David R Hessl

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome
    Jennifer Yuhas
    Medical Investigation of Neurodevelopmental Disorders M I N D Institute, University of California Davis, Medical Center, 2825 50th Street, Sacramento, CA 95817, USA
    J Autism Dev Disord 41:248-53. 2011
  2. ncbi Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation
    David Hessl
    Medical Investigation of Neurodevelopmental Disorders M I N D Institute, University of California Davis, Medical Center, Sacramento, California 95817, USA
    Biol Psychiatry 70:859-65. 2011
  3. ncbi Prepulse inhibition in fragile X syndrome: feasibility, reliability, and implications for treatment
    David Hessl
    Medical Investigation of Neurodevelopmental Disorders M I N D Institute, University of California Davis, Medical Center, Sacramento, California 95817, USA
    Am J Med Genet B Neuropsychiatr Genet 150:545-53. 2009
  4. ncbi Brief report: aggression and stereotypic behavior in males with fragile X syndrome--moderating secondary genes in a "single gene" disorder
    David Hessl
    Medical Investigation of Neurodevelopmental Disorders MIND Institute, University of California Davis, Medical Center, 2825 50th Street, Sacramento, CA 95817, USA
    J Autism Dev Disord 38:184-9. 2008
  5. ncbi Amygdala dysfunction in men with the fragile X premutation
    David Hessl
    Medical Investigation of Neurodevelopmental Disorders MIND Institute, University of California Davis, Medical Center, Sacramento, CA 95817, USA
    Brain 130:404-16. 2007
  6. ncbi Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation
    David Hessl
    Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Med Genet B Neuropsychiatr Genet 139:115-21. 2005
  7. ncbi Autism profiles of males with fragile X syndrome
    Susan W Harris
    M I N D Institute and Department of Pediatrics, University of California at Davis Medical Center, Sacramento, CA 95817, USA
    Am J Ment Retard 113:427-38. 2008
  8. ncbi A review of fragile X premutation disorders: expanding the psychiatric perspective
    James A Bourgeois
    Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, Sacramento, CA 95817, USA
    J Clin Psychiatry 70:852-62. 2009
  9. ncbi Brief report: Visual processing of faces in individuals with fragile X syndrome: an eye tracking study
    Faraz Farzin
    Department of Psychology, University of California, Davis, Davis, CA, USA
    J Autism Dev Disord 39:946-52. 2009
  10. ncbi Towards a neurodevelopmental model of clinical case formulation
    Marjorie Solomon
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA, USA
    Psychiatr Clin North Am 32:199-211. 2009

Research Grants

  1. Genetics and Physiology of Social Anxiety in Fragile X
    David Hessl; Fiscal Year: 2007
  2. Limbic System Function in Carriers of the Fragile X Premutation
    David Hessl; Fiscal Year: 2007
  3. Limbic System Function in Carriers of the Fragile X Premutation
    David R Hessl; Fiscal Year: 2010
  4. Limbic System Function in Carriers of the Fragile X Premutation
    David R Hessl; Fiscal Year: 2011

Collaborators

Detail Information

Publications20

  1. ncbi Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome
    Jennifer Yuhas
    Medical Investigation of Neurodevelopmental Disorders M I N D Institute, University of California Davis, Medical Center, 2825 50th Street, Sacramento, CA 95817, USA
    J Autism Dev Disord 41:248-53. 2011
    ..Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating...
  2. ncbi Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation
    David Hessl
    Medical Investigation of Neurodevelopmental Disorders M I N D Institute, University of California Davis, Medical Center, Sacramento, California 95817, USA
    Biol Psychiatry 70:859-65. 2011
    ....
  3. ncbi Prepulse inhibition in fragile X syndrome: feasibility, reliability, and implications for treatment
    David Hessl
    Medical Investigation of Neurodevelopmental Disorders M I N D Institute, University of California Davis, Medical Center, Sacramento, California 95817, USA
    Am J Med Genet B Neuropsychiatr Genet 150:545-53. 2009
    ..89 overall). This study demonstrates the feasibility and reliability of PPI measurement in a developmentally disabled population and highlights its potential as an outcome measure to test the efficacy of targeted neurotherapeutic agents...
  4. ncbi Brief report: aggression and stereotypic behavior in males with fragile X syndrome--moderating secondary genes in a "single gene" disorder
    David Hessl
    Medical Investigation of Neurodevelopmental Disorders MIND Institute, University of California Davis, Medical Center, 2825 50th Street, Sacramento, CA 95817, USA
    J Autism Dev Disord 38:184-9. 2008
    ..This preliminary study prompts consideration of secondary genes that may modify behavioral phenotype expression in neurodevelopmental disorders, even those with a single gene etiology such as FXS...
  5. ncbi Amygdala dysfunction in men with the fragile X premutation
    David Hessl
    Medical Investigation of Neurodevelopmental Disorders MIND Institute, University of California Davis, Medical Center, Sacramento, CA 95817, USA
    Brain 130:404-16. 2007
    ..The aetiology for this dysfunction may be elevated FMR1 mRNA or reduced FMR1 protein that occurs in carriers with higher premutation CGG repeat alleles...
  6. ncbi Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation
    David Hessl
    Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Med Genet B Neuropsychiatr Genet 139:115-21. 2005
    ....
  7. ncbi Autism profiles of males with fragile X syndrome
    Susan W Harris
    M I N D Institute and Department of Pediatrics, University of California at Davis Medical Center, Sacramento, CA 95817, USA
    Am J Ment Retard 113:427-38. 2008
    ....
  8. ncbi A review of fragile X premutation disorders: expanding the psychiatric perspective
    James A Bourgeois
    Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, Sacramento, CA 95817, USA
    J Clin Psychiatry 70:852-62. 2009
    ..Remarkable advances at the molecular level have enhanced our understanding of fragile X premutation disorders...
  9. ncbi Brief report: Visual processing of faces in individuals with fragile X syndrome: an eye tracking study
    Faraz Farzin
    Department of Psychology, University of California, Davis, Davis, CA, USA
    J Autism Dev Disord 39:946-52. 2009
    ..Such abnormalities have significant implications in terms of understanding causes of gaze avoidance observed in individuals with FXS...
  10. ncbi Towards a neurodevelopmental model of clinical case formulation
    Marjorie Solomon
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA, USA
    Psychiatr Clin North Am 32:199-211. 2009
    ....
  11. ncbi Advances in the treatment of fragile X syndrome
    Randi J Hagerman
    MIND Institute, University of California Davis, School of Medicine, Sacramento, CA 95817, USA
    Pediatrics 123:378-90. 2009
    ..Trials of metabotropic glutamate receptor 5 antagonists are beginning with individuals with fragile X syndrome. Targeted treatments, medical and behavioral interventions, genetic counseling, and family supports are reviewed here...
  12. ncbi Cognitive, anxiety and mood disorders in the fragile X-associated tremor/ataxia syndrome
    James A Bourgeois
    Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA 95817, USA
    Gen Hosp Psychiatry 29:349-56. 2007
    ..We evaluated patients with fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disorder associated with a CGG repeat expansion in the premutation range in the fragile X mental retardation 1 (FMR1) gene...
  13. ncbi A genetic etiology of pervasive developmental disorder guides treatment
    Marjorie Solomon
    Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California, Davis, Sacramento, CA 95817, USA
    Am J Psychiatry 164:575-80. 2007
  14. ncbi Early acceleration of head circumference in children with fragile x syndrome and autism
    Sufen Chiu
    Department of Psychiatry and Behavioral Sciences and MIND Institute, University of California Davis, Davis, CA 95817, USA
    J Dev Behav Pediatr 28:31-5. 2007
    ....
  15. ncbi Dementia with mood symptoms in a fragile X premutation carrier with the fragile X-associated tremor/ataxia syndrome: clinical intervention with donepezil and venlafaxine
    James A Bourgeois
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, Medical Center, 2230 Stockton Blvd, Sacramento, 95817, USA
    J Neuropsychiatry Clin Neurosci 18:171-7. 2006
    ..Psychiatrists are hereby alerted to the description of a novel dementia syndrome that may respond to pharmacological intervention commonly used for other dementias...
  16. ncbi Autoimmune disease in mothers with the FMR1 premutation is associated with seizures in their children with fragile X syndrome
    Weerasak Chonchaiya
    Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Health System, 2825 50th Street, Sacramento, CA 95817, USA
    Hum Genet 128:539-48. 2010
    ..This suggests a potential new mechanism of seizure and tic exacerbation in FXS related to an intergenerational influence from autoimmunity in the carrier mother...
  17. ncbi Broad clinical involvement in a family affected by the fragile X premutation
    Weerasak Chonchaiya
    M I N D Institute, University of California Davis Medical Center, Sacramento, CA, USA
    J Dev Behav Pediatr 30:544-51. 2009
    ..To facilitate the integration of this knowledge into clinical practice, this is the first case report that demonstrates only premutation involvement across 3 generations...
  18. ncbi The neuroanatomy and neuroendocrinology of fragile X syndrome
    David Hessl
    M.I.N.D. Institute, University of California, Davis, Sacramento, California, USA
    Ment Retard Dev Disabil Res Rev 10:17-24. 2004
    ....
  19. ncbi Progression of tremor and ataxia in male carriers of the FMR1 premutation
    Maureen A Leehey
    Department of Neurology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
    Mov Disord 22:203-6. 2007
    ..Preliminary data on life expectancy are variable, with a range from 5 to 25 years...
  20. ncbi fMRI study of cognitive interference processing in females with fragile X syndrome
    Leanne Tamm
    Department of Psychiatry, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cogn Neurosci 14:160-71. 2002
    ....

Research Grants7

  1. Genetics and Physiology of Social Anxiety in Fragile X
    David Hessl; Fiscal Year: 2007
    ..By the end of the award period, the candidate will become a recognized clinical researcher in the area of neurodevelopmental disorders, and will receive funding to conduct research as an independent investigator. ..
  2. Limbic System Function in Carriers of the Fragile X Premutation
    David Hessl; Fiscal Year: 2007
    ..The study of a relatively homogeneous single gene condition such as the fragile X premutation provides a model system for understanding links between molecular genetic, brain, and psychiatric features of more complex disorders. ..
  3. Limbic System Function in Carriers of the Fragile X Premutation
    David R Hessl; Fiscal Year: 2010
    ..The study of a relatively homogeneous single gene condition such as the fragile X premutation provides a model system for understanding links between molecular genetic, brain, and psychiatric features of more complex disorders. ..
  4. Limbic System Function in Carriers of the Fragile X Premutation
    David R Hessl; Fiscal Year: 2011
    ..This research will help to clarify links between genes, brain, and behavior within this condition that may have implications for understanding of these types of mechanisms in other more common neuropsychiatric conditions. ..