Harvey Herschman

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Genes preferentially induced by depolarization after concussive brain injury: effects of age and injury severity
    Christopher C Giza
    Division of Neurosurgery, UCLA School of Medicine, 90095, USA
    J Neurotrauma 19:387-402. 2002
  2. ncbi request reprint Synaptotagmin IV overexpression inhibits depolarization-induced exocytosis in PC12 cells
    Hidevaldo B Machado
    Department of Biological Chemistry, UCLA Center for the Health Sciences, Los Angeles, California, USA
    J Neurosci Res 76:334-41. 2004
  3. ncbi request reprint PET reporter genes for noninvasive imaging of gene therapy, cell tracking and transgenic analysis
    Harvey R Herschman
    Department of Biological Chemistry, Molecular Biology Institute, Crump Institute for Molecular Imaging, David Geffen School of Medicine at UCLA, 341 Boyer Hall, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Crit Rev Oncol Hematol 51:191-204. 2004
  4. ncbi request reprint Reduced anxiety and depression-like behavior in synaptotagmin IV (-/-) mice
    Gregory D Ferguson
    Department of Pharmacology, Health Sciences Building, University of Washington, Seattle, WA, Box 357280, 98195 7280, USA
    Neuropharmacology 47:604-11. 2004
  5. ncbi request reprint Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion protein
    Qianwa Liang
    Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, Los Angeles, CA USA
    Mol Imaging Biol 6:385-94. 2004
  6. doi request reprint A spotlight from prostate cancer
    Harvey R Herschman
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Cancer Discov 2:301-3. 2012
  7. pmc Conditional bicistronic Cre reporter line expressing both firefly luciferase and β-galactosidase
    Tomo o Ishikawa
    Department of Molecular and Medical Pharmacology, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 341 Boyer Hall, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Mol Imaging Biol 13:284-92. 2011
  8. ncbi request reprint Searching for depolarization-induced genes that modulate synaptic plasticity and neurotrophin-induced genes that mediate neuronal differentiation
    H R Herschman
    Department of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA
    Neurochem Res 25:591-602. 2000
  9. ncbi request reprint Molecular imaging: a view from the inside
    Harvey R Herschman
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90025, USA
    J Nucl Cardiol 11:210-4. 2004
  10. ncbi request reprint Cyclooxygenase 2 (COX-2) as a target for therapy and noninvasive imaging
    Harvey R Herschman
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, and Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Imaging Biol 5:286-303. 2003

Detail Information

Publications58

  1. ncbi request reprint Genes preferentially induced by depolarization after concussive brain injury: effects of age and injury severity
    Christopher C Giza
    Division of Neurosurgery, UCLA School of Medicine, 90095, USA
    J Neurotrauma 19:387-402. 2002
    ..Differential expression of these genes may be an important determinant of the distinct molecular responses of the brain to varying severities of trauma experienced at different ages...
  2. ncbi request reprint Synaptotagmin IV overexpression inhibits depolarization-induced exocytosis in PC12 cells
    Hidevaldo B Machado
    Department of Biological Chemistry, UCLA Center for the Health Sciences, Los Angeles, California, USA
    J Neurosci Res 76:334-41. 2004
    ..In addition, rTLE3 overexpression produced only a modest increase in spontaneous vesicle exocytosis, whereas KID-1, SIK, PIM-1, and Nurr1 overexpression had no effect on depolarization-induced exocytosis...
  3. ncbi request reprint PET reporter genes for noninvasive imaging of gene therapy, cell tracking and transgenic analysis
    Harvey R Herschman
    Department of Biological Chemistry, Molecular Biology Institute, Crump Institute for Molecular Imaging, David Geffen School of Medicine at UCLA, 341 Boyer Hall, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Crit Rev Oncol Hematol 51:191-204. 2004
    ....
  4. ncbi request reprint Reduced anxiety and depression-like behavior in synaptotagmin IV (-/-) mice
    Gregory D Ferguson
    Department of Pharmacology, Health Sciences Building, University of Washington, Seattle, WA, Box 357280, 98195 7280, USA
    Neuropharmacology 47:604-11. 2004
    ..These results indicate that Syt IV plays a role in rodent mood-related behavior and suggests Syt IV regulates synaptic function in the neuronal networks that modulate these behaviors...
  5. ncbi request reprint Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion protein
    Qianwa Liang
    Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, Los Angeles, CA USA
    Mol Imaging Biol 6:385-94. 2004
    ..To demonstrate that non-invasive bioluminescent imaging can monitor restricted expression from a nonreplicating adenovirus in which the cyclooxygenase-2 (COX-2) promoter drives firefly luciferase...
  6. doi request reprint A spotlight from prostate cancer
    Harvey R Herschman
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Cancer Discov 2:301-3. 2012
    ....
  7. pmc Conditional bicistronic Cre reporter line expressing both firefly luciferase and β-galactosidase
    Tomo o Ishikawa
    Department of Molecular and Medical Pharmacology, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 341 Boyer Hall, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Mol Imaging Biol 13:284-92. 2011
    ....
  8. ncbi request reprint Searching for depolarization-induced genes that modulate synaptic plasticity and neurotrophin-induced genes that mediate neuronal differentiation
    H R Herschman
    Department of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA
    Neurochem Res 25:591-602. 2000
    ..Antisense oligonucleotide and anti-UPAR antibody experiments demonstrate that NGF-induced UPAR expression is required for NGF-driven PC12 cell differentiation...
  9. ncbi request reprint Molecular imaging: a view from the inside
    Harvey R Herschman
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90025, USA
    J Nucl Cardiol 11:210-4. 2004
  10. ncbi request reprint Cyclooxygenase 2 (COX-2) as a target for therapy and noninvasive imaging
    Harvey R Herschman
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, and Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Imaging Biol 5:286-303. 2003
    ..The ability to noninvasively monitor COX-2 expression with molecular imaging probes will provide a corresponding advance in diagnosing COX-2-based disease, monitoring progression of such diseases, and evaluating alternative therapies...
  11. ncbi request reprint Molecular imaging: looking at problems, seeing solutions
    Harvey R Herschman
    Department of Biological Chemistry, David Geffen School of Medicine at the University of California, Los Angeles, 341 Boyer Hall, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Science 302:605-8. 2003
    ....
  12. ncbi request reprint Micro-PET imaging and small animal models of disease
    Harvey R Herschman
    Department of Biological Chemistry, Molecular Biology Institute, Crump Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, 90095, USA
    Curr Opin Immunol 15:378-84. 2003
    ..Because small animal PET is immediately extrapolatable to the clinic, laboratory advances should rapidly be translated to clinical practice...
  13. ncbi request reprint Non-invasive imaging of reporter genes
    Harvey R Herschman
    Department of Biological Chemistry, Director for Basic Research, UCLA Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Cell Biochem Suppl 39:36-44. 2002
    ..Several somatic delivery paradigms for co-ordinate expression of therapeutic and imaging genes are presented, and our own emphasis on the dopamine D2 receptor and Herpes Simplex Virus Type I thymidine kinase reporter genes are detailed...
  14. pmc Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice
    John M Streicher
    Department of Anesthesiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Mol Cell Cardiol 49:88-94. 2010
    ..Therefore, specific induction of COX-2 and prostaglandin in vivo is sufficient to induce compensated hypertrophy and molecular remodeling...
  15. ncbi request reprint Characterization of the rat urokinase plasminogen activator receptor promoter in PC12 cells
    Feng Su
    Department of Obstetrics and Gynecology, University of California, Los Angeles, California 90095, USA
    J Neurosci Res 85:1952-8. 2007
    ..We conclude that preferential activation of transcription factor binding at this AP-1 site mediates preferential NGF activation of the UPAR gene...
  16. ncbi request reprint Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography
    Shahriar S Yaghoubi
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1770, USA
    Cancer Gene Ther 12:329-39. 2005
    ..18F]FHBG and [18F]FDG imaging data indicate that exposure of C6sr39 tumors to GCV causes the elimination of [18F]FHBG-accumulating C6sr39 cells and selects for re-growth of tumors unable to accumulate [18F]FHBG...
  17. pmc MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart
    John M Streicher
    Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA 91301, USA
    Circ Res 106:1434-43. 2010
    ..MAPK-activated protein kinase-2 (MK2) is a well-established p38 downstream kinase, yet its contribution to p38-mediated pathological response in heart has not been investigated...
  18. ncbi request reprint Targeted identification of glucocorticoid-attenuated response genes: in vitro and in vivo models
    Jeffrey B Smith
    Pediatrics Neonatology, UCLA Center for the Health Sciences, B2 325A, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Proc Am Thorac Soc 1:275-81. 2004
    ..Future studies using microarrays in this and other inflammation models may identify many additional glucocorticoid-regulated genes potentially important in inflammatory diseases...
  19. ncbi request reprint Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene
    Qianwa Liang
    Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, Los Angeles, CA USA
    Mol Imaging Biol 6:395-404. 2004
    ....
  20. ncbi request reprint Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography
    Tatsushi Toyokuni
    Crump Institute for Molecular Imaging and LA Tech Center, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Bioorg Med Chem Lett 15:4699-702. 2005
    ....
  21. ncbi request reprint Molecular imaging in the development of cancer therapeutics
    Johannes Czernin
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Annu Rev Med 57:99-118. 2006
    ..We conclude with a proposal to integrate molecular imaging into the drug development process...
  22. ncbi request reprint Noninvasive imaging of reporter gene expression in living subjects
    Harvey R Herschman
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Johnsson Comprehensive Cancer Center, Los Angeles, California 90095, USA
    Adv Cancer Res 92:29-80. 2004
    ..New developments in multimodality molecular imaging are discussed, and the potential utility of noninvasive reporter gene expression in the diagnosis and management of human cancer is presented...
  23. ncbi request reprint Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5
    Jeffrey B Smith
    Pediatrics Neonatology B2 325, MDCC, David Geffen School of Medicine and Mattel Children s Hospital at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
    Immunogenetics 54:599-603. 2002
    ..The sequence and mapping data suggest that the human ENA78-PBP-PF4 and GCP2- psi PBP-PF4V1 loci arose from an evolutionarily recent duplication of an ancestral locus related to the murine Lix-Pbp-Pf4 locus...
  24. ncbi request reprint Repetitive, noninvasive imaging of cyclooxygenase-2 gene expression in living mice
    Julie T Nguyen
    Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, Los Angeles, CA, USA
    Mol Imaging Biol 5:248-56. 2003
    ..These data suggest expression from the COX-2 promoter will be easily analyzed in transgenic mice, in knock-in mice, and in somatic cell and gene transfer experiments...
  25. ncbi request reprint Glucocorticoid-attenuated response genes induced in the lung during endotoxemia
    Jeffrey B Smith
    Department of Pediatrics, UCLA School of Medicine and Mattel Children s Hospital at UCLA, University of California, 90095, USA
    Am J Physiol Lung Cell Mol Physiol 283:L636-47. 2002
    ..Our results suggest that a full understanding of glucocorticoid effects on lung inflammation will require elucidation of the roles of an extensive network of glucocorticoid-modulated genes...
  26. ncbi request reprint Two inducible, functional cyclooxygenase-2 genes are present in the rainbow trout genome
    Tomo o Ishikawa
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Cell Biochem 102:1486-92. 2007
    ..Thus the rainbow trout has two functional, inducible Cox-2 genes. The zebrafish also contains two Cox-2 genes. However, genome structure analysis suggests diversion of the Cox-2a gene between zebrafish and rainbow trout...
  27. pmc Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery
    Ian Y Chen
    Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, Calif 94305 5427, USA
    Circulation 109:1415-20. 2004
    ....
  28. pmc Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging
    Vania Kenanova
    Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, 700 Westwood Plaza, Los Angeles, CA 90095, USA
    Eur J Nucl Med Mol Imaging 36:104-14. 2009
    ..We have developed a reporter gene based on carcinoembryonic antigen (CEA), a human protein with limited normal tissue expression...
  29. ncbi request reprint Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines
    Richard C Koya
    Department of Surgery, Division of Surgical Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Mol Ther 15:971-80. 2007
    ..Thus, DC precursors can be genetically engineered after a single ex vivo manipulation, resulting in DC vaccines with improved activity...
  30. ncbi request reprint Diesel exhaust particle extracts and associated polycyclic aromatic hydrocarbons inhibit Cox-2-dependent prostaglandin synthesis in murine macrophages and fibroblasts
    Nandini Rudra-Ganguly
    Molecular Biology Institute and the Department of Biological Chemistry, University of California, Los Angeles Center for the Health Sciences, Los Angeles, California 90095, USA
    J Biol Chem 277:39259-65. 2002
    ....
  31. ncbi request reprint Expression of depolarization-induced immediate early gene proteins in PC12 cells
    Wei Liu
    Department of Biological Chemistry, UCLA Center for the Health Sciences, Los Angeles, California, USA
    J Neurosci Res 72:670-8. 2003
    ..Immunofluorescence studies demonstrate distinct distribution patterns of each of these depolarization-induced IEG proteins in PC12 cells...
  32. pmc COX-2 expression and function in the hyperalgesic response to paw inflammation in mice
    Naveen K Jain
    Department of Biological Chemistry, UCLA School of Medicine, 341 Boyer Hall, University of California, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Prostaglandins Leukot Essent Fatty Acids 79:183-90. 2008
    ....
  33. ncbi request reprint Novel anti-inflammatory functions for endothelial and myeloid cyclooxygenase-2 in a new mouse model of Crohn's disease
    Junji Watanabe
    Department of Medicine Cardiology, Univ of California Los Angeles, 650 Charles E Young Drive South, MRL 3736, Los Angeles, CA 90095, USA
    Am J Physiol Gastrointest Liver Physiol 298:G842-50. 2010
    ..The pathology of diet-mediated ileo-ceco-colic inflammation in COX-2(-/-) mice offers an excellent model system to elucidate the protective roles of endothelial and myeloid COX-2 and the molecular pathogenesis of CD...
  34. pmc Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis
    Tomo o Ishikawa
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Mol Oncol 4:119-25. 2010
    ....
  35. pmc Cell-type-specific roles for COX-2 in UVB-induced skin cancer
    Jing Jiao
    Department of Molecular and Medical Pharmacology and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Carcinogenesis 35:1310-9. 2014
    ....
  36. ncbi request reprint Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors
    Helen Su
    Department of Molecular Medicine and Pharmacology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, 650 Charles Young Drive, Los Angeles, CA 90095, USA
    Clin Cancer Res 12:5659-67. 2006
    ....
  37. pmc Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe
    Dean O Campbell
    Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA
    J Biol Chem 287:446-54. 2012
    ..These findings suggest that the TK2-N93D/L109F/L-18F-FMAU PRG-PRP system warrants further evaluation in preclinical and clinical applications of cell-based therapies...
  38. pmc The influence of innate and pre-existing immunity on adenovirus therapy
    Anne K Zaiss
    Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Cell Biochem 108:778-90. 2009
    ..Here we summarize findings using adenovirus vectors in naïve animals, in Ad-immunized animals and in clinical trials, and review strategies proposed to overcome innate immune responses and pre-existing immunity...
  39. ncbi request reprint Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus
    Qianwa Liang
    The Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, California 90095, USA
    Mol Ther 6:73-82. 2002
    ....
  40. ncbi request reprint MAPKAP kinase-2 is a primary response gene induced by depolarization in PC12 cells and in brain
    Linda J Vician
    Department of Biological Chemistry, UCLA Center for the Health Sciences, Los Angeles, CA 90095 1570, USA
    J Neurosci Res 78:315-28. 2004
    ..MAPKAPK2 message is also induced in the dentate gyrus, CA1, and CA3 of the rat hippocampus between 2-4 hr after the onset of kainic acid-induced seizures...
  41. pmc Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression
    Tomo o Ishikawa
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Carcinogenesis 31:729-36. 2010
    ..Our data suggest that the mechanism of colorectal tumor promotion in colitis-associated cancer differs from the mechanism of tumor promotion for hereditary and sporadic colorectal cancer...
  42. ncbi request reprint Transgenic mouse for conditional, tissue-specific Cox-2 overexpression
    Ken ichiro Kamei
    Department of Molecular and Medical Pharmacology, Molecular Biology Institute, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Genesis 44:177-82. 2006
    ..CMV.Cre infection of Cox-2 COE embryo fibroblasts. Cox-2 COE mice should be valuable for the study of Cox-2 overexpression in cardiovascular disease, acute and chronic inflammatory responses, neurodegenerative diseases, and cancer...
  43. pmc Requirement for deoxycytidine kinase in T and B lymphocyte development
    Gerald Toy
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:5551-6. 2010
    ..The dCK KO phenotype challenges this view and indicates that, in contrast to the great majority of other somatic cells, normal lymphocyte development critically requires the deoxyribonucleoside salvage pathway...
  44. pmc Cox-2 gene expression in chemically induced skin papillomas cannot predict subsequent tumor fate
    Tomo o Ishikawa
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Mol Oncol 4:347-56. 2010
    ..Elevated Cox-2 promoter-driven luciferase signal can be detected when papillomas first become visible, but not before this time...
  45. pmc Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells
    Han Ching Tseng
    Division of Oral Biology and Oral Medicine, School of Dentistry and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11590. 2010
    ..Therefore, patients with cancer may benefit from repeated allogeneic NK cell transplantation for specific elimination of cancer stem cells...
  46. pmc Target identification using drug affinity responsive target stability (DARTS)
    Brett Lomenick
    Department of Molecular and Medical Pharmacology and the Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 106:21984-9. 2009
    ..We envisage that DARTS will also be useful in global mapping of protein-metabolite interaction networks and in label-free screening of unlimited varieties of compounds for development as molecular imaging agents...
  47. pmc Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null mice
    Ajay J Narasimha
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Calif 90095, USA
    Arterioscler Thromb Vasc Biol 30:260-8. 2010
    ..The role of myeloid cell cyclooxygenase-2 (COX-2) in the progression of atherosclerosis has not been clearly defined...
  48. ncbi request reprint Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter
    Hua Jung Li
    Department of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California, USA
    Cancer Res 67:5354-61. 2007
    ..c. tumor grafts, and in hepatic tumor grafts. The sCAR-MFE bispecific adapter should, therefore, be a powerful agent to retarget adenovirus vectors to epithelial tumor metastases...
  49. ncbi request reprint The MAPK pathway is required for depolarization-induced "promiscuous" immediate-early gene expression but not for depolarization-restricted immediate-early gene expression in neurons
    Hidevaldo B Machado
    Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, USA
    J Neurosci Res 86:593-602. 2008
    ....
  50. pmc The zebrafish genome contains two inducible, functional cyclooxygenase-2 genes
    Tomo o Ishikawa
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 352:181-7. 2007
    ..Database searching demonstrates that some fish genomes contain multiple Cox-1 or Cox-2 cyclooxygenase genes, suggesting alternate duplication and retention of this gene...
  51. pmc Feedback regulation of cyclooxygenase-2 transcription ex vivo and in vivo
    Tomo o Ishikawa
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 341 Boyer Hall, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 378:534-8. 2009
    ..Our results suggest Cox-2 expression is regulated by cell type specific feedback mechanisms, both in cultured cells and in living animals...
  52. pmc Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors
    Hua Jung Li
    Departments of Biological, Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    Cancer Res 69:554-64. 2009
    ....
  53. pmc Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography
    Rachel E Laing
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 106:2847-52. 2009
    ..DCK-negative tumors, and [(18)F]FAC microPET scans can predict responses to dFdC. We suggest that [(18)F]FAC PET might be useful for guiding treatment decisions in certain cancers by enabling individualized chemotherapy...
  54. ncbi request reprint Altered hippocampal short-term plasticity and associative memory in synaptotagmin IV (-/-) mice
    Gregory D Ferguson
    Department of Pharmacology, Box 357750, Health Sciences Building, University of Washington, Seattle, Washington 98195, USA
    Hippocampus 14:964-74. 2004
    ..These results suggest Syt IV is a presynaptic negative regulator of short-term plasticity in area CA1 of the hippocampus and is required for some, but not all, forms of hippocampus-dependent memory...
  55. pmc Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs
    Wolfgang A Weber
    Nuclear Medicine, University of Freiberg, Germany
    Nat Clin Pract Oncol 5:44-54. 2008
    ..Examples include imaging of the expression and inhibition of drug targets, noninvasive tissue pharmacokinetics, and early assessment of the tumor response...
  56. ncbi request reprint Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia
    Henry J Lin
    Division of Medical Genetics, Department of Pediatrics, and the Research and Education Institute at Harbor University of California, Los Angeles Medical Center, Torrance, California 90502, USA
    Cancer Epidemiol Biomarkers Prev 11:1305-15. 2002
    ..28-1.56; 138 cases and 258 controls). Consistency of the results across all three of the studies is potentially compatible with a protective effect of the polymorphism, mimicking aspirin...
  57. ncbi request reprint DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo
    Vinita Singh
    Department of Neurosurgery, David and Doreen Hermelin Laboratory of Molecular Oncogenetics, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Oncogene 23:7761-71. 2004
    ..1B protein significantly inhibits PRMT3 methylation of cellular substrates. These findings suggest that modulation of post-translational methylation may be an important mechanism through which DAL-1/4.1B affects tumor cell growth...
  58. ncbi request reprint Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo
    Daichi Chikazu
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    J Bone Miner Res 17:1430-40. 2002
    ....

Research Grants29

  1. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2002
    ..These mice will permit investigators to monitor COX-2 expression in a variety of paradigms. ..
  2. The role of epidermal, fibroblast and endothelial cell COX-2 in skin cancer
    Harvey Herschman; Fiscal Year: 2009
    ..We anticipate we will be able to define the critical cells for COX-2 cancer enhancement and suppression. ..
  3. Neurotrophic Factor & Neuronal Primary Responses Genes
    Harvey Herschman; Fiscal Year: 2003
    ..Finally, we will determine mechanisms by which (i) NGF induces UPAR and (ii) UPAR modulates NGF-driven neuron differentiation. ..
  4. Neurotrophic Factor & Neuronal Primary Responses Genes
    Harvey Herschman; Fiscal Year: 2002
    ..Finally, we will determine mechanisms by which (i) NGF induces UPAR and (ii) UPAR modulates NGF-driven neuron differentiation. ..
  5. Neurotrophic Factor & Neuronal Primary Responses Genes
    Harvey Herschman; Fiscal Year: 2001
    ..Finally, we will determine mechanisms by which (i) NGF induces UPAR and (ii) UPAR modulates NGF-driven neuron differentiation. ..
  6. NEUROTROPHIC FACTOR AND NEURONAL PRIMARY RESPONSE GENES
    Harvey Herschman; Fiscal Year: 2000
    ..We will use RDA to identify NGF-induced genes necessary for PC12 differentiation, and to identify additional depolarization-specific IEGs. ..
  7. NEUROTROPHIC FACTOR AND NEURONAL PRIMARY RESPONSE GENES
    Harvey Herschman; Fiscal Year: 1999
    ..We will use RDA to identify NGF-induced genes necessary for PC12 differentiation, and to identify additional depolarization-specific IEGs. ..
  8. NEUROTROPHIC FACTOR AND NEURONAL PRIMARY RESPONSE GENES
    Harvey Herschman; Fiscal Year: 1993
    ....
  9. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2007
    ..Studies with this mouse will correlate optical and microPET imaging technologies. ..
  10. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2009
    ..Studies with this mouse will correlate optical and microPET imaging technologies. ..
  11. The role of epidermal, fibroblast and endothelial cell COX-2 in skin cancer
    Harvey Herschman; Fiscal Year: 2007
    ..We anticipate we will be able to define the critical cells and times for COX-2 cancer enhancement. ..
  12. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2005
    ..Studies with this mouse will correlate optical and microPET imaging technologies. ..
  13. The role of epidermal, fibroblast and endothelial cell COX-2 in skin cancer
    Harvey R Herschman; Fiscal Year: 2010
    ..We anticipate we will be able to define the critical cells and times for COX-2 cancer enhancement. ..
  14. NEUROTROPHIC FACTOR AND NEURONAL PRIMARY RESPONSE GENES
    Harvey Herschman; Fiscal Year: 1992
    ....
  15. NEUROTROPHIC FACTOR AND NEURONAL PRIMARY RESPONSE GENES
    Harvey Herschman; Fiscal Year: 1991
    ....
  16. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2003
    ..These mice will permit investigators to monitor COX-2 expression in a variety of paradigms. ..
  17. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2004
    ..These mice will permit investigators to monitor COX-2 expression in a variety of paradigms. ..
  18. Neurotrophic Factor & Neuronal Primary Responses Genes
    Harvey Herschman; Fiscal Year: 2004
    ..Finally, we will determine mechanisms by which (i) NGF induces UPAR and (ii) UPAR modulates NGF-driven neuron differentiation. ..
  19. RESEARCH TRAINING IN PHARMACOLOGICAL SCIENCES
    Harvey Herschman; Fiscal Year: 2005
    ..Resources of the DMMP and the Crump Institute for Molecular Imaging will be available to all RTPS students, regardless of the department in which they receive their Ph.D. ..
  20. The role of epidermal, fibroblast and endothelial cell COX-2 in skin cancer
    Harvey Herschman; Fiscal Year: 2009
    ..We anticipate we will be able to define the critical cells and times for COX-2 cancer enhancement. ..
  21. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2001
    ..These mice will permit investigators to monitor COX-2 expression in a variety of paradigms. ..
  22. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2006
    ..Studies with this mouse will correlate optical and microPET imaging technologies. ..