M Hetman

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Signaling pathways mediating anti-apoptotic action of neurotrophins
    M Hetman
    Department of Environmental Health, University of Washington, Seattle, WA 98195 7234, USA
    Acta Neurobiol Exp (Wars) 60:531-45. 2000
  2. ncbi Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons
    J E Cavanaugh
    Departments of Environmental Health and Pharmacology, University of Washington, Seattle, Washington 98195-7234, USA
    J Neurosci 21:434-43. 2001
  3. ncbi Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylation
    X A Figueroa-Masot
    Departments of Environmental Health and Pharmacology, Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195-7234, USA
    J Neurosci 21:4657-67. 2001
  4. ncbi p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons
    S Ghatan
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Cell Biol 150:335-47. 2000
  5. ncbi Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
    M Hetman
    Toxicology Program, Department of Environmental Health, the Graduate Program in Neurobiology and Behavior, The Graduate Program in Molecular and Cell Biology, University of Washington, Seattle, Washington 98195 7234, USA
    J Biol Chem 274:22569-80. 1999

Collaborators

  • Z Xia
  • C Yan
  • J Ham
  • J E Cavanaugh
  • X A Figueroa-Masot
  • S Ghatan
  • N Kokot
  • S Poser
  • M J Higgins
  • L Patel
  • R J Youle
  • S Larner
  • Y Kinoshita
  • R S Morrison

Detail Information

Publications5

  1. ncbi Signaling pathways mediating anti-apoptotic action of neurotrophins
    M Hetman
    Department of Environmental Health, University of Washington, Seattle, WA 98195 7234, USA
    Acta Neurobiol Exp (Wars) 60:531-45. 2000
    ..In this review, we discuss the contribution of Erk1/2 and PI-3K to neuroprotection by neurotrophins. We also present data suggesting possible mechanisms by which these pathways might suppress neuronal death...
  2. ncbi Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons
    J E Cavanaugh
    Departments of Environmental Health and Pharmacology, University of Washington, Seattle, Washington 98195-7234, USA
    J Neurosci 21:434-43. 2001
    ..Furthermore, ERK5 is the first MAP kinase identified whose activity is stimulated by neurotrophins but not by neuronal activity...
  3. ncbi Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylation
    X A Figueroa-Masot
    Departments of Environmental Health and Pharmacology, Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195-7234, USA
    J Neurosci 21:4657-67. 2001
    ..These data suggest that taxol induces apoptosis in neurons by a mechanism quite distinct from that of non-neuronal cell lines and emphasize the importance of elucidating apoptotic mechanisms specific for neurons in the CNS...
  4. ncbi p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons
    S Ghatan
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Cell Biol 150:335-47. 2000
    ..These results demonstrate that p38 MAP kinase activity plays a critical role in NO-mediated cell death in neurons by stimulating Bax translocation to the mitochondria, thereby activating the cell death pathway...
  5. ncbi Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
    M Hetman
    Toxicology Program, Department of Environmental Health, the Graduate Program in Neurobiology and Behavior, The Graduate Program in Molecular and Cell Biology, University of Washington, Seattle, Washington 98195 7234, USA
    J Biol Chem 274:22569-80. 1999
    ..Furthermore, the relative contribution of the ERK and PI 3-kinase pathways to neuronal survival may depend on the type of cellular injury...