Research Topics
| J R HessSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocolDebra L Malone
Department of Surgery, University of Maryland Medical Center, Baltimore, USA
J Trauma 60:S91-6. 2006..Patient care and collaborative research might be aided with a common protocol...
Red cell storageJohn R Hess
University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Proteomics 73:368-73. 2010..The increasing power of proteomics and metabolomics offers the potential of deeper understanding of blood function and storage and of better clinical products in the future...- Scientific problems in the regulation of red blood cell productsJohn R Hess
University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
Transfusion 52:1827-35. 2012..Now additional requirements for storage system licensure have being added. The meaning and value of these new requirements have been questioned... 
Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic reviewSibylle Kozek-Langenecker
Department of Anaesthesia and Intensive Care, Evangelical Hospital Vienna, Hans Sachs Gasse 10 12, 1180 Vienna, Austria
Crit Care 15:R239. 2011..In this systematic review, we investigated the current evidence for the use of FFP and fibrinogen concentrate in the perioperative or massive trauma setting...- Alkaline CPD and the preservation of RBC 2,3-DPGJohn R Hess
Blood Research Detachment, Walter Reed Army Institute of Research, Silver Spring, MD 20307, USA
Transfusion 42:747-52. 2002..Alkaline additive solutions, which can preserve RBCs for up to 11 weeks, still do not preserve 2,3-DPG because the starting pH is below 7.2... - Update on alternative oxygen carriersJ R Hess
University of Maryland School of Medicine, Baltimore 21201, USA
Vox Sang 87:132-5. 2004 - The prevalence of abnormal results of conventional coagulation tests on admission to a trauma centerJohn R Hess
Departments of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Transfusion 49:34-9. 2009..These patients have high mortality, but their prevalence in trauma populations is not clear from the reports... - The coagulopathy of trauma: a review of mechanismsJohn R Hess
Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
J Trauma 65:748-54. 2008..Coagulopathy associated with severe injury complicates the control of bleeding and is associated with increased morbidity and mortality in trauma patients. The causes and mechanisms are multiple and yet to be clearly defined... - Interlaboratory comparison of red-cell ATP, 2,3-diphosphoglycerate and haemolysis measurementsJ R Hess
University of Maryland Medical School, Baltimore, MD 21201, USA
Vox Sang 89:44-8. 2005..The reproducibility of RBC ATP, DPG and haemolysis measurements between centres was investigated... - Transfusion practice in military traumaJ R Hess
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Transfus Med 18:143-50. 2008..Component therapy, when available, appears to be as effective as fresh whole blood. In field emergencies, fresh whole blood can be lifesaving... - Optimizing the use of blood products in trauma careJohn R Hess
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Crit Care 9:S10-4. 2005..Less developed trauma systems are primarily concerned with speeding transport to specialized facilities and assembling trauma center resources. This article reviews the factors that effect blood use in urgent trauma care... - Buffering and dilution in red blood cell storageJ R Hess
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Transfusion 46:50-4. 2006..Red blood cell (RBC) storage solutions work in a narrow pH range between 7.2 and 6.4. While keeping RBC within that pH range, ATP production can be increased by buffering or dilution... - Giving plasma at a 1:1 ratio with red cells in resuscitation: who might benefit?John R Hess
Department of Pathology, Trauma Anesthesiology, and Trauma Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Transfusion 48:1763-5. 2008 - An update on solutions for red cell storageJ R Hess
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 20817, USA
Vox Sang 91:13-9. 2006..Improved scientific understanding of the red cell storage lesion has shown a way to make even better storage solutions, which maintain red cell metabolism and reduce membrane loss... - The coagulopathy of trauma versus disseminated intravascular coagulationJohn R Hess
Department of Pathology, University of Maryland Medical Center, Baltimore, 21201, USA
J Trauma 60:S12-9. 2006..The coagulopathy of trauma should be anticipated in massive transfusion situations. Early treatment with plasma can delay its onset. The underlying mechanisms should be confirmed with laboratory testing... - Red cell freezing and its impact on the supply chainJohn R Hess
University of Maryland, Baltimore, MD, USA
Transfus Med 14:1-8. 2004..RBC freezing will have little effect on the logistics of blood supply... - Blood use in war and disaster: lessons from the past centuryJ R Hess
Department of Pathology, University of Maryland, Baltimore, Maryland, USA
Transfusion 43:1622-33. 2003 - Red blood cell hemolysis during blood bank storage: using national quality management data to answer basic scientific questionsJohn R Hess
Department of Pathology, University of Maryland, Baltimore, Maryland 21201, USA
Transfusion 49:2599-603. 2009..Availability of data from national blood systems on large numbers of RBC units used for internal quality control (QC) purposes and stored and processed in uniform ways permits statistical analysis... - Red cell changes during storageJohn R Hess
University of Maryland School of Medicine, Baltimore, MD 21201, USA
Transfus Apher Sci 43:51-9. 2010..Deaths have been reported related to the high potassium and lysophospholipids, but are rare... - Twelve-week RBC storageJohn R Hess
Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC, USA
Transfusion 43:867-72. 2003..Better storage can improve RBC availability and safety. Optimizing RBC ATP production and minimizing hemolysis has allowed progressively longer storage... - Improving the predictive value of red blood cell storage trials: lessons from the Biomedical Excellence for Safer Transfusion (BEST) Collaborative Trial 41John R Hess
University of Maryland School of Medicine, University of Maryland Medical Center, Baltimore, Maryland 21201 1595, USA
Transfusion 51:34S-37S. 2011..Results from one laboratory are often difficult to reproduce in another laboratory, leading to confusion... - Storage of red blood cells: new approachesJohn R Hess
Blood Bank, University of Maryland Medical Center, Baltimore, MD, USA
Transfus Med Rev 16:283-95. 2002.... - The effects of phosphate, pH, and AS volume on RBCs stored in saline-adenine-glucose-mannitol solutionsJ R Hess
Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
Transfusion 40:1000-6. 2000..RBC ATP concentrations are the most important correlate of RBC viability. Tests were performed to determine whether increased AS volume, pH, and phosphate content increased stored RBC ATP concentrations... - The role of electrolytes and pH in RBC ASsJ R Hess
Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
Transfusion 41:1045-51. 2001..The effects of variations in the electrolyte composition and volume of EASs were explored... - The effect of two additive solutions on the postthaw storage of RBCsJ R Hess
Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
Transfusion 41:923-7. 2001..Sterile systems for freezing and for washing thawed blood will allow the storage of RBCs for more than 24 hours after removal of the cryoprotectant glycerol. This study assessed the effect of two ASs in maintaining deglycerolized RBCs... - RBC storage for 11 weeksJ R Hess
Blood Research Detachment, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 7500, USA
Transfusion 41:1586-90. 2001..Increasing the length of RBC storage can increase both RBC availability and quality. This work addresses 11-week RBC storage in experimental ASs (EASs)... - Successful storage of RBCs for 10 weeks in a new additive solutionJ R Hess
Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
Transfusion 40:1012-6. 2000..The effect of storing packed RBCs suspended in 300 mL of an alkaline, experimental additive solution (EAS 64) was explored... - Successful storage of RBCs for 9 weeks in a new additive solutionJ R Hess
Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
Transfusion 40:1007-11. 2000..This study explored the effect of storing packed RBCs suspended in 200 mL of an alkaline, hypotonic, experimental additive solution (EAS 61)... - The effects of polyvinyl chloride and polyolefin blood bags on red blood cells stored in a new additive solutionH R Hill
Blood Research Detachment, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Vox Sang 81:161-6. 2001..CONCLUSIONS: RBCs stored in PVC had markedly less haemolysis and higher RBC ATP concentrations than those stored in PO. Haemolysis would limit RBC storage in PO bags to a duration of 6 weeks, even with EAS-61... - Factor VIIa for correction of traumatic coagulopathyRichard P Dutton
Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Trauma 57:709-18; discussion 718-9. 2004..We present our experience with 81 coagulopathic trauma patients treated using FVIIa in years 2001-2003, compared with "control" patients matched from the trauma registry from the same time period... - Planning for pandemic influenza: effect of a pandemic on the supply and demand for blood products in the United StatesAnn B Zimrin
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
Transfusion 47:1071-9. 2007..Influenza causes episodic pandemics when viral antigens shift in ways that elude herd immunity. Avian influenza A H5N1, currently epizootic in bird populations in Asia and Europe, appears to have pandemic potential... - Controversy in trauma resuscitation: do ratios of plasma to red blood cells matter?Lynn G Stansbury
R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, USA
Transfus Med Rev 23:255-65. 2009..In this review, the authors examine the findings of these initial studies, highlighting the epidemiologic and analytic methodologies used, and the likely influence of these methodologies on the reported outcomes... - Recombinant factor VIIa for control of hemorrhage: early experience in critically ill trauma patientsRichard P Dutton
Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA
J Clin Anesth 15:184-8. 2003..CONCLUSIONS: Administration of rFVIIa shows promise in the treatment of exsanguinating hemorrhage. Prospective, controlled clinical trials of this therapy are strongly recommended... - Blood transfusion rates in the care of acute traumaJohn J Como
R Adams Cowley Shock Trauma Center and the Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
Transfusion 44:809-13. 2004..Transfusion of more than 10 units of RBCs identifies a subgroup where most patients received plasma and PLTs to treat actual or anticipated dilutional coagulopathy. There is no clear threshold beyond which blood use is futile... - Direct measurements of hemoglobin interactions with liposomes using EPR spectroscopyO O Abugo
Blood Research Detachment, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
Artif Cells Blood Substit Immobil Biotechnol 29:5-18. 2001..We suggest that lipid-associated perturbations are responsible for the enhancement of the oxidation observed with the LEH samples compared to the unencapsulated material... - Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patientsThomas M Scalea
R Adams Cowley Shock Trauma Center, Division of Clinical and Outcomes Research, Department of Surgery, Anesthesiology, and Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Ann Surg 248:578-84. 2008..Recent data from Iraq supporting early aggressive use of fresh frozen plasma (FFP) in a 1:1 ratio to packed red blood cells (PRBCs) has led many civilian trauma centers to adopt this resource intensive strategy... - Blood and coagulation support in traumaSarah B Murthi
Division of Trauma and Critical Care Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
Blood Rev 23:149-55. 2009..This paper reviews the epidemiology of injury and modern patterns of trauma care against the background of developing knowledge about the coagulopathies of trauma and blood safety... - Low-dose recombinant factor VIIa for trauma patients with coagulopathyDeborah M Stein
R Adams Cowley Shock Trauma Centress, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Injury 39:1054-61. 2008..Expense has limited use. Recently, we began administering low dose FVIIa (1.2mg) to patients with mild to moderate coagulopathy after trauma, hypothetising that it would be effective and safe... - Current issues relating to the transfusion of stored red blood cellsA B Zimrin
Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Vox Sang 96:93-103. 2009..Several large prospective studies of the safety of stored red blood cells are planned... - Uncross-matched red blood cells save livesJohn R Hess
University of Maryland School of Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA
Hosp Med 66:95-6. 2005 - Trauma mortality in mature trauma systems: are we doing better? An analysis of trauma mortality patterns, 1997-2008Richard P Dutton
Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Trauma 69:620-6. 2010..We examined injury severity, mortality, and preventability in a mature trauma system during a 12-year period to assess the overall benefits of these and other improvements... - Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in traumaLloyd Ketchum
Walter Reed Army Institute of Research, 503 Robert Grant Avenue, MCR, Silver Spring, Maryland 20910, USA
J Trauma 60:S51-8. 2006..Guidelines for the use of non-RBC blood components in the early phase of trauma resuscitation are largely based on extensions of expert recommendations for general surgery... - Treating coagulopathy in trauma patientsRay Armand
Department of Pathology, University of Maryland Medical Center, Baltimore, MD 21201, USA
Transfus Med Rev 17:223-31. 2003..It is exacerbated by dilution, acidosis, and hypothermia. Hemorrhage control, warming, and appropriate blood product support are lifesaving. Further improvements in hemorrhage control will save additional lives and resources... - Thromboembolic complications associated with factor VIIa administrationG O Rhys Thomas
R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, MD 21201, USA
J Trauma 62:564-9. 2007..FVIIa is associated with thromboembolic complications, but the incidence is not known, nor is which patients are at risk. We examined our experience with FVIIa to better understand this issue... - Warm storage of whole blood for 72 hoursJ D Hughes
Blood Bank Fellowship, Walter Reed Army Medical Center, Washington, DC, USA
Transfusion 47:2050-6. 2007..In field emergency medicine, fresh whole-blood units are stored at room temperature up to 24 hours or occasionally longer. Few data exist on the integrity and in vitro functional properties of whole blood stored warm beyond 24 hours... - Impediments to obtaining informed consent for clinical research in trauma patientsRichard P Dutton
Departments of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Trauma 64:1106-12. 2008..Informed consent is required for, but a substantial barrier to, clinic research in trauma care. Exceptions have been established but remain controversial, and little objective data are available to illuminate this debate... - Massive blood transfusion for traumaJohn R Hess
University of Maryland School of Medicine, Baltimore, Maryland, USA
Curr Opin Hematol 12:488-92. 2005..Investment in trauma care and supporting blood supply systems is highly cost effective... - Recombinant factor VIIa for warfarin-associated intracranial bleedingCan Ilyas
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Clin Anesth 20:276-9. 2008..To examine the efficacy of recombinant factor VIIa (rVIIa) in reversing warfarin-induced coagulopathy in trauma patients presenting with intracranial hemorrhage (ICH)... - Putting the pieces together: Roger I. Lee and modern transfusion medicineLynn G Stansbury
Occupational Medical Services NIH, Bethesda, MD, USA
Transfus Med Rev 19:81-4. 2005..Lee put the pieces of modern blood banking and transfusion together... - Blood donors and the challenges in supplying blood products and factor concentratesAnn B Zimrin
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Surgery 142:S15-9. 2007..The development of recombinant coagulation proteins reduces the pressure on this limited supply of donated plasma, and reducing bleeding protects the supply of cellular blood and plasma-derived products... - Blood transfusion in World War I: the roles of Lawrence Bruce Robertson and Oswald Hope Robertson in the "most important medical advance of the war"Lynn G Stansbury
Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA
Transfus Med Rev 23:232-6. 2009..With these demonstrations, the Royal Army Medical Corps adopted transfusion and declared it the most important medical advance of the war... - Washing platelets in neutral, calcium-free, Ringer's acetateWalter E Kelley
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Transfusion 49:1917-23. 2009..Short postwash storage times occasionally conflict with other patient activities and result in the wastage of washed products. Better washing procedures are a start to longer postwash hold times... - Hemostatic efficacy of modified amylopectin powder in a lethal porcine model of extremity arterial injuryMichael Kilbourne
Department of Surgery, R Adams Cowley Shock Trauma Center, Baltimore, MD 21201, USA
Ann Emerg Med 53:804-10. 2009..Rapid hemostasis is crucial in controlling severe extremity hemorrhage. Our objective is to evaluate the hemostatic efficacy of a newly modified amylopectin powder in a model of severe extremity arterial hemorrhage... - Transfusion practice in the intensive care unit: a 10-year analysisGiora Netzer
From the Division of Pulmonary and Critical Care Medicine, the Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Transfusion 50:2125-34. 2010..Clinical guidelines recommend a restrictive transfusion strategy in nonhemorrhaging critically ill patients... - Deconstructing hemoglobin-based oxygen carriersJohn R Hess
Transfusion 48:2051-2. 2008 - Fresh whole blood transfusion: a controversial military practiceDavid S Kauvar
US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
J Trauma 61:181-4. 2006..We review the current military practice of FWB transfusion in combat theaters and conclude that FWB transfusion is convenient, safe, and effective in certain military situations... - Damage control resuscitation: directly addressing the early coagulopathy of traumaJohn B Holcomb
USAISR, Fort Sam Houston, TX 78234-6315, USA
J Trauma 62:307-10. 2007 - Viability does not necessarily reflect the hematopoietic progenitor cell potency of a cord blood unit: results of an interlaboratory exerciseAnneke Brand
Leiden Cord Bloodbank, Sanquin, The Netherlands
Transfusion 48:546-9. 2008..Another reason for a discrepancy between the number of cells in the unit released by the cord blood bank and found in the transplant center may be technical differences in cell counting methods between the two sites... - The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospitalHarry K Stinger
Brooke Army Medical Center, U S Army Institute of Surgical Research, San Antonio, TX 78234 6200, USA
J Trauma 64:S79-85; discussion S85. 2008..Our objective was to determine whether increased ratios of fibrinogen to red blood cells (RBCs) decreased mortality in combat casualties requiring massive transfusion... - Damage control resuscitation: the need for specific blood products to treat the coagulopathy of traumaJohn R Hess
Transfusion 46:685-6. 2006 - Who needs blood?John R Hess
Crit Care Med 33:1171-2. 2005 - Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practiceDavid B Hoyt
Department of Surgery, University of California, Irvine, Orange, CA 92868, USA
J Trauma 65:755-64; discussion 764-5. 2008..Bleeding is one of the leading causes of preventable death after traumatic injury. Trauma-associated coagulopathy complicates the control of bleeding. The published approaches on the management of this coagulopathy differ significantly... - Thrombotic thrombocytopenic purpura: Going with the evidenceAnn B Zimrin
Crit Care Med 34:2247-8. 2006 - Right data, wrong conclusionsGiora Netzer
Crit Care Med 36:1383-4. 2008 - Advanced hemostatic dressing development program: animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in SwineAnthony E Pusateri
US Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
J Trauma 55:518-26. 2003..A systematic approach to the study of dressings is described. We studied the effects of nine hemostatic dressings on blood loss using a model of severe venous hemorrhage and hepatic injury in swine... - Blood product transfusion in association with coronary artery bypass grafting: proceed with cautionDebra L Malone
Crit Care Med 34:1823-4. 2006 - Recombinant factor VIIa and thromboembolic eventsRichard P Dutton
JAMA 296:43-4; author reply 44. 2006 - Traumatic coagulopathy: where are the good experimental models?Michael J Parr
Intensive Care Unit, Liverpool Hospital, University of New South Wales, Sydney, Australia
J Trauma 65:766-71. 2008..This systematic review assessed the primary question "What are relevant experimental models with which to study early traumatic coagulopathy?" and secondary questions on mechanisms...
Research Grants
- Reducing Mortality from Acute Hemorrhage in TraumaJohn Hess; Fiscal Year: 2006..Reducing death from acute hemorrhage in trauma care will be a major step forward in reducing overall trauma mortality. ..