Ray Hershberger

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Coding sequence rare variants identified in MYBPC3, MYH6, TPM1, TNNC1, and TNNI3 from 312 patients with familial or idiopathic dilated cardiomyopathy
    Ray E Hershberger
    University of Miami Miller School of Medicine, Fla 33136, USA
    Circ Cardiovasc Genet 3:155-61. 2010
  2. pmc Update 2011: clinical and genetic issues in familial dilated cardiomyopathy
    Ray E Hershberger
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL 33136, USA
    J Am Coll Cardiol 57:1641-9. 2011
  3. pmc Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals
    Ray E Hershberger
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Genet Med 12:655-67. 2010
  4. doi request reprint Cardiovascular genetic medicine: evolving concepts, rationale, and implementation
    Ray E Hershberger
    Cardiovascular Division, Clinical Research Building, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Cardiovasc Transl Res 1:137-43. 2008
  5. pmc Rare variant mutations in pregnancy-associated or peripartum cardiomyopathy
    Ana Morales
    University of Miami Miller School of Medicine, 1501 NW 10th Ave, Miami, FL 33136, USA
    Circulation 121:2176-82. 2010
  6. pmc Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy
    Ray E Hershberger
    Division of Cardiovascular Medicine, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circ Cardiovasc Genet 2:306-13. 2009
  7. pmc Progress with genetic cardiomyopathies: screening, counseling, and testing in dilated, hypertrophic, and arrhythmogenic right ventricular dysplasia/cardiomyopathy
    Ray E Hershberger
    Cardiovascular Division, University of Miami Miller School of Medicine, Miami, Fla 33136, USA
    Circ Heart Fail 2:253-61. 2009
  8. pmc Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy
    Ray E Hershberger
    Division of Cardiovascular Medicine, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Clin Transl Sci 1:21-6. 2008
  9. doi request reprint Genetic evaluation of cardiomyopathy--a Heart Failure Society of America practice guideline
    Ray E Hershberger
    Cardiovascular Division, University of Miami Miller School of Medicine, Miami, Florida 33101 5138, USA
    J Card Fail 15:83-97. 2009
  10. pmc Common susceptibility variants examined for association with dilated cardiomyopathy
    Evadnie Rampersaud
    Hussman Institute for Human Genomics, Department of Human Genetics, University of Miami, Miami, FL, USA
    Ann Hum Genet 74:110-6. 2010

Research Grants

Collaborators

  • Ana Morales
  • Luisa Mestroni
  • Matthew R G Taylor
  • Jose Renato Pinto
  • E R Martin
  • J A Towbin
  • Nadine Norton
  • Evadnie Rampersaud
  • Duanxiang Li
  • Deirdre Nauman
  • Jason Cowan
  • Jessica D Kushner
  • Sharie B Parks
  • Donna Burgess
  • Susan Ludwigsen
  • Michael Litt
  • Jorge Gonzalez-Quintana
  • Michael Jerosch-Herold
  • Jimena Dagua
  • Emily L Hanson
  • Christopher B Komanapalli
  • Emily L Burkett
  • Petra M Jakobs
  • Kelly Coates
  • Kathy A Crispell
  • Mark Hofmeyer
  • Jill D Siegfried
  • Charles B Porter
  • Diana Dutton
  • Petra Jakobs
  • David C Sheridan
  • Peter S Rahko
  • Rami Alharethi
  • Amanda Peterson
  • Charles N Allen
  • Lars Hegnell
  • Julie Partain
  • Melodie Burdette
  • George Pantely
  • Valerie Sera
  • Emily Burkett
  • Glenn Brady
  • Matthew S Slater
  • Randal R Nixon
  • Howard K Song
  • Pasala S Ravichandran
  • Robert P Irwin
  • Uttam Tripathy
  • Hugh Keegan
  • Sylvia Bousman
  • Nicholas H Dienel
  • Warren Toy

Detail Information

Publications24

  1. pmc Coding sequence rare variants identified in MYBPC3, MYH6, TPM1, TNNC1, and TNNI3 from 312 patients with familial or idiopathic dilated cardiomyopathy
    Ray E Hershberger
    University of Miami Miller School of Medicine, Fla 33136, USA
    Circ Cardiovasc Genet 3:155-61. 2010
    ..We have previously resequenced 9 genes in a cohort of idiopathic or familial DCM probands for rare variants, and now we report resequencing results for 5 more genes with established relationships to DCM...
  2. pmc Update 2011: clinical and genetic issues in familial dilated cardiomyopathy
    Ray E Hershberger
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL 33136, USA
    J Am Coll Cardiol 57:1641-9. 2011
    ..Guidelines for evaluation and testing of FDC and IDC are now available, and when combined with FDC genetic testing and counseling, will bring FDC/IDC genetics to the forefront of cardiovascular genetic medicine...
  3. pmc Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals
    Ray E Hershberger
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Genet Med 12:655-67. 2010
    ..g., DNA structural variants, epigenetics, mitochondrial mutations and others) are operative in DCM. We suggest that such new knowledge will lead to novel approaches to the prevention and treatment of DCM...
  4. doi request reprint Cardiovascular genetic medicine: evolving concepts, rationale, and implementation
    Ray E Hershberger
    Cardiovascular Division, Clinical Research Building, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Cardiovasc Transl Res 1:137-43. 2008
    ..Cardiovascular genetic medicine programs also anchor training and research, thereby enabling the next generation of academic specialists in cardiovascular genetic medicine to continue to improve cardiovascular health...
  5. pmc Rare variant mutations in pregnancy-associated or peripartum cardiomyopathy
    Ana Morales
    University of Miami Miller School of Medicine, 1501 NW 10th Ave, Miami, FL 33136, USA
    Circulation 121:2176-82. 2010
    ..An alternative hypothesis is that PPCM and PACM result, in part, from a genetic cause. In this study, we sought to test the hypothesis that rare DCM-associated mutations underlie a proportion of PACM or PPCM cases...
  6. pmc Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy
    Ray E Hershberger
    Division of Cardiovascular Medicine, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circ Cardiovasc Genet 2:306-13. 2009
    ..This is critically important as genetic DCM, usually presenting with advanced, life-threatening disease, may be preventable with early intervention in relatives known to carry the mutation...
  7. pmc Progress with genetic cardiomyopathies: screening, counseling, and testing in dilated, hypertrophic, and arrhythmogenic right ventricular dysplasia/cardiomyopathy
    Ray E Hershberger
    Cardiovascular Division, University of Miami Miller School of Medicine, Miami, Fla 33136, USA
    Circ Heart Fail 2:253-61. 2009
    ..Genetic counseling is also indicated for patients and their family members regarding the symptoms of their cardiomyopathy, its inheritance pattern, family screening recommendations, and genetic testing options and possible results...
  8. pmc Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy
    Ray E Hershberger
    Division of Cardiovascular Medicine, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Clin Transl Sci 1:21-6. 2008
    ..More than 20 genes have been reported to cause idiopathic and familial dilated cardiomyopathy (IDC/FDC), but the frequency of genetic causation remains poorly understood...
  9. doi request reprint Genetic evaluation of cardiomyopathy--a Heart Failure Society of America practice guideline
    Ray E Hershberger
    Cardiovascular Division, University of Miami Miller School of Medicine, Miami, Florida 33101 5138, USA
    J Card Fail 15:83-97. 2009
    ..Hence the clinical and genetic knowledge for each cardiomyopathy varies, as do the recommendations and strength of evidence...
  10. pmc Common susceptibility variants examined for association with dilated cardiomyopathy
    Evadnie Rampersaud
    Hussman Institute for Human Genomics, Department of Human Genetics, University of Miami, Miami, FL, USA
    Ann Hum Genet 74:110-6. 2010
    ..Our results suggest that examination of common genetic variants may be warranted in future studies of DCM and other Mendelian-like disorders...
  11. ncbi request reprint Family history: an essential tool for cardiovascular genetic medicine
    Ana Morales
    Division of Cardiology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Congest Heart Fail 14:37-45. 2008
    ..Please also give us your feedback, especially to improve the clarity, diversity, and timeliness of the genetic concepts presented. So, away we go...
  12. pmc Morphological analysis of 13 LMNA variants identified in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy
    Jason Cowan
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circ Cardiovasc Genet 3:6-14. 2010
    ....
  13. pmc Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy
    Sharie B Parks
    Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, OR, USA
    Am Heart J 156:161-9. 2008
    ..We sought to examine the frequency of mutations in LMNA, the gene encoding lamin A/C, in patients with idiopathic (IDC) or familial dilated cardiomyopathy (FDC)...
  14. ncbi request reprint The family history as a tool to identify patients at risk for dilated cardiomyopathy
    Deirdre Nauman
    Department of Medicine, Oregon Health and Science University, Portland, OR, USA
    Prog Cardiovasc Nurs 23:41-4. 2008
  15. ncbi request reprint A novel lamin A/C mutation in a family with dilated cardiomyopathy, prominent conduction system disease, and need for permanent pacemaker implantation
    Ray E Hershberger
    Department of Medicine, Oregon Health and Science University, Portland, Ore 97201, USA
    Am Heart J 144:1081-6. 2002
    ..Each family reported to date has a unique mutation and variable degrees of cardiac conduction system, dilated cardiomyopathy, or skeletal muscle disease...
  16. ncbi request reprint Periodic rescreening is indicated for family members at risk of developing familial dilated cardiomyopathy
    Kathy A Crispell
    Department of Medicine Cardiology, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Am Coll Cardiol 39:1503-7. 2002
    ..This study evaluated the role of clinical rescreening of family members at risk for familial dilated cardiomyopathy (FDC)...
  17. pmc Identification of novel mutations in RBM20 in patients with dilated cardiomyopathy
    Duanxiang Li
    Cardiovascular Division, University of Miami Miller School of Medicine, Miami, Florida, USA
    Clin Transl Sci 3:90-7. 2010
    ..This article concludes that DCM in patients with RBM20 mutations is associated with advanced disease...
  18. ncbi request reprint Clinical and genetic issues in familial dilated cardiomyopathy
    Emily L Burkett
    Division of Cardiology, Department of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OT 97239, USA
    J Am Coll Cardiol 45:969-81. 2005
    ..Genetic testing is not yet commonly available, but its emergence will provide new opportunities for presymptomatic diagnosis...
  19. ncbi request reprint Genetic testing and genetic counseling in cardiovascular genetic medicine: overview and preliminary recommendations
    Jason Cowan
    Cardiovascular Division, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Congest Heart Fail 14:97-105. 2008
    ..We also provide our preliminary recommendations for genetic testing in cardiovascular genetic medicine...
  20. ncbi request reprint Clinical characteristics of 304 kindreds evaluated for familial dilated cardiomyopathy
    Jessica D Kushner
    Division of Cardiology, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Card Fail 12:422-9. 2006
    ..Familial dilated cardiomyopathy (FDC) is dilated cardiomyopathy of unknown cause occurring in 2 or more closely related family members...
  21. pmc Mutations of presenilin genes in dilated cardiomyopathy and heart failure
    Duanxiang Li
    Familial Dilated Cardiomyopathy Research Program, Division of Cardiovascular Medicine and the Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Am J Hum Genet 79:1030-9. 2006
    ..These data indicate that PSEN1 and PSEN2 mutations are associated with DCM and heart failure and implicate novel mechanisms of myocardial disease...
  22. ncbi request reprint Cardiac troponin T lysine 210 deletion in a family with dilated cardiomyopathy
    Emily L Hanson
    Department of Medicine, Oregon Health Sciences University, Portland, OR 97201, USA
    J Card Fail 8:28-32. 2002
    ..Identical deletions in exon 13 of TNNT2 have been reported in 2 families with FDC, but little is known about the frequency of this deletion among patients with FDC and idiopathic dilated cardiomyopathy (IDC) and the associated phenotype...
  23. ncbi request reprint Becker's muscular dystrophy and orthotopic heart transplantation: perioperative considerations
    Christopher B Komanapalli
    Department of Surgery, Division of Cardiothoracic Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    Heart Surg Forum 9:E604-6. 2006
    ..We reviewed our recent experience with Becker's muscular dystrophy patients and discuss the management of perioperative issues specific to this patient group...
  24. pmc Cardiac magnetic resonance imaging of myocardial contrast uptake and blood flow in patients affected with idiopathic or familial dilated cardiomyopathy
    Michael Jerosch-Herold
    Division of Cardiology, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Am J Physiol Heart Circ Physiol 295:H1234-H1242. 2008
    ..56; P = 0.019). The expansion of the extracellular space correlated with reduced MBF and ventricular dilation. Expansion of the extracellular matrix may be a key contributor to contractile dysfunction in IDC patients...

Research Grants11

  1. Familial Dilated Cardiomyopathy: Detection/Gene Mapping
    Ray Hershberger; Fiscal Year: 2009
    ..We aim to identify more of the disease genes, which will lead to greater understanding of the causes of human heart failure. ..
  2. Familial Dilated Cardiomyopathy: Detection/Gene Mapping
    Ray Hershberger; Fiscal Year: 2006
    ..We further propose to (2) map the genes responsible for FDC in several FDC pedigrees, of which linkage and additional gene mapping studies are in progress. ..
  3. FAMILIAL DILATED CARDIOMYOPATHY--DETECTION/GENE MAPPING
    Ray Hershberger; Fiscal Year: 2000
    ..Preliminary data suggest that OHSU FDC-1 links to neither of the recently reported cardiomyopathy chromosomal locations, suggesting that an additional locus for FDC is present. ..
  4. Familial Dilated Cardiomyopathy: Detection/Gene Mapping
    Ray E Hershberger; Fiscal Year: 2010
    ..We aim to identify more of the disease genes, which will lead to greater understanding of the causes of human heart failure. ..