Research Topics
Genomes and Genes
| Harvey HerschmanSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Genes preferentially induced by depolarization after concussive brain injury: effects of age and injury severityChristopher C Giza
Division of Neurosurgery, UCLA School of Medicine, 90095, USA
J Neurotrauma 19:387-402. 2002..Differential expression of these genes may be an important determinant of the distinct molecular responses of the brain to varying severities of trauma experienced at different ages...- Synaptotagmin IV overexpression inhibits depolarization-induced exocytosis in PC12 cellsHidevaldo B Machado
Department of Biological Chemistry, UCLA Center for the Health Sciences, Los Angeles, California, USA
J Neurosci Res 76:334-41. 2004..In addition, rTLE3 overexpression produced only a modest increase in spontaneous vesicle exocytosis, whereas KID-1, SIK, PIM-1, and Nurr1 overexpression had no effect on depolarization-induced exocytosis... - PET reporter genes for noninvasive imaging of gene therapy, cell tracking and transgenic analysisHarvey R Herschman
Department of Biological Chemistry, Molecular Biology Institute, Crump Institute for Molecular Imaging, David Geffen School of Medicine at UCLA, 341 Boyer Hall, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
Crit Rev Oncol Hematol 51:191-204. 2004.... - Reduced anxiety and depression-like behavior in synaptotagmin IV (-/-) miceGregory D Ferguson
Department of Pharmacology, Health Sciences Building, University of Washington, Seattle, WA, Box 357280, 98195 7280, USA
Neuropharmacology 47:604-11. 2004..These results indicate that Syt IV plays a role in rodent mood-related behavior and suggests Syt IV regulates synaptic function in the neuronal networks that modulate these behaviors... - Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion proteinQianwa Liang
Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, Los Angeles, CA USA
Mol Imaging Biol 6:385-94. 2004..CONCLUSION: Both tissue restricted expression and transcriptional redirection to tumors expressing COX-2 can be imaged non-invasively following injection of Adenovirus expressing firefly luciferase from the COX-2 promoter... 
A spotlight from prostate cancerHarvey R Herschman
Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Cancer Discov 2:301-3. 2012....
Conditional bicistronic Cre reporter line expressing both firefly luciferase and β-galactosidaseTomo o Ishikawa
Department of Molecular and Medical Pharmacology, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 341 Boyer Hall, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
Mol Imaging Biol 13:284-92. 2011....- Searching for depolarization-induced genes that modulate synaptic plasticity and neurotrophin-induced genes that mediate neuronal differentiationH R Herschman
Department of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA
Neurochem Res 25:591-602. 2000..Antisense oligonucleotide and anti-UPAR antibody experiments demonstrate that NGF-induced UPAR expression is required for NGF-driven PC12 cell differentiation... - Molecular imaging: a view from the insideHarvey R Herschman
Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90025, USA
J Nucl Cardiol 11:210-4. 2004 - Cyclooxygenase 2 (COX-2) as a target for therapy and noninvasive imagingHarvey R Herschman
Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, and Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Mol Imaging Biol 5:286-303. 2003..The ability to noninvasively monitor COX-2 expression with molecular imaging probes will provide a corresponding advance in diagnosing COX-2-based disease, monitoring progression of such diseases, and evaluating alternative therapies... - Molecular imaging: looking at problems, seeing solutionsHarvey R Herschman
Department of Biological Chemistry, David Geffen School of Medicine at the University of California, Los Angeles, 341 Boyer Hall, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
Science 302:605-8. 2003.... - Micro-PET imaging and small animal models of diseaseHarvey R Herschman
Department of Biological Chemistry, Molecular Biology Institute, Crump Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, 90095, USA
Curr Opin Immunol 15:378-84. 2003..Because small animal PET is immediately extrapolatable to the clinic, laboratory advances should rapidly be translated to clinical practice... - Non-invasive imaging of reporter genesHarvey R Herschman
Department of Biological Chemistry, Director for Basic Research, UCLA Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Cell Biochem Suppl 39:36-44. 2002..Several somatic delivery paradigms for co-ordinate expression of therapeutic and imaging genes are presented, and our own emphasis on the dopamine D2 receptor and Herpes Simplex Virus Type I thymidine kinase reporter genes are detailed... - Characterization of the rat urokinase plasminogen activator receptor promoter in PC12 cellsFeng Su
Department of Obstetrics and Gynecology, University of California, Los Angeles, California 90095, USA
J Neurosci Res 85:1952-8. 2007..We conclude that preferential activation of transcription factor binding at this AP-1 site mediates preferential NGF activation of the UPAR gene... - Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in miceJohn M Streicher
Department of Anesthesiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Mol Cell Cardiol 49:88-94. 2010..Therefore, specific induction of COX-2 and prostaglandin in vivo is sufficient to induce compensated hypertrophy and molecular remodeling... - Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomographyShahriar S Yaghoubi
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095-1770, USA
Cancer Gene Ther 12:329-39. 2005..18F]FHBG and [18F]FDG imaging data indicate that exposure of C6sr39 tumors to GCV causes the elimination of [18F]FHBG-accumulating C6sr39 cells and selects for re-growth of tumors unable to accumulate [18F]FHBG... - MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heartJohn M Streicher
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA 91301, USA
Circ Res 106:1434-43. 2010..MAPK-activated protein kinase-2 (MK2) is a well-established p38 downstream kinase, yet its contribution to p38-mediated pathological response in heart has not been investigated... - Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5Jeffrey B Smith
Pediatrics Neonatology B2 325, MDCC, David Geffen School of Medicine and Mattel Children s Hospital at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
Immunogenetics 54:599-603. 2002..The sequence and mapping data suggest that the human ENA78-PBP-PF4 and GCP2- psi PBP-PF4V1 loci arose from an evolutionarily recent duplication of an ancestral locus related to the murine Lix-Pbp-Pf4 locus... - Noninvasive imaging of reporter gene expression in living subjectsHarvey R Herschman
Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Johnsson Comprehensive Cancer Center, Los Angeles, California 90095, USA
Adv Cancer Res 92:29-80. 2004..New developments in multimodality molecular imaging are discussed, and the potential utility of noninvasive reporter gene expression in the diagnosis and management of human cancer is presented... - Molecular imaging in the development of cancer therapeuticsJohannes Czernin
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Annu Rev Med 57:99-118. 2006..We conclude with a proposal to integrate molecular imaging into the drug development process... - Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter geneQianwa Liang
Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, Los Angeles, CA USA
Mol Imaging Biol 6:395-404. 2004..CONCLUSION: Both liver "untargeting" and tumor "retargeting" of adenovirus by recombinant sCAR-EGF can be imaged non-invasively using a luciferase reporter gene... - Targeted identification of glucocorticoid-attenuated response genes: in vitro and in vivo modelsJeffrey B Smith
Pediatrics Neonatology, UCLA Center for the Health Sciences, B2 325A, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Proc Am Thorac Soc 1:275-81. 2004..Future studies using microarrays in this and other inflammation models may identify many additional glucocorticoid-regulated genes potentially important in inflammatory diseases... - Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomographyTatsushi Toyokuni
Crump Institute for Molecular Imaging and LA Tech Center, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Bioorg Med Chem Lett 15:4699-702. 2005.... - Glucocorticoid-attenuated response genes induced in the lung during endotoxemiaJeffrey B Smith
Department of Pediatrics, UCLA School of Medicine and Mattel Children s Hospital at UCLA, University of California, 90095, USA
Am J Physiol Lung Cell Mol Physiol 283:L636-47. 2002..Our results suggest that a full understanding of glucocorticoid effects on lung inflammation will require elucidation of the roles of an extensive network of glucocorticoid-modulated genes... - Repetitive, noninvasive imaging of cyclooxygenase-2 gene expression in living miceJulie T Nguyen
Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, Los Angeles, CA, USA
Mol Imaging Biol 5:248-56. 2003..These data suggest expression from the COX-2 promoter will be easily analyzed in transgenic mice, in knock-in mice, and in somatic cell and gene transfer experiments... - Two inducible, functional cyclooxygenase-2 genes are present in the rainbow trout genomeTomo o Ishikawa
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Cell Biochem 102:1486-92. 2007..Thus the rainbow trout has two functional, inducible Cox-2 genes. The zebrafish also contains two Cox-2 genes. However, genome structure analysis suggests diversion of the Cox-2a gene between zebrafish and rainbow trout... - Recombinant carcinoembryonic antigen as a reporter gene for molecular imagingVania Kenanova
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, 700 Westwood Plaza, Los Angeles, CA 90095, USA
Eur J Nucl Med Mol Imaging 36:104-14. 2009..We have developed a reporter gene based on carcinoembryonic antigen (CEA), a human protein with limited normal tissue expression... - Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene deliveryIan Y Chen
Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, Calif 94305-5427, USA
Circulation 109:1415-20. 2004..CONCLUSIONS: The IRES-based bicistronic adenoviral vector can potentially be used in conjunction with PET for indirect imaging of therapeutic gene expression by replacing 1 of the 2 PET reporter genes with a therapeutic gene of choice... - Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccinesRichard C Koya
Department of Surgery, Division of Surgical Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Mol Ther 15:971-80. 2007..Thus, DC precursors can be genetically engineered after a single ex vivo manipulation, resulting in DC vaccines with improved activity... - COX-2 expression and function in the hyperalgesic response to paw inflammation in miceNaveen K Jain
Department of Biological Chemistry, UCLA School of Medicine, 341 Boyer Hall, University of California, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
Prostaglandins Leukot Essent Fatty Acids 79:183-90. 2008.... - Novel anti-inflammatory functions for endothelial and myeloid cyclooxygenase-2 in a new mouse model of Crohn's diseaseJunji Watanabe
Department of Medicine Cardiology, Univ of California Los Angeles, 650 Charles E Young Drive South, MRL 3736, Los Angeles, CA 90095, USA
Am J Physiol Gastrointest Liver Physiol 298:G842-50. 2010..The pathology of diet-mediated ileo-ceco-colic inflammation in COX-2(-/-) mice offers an excellent model system to elucidate the protective roles of endothelial and myeloid COX-2 and the molecular pathogenesis of CD... - Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesisTomo o Ishikawa
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Mol Oncol 4:119-25. 2010.... - Diesel exhaust particle extracts and associated polycyclic aromatic hydrocarbons inhibit Cox-2-dependent prostaglandin synthesis in murine macrophages and fibroblastsNandini Rudra-Ganguly
Molecular Biology Institute and the Department of Biological Chemistry, University of California, Los Angeles Center for the Health Sciences, Los Angeles, California 90095, USA
J Biol Chem 277:39259-65. 2002.... - Expression of depolarization-induced immediate early gene proteins in PC12 cellsWei Liu
Department of Biological Chemistry, UCLA Center for the Health Sciences, Los Angeles, California, USA
J Neurosci Res 72:670-8. 2003..Immunofluorescence studies demonstrate distinct distribution patterns of each of these depolarization-induced IEG proteins in PC12 cells... - Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitorsHelen Su
Department of Molecular Medicine and Pharmacology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, 650 Charles Young Drive, Los Angeles, CA 90095, USA
Clin Cancer Res 12:5659-67. 2006..CONCLUSION: Glucose metabolic activity closely reflects response to gefitinib therapy. FDG-PET may be a valuable clinical predictor, early in the course of treatment, for therapeutic responses to EGFR kinase inhibitors... - Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probeDean O Campbell
Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA
J Biol Chem 287:446-54. 2012..These findings suggest that the TK2-N93D/L109F/L-18F-FMAU PRG-PRP system warrants further evaluation in preclinical and clinical applications of cell-based therapies... - Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirusQianwa Liang
The Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, California 90095, USA
Mol Ther 6:73-82. 2002.... - Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expressionTomo o Ishikawa
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Carcinogenesis 31:729-36. 2010..Our data suggest that the mechanism of colorectal tumor promotion in colitis-associated cancer differs from the mechanism of tumor promotion for hereditary and sporadic colorectal cancer... - The influence of innate and pre-existing immunity on adenovirus therapyAnne K Zaiss
Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Cell Biochem 108:778-90. 2009..Here we summarize findings using adenovirus vectors in naïve animals, in Ad-immunized animals and in clinical trials, and review strategies proposed to overcome innate immune responses and pre-existing immunity... - Transgenic mouse for conditional, tissue-specific Cox-2 overexpressionKen ichiro Kamei
Department of Molecular and Medical Pharmacology, Molecular Biology Institute, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Genesis 44:177-82. 2006..CMV.Cre infection of Cox-2 COE embryo fibroblasts. Cox-2 COE mice should be valuable for the study of Cox-2 overexpression in cardiovascular disease, acute and chronic inflammatory responses, neurodegenerative diseases, and cancer... - MAPKAP kinase-2 is a primary response gene induced by depolarization in PC12 cells and in brainLinda J Vician
Department of Biological Chemistry, UCLA Center for the Health Sciences, Los Angeles, CA 90095-1570, USA
J Neurosci Res 78:315-28. 2004..MAPKAPK2 message is also induced in the dentate gyrus, CA1, and CA3 of the rat hippocampus between 2-4 hr after the onset of kainic acid-induced seizures... - Noninvasive prediction of tumor responses to gemcitabine using positron emission tomographyRachel E Laing
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 106:2847-52. 2009..DCK-negative tumors, and [(18)F]FAC microPET scans can predict responses to dFdC. We suggest that [(18)F]FAC PET might be useful for guiding treatment decisions in certain cancers by enabling individualized chemotherapy... - The zebrafish genome contains two inducible, functional cyclooxygenase-2 genesTomo o Ishikawa
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Biochem Biophys Res Commun 352:181-7. 2007..Database searching demonstrates that some fish genomes contain multiple Cox-1 or Cox-2 cyclooxygenase genes, suggesting alternate duplication and retention of this gene... - Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cellsHan Ching Tseng
Division of Oral Biology and Oral Medicine, School of Dentistry and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 5:e11590. 2010..Therefore, patients with cancer may benefit from repeated allogeneic NK cell transplantation for specific elimination of cancer stem cells... - Cox-2 gene expression in chemically induced skin papillomas cannot predict subsequent tumor fateTomo o Ishikawa
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Mol Oncol 4:347-56. 2010..Elevated Cox-2 promoter-driven luciferase signal can be detected when papillomas first become visible, but not before this time... - Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapterHua Jung Li
Department of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California, USA
Cancer Res 67:5354-61. 2007..c. tumor grafts, and in hepatic tumor grafts. The sCAR-MFE bispecific adapter should, therefore, be a powerful agent to retarget adenovirus vectors to epithelial tumor metastases... - Requirement for deoxycytidine kinase in T and B lymphocyte developmentGerald Toy
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:5551-6. 2010..The dCK KO phenotype challenges this view and indicates that, in contrast to the great majority of other somatic cells, normal lymphocyte development critically requires the deoxyribonucleoside salvage pathway... - Target identification using drug affinity responsive target stability (DARTS)Brett Lomenick
Department of Molecular and Medical Pharmacology and the Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 106:21984-9. 2009..We envisage that DARTS will also be useful in global mapping of protein-metabolite interaction networks and in label-free screening of unlimited varieties of compounds for development as molecular imaging agents... - Feedback regulation of cyclooxygenase-2 transcription ex vivo and in vivoTomo o Ishikawa
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 341 Boyer Hall, 611 Charles E Young Drive East, Los Angeles, CA 90095, USA
Biochem Biophys Res Commun 378:534-8. 2009..Our results suggest Cox-2 expression is regulated by cell type specific feedback mechanisms, both in cultured cells and in living animals... - Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null miceAjay J Narasimha
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Calif 90095, USA
Arterioscler Thromb Vasc Biol 30:260-8. 2010..The role of myeloid cell cyclooxygenase-2 (COX-2) in the progression of atherosclerosis has not been clearly defined... - The MAPK pathway is required for depolarization-induced "promiscuous" immediate-early gene expression but not for depolarization-restricted immediate-early gene expression in neuronsHidevaldo B Machado
Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, USA
J Neurosci Res 86:593-602. 2008.... - Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumorsHua Jung Li
Departments of Biological, Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
Cancer Res 69:554-64. 2009.... - Altered hippocampal short-term plasticity and associative memory in synaptotagmin IV (-/-) miceGregory D Ferguson
Department of Pharmacology, Box 357750, Health Sciences Building, University of Washington, Seattle, Washington 98195, USA
Hippocampus 14:964-74. 2004..These results suggest Syt IV is a presynaptic negative regulator of short-term plasticity in area CA1 of the hippocampus and is required for some, but not all, forms of hippocampus-dependent memory... - Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugsWolfgang A Weber
Nuclear Medicine, University of Freiberg, Germany
Nat Clin Pract Oncol 5:44-54. 2008..Examples include imaging of the expression and inhibition of drug targets, noninvasive tissue pharmacokinetics, and early assessment of the tumor response... - Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasiaHenry J Lin
Division of Medical Genetics, Department of Pediatrics, and the Research and Education Institute at Harbor University of California, Los Angeles Medical Center, Torrance, California 90502, USA
Cancer Epidemiol Biomarkers Prev 11:1305-15. 2002..28-1.56; 138 cases and 258 controls). Consistency of the results across all three of the studies is potentially compatible with a protective effect of the polymorphism, mimicking aspirin... - DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivoVinita Singh
Department of Neurosurgery, David and Doreen Hermelin Laboratory of Molecular Oncogenetics, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI 48202, USA
Oncogene 23:7761-71. 2004..1B protein significantly inhibits PRMT3 methylation of cellular substrates. These findings suggest that modulation of post-translational methylation may be an important mechanism through which DAL-1/4.1B affects tumor cell growth... - Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivoDaichi Chikazu
Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
J Bone Miner Res 17:1430-40. 2002....
Research Grants
- Neurotrophic Factor & Neuronal Primary Responses GenesHarvey Herschman; Fiscal Year: 2004..Finally, we will determine mechanisms by which (i) NGF induces UPAR and (ii) UPAR modulates NGF-driven neuron differentiation. ..
- RESEARCH TRAINING IN PHARMACOLOGICAL SCIENCESHarvey Herschman; Fiscal Year: 2005..Resources of the DMMP and the Crump Institute for Molecular Imaging will be available to all RTPS students, regardless of the department in which they receive their Ph.D. ..
- The role of epidermal, fibroblast and endothelial cell COX-2 in skin cancerHarvey Herschman; Fiscal Year: 2007..We anticipate we will be able to define the critical cells and times for COX-2 cancer enhancement. ..
- IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORSHarvey Herschman; Fiscal Year: 2007..Studies with this mouse will correlate optical and microPET imaging technologies. ..
- IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORSHarvey Herschman; Fiscal Year: 2009..Studies with this mouse will correlate optical and microPET imaging technologies. ..
- The role of epidermal, fibroblast and endothelial cell COX-2 in skin cancerHarvey Herschman; Fiscal Year: 2009..We anticipate we will be able to define the critical cells for COX-2 cancer enhancement and suppression. ..
- IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORSHarvey Herschman; Fiscal Year: 2004..These mice will permit investigators to monitor COX-2 expression in a variety of paradigms. ..
- NEUROTROPHIC FACTOR AND NEURONAL PRIMARY RESPONSE GENESHarvey Herschman; Fiscal Year: 1993....
- NEUROTROPHIC FACTOR AND NEURONAL PRIMARY RESPONSE GENESHarvey Herschman; Fiscal Year: 2000..We will use RDA to identify NGF-induced genes necessary for PC12 differentiation, and to identify additional depolarization-specific IEGs. ..
- The role of epidermal, fibroblast and endothelial cell COX-2 in skin cancerHarvey R Herschman; Fiscal Year: 2010..We anticipate we will be able to define the critical cells and times for COX-2 cancer enhancement. ..