J R Hess

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocol
    Debra L Malone
    Department of Surgery, University of Maryland Medical Center, Baltimore, USA
    J Trauma 60:S91-6. 2006
  2. doi request reprint Red cell storage
    John R Hess
    University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Proteomics 73:368-73. 2010
  3. doi request reprint Scientific problems in the regulation of red blood cell products
    John R Hess
    University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    Transfusion 52:1827-35. 2012
  4. pmc Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review
    Sibylle Kozek-Langenecker
    Department of Anaesthesia and Intensive Care, Evangelical Hospital Vienna, Hans Sachs Gasse 10 12, 1180 Vienna, Austria
    Crit Care 15:R239. 2011
  5. ncbi request reprint Alkaline CPD and the preservation of RBC 2,3-DPG
    John R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Silver Spring, MD 20307, USA
    Transfusion 42:747-52. 2002
  6. ncbi request reprint Blood use in war and disaster: lessons from the past century
    J R Hess
    Department of Pathology, University of Maryland, Baltimore, Maryland, USA
    Transfusion 43:1622-33. 2003
  7. ncbi request reprint Red cell freezing and its impact on the supply chain
    John R Hess
    University of Maryland, Baltimore, MD, USA
    Transfus Med 14:1-8. 2004
  8. ncbi request reprint Update on alternative oxygen carriers
    J R Hess
    University of Maryland School of Medicine, Baltimore 21201, USA
    Vox Sang 87:132-5. 2004
  9. ncbi request reprint The coagulopathy of trauma versus disseminated intravascular coagulation
    John R Hess
    Department of Pathology, University of Maryland Medical Center, Baltimore, 21201, USA
    J Trauma 60:S12-9. 2006
  10. ncbi request reprint An update on solutions for red cell storage
    J R Hess
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 20817, USA
    Vox Sang 91:13-9. 2006

Research Grants

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocol
    Debra L Malone
    Department of Surgery, University of Maryland Medical Center, Baltimore, USA
    J Trauma 60:S91-6. 2006
    ..Patient care and collaborative research might be aided with a common protocol...
  2. doi request reprint Red cell storage
    John R Hess
    University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Proteomics 73:368-73. 2010
    ..The increasing power of proteomics and metabolomics offers the potential of deeper understanding of blood function and storage and of better clinical products in the future...
  3. doi request reprint Scientific problems in the regulation of red blood cell products
    John R Hess
    University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    Transfusion 52:1827-35. 2012
    ..Now additional requirements for storage system licensure have being added. The meaning and value of these new requirements have been questioned...
  4. pmc Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review
    Sibylle Kozek-Langenecker
    Department of Anaesthesia and Intensive Care, Evangelical Hospital Vienna, Hans Sachs Gasse 10 12, 1180 Vienna, Austria
    Crit Care 15:R239. 2011
    ..In this systematic review, we investigated the current evidence for the use of FFP and fibrinogen concentrate in the perioperative or massive trauma setting...
  5. ncbi request reprint Alkaline CPD and the preservation of RBC 2,3-DPG
    John R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Silver Spring, MD 20307, USA
    Transfusion 42:747-52. 2002
    ..Alkaline additive solutions, which can preserve RBCs for up to 11 weeks, still do not preserve 2,3-DPG because the starting pH is below 7.2...
  6. ncbi request reprint Blood use in war and disaster: lessons from the past century
    J R Hess
    Department of Pathology, University of Maryland, Baltimore, Maryland, USA
    Transfusion 43:1622-33. 2003
  7. ncbi request reprint Red cell freezing and its impact on the supply chain
    John R Hess
    University of Maryland, Baltimore, MD, USA
    Transfus Med 14:1-8. 2004
    ..RBC freezing will have little effect on the logistics of blood supply...
  8. ncbi request reprint Update on alternative oxygen carriers
    J R Hess
    University of Maryland School of Medicine, Baltimore 21201, USA
    Vox Sang 87:132-5. 2004
  9. ncbi request reprint The coagulopathy of trauma versus disseminated intravascular coagulation
    John R Hess
    Department of Pathology, University of Maryland Medical Center, Baltimore, 21201, USA
    J Trauma 60:S12-9. 2006
    ..The coagulopathy of trauma should be anticipated in massive transfusion situations. Early treatment with plasma can delay its onset. The underlying mechanisms should be confirmed with laboratory testing...
  10. ncbi request reprint An update on solutions for red cell storage
    J R Hess
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 20817, USA
    Vox Sang 91:13-9. 2006
    ..Improved scientific understanding of the red cell storage lesion has shown a way to make even better storage solutions, which maintain red cell metabolism and reduce membrane loss...
  11. ncbi request reprint Buffering and dilution in red blood cell storage
    J R Hess
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Transfusion 46:50-4. 2006
    ..Red blood cell (RBC) storage solutions work in a narrow pH range between 7.2 and 6.4. While keeping RBC within that pH range, ATP production can be increased by buffering or dilution...
  12. pmc Optimizing the use of blood products in trauma care
    John R Hess
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Crit Care 9:S10-4. 2005
    ..Less developed trauma systems are primarily concerned with speeding transport to specialized facilities and assembling trauma center resources. This article reviews the factors that effect blood use in urgent trauma care...
  13. ncbi request reprint Giving plasma at a 1:1 ratio with red cells in resuscitation: who might benefit?
    John R Hess
    Department of Pathology, Trauma Anesthesiology, and Trauma Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Transfusion 48:1763-5. 2008
  14. doi request reprint Transfusion practice in military trauma
    J R Hess
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Transfus Med 18:143-50. 2008
    ..Component therapy, when available, appears to be as effective as fresh whole blood. In field emergencies, fresh whole blood can be lifesaving...
  15. ncbi request reprint Twelve-week RBC storage
    John R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC, USA
    Transfusion 43:867-72. 2003
    ..Better storage can improve RBC availability and safety. Optimizing RBC ATP production and minimizing hemolysis has allowed progressively longer storage...
  16. doi request reprint Improving the predictive value of red blood cell storage trials: lessons from the Biomedical Excellence for Safer Transfusion (BEST) Collaborative Trial 41
    John R Hess
    University of Maryland School of Medicine, University of Maryland Medical Center, Baltimore, Maryland 21201 1595, USA
    Transfusion 51:34S-37S. 2011
    ..Results from one laboratory are often difficult to reproduce in another laboratory, leading to confusion...
  17. doi request reprint Red cell changes during storage
    John R Hess
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transfus Apher Sci 43:51-9. 2010
    ..Deaths have been reported related to the high potassium and lysophospholipids, but are rare...
  18. doi request reprint Red blood cell hemolysis during blood bank storage: using national quality management data to answer basic scientific questions
    John R Hess
    Department of Pathology, University of Maryland, Baltimore, Maryland 21201, USA
    Transfusion 49:2599-603. 2009
    ..Availability of data from national blood systems on large numbers of RBC units used for internal quality control (QC) purposes and stored and processed in uniform ways permits statistical analysis...
  19. doi request reprint The prevalence of abnormal results of conventional coagulation tests on admission to a trauma center
    John R Hess
    Departments of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Transfusion 49:34-9. 2009
    ..These patients have high mortality, but their prevalence in trauma populations is not clear from the reports...
  20. ncbi request reprint Storage of red blood cells: new approaches
    John R Hess
    Blood Bank, University of Maryland Medical Center, Baltimore, MD, USA
    Transfus Med Rev 16:283-95. 2002
    ....
  21. doi request reprint The coagulopathy of trauma: a review of mechanisms
    John R Hess
    Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    J Trauma 65:748-54. 2008
    ..Coagulopathy associated with severe injury complicates the control of bleeding and is associated with increased morbidity and mortality in trauma patients. The causes and mechanisms are multiple and yet to be clearly defined...
  22. ncbi request reprint Interlaboratory comparison of red-cell ATP, 2,3-diphosphoglycerate and haemolysis measurements
    J R Hess
    University of Maryland Medical School, Baltimore, MD 21201, USA
    Vox Sang 89:44-8. 2005
    ..The reproducibility of RBC ATP, DPG and haemolysis measurements between centres was investigated...
  23. ncbi request reprint The effects of phosphate, pH, and AS volume on RBCs stored in saline-adenine-glucose-mannitol solutions
    J R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Transfusion 40:1000-6. 2000
    ..RBC ATP concentrations are the most important correlate of RBC viability. Tests were performed to determine whether increased AS volume, pH, and phosphate content increased stored RBC ATP concentrations...
  24. ncbi request reprint The role of electrolytes and pH in RBC ASs
    J R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Transfusion 41:1045-51. 2001
    ..The effects of variations in the electrolyte composition and volume of EASs were explored...
  25. ncbi request reprint The effect of two additive solutions on the postthaw storage of RBCs
    J R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Transfusion 41:923-7. 2001
    ..Sterile systems for freezing and for washing thawed blood will allow the storage of RBCs for more than 24 hours after removal of the cryoprotectant glycerol. This study assessed the effect of two ASs in maintaining deglycerolized RBCs...
  26. ncbi request reprint RBC storage for 11 weeks
    J R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 7500, USA
    Transfusion 41:1586-90. 2001
    ..Increasing the length of RBC storage can increase both RBC availability and quality. This work addresses 11-week RBC storage in experimental ASs (EASs)...
  27. ncbi request reprint Successful storage of RBCs for 10 weeks in a new additive solution
    J R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Transfusion 40:1012-6. 2000
    ..The effect of storing packed RBCs suspended in 300 mL of an alkaline, experimental additive solution (EAS 64) was explored...
  28. ncbi request reprint Successful storage of RBCs for 9 weeks in a new additive solution
    J R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Transfusion 40:1007-11. 2000
    ..This study explored the effect of storing packed RBCs suspended in 200 mL of an alkaline, hypotonic, experimental additive solution (EAS 61)...
  29. ncbi request reprint The effects of polyvinyl chloride and polyolefin blood bags on red blood cells stored in a new additive solution
    H R Hill
    Blood Research Detachment, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Vox Sang 81:161-6. 2001
    ..CONCLUSIONS: RBCs stored in PVC had markedly less haemolysis and higher RBC ATP concentrations than those stored in PO. Haemolysis would limit RBC storage in PO bags to a duration of 6 weeks, even with EAS-61...
  30. ncbi request reprint Factor VIIa for correction of traumatic coagulopathy
    Richard P Dutton
    Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Trauma 57:709-18; discussion 718-9. 2004
    ..We present our experience with 81 coagulopathic trauma patients treated using FVIIa in years 2001-2003, compared with "control" patients matched from the trauma registry from the same time period...
  31. ncbi request reprint Recombinant factor VIIa for control of hemorrhage: early experience in critically ill trauma patients
    Richard P Dutton
    Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA
    J Clin Anesth 15:184-8. 2003
    ..To examine our institutional experience with recombinant Factor VIIa (rFVIIa) as a treatment for exsanguinating hemorrhage in critically ill trauma patients...
  32. ncbi request reprint Planning for pandemic influenza: effect of a pandemic on the supply and demand for blood products in the United States
    Ann B Zimrin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Transfusion 47:1071-9. 2007
    ..Influenza causes episodic pandemics when viral antigens shift in ways that elude herd immunity. Avian influenza A H5N1, currently epizootic in bird populations in Asia and Europe, appears to have pandemic potential...
  33. ncbi request reprint Blood transfusion rates in the care of acute trauma
    John J Como
    R Adams Cowley Shock Trauma Center and the Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Transfusion 44:809-13. 2004
    ..Understanding patterns of RBC use is important. Routine resource allocation, planning for mass casualty situations, designing research, and optimizing triage all can be usefully informed...
  34. doi request reprint Controversy in trauma resuscitation: do ratios of plasma to red blood cells matter?
    Lynn G Stansbury
    R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, USA
    Transfus Med Rev 23:255-65. 2009
    ..In this review, the authors examine the findings of these initial studies, highlighting the epidemiologic and analytic methodologies used, and the likely influence of these methodologies on the reported outcomes...
  35. ncbi request reprint Direct measurements of hemoglobin interactions with liposomes using EPR spectroscopy
    O O Abugo
    Blood Research Detachment, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Artif Cells Blood Substit Immobil Biotechnol 29:5-18. 2001
    ..We suggest that lipid-associated perturbations are responsible for the enhancement of the oxidation observed with the LEH samples compared to the unencapsulated material...
  36. doi request reprint Low-dose recombinant factor VIIa for trauma patients with coagulopathy
    Deborah M Stein
    R Adams Cowley Shock Trauma Centress, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Injury 39:1054-61. 2008
    ..Expense has limited use. Recently, we began administering low dose FVIIa (1.2mg) to patients with mild to moderate coagulopathy after trauma, hypothetising that it would be effective and safe...
  37. doi request reprint Blood and coagulation support in trauma
    Sarah B Murthi
    Division of Trauma and Critical Care Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Blood Rev 23:149-55. 2009
    ..This paper reviews the epidemiology of injury and modern patterns of trauma care against the background of developing knowledge about the coagulopathies of trauma and blood safety...
  38. doi request reprint Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients
    Thomas M Scalea
    R Adams Cowley Shock Trauma Center, Division of Clinical and Outcomes Research, Department of Surgery, Anesthesiology, and Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann Surg 248:578-84. 2008
    ..Recent data from Iraq supporting early aggressive use of fresh frozen plasma (FFP) in a 1:1 ratio to packed red blood cells (PRBCs) has led many civilian trauma centers to adopt this resource intensive strategy...
  39. doi request reprint Current issues relating to the transfusion of stored red blood cells
    A B Zimrin
    Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vox Sang 96:93-103. 2009
    ..Several large prospective studies of the safety of stored red blood cells are planned...
  40. ncbi request reprint Treating coagulopathy in trauma patients
    Ray Armand
    Department of Pathology, University of Maryland Medical Center, Baltimore, MD 21201, USA
    Transfus Med Rev 17:223-31. 2003
    ..It is exacerbated by dilution, acidosis, and hypothermia. Hemorrhage control, warming, and appropriate blood product support are lifesaving. Further improvements in hemorrhage control will save additional lives and resources...
  41. ncbi request reprint Uncross-matched red blood cells save lives
    John R Hess
    University of Maryland School of Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA
    Hosp Med 66:95-6. 2005
  42. ncbi request reprint Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in trauma
    Lloyd Ketchum
    Walter Reed Army Institute of Research, 503 Robert Grant Avenue, MCR, Silver Spring, Maryland 20910, USA
    J Trauma 60:S51-8. 2006
    ..Guidelines for the use of non-RBC blood components in the early phase of trauma resuscitation are largely based on extensions of expert recommendations for general surgery...
  43. ncbi request reprint Thromboembolic complications associated with factor VIIa administration
    G O Rhys Thomas
    R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, MD 21201, USA
    J Trauma 62:564-9. 2007
    ..FVIIa is associated with thromboembolic complications, but the incidence is not known, nor is which patients are at risk. We examined our experience with FVIIa to better understand this issue...
  44. doi request reprint Trauma mortality in mature trauma systems: are we doing better? An analysis of trauma mortality patterns, 1997-2008
    Richard P Dutton
    Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Trauma 69:620-6. 2010
    ..We examined injury severity, mortality, and preventability in a mature trauma system during a 12-year period to assess the overall benefits of these and other improvements...
  45. ncbi request reprint Warm storage of whole blood for 72 hours
    J D Hughes
    Blood Bank Fellowship, Walter Reed Army Medical Center, Washington, DC, USA
    Transfusion 47:2050-6. 2007
    ..In field emergency medicine, fresh whole-blood units are stored at room temperature up to 24 hours or occasionally longer. Few data exist on the integrity and in vitro functional properties of whole blood stored warm beyond 24 hours...
  46. doi request reprint Recombinant factor VIIa for warfarin-associated intracranial bleeding
    Can Ilyas
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Clin Anesth 20:276-9. 2008
    ..To examine the efficacy of recombinant factor VIIa (rVIIa) in reversing warfarin-induced coagulopathy in trauma patients presenting with intracranial hemorrhage (ICH)...
  47. doi request reprint Impediments to obtaining informed consent for clinical research in trauma patients
    Richard P Dutton
    Departments of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Trauma 64:1106-12. 2008
    ..Informed consent is required for, but a substantial barrier to, clinic research in trauma care. Exceptions have been established but remain controversial, and little objective data are available to illuminate this debate...
  48. ncbi request reprint Massive blood transfusion for trauma
    John R Hess
    University of Maryland School of Medicine, Baltimore, Maryland, USA
    Curr Opin Hematol 12:488-92. 2005
    ..This article reviews recent knowledge and advances that impact on the use and effectiveness of massive transfusion...
  49. ncbi request reprint Putting the pieces together: Roger I. Lee and modern transfusion medicine
    Lynn G Stansbury
    Occupational Medical Services NIH, Bethesda, MD, USA
    Transfus Med Rev 19:81-4. 2005
    ..Lee put the pieces of modern blood banking and transfusion together...
  50. doi request reprint Washing platelets in neutral, calcium-free, Ringer's acetate
    Walter E Kelley
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Transfusion 49:1917-23. 2009
    ..Short postwash storage times occasionally conflict with other patient activities and result in the wastage of washed products. Better washing procedures are a start to longer postwash hold times...
  51. doi request reprint Blood transfusion in World War I: the roles of Lawrence Bruce Robertson and Oswald Hope Robertson in the "most important medical advance of the war"
    Lynn G Stansbury
    Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA
    Transfus Med Rev 23:232-6. 2009
    ..With these demonstrations, the Royal Army Medical Corps adopted transfusion and declared it the most important medical advance of the war...
  52. ncbi request reprint Blood donors and the challenges in supplying blood products and factor concentrates
    Ann B Zimrin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Surgery 142:S15-9. 2007
    ..The development of recombinant coagulation proteins reduces the pressure on this limited supply of donated plasma, and reducing bleeding protects the supply of cellular blood and plasma-derived products...
  53. pmc Transfusion practice in the intensive care unit: a 10-year analysis
    Giora Netzer
    From the Division of Pulmonary and Critical Care Medicine, the Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Transfusion 50:2125-34. 2010
    ..Clinical guidelines recommend a restrictive transfusion strategy in nonhemorrhaging critically ill patients...
  54. doi request reprint Hemostatic efficacy of modified amylopectin powder in a lethal porcine model of extremity arterial injury
    Michael Kilbourne
    Department of Surgery, R Adams Cowley Shock Trauma Center, Baltimore, MD 21201, USA
    Ann Emerg Med 53:804-10. 2009
    ..Rapid hemostasis is crucial in controlling severe extremity hemorrhage. Our objective is to evaluate the hemostatic efficacy of a newly modified amylopectin powder in a model of severe extremity arterial hemorrhage...
  55. ncbi request reprint Who needs blood?
    John R Hess
    Crit Care Med 33:1171-2. 2005
  56. ncbi request reprint Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma
    John R Hess
    Transfusion 46:685-6. 2006
  57. doi request reprint The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital
    Harry K Stinger
    Brooke Army Medical Center, U S Army Institute of Surgical Research, San Antonio, TX 78234 6200, USA
    J Trauma 64:S79-85; discussion S85. 2008
    ..Our objective was to determine whether increased ratios of fibrinogen to red blood cells (RBCs) decreased mortality in combat casualties requiring massive transfusion...
  58. ncbi request reprint Fresh whole blood transfusion: a controversial military practice
    David S Kauvar
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 61:181-4. 2006
    ..We review the current military practice of FWB transfusion in combat theaters and conclude that FWB transfusion is convenient, safe, and effective in certain military situations...
  59. ncbi request reprint Damage control resuscitation: directly addressing the early coagulopathy of trauma
    John B Holcomb
    USAISR, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 62:307-10. 2007
  60. doi request reprint Deconstructing hemoglobin-based oxygen carriers
    John R Hess
    Transfusion 48:2051-2. 2008
  61. ncbi request reprint Viability does not necessarily reflect the hematopoietic progenitor cell potency of a cord blood unit: results of an interlaboratory exercise
    Anneke Brand
    Leiden Cord Bloodbank, Sanquin, The Netherlands
    Transfusion 48:546-9. 2008
    ..Another reason for a discrepancy between the number of cells in the unit released by the cord blood bank and found in the transplant center may be technical differences in cell counting methods between the two sites...
  62. doi request reprint Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice
    David B Hoyt
    Department of Surgery, University of California, Irvine, Orange, CA 92868, USA
    J Trauma 65:755-64; discussion 764-5. 2008
    ..Bleeding is one of the leading causes of preventable death after traumatic injury. Trauma-associated coagulopathy complicates the control of bleeding. The published approaches on the management of this coagulopathy differ significantly...
  63. doi request reprint Right data, wrong conclusions
    Giora Netzer
    Crit Care Med 36:1383-4. 2008
  64. ncbi request reprint Advanced hemostatic dressing development program: animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in Swine
    Anthony E Pusateri
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 55:518-26. 2003
    ..A systematic approach to the study of dressings is described. We studied the effects of nine hemostatic dressings on blood loss using a model of severe venous hemorrhage and hepatic injury in swine...
  65. ncbi request reprint Recombinant factor VIIa and thromboembolic events
    Richard P Dutton
    JAMA 296:43-4; author reply 44. 2006
  66. ncbi request reprint Blood product transfusion in association with coronary artery bypass grafting: proceed with caution
    Debra L Malone
    Crit Care Med 34:1823-4. 2006
  67. doi request reprint Traumatic coagulopathy: where are the good experimental models?
    Michael J Parr
    Intensive Care Unit, Liverpool Hospital, University of New South Wales, Sydney, Australia
    J Trauma 65:766-71. 2008
    ..This systematic review assessed the primary question "What are relevant experimental models with which to study early traumatic coagulopathy?" and secondary questions on mechanisms...
  68. ncbi request reprint Thrombotic thrombocytopenic purpura: Going with the evidence
    Ann B Zimrin
    Crit Care Med 34:2247-8. 2006

Research Grants1

  1. Reducing Mortality from Acute Hemorrhage in Trauma
    John Hess; Fiscal Year: 2006
    ..Reducing death from acute hemorrhage in trauma care will be a major step forward in reducing overall trauma mortality. ..