Affiliation: University of Florida
- Herzog R. Complexity of immune responses to AAV transgene products - Example of factor IX. Cell Immunol. 2017;: pubmed publisher..Furthermore, the potential for tolerance induction by hepatic gene transfer or combination with immune modulation is discussed. ..
- Herzog R, Cooper M, Perrin G, Biswas M, Martino A, Morel L, et al. Regulatory T cells and TLR9 activation shape antibody formation to a secreted transgene product in AAV muscle gene transfer. Cell Immunol. 2017;: pubmed publisher..Further, Treg re-population eventually resolved humoral and cellular immune responses. Therefore, specific modes of TLR9 activation and Tregs orchestrate antibody formation in muscle gene transfer. ..
- Corti M, Liberati C, Smith B, Lawson L, Tuna I, Conlon T, et al. Safety of Intradiaphragmatic Delivery of Adeno-Associated Virus-Mediated Alpha-Glucosidase (rAAV1-CMV-hGAA) Gene Therapy in children affected by Pompe Disease. Hum Gene Ther Clin Dev. 2017;: pubmed publisher..This observation is significant for future gene therapy studies and serves to establish a clinically relevant approach to blocking immune responses to both the AAV capsid protein and transgene product...