David Herndon

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 7:e35465. 2012
  2. pmc Burns: an update on current pharmacotherapy
    Yesenia Rojas
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Expert Opin Pharmacother 13:2485-94. 2012
  3. pmc Long-term propranolol use in severely burned pediatric patients: a randomized controlled study
    David N Herndon
    Shriners Hospitals for Children Galveston, Galveston, TX 77550, USA
    Ann Surg 256:402-11. 2012
  4. pmc Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock
    Marc O Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, 301 University Blvd, Galveston, TX 77555 0591, USA
    Crit Care 14:R217. 2010
  5. pmc Transpulmonary thermodilution for hemodynamic measurements in severely burned children
    Ludwik K Branski
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Crit Care 15:R118. 2011
  6. pmc Tissue engineered fetal skin constructs for pediatric burns
    William B Norbury
    Department of Surgery, Shriners Hospitals for Children, Galveston, Texas, USA
    Crit Care 9:533-4. 2005
  7. pmc The leading causes of death after burn injury in a single pediatric burn center
    Felicia N Williams
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Crit Care 13:R183. 2009
  8. pmc The use of exenatide in severely burned pediatric patients
    Gabriel A Mecott
    Department of Surgery, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555, USA
    Crit Care 14:R153. 2010
  9. pmc Inhalation injury in severely burned children does not augment the systemic inflammatory response
    Celeste C Finnerty
    Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care 11:R22. 2007
  10. pmc Burn size determines the inflammatory and hypermetabolic response
    Marc G Jeschke
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Crit Care 11:R90. 2007

Detail Information

Publications105 found, 100 shown here

  1. pmc The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 7:e35465. 2012
    ..Ketoconazole, an anti-fungal agent, inhibits cortisol synthesis. We, therefore, studied the effect of ketoconazole on post-burn cortisol levels and the hyper-catabolic response in a prospective randomized trial (block randomization 2:1)...
  2. pmc Burns: an update on current pharmacotherapy
    Yesenia Rojas
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Expert Opin Pharmacother 13:2485-94. 2012
    ..Incorporation of pharmacotherapeutics into treatment regimens may further reduce complications of severe burn injuries...
  3. pmc Long-term propranolol use in severely burned pediatric patients: a randomized controlled study
    David N Herndon
    Shriners Hospitals for Children Galveston, Galveston, TX 77550, USA
    Ann Surg 256:402-11. 2012
    ..To determine the safety and efficacy of propranolol given for 1 year on cardiac function, resting energy expenditure, and body composition in a prospective, randomized, single-center, controlled study in pediatric patients with large burns...
  4. pmc Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock
    Marc O Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, 301 University Blvd, Galveston, TX 77555 0591, USA
    Crit Care 14:R217. 2010
    ....
  5. pmc Transpulmonary thermodilution for hemodynamic measurements in severely burned children
    Ludwik K Branski
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Crit Care 15:R118. 2011
    ..Pulmonary artery catheters, however, have been associated with many risks. Our aim was to show the feasibility of continuous monitoring with minimally invasive transpulmonary thermodilution (TPTD) in severely burned pediatric patients...
  6. pmc Tissue engineered fetal skin constructs for pediatric burns
    William B Norbury
    Department of Surgery, Shriners Hospitals for Children, Galveston, Texas, USA
    Crit Care 9:533-4. 2005
    ..The use of FSCs gives us an additional option in a range of possible treatments for this notoriously difficult-to-treat patient group...
  7. pmc The leading causes of death after burn injury in a single pediatric burn center
    Felicia N Williams
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Crit Care 13:R183. 2009
    ..Despite these advances, death still occurs. Our aim was to determine the predominant causes of death in burned pediatric patients in order to develop new treatment avenues and future trajectories associated with increased survival...
  8. pmc The use of exenatide in severely burned pediatric patients
    Gabriel A Mecott
    Department of Surgery, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555, USA
    Crit Care 14:R153. 2010
    ..We hypothesized that exenatide would decrease plasma glucose levels post-burn to levels similar to those achieved with IIT, and reduce the amount of exogenous insulin administered...
  9. pmc Inhalation injury in severely burned children does not augment the systemic inflammatory response
    Celeste C Finnerty
    Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care 11:R22. 2007
    ..The aim of the present study was to determine the effect of inhalation injury on cytokine expression in severely burned children...
  10. pmc Burn size determines the inflammatory and hypermetabolic response
    Marc G Jeschke
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Crit Care 11:R90. 2007
    ..The purpose of the present study was to determine in a large prospective clinical trial whether different burn sizes are associated with differences in inflammation, body composition, protein synthesis, or organ function...
  11. pmc Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive?
    Gerd G Gauglitz
    Shriners Hospitals for Children, 815 Market Street, Galveston, Texas, 77550, USA
    Crit Care 12:R81. 2008
    ..Early identification followed by appropriate management of these high-risk patients may lead to improved clinical outcome...
  12. pmc Pulmonary vascular permeability changes in an ovine model of methicillin-resistant Staphylococcus aureus sepsis
    Collette C Jonkam
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Hospital for Children, Galveston, TX 77555 1102, USA
    Crit Care 13:R19. 2009
    ..We tested the hypothesis that methicillin-resistant Staphylococcus aureus (MRSA) sepsis following smoke inhalation increases pulmonary transvascular fluid flux via excessive nitric oxide (NO) production...
  13. ncbi request reprint Support of the metabolic response to burn injury
    David N Herndon
    Shriners Hospital for Children, 815 Market Street, Galveston, TX 77550, USA
    Lancet 363:1895-902. 2004
    ..Exogenous continuous low-dose insulin infusion, beta blockade with propranolol, and use of the synthetic testosterone analogue oxandrolone are the most cost effective and least toxic pharmacological treatments to date...
  14. ncbi request reprint Reversal of catabolism by beta-blockade after severe burns
    D N Herndon
    Department of Surgery, University of Texas Medical Branch, Shriners Hospitals for Children, Galveston 77550, USA
    N Engl J Med 345:1223-9. 2001
    ..We hypothesized that blockade of beta-adrenergic stimulation with propranolol would decrease resting energy expenditure and muscle catabolism in patients with severe burns...
  15. ncbi request reprint Nutritional and pharmacological support of the metabolic response to injury
    D N Herndon
    Shriners Hospitals for Children Galveston Burns Hospital, SHC G, Professor of Pediatrics and Surgery, University of Texas Medical Branch, UTMB, USA
    Minerva Anestesiol 69:264-74. 2003
    ..Exogenous continuous low dose insulin infusion, beta blockade with propranolol and the use of the synthetic testosterone analog, oxandrolone are the most cost effective and least toxic pharmaco therapies to date...
  16. ncbi request reprint Combined anticoagulants ameliorate acute lung injury in sheep after burn and smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Clin Sci (Lond) 114:321-9. 2008
    ..In conclusion, the results provide definitive evidence that anticoagulant therapy may be a novel and effective treatment tool in the management of burn patients with concomitant smoke inhalation injury...
  17. doi request reprint Role of neuronal nitric oxide synthase in ovine sepsis model
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 32:253-7. 2009
    ..The above results suggest that the nNOS-derived NO may be involved in the pathophysiology of sepsis-related multiorgan dysfunction...
  18. ncbi request reprint L-arginine attenuates acute lung injury after smoke inhalation and burn injury in sheep
    Kazunori Murakami
    Department of Anesthesiology, University of Texas Medical Branch, TX 77555 0833, USA
    Shock 28:477-83. 2007
    ..Therefore, L-Arg supplementation improved gas exchange and pulmonary function in ovine after B + S injury via its, at least in part, effect on reduction of oxidative stress through the peroxynitrite pathway...
  19. ncbi request reprint Ketorolac attenuates cardiopulmonary derangements in sheep with combined burn and smoke inhalation injury
    Perenlei Enkhbaatar
    Department of Anesthesiology, University Texas Medical Branch and Shriners Hospital for Children Burn Unit, Galveston, TX 77555 0833, USA
    Clin Sci (Lond) 105:621-8. 2003
    ..These results suggest that ketorolac may ameliorate cardiopulmonary morbidity, at least in part, by inhibiting excessive NO...
  20. ncbi request reprint Growth hormone down-regulation of Interleukin-1beta and Interleukin-6 induced acute phase protein gene expression is associated with increased gene expression of suppressor of cytokine signal-3
    Xiaowu Wu
    Shriner s Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 19:314-20. 2003
    ..This study suggests that SOCS-3 plays an important role in the suppression of cytokine signaling by GH in down-regulating the acute phase response after injury...
  21. ncbi request reprint Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis
    Marc O Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, and Shriners Burn Hospital for Children, Galveston, USA
    Crit Care Med 34:2432-8. 2006
    ..To investigate the effects of recombinant human activated protein C (rhAPC) on pulmonary function in acute lung injury (ALI) resulting from smoke inhalation in association with a bacterial challenge...
  22. pmc Gene expression changes with time in skeletal muscle of severely burned children
    Mohan R K Dasu
    Department of Surgery, The University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, TX 77550, USA
    Ann Surg 241:647-53. 2005
    ..The purpose of this study was to identify gene-expression changes in leg muscle for up to 24 months after a severe thermal injury...
  23. ncbi request reprint Altering metabolism
    Clifford T Pereira
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    J Burn Care Rehabil 26:194-9. 2005
    ..This review article discusses these modulators of postburn metabolism...
  24. pmc Insulin increases resistance to burn wound infection-associated sepsis
    Gerd G Gauglitz
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, USA
    Crit Care Med 38:202-8. 2010
    ..This study was designed to determine the ability of insulin to improve outcome following a Pseudomonas aeruginosa wound infection in a rodent model of severe burn injury...
  25. ncbi request reprint Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, 610 Texas Ave, Galveston, TX 77555, USA
    Am J Physiol Heart Circ Physiol 285:H2430-6. 2003
    ..The results identify a major role for iNOS in mediating extrapulmonary comorbidity in a clinically relevant and severe trauma model and support the use of highly selective iNOS inhibitors as novel treatments in critical care medicine...
  26. ncbi request reprint Aerosolized alpha-tocopherol ameliorates acute lung injury following combined burn and smoke inhalation injury in sheep
    Naoki Morita
    Department of Anaesthesiology, The University of Texas Medical Branch, Galveston, Texas 77555 0833, USA
    Shock 25:277-82. 2006
    ..Vitamin E nebulization therapy improved the clinical responses to burn and smoke inhalation-induced acute lung injury...
  27. pmc Intensive insulin therapy improves insulin sensitivity and mitochondrial function in severely burned children
    Ricki Y Fram
    Metabolism Unit and Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 38:1475-83. 2010
    ..To institute intensive insulin therapy protocol in an acute pediatric burn unit and study the mechanisms underlying its benefits...
  28. ncbi request reprint Effects of early excision and aggressive enteral feeding on hypermetabolism, catabolism, and sepsis after severe burn
    David W Hart
    Department of Surgery, The University of Texas Medical Branch, Galveston, USA
    J Trauma 54:755-61; discussion 761-4. 2003
    ..We hypothesized that early burn excision and aggressive enteral feeding diminish hypermetabolism...
  29. ncbi request reprint Ceftazidime improves hemodynamics and oxygenation in ovine smoke inhalation injury and septic shock
    Marc O Maybauer
    Investigational Intensive Care Unit, University of Texas Medical Branch and Shriners Burns Hospital, 301 University Blvd, Galveston, TX 77555 0833, USA
    Intensive Care Med 33:1219-27. 2007
    ..To investigate ceftazidime in acute lung injury (ALI) and sepsis...
  30. ncbi request reprint Muscarinic receptor antagonist therapy improves acute pulmonary dysfunction after smoke inhalation injury in sheep
    Collette Jonkam
    Shriners Hospitals for Children and The University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 38:2339-44. 2010
    ....
  31. ncbi request reprint The effect of hepatocyte growth factor on gut mucosal apoptosis and proliferation, and cellular mediators after severe trauma
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, Galveston, TX 77550, USA
    Surgery 138:482-9. 2005
    ..The purpose of this study was to determine whether HGF can improve small-bowel homeostasis after injury and the cellular mechanisms by which these changes occur...
  32. ncbi request reprint Insulin decreases hepatic acute phase protein levels in severely burned children
    Xiaowu Wu
    Shriners Hospitals for Children and Department of Surgery, The University of Texas Medical Branch, Galveston, Tex 77550, USA
    Surgery 135:196-202. 2004
    ..Severe burn induces the hepatic acute phase response. In this study, we wondered whether continuous insulin treatment decreases acute phase protein levels in the severely burned...
  33. ncbi request reprint Body composition changes with time in pediatric burn patients
    Rene Przkora
    Department of Surgery, University of Texas Medical Branch, Texas, USA
    J Trauma 60:968-71; discussion 971. 2006
    ..Major trauma and burns are associated with whole body catabolism which can persist for 1 or more years after injury. This study investigates body composition in massively burned children for up to 2 years...
  34. ncbi request reprint The effect of growth hormone on gut mucosal homeostasis and cellular mediators after severe trauma
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas 77550, USA
    J Surg Res 127:183-9. 2005
    ..The purpose of this study was to determine whether growth hormone can improve small bowel homeostasis after injury and by which cellular mechanisms these changes occur...
  35. ncbi request reprint Aerosolized tissue plasminogen inhibitor improves pulmonary function in sheep with burn and smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 22:70-5. 2004
    ..The results provide evidence that clearance of airway obstructive cast material is crucial in managing acute respiratory distress syndrome resulting from combined burn and smoke inhalation injury...
  36. ncbi request reprint Novel ovine model of methicillin-resistant Staphylococcus aureus-induced pneumonia and sepsis
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, and Shriners Hospital for Children, Galveston, TX 77551, USA
    Shock 29:642-9. 2008
    ..The smoke inhalation alone had a little or no effect on these variables. This model closely mimics hyperdynamic human sepsis. The excessive production of NO may be extensively involved in the pathogenic process...
  37. ncbi request reprint Acute bronchial obstruction in sheep: histopathology and gland cytokine expression
    Robert A Cox
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Exp Lung Res 31:819-37. 2005
    ..05...
  38. pmc The effects of oxandrolone and exercise on muscle mass and function in children with severe burns
    Rene Przkora
    Shriners Hospitals for Children, 815 Market St, Galveston, TX 77550, USA
    Pediatrics 119:e109-16. 2007
    ..We hypothesized that oxandrolone, in combination with exercise, would increase lean body mass and muscle strength in severely burned children more than oxandrolone alone or exercise alone...
  39. ncbi request reprint Standard operating procedures for the clinical management of patients enrolled in a prospective study of Inflammation and the Host Response to Thermal Injury
    Geoffrey M Silver
    Department of Surgery, Loyola University Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Burn Care Res 28:222-30. 2007
    ..The SOPs are easily adaptable to other burn-related clinical protocols as well as to the routine daily management burn patients...
  40. ncbi request reprint Production of pro-inflammatory polypeptides by airway mucous glands and its potential significance
    Robert A Cox
    Department of Pathology, The University of Texas Medical Branch, and Shriners Burns Hospital, Galveston, TX, USA
    Pulm Pharmacol Ther 20:172-7. 2007
    ..In addition, a proinflammatory function of mucous glands might prove to be important in chronic lung diseases such as chronic bronchitis and asthma...
  41. pmc Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn
    Gerd G Gauglitz
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 94:1656-64. 2009
    ..The acute hypermetabolic response post-burn is associated with insulin resistance and hyperglycemia, significantly contributing to adverse outcome of these patients...
  42. ncbi request reprint Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555 0833, USA
    Am J Physiol Regul Integr Comp Physiol 285:R366-72. 2003
    ..The results of the present study show that nNOS may be involved in the pathogenesis of ALI after smoke inhalation injury followed by bacterial instillation in the airway...
  43. pmc Beta-blockade and growth hormone after burn
    David W Hart
    Department of Surgery, The University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Ann Surg 236:450-6; discussion 456-7. 2002
    ..To determine whether propranolol and growth hormone (GH) have additive effects to combat burn-induced catabolism...
  44. ncbi request reprint Modulation of types I and II acute phase reactants with insulin-like growth factor-1/binding protein-3 complex in severely burned children
    Marcus Spies
    Shriners Hospital for Children and Department of Surgery, The University Texas Medical Branch, Galveston 77550, USA
    Crit Care Med 30:83-8. 2002
    ..To determine whether 0.5 mg/kg insulin-like growth factor (IGF)-1/binding protein (IGFBP)-3, given intravenously, effectively alters the acute phase response in severely burned children...
  45. ncbi request reprint Modulation of inflammatory and catabolic responses in severely burned children by early burn wound excision in the first 24 hours
    Juan P Barret
    Department of Surgery, University of Texas Medical Branch, and Galveston Shriners Hospital, Galveston, USA
    Arch Surg 138:127-32. 2003
    ..Early burn wound excision modulates the hypermetabolic response in severe pediatric burn injuries...
  46. pmc Effects of interleukin-1alpha administration on intestinal ischemia and reperfusion injury, mucosal permeability, and bacterial translocation in burn and sepsis
    Tamer Tadros
    Shriners Burns Institute, Galveston, Texas, USA
    Ann Surg 237:101-9. 2003
    ..To evaluate the effect of interleukin-1alpha (IL-1alpha) on the mesenteric circulation, intestinal mucosal integrity, and bacterial translocation in a burn/endotoxemia chronic porcine model...
  47. ncbi request reprint P-selectin blockade fails to improve acute lung injury in sheep
    Abhijit Chandra
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX 77555, USA
    Clin Sci (Lond) 104:313-21. 2003
    ..In conclusion, although the anti-(P-selectin) antibody did not protect against lung injury during the initial 48 h of burn and smoke, it decreased some aspects of injury in the peripheral microcirculation...
  48. ncbi request reprint Modulation of the post-burn hypermetabolic state
    Jong O Lee
    University of Texas Medical Branch, Shriners Hospital for Children, Galveston, Tex, USA
    Nestle Nutr Workshop Ser Clin Perform Programme 8:39-49; discussion 49-56. 2003
  49. ncbi request reprint A novel animal model of sepsis after acute lung injury in sheep
    Kazunori Murakami
    Department of Anesthesiology, The University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX 77555, USA
    Crit Care Med 30:2083-90. 2002
    ..This often is a fatal complication. The aim of this study was to develop a standardized and reproducible model of hyperdynamic sepsis after smoke inhalation in sheep...
  50. ncbi request reprint Recovery from the hepatic acute phase response in the severely burned and the effects of long-term growth hormone treatment
    Suchmor Thomas
    Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Burns 30:675-9. 2004
    ..Administration of growth hormone (GH) to burned children decreases acute phase proteins and increases constitutive proteins when used during the acute hospitalization. Treatment during convalescence has not been examined...
  51. pmc Insulin resistance postburn: underlying mechanisms and current therapeutic strategies
    Gerd G Gauglitz
    Shriners Burns Hospital for Children, Galveston, Texas 77550, USA
    J Burn Care Res 29:683-94. 2008
    ..This review aims to discuss the mechanisms underlying insulin resistance induced hyperglycemia postburn and outlines current therapeutic strategies that are being used to modulate hyperglycemia after thermal trauma...
  52. pmc Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury
    Fiona D Saunders
    Investigational Intensive Care Unit, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Am J Physiol Lung Cell Mol Physiol 298:L427-36. 2010
    ....
  53. pmc Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity
    Dirk M Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children at Galveston, 301 University Blvd, Galveston, TX 77555 0833, USA
    Biochem Biophys Res Commun 377:786-91. 2008
    ..These findings suggest that ONOO(-) plays a pivotal role in the pathology of IL-2-induced pulmonary VLS, and that WW-85 may become a useful treatment option...
  54. ncbi request reprint Insulin attenuates the cytokine response in a burn wound infection model
    Rene Przkora
    Shriners Hospital for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550, USA
    Shock 27:205-8. 2007
    ..05). We conclude, that insulin treatment selectively modulates specific cytokines in a burn wound infection model...
  55. ncbi request reprint Characterization of the inflammatory response during acute and post-acute phases after severe burn
    Gerd G Gauglitz
    Shriners Hospital for Children, Galveston, Texas 77550, USA
    Shock 30:503-7. 2008
    ....
  56. pmc Extent and magnitude of catecholamine surge in pediatric burned patients
    Gabriela A Kulp
    Shriners Hospitals for Children, Department of Surgery, University Texas Medical Branch Galveston, Texas 77550, USA
    Shock 33:369-74. 2010
    ..Inflammatory cytokines show a similar profile during the study period. Our study gives clinicians a useful insight into the extent and magnitude of CA elevation to better design treatment strategies...
  57. pmc Role of calcitonin gene-related peptide (CGRP) in ovine burn and smoke inhalation injury
    Matthias Lange
    Investigational Intensive Care Unit, Dept of Anesthesiology, The Univ of Texas Medical Branch, 301 Univ Blvd, Galveston, TX 77550, USA
    J Appl Physiol (1985) 107:176-84. 2009
    ..Future studies will be needed to clarify the potential therapeutic benefit for patients with this injury...
  58. pmc Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment
    Rene Przkora
    Department of Surgery, University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, TX 77550, USA
    Ann Surg 242:384-9, discussion 390-1. 2005
    ..To study the efficacy of oxandrolone in severely burned children for 12 months after burn and 12 months after the drug was discontinued...
  59. pmc Energy expenditure and caloric balance after burn: increased feeding leads to fat rather than lean mass accretion
    David W Hart
    University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas 77550 1220, USA
    Ann Surg 235:152-61. 2002
    ..Resting energy expenditure (REE) is commonly measured in critical illness to determine caloric "demands" and thus nutritive needs...
  60. ncbi request reprint Effect of a combination therapy between IL-12 and soluble IL-4 receptor (sIL-4R) on Candida albicans and herpes simplex virus type I infections in thermally injured mice
    Makiko Kobayashi
    Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Can J Microbiol 48:886-94. 2002
    ..These results suggest that therapeutic treatment with a combination of IL-12 and sIL-4R may be effective by inducing type 1 T-cell responses in thermally injured mice exposed to large amounts of HSV-1 or C. albicans...
  61. ncbi request reprint The inhibition of inducible nitric oxide synthase in ovine sepsis model
    Perenlei Enkhbaatar
    Department of Anesthesiology, Pathology, Pediatrics and Surgery, University Texas Medical Branch, Galveston, TX 77555, USA
    Shock 25:522-7. 2006
    ..The results of present study show that iNOS may be partially involved in the pathogenesis of acute lung injury induced by smoke inhalation followed by bacterial instillation in the airway...
  62. ncbi request reprint The pharmacologic modulation of the hypermetabolic response to burns
    Clifford T Pereira
    Department of Surgery, University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, Texas, USA
    Adv Surg 39:245-61. 2005
    ..Adverse effects, cost benefits, and the ease of administration and monitoring must be examined when considering the possibility of their use...
  63. ncbi request reprint Post burn muscle wasting and the effects of treatments
    Clifford Pereira
    Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Int J Biochem Cell Biol 37:1948-61. 2005
    ..This paper aims to review the current understanding of post-burn muscle proteolysis and the effects of clinical and pharmacological strategies currently being studied to reverse it curb these debilitating sequelae of severe burns...
  64. ncbi request reprint Effects of the bradykinin B2 receptor antagonist icatibant on microvascular permeability after thermal injury in sheep
    Collette C Jonkam
    Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospital for Children, 610 Texas Avenue, Galveston, TX 77551, USA
    Shock 28:704-9. 2007
    ....
  65. ncbi request reprint Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients
    Dennis C Gore
    Blocker Burn Unit, University of Texas Medical Branch, Galveston, USA
    Crit Care Med 30:2438-42. 2002
    ..The purpose of this study was to assess if hyperglycemia influences energy expenditure or the extent of muscle protein catabolism in severely burned adults...
  66. pmc Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury
    Melanie G Cree
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas, USA
    J Burn Care Res 29:585-94. 2008
    ..Insulin resistance following burn injury is accompanied by decreased insulin signaling and increased protein kinase C-beta activation. The best metabolic predictor of insulin resistance in burned patients was palmitate oxidation...
  67. pmc Opposite effects of prostacyclin on hepatic blood flow and oxygen consumption after burn and sepsis
    Tamer Tadros
    Shriners Burns Institute and The University of Texas Medical Branch, Galveston, TX, USA
    Ann Surg 239:67-74. 2004
    ..Burn and sepsis are associated with hepatic ischemia and reperfusion injury. This study examines the hypothesis that postburn treatment with the vasodilator prostacyclin would be beneficial for hepatic perfusion and oxygenation...
  68. pmc Clinical microfluidics for neutrophil genomics and proteomics
    Kenneth T Kotz
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:1042-7. 2010
    ....
  69. ncbi request reprint Recombinant human growth hormone increases thyroid hormone-binding sites in recovering severely burned children
    Cara M Connolly
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 19:399-403. 2003
    ..rhGH significantly increases THBS in severely burned children, possibly through increases in serum Alb and PreAlb. The increases in circulating thyroxine observed in this group may be involved in the attenuation of growth arrest...
  70. doi request reprint Inhalation injury in children: a 10 year experience at Shriners Hospitals for Children
    Tina L Palmieri
    Department of Burn Surgery, Shriners Hospitals for Children, Northern California, USA
    J Burn Care Res 30:206-8. 2009
    ..Further studies are required to standardize diagnostic criteria for inhalation injury and to optimize the treatment of children with inhalation injury...
  71. ncbi request reprint Inverse regulation of protein turnover and amino acid transport in skeletal muscle of hypercatabolic patients
    Gianni Biolo
    Shriners Burns Hospital, 815 Market Street, Galveston, TX 77550, USA
    J Clin Endocrinol Metab 87:3378-84. 2002
    ..In contrast, transmembrane transport in the inward direction is impaired relatively to the increased delivery of circulating amino acid to skeletal muscle secondary to accelerated blood flow...
  72. pmc The role of hyperglycemia in burned patients: evidence-based studies
    Gabriel A Mecott
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA
    Shock 33:5-13. 2010
    ....
  73. ncbi request reprint An increase in the susceptibility of burned patients to infectious complications due to impaired production of macrophage inflammatory protein 1 alpha
    Makiko Kobayashi
    Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    J Immunol 169:4460-6. 2002
    ..Burned patients seemed to be more susceptible to infectious complications when the production of MIP-1alpha was impaired...
  74. ncbi request reprint Gene expression profiles and protein balance in skeletal muscle of burned children after beta-adrenergic blockade
    David N Herndon
    Department of Surgery, The University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
    Am J Physiol Endocrinol Metab 285:E783-9. 2003
    ..The upregulation of genes involved in muscle metabolism correlates well with the increase in net protein balance across the leg...
  75. doi request reprint Assessment of vascular permeability in an ovine model of acute lung injury and pneumonia-induced Pseudomonas aeruginosa sepsis
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX, USA
    Crit Care Med 36:1284-9. 2008
    ..To assess the time changes and mechanism of pulmonary and peripheral vascular permeability in sheep with acute lung injury and sepsis...
  76. ncbi request reprint Enteral resuscitation of burn shock using World Health Organization oral rehydration solution: a potential solution for mass casualty care
    Michael W Michell
    Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555 0801, USA
    J Burn Care Res 27:819-25. 2006
    ..Intestinal absorption rates after burn injury are sufficient to resuscitate a 40% TBSA burn...
  77. ncbi request reprint Effect of transforming growth factor-beta neutralization on survival and bacterial clearance in a murine model of Pseudomonas aeruginosa burn wound infection
    Zhiyu Huang
    Shriners Hospitals for Children, Galveston, Texas, USA
    J Burn Care Res 27:682-7. 2006
    ..Our data suggest that neutralization of TGF-beta at 4 days after burn injury in mice improves local and systemic clearance of P. aeruginosa and enhances survival after P. aeruginosa challenge...
  78. ncbi request reprint Recovery of labeled CO2 from acetate in severely burned children
    Ricki Y Fram
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    Am J Physiol Endocrinol Metab 293:E1726-9. 2007
    ..Minimal correction of expired CO(2) data is needed in this circumstance to quantify fatty acid oxidation using (13)C-labeled fatty acids...
  79. ncbi request reprint The factor age and the recovery of severely burned children
    Rene Przkora
    Shriners Hospital for Children and Department of Surgery, University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
    Burns 34:41-4. 2008
    ..It is not known if the recovery of pediatric burn patients is age-dependent. The aim of this study was to investigate the effect of age on the recovery of body composition of severely burned children...
  80. ncbi request reprint Gene expression analysis in burn wounds of rats
    Marcus Spies
    Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston 77550, USA
    Am J Physiol Regul Integr Comp Physiol 283:R918-30. 2002
    ..The functional gene cluster detected and their time appearance matched the time sequence known to occur in burn wound healing...
  81. pmc Pathogenic role of macrophages in intradermal infection of methicillin-resistant Staphylococcus aureus in thermally injured mice
    Akira Asai
    The University of Texas Medical Branch, Department of Internal Medicine, Galveston, TX 77555 0435, USA
    Infect Immun 78:4311-9. 2010
    ..M2Mφ have been described as inhibitor cells for Mφ conversion from resident Mφ to M1Mφ...
  82. pmc gamma-Tocopherol nebulization by a lipid aerosolization device improves pulmonary function in sheep with burn and smoke inhalation injury
    Atsumori Hamahata
    University of Texas Medical Branch, Galveston, TX 77555, USA
    Free Radic Biol Med 45:425-33. 2008
    ..Pulmonary gT delivery along with a FO source may be a novel effective treatment strategy in management of patients with acute lung injury...
  83. ncbi request reprint Interaction of exogenous liposomal insulin-like growth factor-I cDNA gene transfer with growth factors on collagen expression in acute wounds
    Marc G Jeschke
    Shriners Hospital for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Wound Repair Regen 13:269-77. 2005
    ..We conclude that liposomal IGF-I gene transfer can accelerate wound healing without causing an increase in types I and III collagen expression...
  84. ncbi request reprint Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation
    Mohan R K Dasu
    Shriners Hospitals for Children, and Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Pathol 202:476-85. 2004
    ....
  85. ncbi request reprint Review paper: burn coverage technologies: current concepts and future directions
    Clifford Pereira
    Department of Surgery, Harbor UCLA Medical Center, Torrance, Los Angeles, California 90502, USA
    J Biomater Appl 22:101-21. 2007
  86. ncbi request reprint The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, 610 Texas Ave, Galveston, TX 77555, USA
    Am J Respir Crit Care Med 167:1021-6. 2003
    ..The results provide definitive evidence that iNOS is a key mediator of pulmonary pathology in sheep with ARDS resulting from combined burn and smoke inhalation injury...
  87. doi request reprint Skull burns resulting in calvarial defects: cognitive and affective outcomes
    Neema Nayeb-Hashemi
    School of Medicine, University of Texas Medical Branch, Galveston, TX, United States
    Burns 35:237-46. 2009
    ..To determine the extent of cognitive and affective difficulties experienced in children with full thickness burns of the calvaria caused by flame and electrical sources...
  88. ncbi request reprint Outcome measures in burn care. Is mortality dead?
    Clifford Pereira
    Department of Surgery, Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Burns 30:761-71. 2004
    ..We further discuss long-term outcome measures (such as, quality of life measures, exercise tolerance and evaluation of return to pre-burn activities) that are now becoming of equal importance as the numbers of burn survivors increase...
  89. ncbi request reprint Role of TNF-alpha in gut mucosal changes after severe burn
    Marcus Spies
    Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Gastrointest Liver Physiol 283:G703-8. 2002
    ..Changes in gut mucosal homeostasis after severe burn are affected, in part, by the activation of apoptosis by TNF-alpha-TNFR interaction...
  90. ncbi request reprint Effects of delayed wound excision and grafting in severely burned children
    Wu Xiao-Wu
    Shriners Hospitals for Children, 815 Market St, Galveston, TX 77550, USA
    Arch Surg 137:1049-54. 2002
    ..We hypothesized that the patients with delayed wound excision and grafting would experience deleterious outcomes...
  91. pmc Appearance of monocyte chemoattractant protein 1 (MCP-1) early after thermal injury: role in the subsequent development of burn-associated type 2 T-cell responses
    Katsunori Furukawa
    Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas 77555 0435, USA
    Ann Surg 236:112-9. 2002
    ..To determine whether monocyte chemoattractant protein-1 (MCP-1), which initiates subsequent development of burn-associated type 2 T cells, is produced in mice early after thermal injury...
  92. ncbi request reprint The effects of gammahydroxybutyrate on hypermetabolism and wound healing in a rat model of large thermal injury
    Kevin D Murphy
    Northern Ireland Plastic and Maxillofacial Service, The Ulster Hospital, Dundonald, Belfast, Ireland
    J Trauma 63:1099-107. 2007
    ..In this study, improvement in GH levels in turn has been shown to accelerate wound healing...
  93. ncbi request reprint Effects of severe smoke inhalation injury and septic shock on global hemodynamics and microvascular blood flow in sheep
    Dirk M Maybauer
    Departments of Anesthesiology and Surgery, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas, U S A
    Shock 26:489-95. 2006
    ..aeruginosa infusion. The results of this study reflect the complex pathophysiological variances of the combined injury and may provide a basis for future investigations for the treatment of this kind of injury...
  94. pmc Insulin treatment improves the systemic inflammatory reaction to severe trauma
    Marc G Jeschke
    Klinik und Poliklinik für Chirurgie, Klinikum der Universitat Regensburg, Germany
    Ann Surg 239:553-60. 2004
    ..Determine the effect of insulin on the systemic inflammatory response, pro- and anti-inflammatory cytokines and hepatic acute-phase-response in severely burned pediatric patients...
  95. ncbi request reprint Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep
    Kazunori Murakami
    Department of Anesthesiology, The University of Texas Medical Branch, and Shriners Burns Hospital, Galveston 77555, USA
    Shock 18:236-41. 2002
    ..Histological changes consisting of cellular infiltrates, lung edema, congestion, and cast formation were reduced by heparin. These data suggest that nebulized inhaled heparin is a beneficial therapy for sepsis-induced ALI...
  96. pmc IGF-I/IGFBP-3 equilibrates ratios of pro- to anti-inflammatory cytokines, which are predictors for organ function in severely burned pediatric patients
    Marc G Jeschke
    University of Regensburg, Department of Surgery, Regensburg, Germany
    Mol Med 8:238-46. 2002
    ..Furthermore, insulin-like growth factor-I (IGF-I) in combination with its principle binding protein (IGFBP-3) equilibrates pro- to anti-inflammatory cytokine ratios and improves homeostasis of severely burned pediatric patients...
  97. ncbi request reprint Interferon-gamma production is suppressed in thermally injured mice: decreased production of regulatory cytokines and corresponding receptors
    Tracy E Toliver-Kinsky
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston 77555 0591, USA
    Shock 18:322-30. 2002
    ..We conclude that burn-associated suppression of IFN-gamma is due to deficient production of inducing factors and their receptors, leading to severe impairments in cellular IFN-gamma induction pathways...
  98. ncbi request reprint Evaluation of hyperdynamic resuscitation in 60% TBSA burn-injured sheep
    Alia Shah
    Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Shock 21:86-92. 2004
    ..5 +/- 1 mmol/L) and Parkland (+1.5 +/- 1.7 mmol/L), and declined to -4.0 +/- 3.6 mmol/L in HD-Fluid group (P = 0.036). We conclude that there may be no benefit to using hyperdynamic regimens for the initial resuscitation of burn injury...
  99. ncbi request reprint Impaired zinc and copper status in children with burn injuries: need to reassess nutritional requirements
    V Saroja Voruganti
    Division of Nutritional Sciences, University of Texas at Austin, Austin, TX, USA
    Burns 31:711-6. 2005
    ..We demonstrate that burn injury in children results in low plasma levels of Zn and Cu that are inadequately compensated during hospitalization...
  100. pmc Human mitochondrial oxidative capacity is acutely impaired after burn trauma
    Melanie G Cree
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA
    Am J Surg 196:234-9. 2008
    ..Mitochondrial proteins and genes are damaged after burn injury in animals and are assessed in human burn patients in this study...
  101. ncbi request reprint A combination therapy using IL-12 and soluble IL-4 receptor on herpes simplex virus Type 1 infection in a human-SCID chimera model of thermal injury
    Tatsushi Katakura
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Clin Immunol 105:363-70. 2002
    ..These results indicate that HSV-1 infection in patient PBL-SCID chimeras was therapeutically controlled by the inducer of type 1 T cell responses and the inhibitor of type 2 T cell responses in combination...

Research Grants17

  1. Effect of Insulin and Propranolol on Post Burn Hypermetabolism and Inflammation
    David N Herndon; Fiscal Year: 2010
    ..Project Description Page 7 ..
  2. Effect of Insulin and Propranolol on Post Burn Hypermetabolism and Inflammation
    David N Herndon; Fiscal Year: 2011
    ....
  3. Effect of Insulin and Propranolol on Post Burn Hypermetabolism and Inflammation
    David N Herndon; Fiscal Year: 2010
    ....
  4. Effect of Insulin and Propranolol on Post Burn Hypermetabolism and Inflammation
    David Herndon; Fiscal Year: 2009
    ....
  5. Assess Anabolic Agents/Exercise in Burned Children
    David Herndon; Fiscal Year: 2007
    ....
  6. POSTDOCTORAL TRAINING IN TRAUMA AND BURNS
    David Herndon; Fiscal Year: 2007
    ..The postdoctoral fellows' contributions from both animal and human studies have led to the current use of new drugs and therapies to improve morbidity, long term outcomes and in integrating severely burned children back into society. ..
  7. MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSE
    David Herndon; Fiscal Year: 2005
    ..Identifying the mechanisms by which these changes take place will provide further basis and support for the use of anabolic agent therapy for catabolic burned children. ..
  8. MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSE
    David Herndon; Fiscal Year: 2004
    ..Identifying the mechanisms by which these changes take place will provide further basis and support for the use of anabolic agent therapy for catabolic burned children. ..
  9. MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSE
    David Herndon; Fiscal Year: 2003
    ..Identifying the mechanisms by which these changes take place will provide further basis and support for the use of anabolic agent therapy for catabolic burned children. ..
  10. MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSE
    David Herndon; Fiscal Year: 2002
    ..Identifying the mechanisms by which these changes take place will provide further basis and support for the use of anabolic agent therapy for catabolic burned children. ..
  11. MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSE
    David Herndon; Fiscal Year: 2001
    ..The studies are therefore relevant to the treatment of massively burned patients of all ages in order to shorten hospital stay, decrease their hospital morbidity and provide improved functional outcome following this devastating injury. ..
  12. MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSE
    David Herndon; Fiscal Year: 2000
    ..The studies are therefore relevant to the treatment of massively burned patients of all ages in order to shorten hospital stay, decrease their hospital morbidity and provide improved functional outcome following this devastating injury. ..
  13. MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSE
    David Herndon; Fiscal Year: 1999
    ..The studies are therefore relevant to the treatment of massively burned patients of all ages in order to shorten hospital stay, decrease their hospital morbidity and provide improved functional outcome following this devastating injury. ..
  14. Effect of Insulin and Propranolol on Post Burn Hypermetabolism and Inflammation
    David N Herndon; Fiscal Year: 2010
    ....