively these observations suggest that vitamin D is a key factor linking innate and adaptive immunity, and both of these functions may be compromised under conditions of vitamin D insufficiency... 
Vitamin D and the intracrinology of innate immunityMartin Hewison
Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Mol Cell Endocrinol 321:103-11. 2010..The current review details these new developments with specific reference to the metabolic and signaling mechanisms associated with innate immune regulation by vitamin D and implications for human disease...- Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunityJohn S Adams
Department of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Nat Clin Pract Endocrinol Metab 4:80-90. 2008..Specific examples of this will be detailed in the current Review, with particular emphasis on the immunomodulatory properties of vitamin D... - Vitamin D and the immune system: new perspectives on an old themeMartin Hewison
Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Endocrinol Metab Clin North Am 39:365-79, table of contents. 2010..This article describes some of the recent developments with respect to vitamin D and the immune system, and possible clinical implications... - Antibacterial effects of vitamin DMartin Hewison
Department of Orthopaedic Surgery, Room 410D, Orthopaedic Hospital Research Center, 615 Charles E Young Drive South, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
Nat Rev Endocrinol 7:337-45. 2011.... - Vitamin D and innate immunityMartin Hewison
University of California, Los Angeles, David Geffen School of Medicine, Department of Orthopedic Surgery, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
Curr Opin Investig Drugs 9:485-90. 2008..This new facet of 'non-classical' roles of vitamin D action is discussed in this review... - Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophagesMario Fabri
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
Sci Transl Med 3:104ra102. 2011..The present findings underscore the importance of adequate amounts of vitamin D in all human populations for sustaining both innate and acquired immunity against infection... - T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolismKristina Edfeldt
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:22593-8. 2010.... - 1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell linesVenu Lagishetty
Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Steroid Biochem Mol Biol 121:228-33. 2010..Thus, in common with other barrier sites such as the skin or placenta, colonic epithelial cells may require specific factors to initiate intracrine responses to vitamin D... - Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitisVenu Lagishetty
Room 410D, Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California 90095, USA
Endocrinology 151:2423-32. 2010..This may be a pivotal mechanism linking vitamin D status with IBD in humans... - IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathwayStephan R Krutzik
Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles, CA 90095, USA
J Immunol 181:7115-20. 2008..Therefore, IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway... - Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesisSongyang Ren
Department of Medicine, Division of Endocrinology, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Biol Chem 280:20604-11. 2005..We theorize that expression of the CYP24-SV may contribute to the extracellular accumulation of 1,25(OH)(2)D in human health and disease... - Vitamin D in defense of the human immune responseJohn S Adams
Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room B 131, Los Angeles, CA 90048, USA
Ann N Y Acad Sci 1117:94-105. 2007.... - Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune responseJohn S Adams
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Bone Miner Res 22:V20-4. 2007..In this review, we use vitamin D-directed events in the human innate immune response to Mycobacterium tuberculosis as a physiologically relevant model system in which to highlight the importance of these intracellular traffic patterns... - Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responsesRosane M B Teles
Division of Dermatology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Science 339:1448-53. 2013.... - Vitamin D and the regulation of placental inflammationNancy Q Liu
Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA
J Immunol 186:5968-74. 2011..These data indicate that fetal (trophoblastic) vitamin D plays a pivotal role in controlling placental inflammation. In humans, this may be a key factor in placental responses to infection and associated adverse outcomes of pregnancy... - Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammationNancy Liu
Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
Endocrinology 149:4799-808. 2008..These data indicate that both local and endocrine synthesis of 1,25(OH)2D3 affect colitis in DSS-treated mice. Lack of Cyp27b1 exacerbates disease in this model, suggesting that similar effects may occur with vitamin D deficiency... - Functional characterization of heterogeneous nuclear ribonuclear protein C1/C2 in vitamin D resistance: a novel response element-binding proteinHong Chen
Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
J Biol Chem 281:39114-20. 2006..In particular, chromatin immunoprecipitation data suggest that, in addition to its RNA-processing functions, hnRNP C1/C2 may be a key determinant of the temporal patterns of VDRE occupancy... - Toll-like receptor triggering of a vitamin D-mediated human antimicrobial responsePhilip T Liu
Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
Science 311:1770-3. 2006..These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection... - Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin DRene F Chun
Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA
J Clin Endocrinol Metab 95:3368-76. 2010..Both vitamin D metabolites circulate bound to vitamin D-binding protein (DBP), but the effect of this on induction of monocyte cathelicidin remains unclear... - Divergence of macrophage phagocytic and antimicrobial programs in leprosyDennis Montoya
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell Host Microbe 6:343-53. 2009..These data indicate that macrophage programs for phagocytosis and antimicrobial responses are distinct and differentially regulated in innate immunity to bacterial infections... - Vitamin D metabolism and innate immunityVenu Lagishetty
Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Mol Cell Endocrinol 347:97-105. 2011..The following review describes some of the key developments in innate immune responses to vitamin D with particular emphasis on the role of key metabolic enzyme as determinants of localized immune activity of vitamin D... - Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signalingThomas S Lisse
Orthopaedic Hospital Research Center, University of California Los Angeles, 615 Charles E Young Dr, South Los Angeles, CA 90095, USA
FASEB J 25:937-47. 2011..DDIT4, an inhibitor of mTOR signaling, is a direct target for 1,25(OH)(2)D(3) and VDRE-BP, and functions to suppress cell proliferation in response to vitamin D... - Adenosine 5'-triphosphate-dependent vitamin D sterol binding to heat shock protein-70 chaperonesRene Chun
Burns and Allen Research Institute and Division of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, David Geffen School of Medicine at University of California, Los Angeles, 90048, USA
Endocrinology 146:5540-4. 2005.... - Back to the future: a new look at 'old' vitamin DRene F Chun
Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
J Endocrinol 198:261-9. 2008..In the following review, we provide a fresh perspective on vitamin D signaling in non-classical target cells such as macrophages by highlighting novel factors associated with the transport and action of this pluripotent secosteroid... - Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunizationAlexander Misharin
Autoimmune Disease Unit, Cedars Sinai Research Institute and University of California Los Angeles, UCLA School of Medicine, Los Angeles, CA 90095, USA
Endocrinology 150:1051-60. 2009..thyroid function. Our present studies provide evidence that an environmental factor, vitamin D, has only minor effects on induced immunity to the TSHR but directly affects thyroid function in mice... - Immunomodulation by vitamin D: implications for TBRene F Chun
Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
Expert Rev Clin Pharmacol 4:583-91. 2011..The overall aim will be to provide a fresh perspective on the potential benefits of vitamin D supplementation in the prevention and treatment of TB... - Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and diseaseMartin Hewison
Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
J Steroid Biochem Mol Biol 103:316-21. 2007..Data suggest that local synthesis of 1,25(OH)(2)D(3) may be a preferred mode of response to antigenic challenge in many tissues... - An Hsp27-related, dominant-negative-acting intracellular estradiol-binding proteinHong Chen
Division of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
J Biol Chem 279:29944-51. 2004..In summary, by inhibiting the ERalpha-E2 interaction, IEBP acts to squelch ERalpha-directed ERE-regulated transactivation and promote estrogen resistance in NWP cells... - Update in vitamin DJohn S Adams
UCLA Orthopaedic Hospital Research Center, 615 Charles Young Drive South, Room 410E, Los Angeles, California 90095 7358, USA
J Clin Endocrinol Metab 95:471-8. 2010.... - Vitamin D-mediated hypercalcemia in slack skin disease: evidence for involvement of extrarenal 25-hydroxyvitamin D 1alpha-hydroxylaseHelen Karakelides
Department of Endocrinology, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
J Bone Miner Res 21:1496-9. 2006..This contrasts with psoriasis and sarcoidosis of the skin, in which overexpression of the enzyme is restricted to keratinocytes and granulomata, respectively... - Vitamin D-mediated hypercalcemia and Cushing syndrome as manifestations of malignant pleural mesotheliomaJay M Lee
Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Endocr Pract 14:1011-6. 2008..To report a case of coincident hypercalcemia and Cushing syndrome arising from mesothelioma... - Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytesJustine Bacchetta
UCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
J Bone Miner Res 28:46-55. 2013..Elevated expression of FGF23 may therefore play a crucial role in defining immune responses to vitamin D and this, in turn, may be a key determinant of infection in patients with chronic kidney disease (CKD)... - Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolismJohn S Adams
The Burns and Allen Research Institute, Cedars-Sinai Medical Center, UCLA School of Medicine, B131, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA
J Steroid Biochem Mol Biol 89:461-5. 2004..Our ongoing studies indicate directly or indirectly through a series of protein interactions that the IDBPs interact with hydroxylated vitamin D metabolites and facilitate their intracellular targeting... - Hormone response element binding proteins: novel regulators of vitamin D and estrogen signalingThomas S Lisse
Department of Orthopaedic Surgery and Molecular Biology Institute, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
Steroids 76:331-9. 2011..In addition the review also describes other molecules that are known to influence nuclear receptor signaling through interaction with hormone response elements... - Vitamin D and innate and adaptive immunityMartin Hewison
Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Vitam Horm 86:23-62. 2011..Finally, the review will consider the role of immunomodulatory vitamin D in human health, with specific emphasis on infectious and autoimmune disease... - Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistanceHong Chen
Burns and Allen Research Institute and the Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Boulevard, Room B-131, Los Angeles, CA 90048, USA
Proc Natl Acad Sci U S A 100:6109-14. 2003..That this protein is a member of the hnRNP family capable of interacting with double-stranded DNA highlights a potentially important new component of the complex machinery required for steroid hormone signal transduction... - 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patientsAva Masoumi
Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, CA 90095 7358, USA
J Alzheimers Dis 17:703-17. 2009..Human macrophages are a new paradigm for testing immune therapies for AD... - Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapyShehla Pervin
Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA, USA
PLoS ONE 8:e53287. 2013..Our findings therefore, suggest that combination therapy using 1,25D with drugs specifically targeting key survival pathways in MCSCs warrant testing in prospective clinical trial for treatment of aggressive breast cancer... - Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylaseMartin Hewison
Division of Medical Sciences, Institute of Clinical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
Mol Cell Endocrinol 215:31-8. 2004.... - Vitamin D and placental-decidual functionKatie N Evans
Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
J Soc Gynecol Investig 11:263-71. 2004..In particular, we describe how induction of the vitamin D-activating enzyme 1alpha-hydroxylase in early gestation might provide a mechanism by which environmental or dietary vitamin D can influence fetal-placental development... - Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cellsJian Feng Ma
Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Cell Endocrinol 221:67-74. 2004..We conclude that diminished 1alpha(OH)ase activity in prostate cancer cell lines is through decreased gene expression, whereas decreased activity in primary cultures and tissues is post-translational... - Increased expression of 25-hydroxyvitamin D-1alpha-hydroxylase in dysgerminomas: a novel form of humoral hypercalcemia of malignancyKatie N Evans
Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham, United Kingdom
Am J Pathol 165:807-13. 2004..We further postulate that this autocrine/paracrine action of 1alpha-hydroxylase may lead to increased circulating levels of 1,25(OH)2D3 and a form of HHM which is distinct from that seen with PTHrP-secreting tumors... - Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatmentKelly Townsend
Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham B15 2TH, UK
J Steroid Biochem Mol Biol 97:103-9. 2005..The role of 1alpha-hydroxylase in protection against cancer is likely to be more complicated and may involve anti-tumor immune responses... - Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophagesMartin Hewison
Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
J Bone Miner Res 18:579-82. 2003..Based on this case study, we propose that the abnormal synthesis of 1,25(OH)2D3 associated with some lymphomas is because of paracrine regulation of tumor-associated macrophages... - Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cellsKatie N Evans
Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham, B15 2TT, United Kingdom
Biol Reprod 75:816-22. 2006.... - Cross-sectional analysis of abnormalities of mineral homeostasis, vitamin D and parathyroid hormone in a cohort of pre-dialysis patients. The chronic renal impairment in Birmingham (CRIB) studyDaniel Zehnder
Department of Nephrology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK
Nephron Clin Pract 107:c109-16. 2007..However, it is unclear at what stage of chronic kidney disease (CKD) these abnormalities develop...
Research Grants
- Vitamin D and Barrier FunctionMartin Hewison; Fiscal Year: 2007..abstract_text> ..